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2MOA
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SOLUTION NMR STRUCTURE OF PEPTIDE IMI1 (PEAK 2)
Descriptor:Alpha-conotoxin ImI
Authors:Heinis, C., Chen, S.
Deposit date:2014-04-24
Release date:2014-09-24
Last modified:2014-11-05
Method:SOLUTION NMR
Cite:Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
3QN7
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POTENT AND SELECTIVE BICYCLIC PEPTIDE INHIBITOR (UK18) OF HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR(UPA)
Descriptor:Urokinase-type plasminogen activator, Bicyclic peptide inhibitor, 1,3,5-tris(bromomethyl)benzene
Authors:Angelini, A., Cendron, L., Touati, J., Winter, G., Zanotti, G., Heinis, C.
Deposit date:2011-02-08
Release date:2012-02-15
Last modified:2013-04-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Bicyclic peptide inhibitor reveals large contact interface with a protease target
Acs Chem.Biol., 7, 2012
4GLY
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HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR UPA IN COMPLEX WITH THE TWO-DISULFIDE BRIDGE PEPTIDE UK504
Descriptor:Urokinase-type plasminogen activator, BICYCLIC PEPTIDE INHIBITOR UK504, SULFATE ION, ...
Authors:Buth, S.A., Leiman, P.G., Chen, S., Heinis, C.
Deposit date:2012-08-15
Release date:2013-05-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.518 Å)
Cite:Bicyclic Peptide Ligands Pulled out of Cysteine-Rich Peptide Libraries.
J.Am.Chem.Soc., 135, 2013
4JK5
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HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) IN COMPLEX WITH A BICYCLIC PEPTIDE INHIBITOR (UK18-D-SER)
Descriptor:Urokinase-type plasminogen activator, bicyclic peptide UK18-D-Ser, uPA inhibitor, ...
Authors:Buth, S.A., Leiman, P.G., Chen, S., Heinis, C.
Deposit date:2013-03-09
Release date:2013-07-17
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Improving binding affinity and stability of Peptide ligands by substituting glycines with d-amino acids.
Chembiochem, 14, 2013
4JK6
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HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) IN COMPLEX WITH A BICYCLIC PEPTIDE INHIBITOR (UK18-D-ABA)
Descriptor:Urokinase-type plasminogen activator, bicyclic peptide UK18-D-Aba inhibitor of uPA, SULFATE ION, ...
Authors:Buth, S.A., Leiman, P.G., Chen, S., Heinis, C.
Deposit date:2013-03-09
Release date:2013-07-17
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Improving binding affinity and stability of Peptide ligands by substituting glycines with d-amino acids.
Chembiochem, 14, 2013
4MNV
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CRYSTAL STRUCTURE OF BICYCLIC PEPTIDE UK729 BOUND AS AN ACYL-ENZYME INTERMEDIATE TO UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA)
Descriptor:Urokinase-type plasminogen activator chain B, acyl-enzyme intermediate of bicyclic peptide UK729, SULFATE ION, ...
Authors:Chen, S., Pojer, F., Heinis, C.
Deposit date:2013-09-11
Release date:2014-02-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Peptide ligands stabilized by small molecules.
Angew.Chem.Int.Ed.Engl., 53, 2014
4MNW
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CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK749
Descriptor:Urokinase-type plasminogen activator chain B, bicyclic peptide UK749, SULFATE ION, ...
Authors:Chen, S., Pojer, F., Heinis, C.
Deposit date:2013-09-11
Release date:2014-02-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Peptide ligands stabilized by small molecules.
Angew.Chem.Int.Ed.Engl., 53, 2014
4MNX
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CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK811
Descriptor:Urokinase-type plasminogen activator chain B, bicyclic peptide UK811, SULFATE ION, ...
Authors:Chen, S., Pojer, F., Heinis, C.
Deposit date:2013-09-11
Release date:2014-02-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Peptide ligands stabilized by small molecules.
Angew.Chem.Int.Ed.Engl., 53, 2014
4MNY
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CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK903
Descriptor:Urokinase-type plasminogen activator chain B, bicyclic peptide UK903, SULFATE ION, ...
Authors:Chen, S., Pojer, F., Heinis, C.
Deposit date:2013-09-11
Release date:2014-02-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Peptide ligands stabilized by small molecules.
Angew.Chem.Int.Ed.Engl., 53, 2014
4OS1
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CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK601 (BICYCLIC 1)
Descriptor:Urokinase-type plasminogen activator, bicyclic peptide UK601 (bicyclic 1), SULFATE ION, ...
Authors:Chen, S., Pojer, F., Heinis, C.
Deposit date:2014-02-12
Release date:2014-09-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
4OS2
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CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK602 (BICYCLIC 1)
Descriptor:Urokinase-type plasminogen activator, bicyclic peptide UK602 (bicyclic 1), SULFATE ION, ...
Authors:Chen, S., Pojer, F., Heinis, C.
Deposit date:2014-02-12
Release date:2014-09-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
4OS4
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CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK603 (BICYCLIC 1)
Descriptor:Urokinase-type plasminogen activator, bicyclic peptide UK603 (bicyclic 1), SULFATE ION, ...
Authors:Chen, S., Pojer, F., Heinis, C.
Deposit date:2014-02-12
Release date:2014-09-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
4OS5
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CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK603 (BICYCLIC 2)
Descriptor:Urokinase-type plasminogen activator, bicyclic peptide UK603 (bicyclic 2), SULFATE ION
Authors:Chen, S., Pojer, F., Heinis, C.
Deposit date:2014-02-12
Release date:2014-09-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
4OS6
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CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK604 (BICYCLIC 2)
Descriptor:Urokinase-type plasminogen activator, bicyclic peptide UK604 (bicyclic 2), SULFATE ION, ...
Authors:Chen, S., Pojer, F., Heinis, C.
Deposit date:2014-02-12
Release date:2014-09-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
4OS7
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CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK607 (BICYCLIC)
Descriptor:Urokinase-type plasminogen activator, bicyclic peptide UK607 (bicyclic), SULFATE ION, ...
Authors:Chen, S., Pojer, F., Heinis, C.
Deposit date:2014-02-12
Release date:2014-09-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014