Author results

4C4Q
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CRYO-EM MAP OF THE CSFV IRES IN COMPLEX WITH THE SMALL RIBOSOMAL 40S SUBUNIT AND DHX29
Descriptor:INTERNAL RIBOSOMAL ENTRY SITE
Authors:Hashem, Y., desGeorges, A., Dhote, V., Langlois, R., Liao, H.Y., Grassucci, R.A., Pestova, T.V., Hellen, C.U.T., Frank, J.
Deposit date:2013-09-07
Release date:2013-10-30
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (8.5 Å)
Cite:Hepatitis-C-Virus-Like Internal Ribosome Entry Sites Displace Eif3 to Gain Access to the 40S Subunit
Nature, 503, 2013
4V8M
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HIGH-RESOLUTION CRYO-ELECTRON MICROSCOPY STRUCTURE OF THE TRYPANOSOMA BRUCEI RIBOSOME
Descriptor:40S RIBOSOMAL PROTEIN S3A, PUTATIVE, 40S RIBOSOMAL PROTEIN S4, ...
Authors:Hashem, Y., des Georges, A., Fu, J., Buss, S.N., Jossinet, F., Jobe, A., Zhang, Q., Liao, H.Y., Grassucci, R.A., Bajaj, C., Westhof, E., Madison-Antenucci, S., Frank, J.
Deposit date:2012-12-09
Release date:2014-07-09
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (5.57 Å)
Cite:High-Resolution Cryo-Electron Microscopy Structure of the Trypanosoma Brucei Ribosome.
Nature, 494, 2013
3J5S
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ETTA BINDS TO RIBOSOME EXIT SITE AND REGULATES TRANSLATION BY RESTRICTING RIBOSOME AND TRNA DYNAMICS
Descriptor:16S ribosomal RNA, 23S ribosomal RNA, P-site tRNA FMet, ...
Authors:Hashem, Y.
Deposit date:2013-11-15
Release date:2014-01-08
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (7.5 Å)
Cite:EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics.
Nat.Struct.Mol.Biol., 21, 2014
3IZ4
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MODIFIED E. COLI TMRNA IN THE RESUME STATE WITH THE TRNA-LIKE DOMAIN IN THE RIBOSOMAL P SITE INTERACTING WITH THE SMPB
Descriptor:Modified E. coli transfer-messenger RNA, SsrA-binding protein
Authors:Hashem, Y., Fu, J., Frank, J.
Deposit date:2010-09-21
Release date:2010-10-20
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (13.6 Å)
Cite:Visualizing the transfer-messenger RNA as the ribosome resumes translation.
Embo J., 29, 2010
3J5Y
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STRUCTURE OF THE MAMMALIAN RIBOSOMAL PRE-TERMINATION COMPLEX ASSOCIATED WITH ERF1-ERF3-GDPNP
Descriptor:Eukaryotic peptide chain release factor subunit 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, 5'-R(*AP*UP*UP*GP*UP*AP*AP*AP*AP*A)-3', ...
Authors:des Georges, A., Hashem, Y., Unbehaun, A., Grassucci, R.A., Taylor, D., Hellen, C.U.T., Pestova, T.V., Frank, J.
Deposit date:2013-11-21
Release date:2013-12-25
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9.7 Å)
Cite:Structure of the mammalian ribosomal pre-termination complex associated with eRF1*eRF3*GDPNP.
Nucleic Acids Res., 42, 2014
3JBN
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CRYO-ELECTRON MICROSCOPY RECONSTRUCTION OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO P-TRNA
Descriptor:18S ribosomal RNA, P-tRNA, 40S ribosomal protein uS3, ...
Authors:Sun, M., Li, W., Blomqvist, K., Das, S., Hashem, Y., Dvorin, J.D., Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
3JBO
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CRYO-ELECTRON MICROSCOPY RECONSTRUCTION OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO P/E-TRNA
Descriptor:18S ribosomal RNA, P/E-tRNA, 40S ribosomal protein uS12, ...
Authors:Sun, M., Li, W., Blomqvist, K., Das, S., Hashem, Y., Dvorin, J.D., Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
3JBP
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CRYO-ELECTRON MICROSCOPY RECONSTRUCTION OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO E-TRNA
Descriptor:18S ribosomal RNA, E-tRNA, 40S ribosomal protein uS3, ...
Authors:Sun, M., Li, W., Blomqvist, K., Das, S., Hashem, Y., Dvorin, J.D., Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
5A5T
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STRUCTURE OF MAMMALIAN EIF3 IN THE CONTEXT OF THE 43S PREINITIATION COMPLEX
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E, ...
Authors:des-Georges, A., Dhote, V., Kuhn, L., Hellen, C.U.T., Pestova, T.V., Frank, J., Hashem, Y.
Deposit date:2015-06-21
Release date:2015-09-09
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Structure of Mammalian Eif3 in the Context of the 43S Preinitiation Complex.
Nature, 525, 2015
5A5U
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STRUCTURE OF MAMMALIAN EIF3 IN THE CONTEXT OF THE 43S PREINITIATION COMPLEX
Descriptor:EUKARYOTIC INITIATION FACTOR 3, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I
Authors:des-Georges, A., Dhote, V., Kuhn, L., Hellen, C.U.T., Pestova, T.V., Frank, J., Hashem, Y.
Deposit date:2015-06-21
Release date:2015-09-09
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Structure of Mammalian Eif3 in the Context of the 43S Preinitiation Complex.
Nature, 525, 2015
5K0Y
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M48S LATE-STAGE INITIATION COMPLEX, PURIFIED FROM RABBIT RETICULOCYTES LYSATES, DISPLAYING EIF2 TERNARY COMPLEX AND EIF3 I AND G SUBUNITS RELOCATED TO THE INTERSUBUNIT FACE
Descriptor:tRNA, 18S ribosomal RNA, mRNA, ...
Authors:Simonetti, A., Brito Querido, J., Myasnikov, A.G., Mancera-Martinez, E., Renaud, A., Kuhn, L., Hashem, Y.
Deposit date:2016-05-17
Release date:2016-07-13
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Mol.Cell, 63, 2016
5K1H
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EIF3B RELOCATED TO THE INTERSUBUNIT FACE TO INTERACT WITH EIF1 AND BELOW THE EIF2 TERNARY-COMPLEX. FROM THE STRUCTURE OF A PARTIAL YEAST 48S PREINITIATION COMPLEX IN CLOSED CONFORMATION.
Descriptor:Eukaryotic translation initiation factor 3 subunit B, eIF3a C-terminal tail
Authors:Simonetti, A., Brito Querido, J., Myasnikov, A.G., Mancera-Martinez, E., Renaud, A., Kuhn, L., Hashem, Y.
Deposit date:2016-05-18
Release date:2016-07-13
Last modified:2018-01-31
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Mol.Cell, 63, 2016
5LI0
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70S RIBOSOME FROM STAPHYLOCOCCUS AUREUS
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Khusainov, I., Vicens, Q., Bochler, A., Grosse, F., Myasnikov, A., Menetret, J.F., Chicher, J., Marzi, S., Romby, P., Yusupova, G., Yusupov, M., Hashem, Y.
Deposit date:2016-07-13
Release date:2016-12-28
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the 70S ribosome from human pathogen Staphylococcus aureus.
Nucleic Acids Res., 44, 2016
5ND8
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HIBERNATING RIBOSOME FROM STAPHYLOCOCCUS AUREUS (UNROTATED STATE)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Khusainov, I., Vicens, Q., Ayupov, R., Usachev, K., Myasnikov, A., Simonetti, A., Validov, S., Kieffer, B., Yusupova, G., Yusupov, M., Hashem, Y.
Deposit date:2017-03-07
Release date:2017-06-28
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.
EMBO J., 36, 2017
5ND9
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HIBERNATING RIBOSOME FROM STAPHYLOCOCCUS AUREUS (ROTATED STATE)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Khusainov, I., Vicens, Q., Ayupov, R., Usachev, K., Myasnikov, A., Simonetti, A., Validov, S., Kieffer, B., Yusupova, G., Yusupov, M., Hashem, Y.
Deposit date:2017-03-07
Release date:2017-06-28
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.
EMBO J., 36, 2017
5OPT
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STRUCTURE OF KSRP IN CONTEXT OF TRYPANOSOMA CRUZI 40S
Descriptor:Activated protein kinase C receptor, putative, Ribosomal protein S29, ...
Authors:Brito Querido, J., Mancera-Martinez, E., Vicens, Q., Bochler, A., Chicher, J., Simonetti, A., Hashem, Y.
Deposit date:2017-08-10
Release date:2017-11-15
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.
Structure, 25, 2017
5OSG
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STRUCTURE OF KSRP IN CONTEXT OF LEISHMANIA DONOVANI 80S
Descriptor:RNA binding protein, putative, 18S rRNA, ...
Authors:Brito Querido, J., Mancera-Martinez, E., Vicens, Q., Bochler, A., Chicher, J., Simonetti, A., Hashem, Y.
Deposit date:2017-08-17
Release date:2017-11-15
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.
Structure, 25, 2017
6GQ1
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CRYO-EM RECONSTRUCTION OF YEAST 80S RIBOSOME IN COMPLEX WITH MRNA, TRNA AND EEF2 (GMPPCP/SORDARIN)
Descriptor:Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA, 5.8S ribosomal RNA, ...
Authors:Pellegrino, S., Demeshkina, N., Mancera-Martinez, E., Melnikov, S., Simonetti, A., Myasnikov, A., Yusupov, M., Yusupova, G., Hashem, Y.
Deposit date:2018-06-07
Release date:2018-07-11
Last modified:2018-08-08
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
6GQB
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CRYO-EM RECONSTRUCTION OF YEAST 80S RIBOSOME IN COMPLEX WITH MRNA, TRNA AND EEF2 (GDP+ALF4/SORDARIN)
Descriptor:Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA, 5S ribosomal RNA, ...
Authors:Pellegrino, S., Yusupov, M., Yusupova, G., Hashem, Y.
Deposit date:2018-06-07
Release date:2018-07-11
Last modified:2018-11-28
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
6GQV
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CRYO-EM RECOSNTRUCTION OF YEAST 80S RIBOSOME IN COMPLEX WITH MRNA, TRNA AND EEF2 (GMPPCP)
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Pellegrino, S., Yusupov, M., Yusupova, G., Hashem, Y.
Deposit date:2018-06-08
Release date:2018-07-11
Last modified:2018-08-08
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
4FIN
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CRYSTAL STRUCTURE OF ETTA (FORMERLY YJJK) - AN E. COLI ABC-TYPE ATPASE
Descriptor:EttA (YjjK) ABCF family protein, SULFATE ION, CITRIC ACID, ...
Authors:Smith, P., Yuan, Y., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2012-06-09
Release date:2013-07-03
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The ABC-F protein EttA gates ribosome entry into the translation elongation cycle.
Nat.Struct.Mol.Biol., 21, 2014
5NKO
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SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF S. AUREUS HIBERNATING PROMOTING FACTOR (CTD-SAHPF)
Descriptor:Ribosome hibernation promotion factor
Authors:Usachev, K.S., Khusainov, I.S., Ayupov, R.K., Validov, S.Z., Kieffer, B., Yusupov, M.M.
Deposit date:2017-03-31
Release date:2017-07-05
Last modified:2017-07-26
Method:SOLUTION NMR
Cite:Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.
EMBO J., 36, 2017
3J8B
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MODEL OF THE HUMAN EIF3 PCI-MPN OCTAMER DOCKED INTO THE 43S-HCV IRES EM MAP
Descriptor:Eukaryotic translation initiation factor 3 subunit A, Eukaryotic translation initiation factor 3 subunit C, Eukaryotic translation initiation factor 3 subunit E, ...
Authors:Erzberger, J.P., Ban, N.
Deposit date:2014-10-08
Release date:2014-10-22
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9.3 Å)
Cite:Molecular Architecture of the 40SeIF1eIF3 Translation Initiation Complex.
Cell(Cambridge,Mass.), 158, 2014
3J8C
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MODEL OF THE HUMAN EIF3 PCI-MPN OCTAMER DOCKED INTO THE 43S EM MAP
Descriptor:Eukaryotic translation initiation factor 3 subunit A, Eukaryotic translation initiation factor 3 subunit C, Eukaryotic translation initiation factor 3 subunit E, ...
Authors:Erzberger, J.P., Ban, N.
Deposit date:2014-10-08
Release date:2014-10-22
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (11.6 Å)
Cite:Molecular Architecture of the 40SeIF1eIF3 Translation Initiation Complex.
Cell(Cambridge,Mass.), 158, 2014