Author results

1A29
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CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:2 COMPLEX)
Descriptor:CALMODULIN, CALCIUM ION, 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE
Authors:Bocskei, Zs., Harmat, V., Vertessy, B.G., Ovadi, J., Naray-Szabo, G.
Deposit date:1998-01-19
Release date:1998-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Simultaneous binding of drugs with different chemical structures to Ca2+-calmodulin: crystallographic and spectroscopic studies.
Biochemistry, 37, 1998
1QIV
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CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD), 1:2 COMPLEX
Descriptor:CALMODULIN, CALCIUM ION, N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(2 3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE
Authors:Harmat, V., Bocskei, Z.S., Vertessy, B.G., Naray-Szabo, G., Ovadi, J.
Deposit date:1999-06-17
Release date:2000-03-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:A New Potent Calmodulin Antagonist with Arylalkylamine Structure: Crystallographic, Spectroscopic and Functional Studies
J.Mol.Biol., 297, 2000
1QIW
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CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD)
Descriptor:CALMODULIN, CALCIUM ION, N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(2 3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE
Authors:Harmat, V., Bocskei, Z.S., Vertessy, B.G., Ovadi, J., Naray-Szabo, G.
Deposit date:1999-06-17
Release date:2000-03-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A New Potent Calmodulin Antagonist with Arylalkylamine Structure: Crystallographic, Spectroscopic and Functional Studies
J.Mol.Biol., 297, 2000
1Q3X
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CRYSTAL STRUCTURE OF THE CATALYTIC REGION OF HUMAN MASP-2
Descriptor:Mannan-binding lectin serine protease 2, SODIUM ION, GLYCEROL
Authors:Harmat, V., Gal, P., Kardos, J., Szilagyi, K., Ambrus, G., Naray-Szabo, G., Zavodszky, P.
Deposit date:2003-08-01
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions
J.Mol.Biol., 342, 2004
1XA5
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STRUCTURE OF CALMODULIN IN COMPLEX WITH KAR-2, A BIS-INDOL ALKALOID
Descriptor:Calmodulin, CALCIUM ION, 3"-(BETA-CHLOROETHYL)-2",4"-DIOXO-3, ...
Authors:Horvath, I., Harmat, V., Hlavanda, E., Naray-Szabo, G., Ovadi, J.
Deposit date:2004-08-25
Release date:2004-12-21
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug
J.Biol.Chem., 280, 2005
2BL0
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PHYSARUM POLYCEPHALUM MYOSIN II REGULATORY DOMAIN
Descriptor:MAJOR PLASMODIAL MYOSIN HEAVY CHAIN, MYOSIN REGULATORY LIGHT CHAIN, CALCIUM ION
Authors:Debreczeni, J.E., Farkas, L., Harmat, V., Nyitray, L.
Deposit date:2005-02-23
Release date:2005-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Evidence for Non-Canonical Binding of Ca2+ to a Canonical EF-Hand of a Conventional Myosin.
J.Biol.Chem., 280, 2005
1ZJK
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CRYSTAL STRUCTURE OF THE ZYMOGEN CATALYTIC REGION OF HUMAN MASP-2
Descriptor:Mannan-binding lectin serine protease 2
Authors:Gal, P., Harmat, V., Kocsis, A., Bian, T., Barna, L., Ambrus, G., Vegh, B., Balczer, J., Sim, R.B., Naray-Szabo, G., Zavodszky, P.
Deposit date:2005-04-29
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:A True Autoactivating Enzyme: Structural insight into mannose-binding lectin-associated serine protease-2 activations
J.Biol.Chem., 280, 2005
2D4L
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CRYSTAL STRUCTURE OF TRUNCATED IN C-TERMINAL M-PMV DUTPASE
Descriptor:DU
Authors:Nemeth, V., Barabas, O., Vertessy, G.B.
Deposit date:2005-10-20
Release date:2006-11-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins.
Nucleic Acids Res., 35, 2007
2D4M
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CRYSTAL STRUCTURE OF APO M-PMV DUTPASE
Descriptor:DU
Authors:Nemeth, V., Barabas, O., Vertessy, G.B.
Deposit date:2005-10-20
Release date:2006-11-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins.
Nucleic Acids Res., 35, 2007
2D4N
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CRYSTAL STRUCTURE OF M-PMV DUTPASE COMPLEXED WITH DUPNPP, SUBSTRATE ANALOGUE
Descriptor:DU, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ...
Authors:Nemeth, V., Barabas, O., Vertessy, G.B.
Deposit date:2005-10-20
Release date:2006-11-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins.
Nucleic Acids Res., 35, 2007
2F91
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1.2A RESOLUTION STRUCTURE OF A CRAYFISH TRYPSIN COMPLEXED WITH A PEPTIDE INHIBITOR, SGTI
Descriptor:hepatopancreas trypsin, Serine protease inhibitor I/II, CADMIUM ION, ...
Authors:Fodor, K., Harmat, V., Hetenyi, C., Kardos, J., Antal, J., Perczel, A., Patthy, A., Katona, G., Graf, L.
Deposit date:2005-12-05
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Enzyme:Substrate Hydrogen Bond Shortening during the Acylation Phase of Serine Protease Catalysis.
Biochemistry, 45, 2006
2HU5
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BINDING OF INHIBITORS BY ACYLAMINOACYL-PEPTIDASE
Descriptor:Acylamino-acid-releasing enzyme, GLYCINE, PHENYLALANINE, ...
Authors:Kiss, A.L., Hornung, B., Radi, K., Gengeliczki, Z., Sztaray, B., Harmat, V., Polgar, L.
Deposit date:2006-07-26
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
2HU7
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BINDING OF INHIBITORS BY ACYLAMINOACYL PEPTIDASE
Descriptor:Acylamino-acid-releasing enzyme, ACETYL GROUP, PHENYLALANINE, ...
Authors:Kiss, A.L., Hornung, B., Radi, K., Gengeliczki, Z., Sztaray, B., Harmat, V., Polgar, L.
Deposit date:2006-07-26
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
2HU8
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BINDING OF INHIBITORS BY ACYLAMINOACYL PEPTIDASE
Descriptor:Acylamino-acid-releasing enzyme, 2-AMINOBENZOIC ACID, GLYCINE, ...
Authors:Kiss, A.L., Hornung, B., Radi, K., Gengeliczki, Z., Sztaray, B., Harmat, V., Polgar, L.
Deposit date:2006-07-26
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
2OAY
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CRYSTAL STRUCTURE OF LATENT HUMAN C1-INHIBITOR
Descriptor:Plasma protease C1 inhibitor, N-ACETYL-D-GLUCOSAMINE, GLYCEROL
Authors:Harmat, V., Beinrohr, L., Gal, P., Dobo, J.
Deposit date:2006-12-18
Release date:2007-05-01
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease
J.Biol.Chem., 282, 2007
2QR5
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AEROPYRUM PERNIX ACYLAMINOACYL PEPTIDASE, H367A MUTANT
Descriptor:Acylamino-acid-releasing enzyme
Authors:Harmat, V., Pallo, A., Kiss, A.L., Polgar, L.
Deposit date:2007-07-27
Release date:2008-05-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and kinetic contributions of the oxyanion binding site to the catalytic activity of acylaminoacyl peptidase
J.Struct.Biol., 162, 2008
2QY0
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ACTIVE DIMERIC STRUCTURE OF THE CATALYTIC DOMAIN OF C1R REVEALS ENZYME-PRODUCT LIKE CONTACTS
Descriptor:Complement C1r subcomponent, GLYCEROL
Authors:Kardos, J., Harmat, V., Pallo, A., Barabas, O., Szilagyi, K., Graf, L., Naray-Szabo, G., Goto, Y., Zavodszky, P., Gal, P.
Deposit date:2007-08-13
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r.
Mol.Immunol., 45, 2008
3EQ7
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PROLYL OLIGOPEPTIDASE COMPLEXED WITH R-PRO-(DECARBOXY-PRO)-TYPE INHIBITORS
Descriptor:Prolyl endopeptidase, 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione
Authors:Kanai, K., Aranyi, P., Bocskei, Z., Ferenczy, G., Harmat, V., Simon, K., Naray-Szabo, G., Hermecz, I.
Deposit date:2008-09-30
Release date:2009-08-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules
J.Med.Chem., 51, 2008
3EQ8
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PROLYL OLIGOPEPTIDASE COMPLEXED WITH R-PRO-(DECARBOXY-PRO)-TYPE INHIBITORS
Descriptor:Prolyl endopeptidase, 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one
Authors:Kanai, K., Aranyi, P., Bocskei, Z., Ferenczy, G., Harmat, V., Simon, K., Naray-Szabo, G., Hermecz, I.
Deposit date:2008-09-30
Release date:2009-08-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules
J.Med.Chem., 51, 2008
3EQ9
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PROLYL OLIGOPEPTIDASE COMPLEXED WITH R-PRO-(DECARBOXY-PRO)-TYPE INHIBITORS
Descriptor:Prolyl endopeptidase, 3-{4-oxo-4-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]butyl}-5,5-diphenylimidazolidine-2,4-dione
Authors:Kanai, K., Aranyi, P., Bocskei, Z., Ferenczy, G., Harmat, V., Simon, K., Naray-Szabo, G., Hermecz, I.
Deposit date:2008-09-30
Release date:2009-08-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules
J.Med.Chem., 51, 2008
3GOV
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CRYSTAL STRUCTURE OF THE CATALYTIC REGION OF HUMAN MASP-1
Descriptor:MASP-1, GLYCEROL
Authors:Harmat, V., Dobo, J., Beinrohr, L., Sebestyen, E., Zavodszky, P., Gal, P.
Deposit date:2009-03-20
Release date:2009-06-09
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity.
J.Immunol., 183, 2009
3H6D
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STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS DUTPASE D28N MUTANT
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ...
Authors:Leveles, I., Harmat, V., Nagy, G., Takacs, E., Lopata, A., Toth, J., Vertessy, B.G.
Deposit date:2009-04-23
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases.
Febs Lett., 584, 2010
3HZA
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CRYSTAL STRUCTURE OF DUTPASE H145W MUTANT
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ...
Authors:Leveles, I., Harmat, V., Pecsi, I., Toth, J., Vertessy, B.G.
Deposit date:2009-06-23
Release date:2009-11-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase.
Nucleic Acids Res., 38, 2010
3I93
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DUTPASE STOP138T MUTANT
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ...
Authors:Leveles, I., Harmat, V., Lopata, A., Toth, J., Vertessy, B.G.
Deposit date:2009-07-10
Release date:2009-11-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases.
Febs Lett., 584, 2010
3IF7
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STRUCTURE OF CALMODULIN COMPLEXED WITH ITS FIRST ENDOGENOUS INHIBITOR, SPHINGOSYLPHOSPHORYLCHOLINE
Descriptor:Calmodulin, CALCIUM ION, 2-{[(R)-{[(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}(hydroxy)phosphoryl]oxy}-N,N,N-trimethylethanaminium
Authors:Kovacs, E., Harmat, V., Toth, J., Vertessy, B.G., Modos, K., Kardos, J., Liliom, K.
Deposit date:2009-07-24
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and mechanism of calmodulin binding to a signaling sphingolipid reveal new aspects of lipid-protein interactions
Faseb J., 24, 2010
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