7AK8
 
 | | Structure of Salmonella TacT1 toxin bound to TacA1 antitoxin C-terminal peptide | | Descriptor: | ACETYL COENZYME *A, GCN5 family acetyltransferase, GLYCEROL, ... | | Authors: | Grabe, G.J, Morgan, R.M.L, Helaine, S, Hare, S.A. | | Deposit date: | 2020-09-30 | | Release date: | 2021-08-18 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing.
Nat.Chem.Biol., 17, 2021
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7AK7
 | | Structure of Salmonella TacT2 toxin bound to TacA2 antitoxin | | Descriptor: | ACETYL COENZYME *A, Acetyltransferase, CHLORIDE ION, ... | | Authors: | Grabe, G.J, Morgan, R.M.L, Hare, S.A, Helaine, S. | | Deposit date: | 2020-09-30 | | Release date: | 2021-08-18 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing.
Nat.Chem.Biol., 17, 2021
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7AK9
 | | Structure of Salmonella TacT3 toxin bound to TacA3 antitoxin C-terminal peptide | | Descriptor: | ABC transporter, Acetyltransferase, DEPHOSPHO COENZYME A | | Authors: | Grabe, G.J, Morgan, R.M.L, Hare, S.A, Helaine, S. | | Deposit date: | 2020-09-30 | | Release date: | 2021-08-18 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing.
Nat.Chem.Biol., 17, 2021
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5EC6
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5EE2
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5EE4
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5FVJ
 | | Crystal structure of TacT (tRNA acetylating toxin) from Salmonella | | Descriptor: | ACETYL COENZYME *A, PUTATIVE ACETYLTRANSFERASE | | Authors: | Przydacz, M, Wong, C.T, Cheverton, A.M, Gollan, B, Mylona, A, Helaine, S, Hare, S.A. | | Deposit date: | 2016-02-08 | | Release date: | 2016-06-01 | | Last modified: | 2016-07-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | A Salmonella Toxin Promotes Persister Formation Through Acetylation of tRNA.
Mol.Cell, 63, 2016
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5LQ6
 | | Salmonella effector SpvD - R161 variant | | Descriptor: | SODIUM ION, Virulence protein vsdE | | Authors: | Zhang, Y, Grabe, G.J, Rolhion, N, Yang, Y, Holden, D.W, Hare, S.A. | | Deposit date: | 2016-08-16 | | Release date: | 2016-11-02 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence.
J. Biol. Chem., 291, 2016
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5LQ7
 | | Salmonella effector SpvD - G161 variant | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Przydacz, M, Grabe, G.J, Holden, D.W, Hare, S.A. | | Deposit date: | 2016-08-16 | | Release date: | 2016-11-02 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence.
J. Biol. Chem., 291, 2016
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5N3W
 | | Crystal structure of LTA4H bound to a selective inhibitor against LTB4 generation | | Descriptor: | 3-[2-(2-hydroxyphenyl)ethyl]-5-methoxy-phenol, ACETATE ION, IMIDAZOLE, ... | | Authors: | Wong, C.T, Low, C.M, Snelgrove, R.J, Hare, S.A. | | Deposit date: | 2017-02-09 | | Release date: | 2017-03-29 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The development of novel LTA4H modulators to selectively target LTB4 generation.
Sci Rep, 7, 2017
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6G96
 | | Crystal structure of TacT3 (tRNA acetylating toxin) from Salmonella | | Descriptor: | ACETYL COENZYME *A, Acetyltransferase, BICINE, ... | | Authors: | Grabe, G.J, Rycroft, J.A, Gollan, B, Hall, A, Cheverton, A.M, Larrouy-Maumus, G, Hare, S.A, Helaine, S. | | Deposit date: | 2018-04-10 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.4766078 Å) | | Cite: | Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection.
Nat Commun, 9, 2018
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7ZG6
 | | TacA1 antitoxin | | Descriptor: | DUF1778 domain-containing protein, MAGNESIUM ION | | Authors: | Grabe, G.J, Morgan, R.M.L, Helaine, S. | | Deposit date: | 2022-04-01 | | Release date: | 2023-10-11 | | Last modified: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Molecular stripping underpins derepression of a toxin-antitoxin system.
Nat.Struct.Mol.Biol., 2024
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7ZG5
 | | The crystal structure of Salmonella TacAT3-DNA complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Acetyltransferase, BARIUM ION, ... | | Authors: | Grabe, G.J, Morgan, R.M.L, Helaine, S. | | Deposit date: | 2022-04-01 | | Release date: | 2023-10-11 | | Last modified: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular stripping underpins derepression of a toxin-antitoxin system.
Nat.Struct.Mol.Biol., 2024
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5COF
 | | Crystal structure of Uncharacterised protein Q1R1X2 from Escherichia coli UTI89 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Taylor, J.D, Hare, S, Matthews, S.J. | | Deposit date: | 2015-07-20 | | Release date: | 2016-02-03 | | Last modified: | 2016-03-02 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.
J.Mol.Biol., 428, 2016
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5CQV
 | | Crystal structure of uncharacterized protein Q8DWV2 from Streptococcus agalactiae | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Uncharacterized protein | | Authors: | Taylor, J.D, Hare, S, Matthews, S.J. | | Deposit date: | 2015-07-22 | | Release date: | 2016-02-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.
J.Mol.Biol., 428, 2016
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5CIV
 | | Sibling Lethal Factor Precursor - DfsB | | Descriptor: | Sibling bacteriocin | | Authors: | Taylor, J.D, Matthews, S.J. | | Deposit date: | 2015-07-13 | | Release date: | 2016-02-03 | | Last modified: | 2016-03-02 | | Method: | X-RAY DIFFRACTION (1.384 Å) | | Cite: | Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.
J.Mol.Biol., 428, 2016
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5COG
 | | Crystal structure of Yeast IRC4 | | Descriptor: | CHLORIDE ION, IRC4, PHOSPHATE ION, ... | | Authors: | Taylor, J.D, Matthews, S.J. | | Deposit date: | 2015-07-20 | | Release date: | 2016-02-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.613 Å) | | Cite: | Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.
J.Mol.Biol., 428, 2016
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5COM
 | | Crystal structure of Uncharacterized Protein Q187F5 from Clostridium difficile 630 | | Descriptor: | D(-)-TARTARIC ACID, Putative conjugative transposon protein Tn1549-like, CTn5-Orf2, ... | | Authors: | Taylor, J.D, Taylor, G, Matthews, S.J. | | Deposit date: | 2015-07-20 | | Release date: | 2016-02-03 | | Last modified: | 2016-03-02 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.
J.Mol.Biol., 428, 2016
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