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5G5W
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STRUCTURE GUIDED DESIGN AND DISCOVERY OF INDAZOLE ETHERS AS HIGHLY POTENT, NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS
Descriptor:GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 1,2-ETHANEDIOL, ...
Authors:Hemmerling, M., Edman, K., Lepisto, M., Eriksson, A., Ivanova, S., Dahmen, J., Rehwinkel, H., Berger, M., Hendrickx, R., Dearman, M., Jellesmark-Jensen, T., Wissler, L., Hansson, T.
Deposit date:2016-06-08
Release date:2017-02-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of Indazole Ethers as Novel, Potent, Non-Steroidal Glucocorticoid Receptor Modulators.
Bioorg.Med.Chem.Lett., 26, 2017
4CSJ
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THE DISCOVERY OF POTENT SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS, SUITABLE FOR INHALATION
Descriptor:GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 1,2-ETHANEDIOL, ...
Authors:Edman, K., Ahlgren, R., Bengtsson, M., Bladh, H., Backstrom, S., Dahmen, J., Henriksson, K., Hillertz, P., Hulikal, V., Jerre, A., Kinchin, L., Kase, C., Lepisto, M., Mile, I., Nilsson, S., Smailagic, A., Taylor, J., Tjornebo, A., Wissler, L., Hansson, T.
Deposit date:2014-03-07
Release date:2014-05-07
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Discovery of Potent and Selective Non-Steroidal Glucocorticoid Receptor Modulators, Suitable for Inhalation.
Bioorg.Med.Chem.Lett., 24, 2014
5AIS
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COMPLEX OF HUMAN HEMATOPOIETIC PROSTAGANDIN D2 SYNTHASE (HH-PGDS) IN COMPLEX WITH AN ACTIVE SITE INHIBITOR.
Descriptor:HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, 4-(dimethylamino)-N-[5-(1H-indol-4-yl)pyridin-3-yl]butanamide, GLUTATHIONE, ...
Authors:Edfeldt, F., Evenas, J., Lepisto, M., Ward, A., Petersen, J., Wissler, L., Rohman, M., Sivars, U., Svensson, K., Perry, M., Feierberg, I., Zhou, X., Hansson, T., Narjes, F.
Deposit date:2015-02-17
Release date:2015-06-03
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds).
Bioorg.Med.Chem.Lett., 25, 2015
5AIV
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COMPLEX OF HUMAN HEMATOPOIETIC PROSTAGANDIN D2 SYNTHASE (HH-PGDS) IN COMPLEX WITH AN ACTIVE SITE INHIBITOR.
Descriptor:HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, 3-(1H-indol-4-yl)-N-(3-methoxypropyl)-1,2,4-oxadiazole-5-carboxamide, GLUTATHIONE, ...
Authors:Edfeldt, F., Evenas, J., Lepisto, M., Ward, A., Petersen, J., Wissler, L., Rohman, M., Sivars, U., Svensson, K., Perry, M., Feierberg, I., Zhou, X., Hansson, T., Narjes, F.
Deposit date:2015-02-17
Release date:2015-06-03
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds).
Bioorg.Med.Chem.Lett., 25, 2015
5AIX
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COMPLEX OF HUMAN HEMATOPOIETIC PROSTAGANDIN D2 SYNTHASE (HH-PGDS) IN COMPLEX WITH AN ACTIVE SITE INHIBITOR.
Descriptor:HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, MAGNESIUM ION, GLUTATHIONE, ...
Authors:Edfeldt, F., Evenas, J., Lepisto, M., Ward, A., Petersen, J., Wissler, L., Rohman, M., Sivars, U., Svensson, K., Perry, M., Feierberg, I., Zhou, X., Hansson, T., Narjes, F.
Deposit date:2015-02-18
Release date:2015-06-03
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds).
Bioorg.Med.Chem.Lett., 25, 2015
5NFP
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GLUCOCORTICOID RECEPTOR IN COMPLEX WITH BUDESONIDE
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
Authors:Edman, K., Wissler, L.
Deposit date:2017-03-15
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.
J. Med. Chem., 60, 2017
5NFT
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GLUCOCORTICOID RECEPTOR IN COMPLEX WITH AZD5423
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ...
Authors:Edman, K., Wissler, L.
Deposit date:2017-03-15
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.
J. Med. Chem., 60, 2017