Author results

1GOT
  • Download 1got
  • View 1got
Molmil generated image of 1got
HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
Descriptor:GT-ALPHA/GI-ALPHA CHIMERA, GT-BETA, GT-GAMMA, ...
Authors:Lambright, D.G., Sondek, J., Bohm, A., Skiba, N.P., Hamm, H.E., Sigler, P.B.
Deposit date:1996-08-07
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0 A crystal structure of a heterotrimeric G protein.
Nature, 379, 1996
1TBG
  • Download 1tbg
  • View 1tbg
Molmil generated image of 1tbg
BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN
Descriptor:TRANSDUCIN
Authors:Sondek, J.S., Bohm, A., Lambright, D.G., Hamm, H.E., Sigler, P.B.
Deposit date:1996-06-15
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a G-protein beta gamma dimer at 2.1A resolution.
Nature, 379, 1996
1TAD
  • Download 1tad
  • View 1tad
Molmil generated image of 1tad
GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4-
Descriptor:TRANSDUCIN-ALPHA, CALCIUM ION, CACODYLATE ION, ...
Authors:Sondek, J., Lambright, D.G., Noel, J.P., Hamm, H.E., Sigler, P.B.
Deposit date:1995-01-05
Release date:1995-05-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4.
Nature, 372, 1994
1TAG
  • Download 1tag
  • View 1tag
Molmil generated image of 1tag
STRUCTURAL DETERMINANTS FOR ACTIVATION OF THE ALPHA-SUBUNIT OF A HETEROTRIMERIC G PROTEIN
Descriptor:TRANSDUCIN-ALPHA, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Lambright, D.G., Noel, J.P., Hamm, H.E., Sigler, P.B.
Deposit date:1994-11-23
Release date:1995-02-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.
Nature, 369, 1994
1TND
  • Download 1tnd
  • View 1tnd
Molmil generated image of 1tnd
THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S
Descriptor:TRANSDUCIN, MAGNESIUM ION, CACODYLATE ION, ...
Authors:Noel, J.P., Hamm, H.E., Sigler, P.B.
Deposit date:1994-03-31
Release date:1994-07-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.
Nature, 366, 1993
3D7M
  • Download 3d7m
  • View 3d7m
Molmil generated image of 3d7m
CRYSTAL STRUCTURE OF THE G PROTEIN FAST-EXCHANGE DOUBLE MUTANT I56C/Q333C
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, MAGNESIUM ION, ...
Authors:Funk, M.A., Preininger, A.M., Oldham, W.M., Meier, S.M., Hamm, H.E., Iverson, T.M.
Deposit date:2008-05-21
Release date:2009-03-03
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.
Biochemistry, 48, 2009
4N0D
  • Download 4n0d
  • View 4n0d
Molmil generated image of 4n0d
CRYSTAL STRUCTURE OF THE K345L VARIANT OF THE GI ALPHA1 SUBUNIT BOUND TO GTPGAMMAS
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, SULFITE ION, MAGNESIUM ION, ...
Authors:Thaker, T.M., Preininger, A.M., Sarwar, M., Hamm, H.E., Iverson, T.M.
Deposit date:2013-10-01
Release date:2014-03-12
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in G alpha i1.
J.Biol.Chem., 289, 2014
4N0E
  • Download 4n0e
  • View 4n0e
Molmil generated image of 4n0e
CRYSTAL STRUCTURE OF THE K345L VARIANT OF THE GI ALPHA1 SUBUNIT BOUND TO GDP
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION
Authors:Thaker, T.M., Preininger, A.M., Sarwar, M., Hamm, H.E., Iverson, T.M.
Deposit date:2013-10-01
Release date:2014-03-12
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in G alpha i1.
J.Biol.Chem., 289, 2014
4PAM
  • Download 4pam
  • View 4pam
Molmil generated image of 4pam
A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFITE ION, ...
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4PAN
  • Download 4pan
  • View 4pan
Molmil generated image of 4pan
A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFITE ION, ...
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4PAO
  • Download 4pao
  • View 4pao
Molmil generated image of 4pao
A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4PAQ
  • Download 4paq
  • View 4paq
Molmil generated image of 4paq
A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
5KDL
  • Download 5kdl
  • View 5kdl
Molmil generated image of 5kdl
CRYSTAL STRUCTURE OF THE 4 ALANINE INSERTION VARIANT OF THE GI ALPHA1 SUBUNIT BOUND TO GTPGAMMAS
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2016-06-08
Release date:2016-08-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.665 Å)
Cite:A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291, 2016
5KDO
  • Download 5kdo
  • View 5kdo
Molmil generated image of 5kdo
HETEROTRIMERIC COMPLEX OF THE 4 ALANINE INSERTION VARIANT OF THE GI ALPHA1 SUBUNIT AND THE GBETA1-GGAMMA1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2016-06-08
Release date:2016-08-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291, 2016
1B9X
  • Download 1b9x
  • View 1b9x
Molmil generated image of 1b9x
STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN
Descriptor:PROTEIN (TRANSDUCIN), PROTEIN (PHOSDUCIN), GADOLINIUM ATOM
Authors:Gaudet, R., Sigler, P.B.
Deposit date:1999-02-16
Release date:1999-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin.
Mol.Cell, 3, 1999
1B9Y
  • Download 1b9y
  • View 1b9y
Molmil generated image of 1b9y
STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA
Descriptor:PROTEIN (TRANSDUCIN), PROTEIN (PHOSDUCIN), GADOLINIUM ATOM
Authors:Gaudet, R., Sigler, P.B.
Deposit date:1999-02-16
Release date:1999-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin.
Mol.Cell, 3, 1999
2TRC
  • Download 2trc
  • View 2trc
Molmil generated image of 2trc
PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX
Descriptor:TRANSDUCIN, PHOSDUCIN, GADOLINIUM ATOM
Authors:Gaudet, R., Bohm, A., Sigler, P.B.
Deposit date:1997-01-06
Release date:1997-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin.
Cell(Cambridge,Mass.), 87, 1996