Author results

2C1E
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CRYSTAL STRUCTURES OF CASPASE-3 IN COMPLEX WITH AZA-PEPTIDE MICHAEL ACCEPTOR INHIBITORS.
Descriptor:CASPASE-3 SUBUNIT P17, CASPASE-3 SUBUNIT P12, AZA-PEPTIDE INHIBITOR (5S, ...
Authors:Grutter, M.G.
Deposit date:2005-09-14
Release date:2006-09-20
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49, 2006
2V0Z
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CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 10 (ALISKIREN)
Descriptor:RENIN, N-ACETYL-D-GLUCOSAMINE, ALISKIREN
Authors:Rahuel, J., Rasetti, V., Maibaum, J., Rueger, H., Goschke, R., Cohen, N.C., Stutz, S., Cumin, F., Fuhrer, W., Wood, J.M., Grutter, M.G.
Deposit date:2007-05-21
Release date:2007-07-03
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
Chem.Biol., 7, 2000
2V10
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CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 9
Descriptor:RENIN, (2R,4S,5S,7S)-5-AMINO-N-BUTYL-4-HYDROXY-7-[4-METHOXY-3-(3-METHOXYPROPOXY)BENZYL]-2,8-DIMETHYLNONANAMIDE
Authors:Rahuel, J., Rasetti, V., Maibaum, J., Rueger, H., Goschke, R., Cohen, N.C., Stutz, S., Cumin, F., Fuhrer, W., Wood, J.M., Grutter, M.G.
Deposit date:2007-05-21
Release date:2007-07-03
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
Chem.Biol., 7, 2000
2V11
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CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 6
Descriptor:RENIN, (2S,4S,5R,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL 1-BENZYL-1H-INDOLE-3-CARBOXYLATE
Authors:Rahuel, J., Rasetti, V., Maibaum, J., Rueger, H., Goschke, R., Cohen, N.C., Stutz, S., Cumin, F., Fuhrer, W., Wood, J.M., Grutter, M.G.
Deposit date:2007-05-21
Release date:2007-07-03
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
Chem.Biol., 7, 2000
2V12
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CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 8
Descriptor:RENIN, N-[(2S,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-7-METHYL-2-(1-METHYLETHYL)-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE
Authors:Rahuel, J., Rasetti, V., Maibaum, J., Rueger, H., Goschke, R., Cohen, N.C., Stutz, S., Cumin, F., Fuhrer, W., Wood, J.M., Grutter, M.G.
Deposit date:2007-05-21
Release date:2007-07-03
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
Chem.Biol., 7, 2000
2V13
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CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 7
Descriptor:RENIN, N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE
Authors:Rahuel, J., Rasetti, V., Maibaum, J., Rueger, H., Goschke, R., Cohen, N.C., Stutz, S., Cumin, F., Fuhrer, W., Wood, J.M., Grutter, M.G.
Deposit date:2007-05-21
Release date:2008-07-08
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
Chem.Biol., 7, 2000
2V16
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CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 3
Descriptor:RENIN, METHYL (3R)-1-[(5S,6S,8R)-5-AMINO-9-BUTYLAMINO-6-HYDROXY-3,3,8-TRIMETHYL-9-OXO-NONANOYL]-3,4-DIHYDRO-2H-QUINOLINE-3-CARBOXYLATE
Authors:Rahuel, J., Rasetti, V., Maibaum, J., Rueger, H., Goschke, R., Cohen, N.C., Stutz, S., Cumin, F., Fuhrer, W., Wood, J.M., Grutter, M.G.
Deposit date:2007-05-22
Release date:2008-07-08
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
Chem.Biol., 7, 2000
1F9E
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CASPASE-8 SPECIFICITY PROBED AT SUBSITE S4: CRYSTAL STRUCTURE OF THE CASPASE-8-Z-DEVD-CHO
Descriptor:CASPASE-8 ALPHA CHAIN, CASPASE-8 BETA CHAIN, (PHQ)DEVD
Authors:Blanchard, H., Donepudi, M., Tschopp, M., Kodandapani, L., Wu, J.C., Grutter, M.G.
Deposit date:2000-07-10
Release date:2001-07-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex.
J.Mol.Biol., 302, 2000
1J0X
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CRYSTAL STRUCTURE OF THE RABBIT MUSCLE GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH)
Descriptor:glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Cowan-Jacob, S.W., Kaufmann, M., Anselmo, A.N., Stark, W., Grutter, M.G.
Deposit date:2002-11-25
Release date:2003-12-09
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase.
Acta Crystallogr.,Sect.D, 59, 2003
1JPF
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CRYSTAL STRUCTURE OF THE LCMV PEPTIDIC EPITOPE GP276 IN COMPLEX WITH THE MURINE CLASS I MHC MOLECULE H-2DB
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Ciatto, C., Tissot, A.C., Tschopp, M., Capitani, G., Pecorari, F., Pluckthun, A., Grutter, M.G.
Deposit date:2001-08-02
Release date:2001-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides.
J.Mol.Biol., 312, 2001
1JPG
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CRYSTAL STRUCTURE OF THE LCMV PEPTIDIC EPITOPE NP396 IN COMPLEX WITH THE MURINE CLASS I MHC MOLECULE H-2DB
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Ciatto, C., Tissot, A.C., Tschopp, M., Capitani, G., Pecorari, F., Pluckthun, A., Grutter, M.G.
Deposit date:2001-08-02
Release date:2001-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides.
J.Mol.Biol., 312, 2001
1KKC
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS MNSOD
Descriptor:Manganese Superoxide Dismutase, MANGANESE (II) ION
Authors:Fluckiger, S., Mittl, P.R.E., Scapozza, L., Fijten, H., Folkers, G., Grutter, M.G., Blaser, K., Crameri, R.
Deposit date:2001-12-07
Release date:2001-12-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comparison of the crystal structures of the human manganese superoxide dismutase and the homologous Aspergillus fumigatus allergen at 2-A resolution.
J.Immunol., 168, 2002
1KSO
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CRYSTAL STRUCTURE OF APO S100A3
Descriptor:S100 CALCIUM-BINDING PROTEIN A3
Authors:Mittl, P.R., Fritz, G., Sargent, D.F., Richmond, T.J., Heizmann, C.W., Grutter, M.G.
Deposit date:2002-01-14
Release date:2002-07-31
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Metal-free MIRAS phasing: structure of apo-S100A3.
Acta Crystallogr.,Sect.D, 58, 2002
1M4N
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CRYSTAL STRUCTURE OF APPLE ACC SYNTHASE IN COMPLEX WITH [2-(AMINO-OXY)ETHYL](5'-DEOXYADENOSIN-5'-YL)(METHYL)SULFONIUM
Descriptor:1-aminocyclopropane-1-carboxylate synthase, PYRIDOXAL-5'-PHOSPHATE, (2-AMINOOXY-ETHYL)-[5-(6-AMINO-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDRO-FURAN-2-YLMETHYL]-METHYL-SULFONIUM, ...
Authors:Capitani, G., Eliot, A.C., Gut, H., Khomutov, R.M., Kirsch, J.F., Grutter, M.G.
Deposit date:2002-07-03
Release date:2003-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structure of 1-aminocyclopropane-1-carboxylate synthase in complex with an amino-oxy analogue of the substrate: implications for substrate binding.
BIOCHEM.BIOPHYS.ACTA PROTEINS & PROTEOMICS, 1647, 2003
1NQ3
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CRYSTAL STRUCTURE OF THE MAMMALIAN TUMOR ASSOCIATED ANTIGEN UK114
Descriptor:14.3 kDa perchloric acid soluble protein
Authors:Deriu, D., Briand, C., Mistiniene, E., Naktinis, V., Grutter, M.G.
Deposit date:2003-01-21
Release date:2003-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and oligomeric state of the mammalian tumour-associated antigen UK114.
Acta Crystallogr.,Sect.D, 59, 2003
1PMM
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI GADB (LOW PH)
Descriptor:Glutamate decarboxylase beta, PYRIDOXAL-5'-PHOSPHATE, ACETIC ACID
Authors:Capitani, G., De Biase, D., Aurizi, C., Gut, H., Bossa, F., Grutter, M.G.
Deposit date:2003-06-11
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure and functional analysis of escherichia coli glutamate decarboxylase
Embo J., 22, 2003
1PMO
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI GADB (NEUTRAL PH)
Descriptor:Glutamate decarboxylase beta, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Capitani, G., De Biase, D., Aurizi, C., Gut, H., Bossa, F., Grutter, M.G.
Deposit date:2003-06-11
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure and functional analysis of escherichia coli glutamate decarboxylase
Embo J., 22, 2003
1PN5
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NMR STRUCTURE OF THE NALP1 PYRIN DOMAIN (PYD)
Descriptor:NACHT-, LRR- and PYD-containing protein 2
Authors:Hiller, S., Kohl, A., Fiorito, F., Herrmann, T., Wider, G., Tschopp, J., Grutter, M.G., Wuthrich, K.
Deposit date:2003-06-12
Release date:2003-10-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain
Structure, 11, 2003
1PYO
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CRYSTAL STRUCTURE OF HUMAN CASPASE-2 IN COMPLEX WITH ACETYL-LEU-ASP-GLU-SER-ASP-CHO
Descriptor:Caspase-2, ACETYL-LEU-ASP-GLU-SER-ASJ
Authors:Schweizer, A., Briand, C., Grutter, M.G.
Deposit date:2003-07-09
Release date:2003-08-26
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.
J.Biol.Chem., 278, 2003
1QDU
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CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TRIPEPTIDE KETONE INHIBITOR ZEVD-DCBMK
Descriptor:CASPASE-8 ALPHA-CHAIN, CASPASE-8 BETA-CHAIN, PHQ-GLU-VAL-ASP-DICHLOROMETHYLKETONE INHIBITOR
Authors:Blanchard, H., Grutter, M.G.
Deposit date:1999-07-10
Release date:2000-07-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.
Structure Fold.Des., 7, 1999
1TZE
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SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2)
Descriptor:GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2
Authors:Rahuel, J., Grutter, M.G.
Deposit date:1996-06-06
Release date:1997-07-07
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode.
Nat.Struct.Biol., 3, 1996
1YNU
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CRYSTAL STRUCTURE OF APPLE ACC SYNTHASE IN COMPLEX WITH L-VINYLGLYCINE
Descriptor:1-aminocyclopropane-1-carboxylate synthase, NICKEL (II) ION, POTASSIUM ION, ...
Authors:Capitani, G., Tschopp, M., Eliot, A.C., Kirsch, J.F., Grutter, M.G.
Deposit date:2005-01-25
Release date:2005-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of ACC synthase inactivated by the mechanism-based inhibitor L-vinylglycine.
Febs Lett., 579, 2005
2BKG
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CRYSTAL STRUCTURE OF E3_19 A DESIGNED ANKYRIN REPEAT PROTEIN
Descriptor:SYNTHETIC CONSTRUCT ANKYRIN REPEAT PROTEIN E3_19
Authors:Binz, H.K., Kohl, A., Pluckthun, A., Grutter, M.G.
Deposit date:2005-02-16
Release date:2006-06-21
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of a Consensus-Designed Ankyrin Repeat Protein: Implications for Stability
Proteins: Struct., Funct., Bioinf., 65, 2006
2BKK
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IIIA IN COMPLEX WITH THE INHIBITOR AR_3A
Descriptor:AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE, DESIGNED ANKYRIN REPEAT INHIBITOR AR_3A, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Kohl, A., Amstutz, P., Parizek, P., Binz, H.K., Briand, C., Capitani, G., Forrer, P., Pluckthun, A., Grutter, M.G.
Deposit date:2005-02-16
Release date:2005-08-09
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Allosteric Inhibition of Aminoglycoside Phosphotransferase by a Designed Ankyrin Repeat Protein
Structure, 13, 2005
2C6Z
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CRYSTAL STRUCTURE OF DIMETHYLARGININE DIMETHYLAMINOHYDROLASE I IN COMPLEX WITH CITRULLINE
Descriptor:NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1, CITRULLINE, ...
Authors:Frey, D., Braun, O., Briand, C., Vasak, M., Grutter, M.G.
Deposit date:2005-11-16
Release date:2006-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inbitors
Structure, 14, 2006