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3P24
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BU of 3p24 by Molmil
Structure of profragilysin-3 from Bacteroides fragilis
Descriptor: AZIDE ION, BFT-3, GLYCEROL, ...
Authors:Goulas, T, Arolas, J.L, Gomis-Ruth, F.X.
Deposit date:2010-10-01
Release date:2010-12-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog.
Proc.Natl.Acad.Sci.USA, 108, 2011
5CX8
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BU of 5cx8 by Molmil
Structure of RagB, a major immunodominant virulence factor of Porphyromonas gingivalis.
Descriptor: 3-deoxy-5-O-phosphono-beta-D-ribofuranose, 3-deoxy-beta-D-glucopyranose, 6-O-phosphono-D-tagatose, ...
Authors:Goulas, T, Garcia-Ferrer, I, Hutcherson, J.A, Potempa, B.A, Potempa, J, Scott, D.A, Gomis-Ruth, F.X.
Deposit date:2015-07-28
Release date:2015-10-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of RagB, a major immunodominant outer-membrane surface receptor antigen of Porphyromonas gingivalis.
Mol Oral Microbiol, 31, 2016
4YT9
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BU of 4yt9 by Molmil
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) substrate-unbound.
Descriptor: GLYCEROL, Peptidylarginine deiminase, SODIUM ION
Authors:Goulas, T, Mizgalska, D, Garcia-Ferrer, I, Kantyka, T, Guevara, T, Szmigielski, B, Sroka, A, Millan, C, Uson, I, Veillard, F, Potempa, B, Mydel, P, Sola, M, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
4YTB
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BU of 4ytb by Molmil
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in complex with dipeptide Asp-Gln.
Descriptor: ASPARTIC ACID, AZIDE ION, CHLORIDE ION, ...
Authors:Goulas, T, Mizgalska, D, Garcia-Ferrer, I, Kantyka, T, Guevara, T, Szmigielski, B, Sroka, A, Millan, C, Uson, I, Veillard, F, Potempa, B, Mydel, P, Sola, M, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
4YTG
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BU of 4ytg by Molmil
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) mutant C351A in complex with dipeptide Met-Arg.
Descriptor: ARGININE, AZIDE ION, CHLORIDE ION, ...
Authors:Goulas, T, Mizgalska, D, Garcia-Ferrer, I, Kantyka, T, Guevara, T, Szmigielski, B, Sroka, A, Millan, C, Uson, I, Veillard, F, Potempa, B, Mydel, P, Sola, M, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
5NCW
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BU of 5ncw by Molmil
Structure of the trypsin induced serpin-type proteinase inhibitor, miropin (V367K/K368A mutant).
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
5NCS
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BU of 5ncs by Molmil
Structure of the native serpin-type proteinase inhibitor, miropin.
Descriptor: Serpin
Authors:Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
5NCT
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BU of 5nct by Molmil
Structure of the trypsin induced serpin-type proteinase inhibitor, miropin.
Descriptor: ASPARTIC ACID, GLYCEROL, SERINE, ...
Authors:Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
5NCU
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BU of 5ncu by Molmil
Structure of the subtilisin induced serpin-type proteinase inhibitor, miropin.
Descriptor: CHLORIDE ION, GLYCEROL, IODIDE ION, ...
Authors:Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
6TAV
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BU of 6tav by Molmil
Crystal structure of endopeptidase-induced alpha2-macroglobulin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
Authors:Gomis-Ruth, F.X, Duquerroy, S, Trapani, S, Marrero, A, Goulas, T, Guevara, T, Andersen, G.A, Sottrup-Jensen, L, Navaza, J.
Deposit date:2019-10-30
Release date:2021-05-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Cryo-EM structures shows the mechanistic basis of pan-peptidase inhibition by human alpha2-macroglobulin
Proc.Natl.Acad.Sci.USA, 2022
8QB1
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BU of 8qb1 by Molmil
C-terminal domain of mirolase from Tannerella forsythia
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Mirolase, ...
Authors:Gomis-Ruth, F.X, Rodriguez-Banqueri, A, Mizgalska, D, Veillard, F, Goulas, T, Eckhard, U, Potempa, J.
Deposit date:2023-08-23
Release date:2024-02-28
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Structural and functional insights into the C-terminal signal domain of the Bacteroidetes type-IX secretion system
Open Biology, 2024
6ZA2
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BU of 6za2 by Molmil
Crystal structure of dimeric latent PorU from Porphyromonas gingivalis
Descriptor: CALCIUM ION, Por secretion system protein porU
Authors:Gomis-Ruth, F.X, Goulas, T, Guevara, T, Rodriguez-Banqueri, A, Potempa, J.
Deposit date:2020-06-04
Release date:2021-09-29
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the Porphyromonas gingivalis type-IX secretion system.
Proc.Natl.Acad.Sci.USA, 118, 2021
8B2Q
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BU of 8b2q by Molmil
Matrix-metallopeptidase inhibitor Potempin A (PotA) from Tannerella forsythia in complex with T. forsythia karilysin.
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
Authors:Potempa, J, Ksiazek, M, Goulas, T, Cuppari, A, Rodriguez-Banqueri, A, Arolas, J.L, Lopez-Pelegrin, M, Garcia-Ferrer, I, Guevara, T.
Deposit date:2022-09-14
Release date:2022-12-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia.
Chem Sci, 14, 2023
8B2M
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BU of 8b2m by Molmil
Matrix-metallopeptidase inhibitor Potempin A (PotA) from Tannerella forsythia
Descriptor: NICKEL (II) ION, Tannerella forsythia Potempin A (PotA)
Authors:Potempa, J, Ksiazek, M, Goulas, T, Cuppari, A, Rodriguez-Banqueri, A, Arolas, J.L, Lopez-Pelegrin, M, Garcia-Ferrer, I, Guevara, T.
Deposit date:2022-09-14
Release date:2022-12-21
Last modified:2023-02-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia.
Chem Sci, 14, 2023
8B2N
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BU of 8b2n by Molmil
Potempin A (PotA) from Tannerella forsythia in complex with the catalytic domain of human MMP-12
Descriptor: CALCIUM ION, Macrophage metalloelastase, Tannerella forsythia potempin A (PotA), ...
Authors:Potempa, J, Ksiazek, M, Goulas, T, Cuppari, A, Rodriguez-Banqueri, A, Arolas, J.L, Lopez-Pelegrin, M, Garcia-Ferrer, I, Guevara, T.
Deposit date:2022-09-14
Release date:2022-12-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia.
Chem Sci, 14, 2023
6I0X
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BU of 6i0x by Molmil
Porphyromonas gingivalis peptidylarginine deminase (PPAD) mutant G231N/E232T/N235D in complex with Cl-amidine.
Descriptor: GLYCEROL, N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE, Peptidylarginine deiminase, ...
Authors:Gomis-Ruth, F.X, Goulas, T, Sola, M, Potempa, J.
Deposit date:2018-10-26
Release date:2019-01-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure, function, and inhibition of a genomic/clinical variant of Porphyromonas gingivalis peptidylarginine deiminase.
Protein Sci., 28, 2019
6I9J
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BU of 6i9j by Molmil
Human transforming growth factor beta2 in a tetragonal crystal form
Descriptor: Transforming growth factor beta-2 proprotein
Authors:Gomis-Ruth, F.X, Marino-Puertas, L, del Amo-Maestro, L, Goulas, T.
Deposit date:2018-11-23
Release date:2019-07-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor beta 2 in a new conformation.
Sci Rep, 9, 2019
5M11
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BU of 5m11 by Molmil
Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Descriptor: CACODYLATE ION, CALCIUM ION, CHLORIDE ION, ...
Authors:Lasica, A.M, Goulas, T, Mizgalska, D, Zhou, X, Ksiazek, M, Madej, M, Guo, Y, Guevara, T, Nowak, M, Potempa, B, Goel, A, Sztukowska, M, Prabhakar, A.T, Bzowska, M, Widziolek, M, Thogersen, I.B, Enghild, J.J, Simonian, M, Kulczyk, A.W, Nguyen, K.-A, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2016-10-07
Release date:2016-11-09
Last modified:2022-03-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Sci Rep, 6, 2016
6HT9
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BU of 6ht9 by Molmil
Mouse fetuin-B in complex with crayfish astacin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Astacin, ...
Authors:Gomis-Ruth, F.X, Goulas, T, Guevara, T, Cuppari, A.
Deposit date:2018-10-03
Release date:2019-03-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition.
Iucrj, 6, 2019
5MUN
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BU of 5mun by Molmil
Structural insight into zymogenic latency of gingipain K from Porphyromonas gingivalis.
Descriptor: AZIDE ION, Lys-gingipain W83
Authors:Pomowski, A, Uson, I, Nowakovska, Z, Veillard, F, Sztukowska, M.N, Guevara, T, Goulas, T, Mizgalska, D, Nowak, M, Potempa, B, Huntington, J.A, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2017-01-13
Release date:2017-02-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.
J. Biol. Chem., 292, 2017
5NV6
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BU of 5nv6 by Molmil
Structure of human transforming growth factor beta-induced protein (TGFBIp).
Descriptor: ACETATE ION, Transforming growth factor-beta-induced protein ig-h3
Authors:Garcia-Castellanos, R, Nielsen, S.N, Runager, K, Thogersen, B.I, Goulas, T, Enghild, J.J, Gomis-Ruth, F.X.
Deposit date:2017-05-03
Release date:2017-08-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural and Functional Implications of Human Transforming Growth Factor beta-Induced Protein, TGFBIp, in Corneal Dystrophies.
Structure, 25, 2017
7O7O
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BU of 7o7o by Molmil
(h-alpha2M)4 semiactivated II state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
Authors:Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
Deposit date:2021-04-13
Release date:2022-04-13
Last modified:2022-05-11
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7O7S
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BU of 7o7s by Molmil
(h-alpha2M)4 plasmin-activated II state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
Authors:Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
Deposit date:2021-04-13
Release date:2022-04-13
Last modified:2022-05-11
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7O7M
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BU of 7o7m by Molmil
(h-alpha2M)4 native II
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
Authors:Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
Deposit date:2021-04-13
Release date:2022-04-13
Last modified:2022-05-11
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7O7R
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BU of 7o7r by Molmil
(h-alpha2M)4 plasmin-activated I state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
Authors:Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
Deposit date:2021-04-13
Release date:2022-04-13
Last modified:2022-05-11
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022

 

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