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1JL1
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BU of 1jl1 by Molmil
D10A E. coli ribonuclease HI
Descriptor: RIBONUCLEASE HI
Authors:Goedken, E.R, Marqusee, S.
Deposit date:2001-07-13
Release date:2002-02-27
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Native-state energetics of a thermostabilized variant of ribonuclease HI.
J.Mol.Biol., 314, 2001
1F21
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BU of 1f21 by Molmil
DIVALENT METAL COFACTOR BINDING IN THE KINETIC FOLDING TRAJECTORY OF E. COLI RIBONUCLEASE HI
Descriptor: RIBONUCLEASE HI
Authors:Goedken, E.R, Keck, J.L, Berger, J.M, Marqusee, S.
Deposit date:2000-05-22
Release date:2000-12-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Divalent metal cofactor binding in the kinetic folding trajectory of Escherichia coli ribonuclease HI.
Protein Sci., 9, 2000
1G15
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BU of 1g15 by Molmil
CO-CRYSTAL OF E. COLI RNASE HI WITH TWO MN2+ IONS BOUND IN THE THE ACTIVE SITE
Descriptor: MANGANESE (II) ION, RIBONUCLEASE HI
Authors:Goedken, E.R, Marqusee, S.
Deposit date:2000-10-10
Release date:2001-03-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Co-crystal of Escherichia coli RNase HI with Mn2+ ions reveals two divalent metals bound in the active site.
J.Biol.Chem., 276, 2001
4QPS
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BU of 4qps by Molmil
Crystal structure of Jak3 complexed to N-[3-(6-Phenylamino-pyrazin-2-yl)-3H-benzoimidazol-5-yl]-acrylamide
Descriptor: N-{1-[6-(phenylamino)pyrazin-2-yl]-1H-benzimidazol-6-yl}prop-2-enamide, Tyrosine-protein kinase JAK3
Authors:Argiriadi, M.A, Goedken, E.R.
Deposit date:2014-06-24
Release date:2015-01-14
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol.
J.Biol.Chem., 290, 2015
8DYG
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BU of 8dyg by Molmil
IL17A homodimer bound to Compound 7
Descriptor: (5P)-2-hydroxy-5-(6-methylquinolin-5-yl)benzoic acid, Interleukin-17A
Authors:Argiriadi, M.A, Goedken, E.R.
Deposit date:2022-08-04
Release date:2022-09-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
8DYH
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BU of 8dyh by Molmil
IL17A homodimer bound to Compound 6
Descriptor: (5P)-N-benzyl-6-chloro-5-(quinolin-5-yl)pyridin-3-amine, GLYCEROL, Interleukin-17A
Authors:Argiriadi, M.A, Goedken, E.R.
Deposit date:2022-08-04
Release date:2022-09-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
8DYI
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BU of 8dyi by Molmil
IL17A homodimer bound to Compound 5
Descriptor: (5P)-5-[5-(benzylamino)pyridin-3-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indazol-3-amine, Interleukin-17A
Authors:Argiriadi, M.A, Goedken, E.R.
Deposit date:2022-08-04
Release date:2022-09-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
8DYF
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BU of 8dyf by Molmil
IL17A homodimer bound to Compound 10
Descriptor: (5M)-3-[({2-[2-(2-{2-[2-({[(5M)-3-carboxy-5-(5,8-dihydroquinolin-4-yl)phenyl]amino}methyl)phenoxy]ethoxy}ethoxy)ethoxy]phenyl}methyl)amino]-5-(quinolin-4-yl)benzoic acid, Interleukin-17A
Authors:Argiriadi, M.A, Goedken, E.R.
Deposit date:2022-08-04
Release date:2022-09-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
3NEW
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BU of 3new by Molmil
p38-alpha complexed with Compound 10
Descriptor: 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one, Mitogen-activated protein kinase 14
Authors:Goedken, E.R, Comess, K.M, Sun, C, Argiriadi, M, Jia, Y, Quinn, C.M, Banach, D.L, Marcotte, D, Borhani, D.
Deposit date:2010-06-09
Release date:2010-12-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases.
Acs Chem.Biol., 6, 2011
2AVT
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BU of 2avt by Molmil
Crystal structure of the beta subunit from DNA polymerase of Streptococcus pyogenes
Descriptor: DNA polymerase III beta subunit
Authors:Argiriadi, M.A, Goedken, E.R, Bruck, I, O'donnell, M, Kuriyan, J.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium.
Bmc Struct.Biol., 6, 2006
1DOF
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BU of 1dof by Molmil
THE CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE FROM PYROBACULUM AEROPHILUM: INSIGHTS INTO THERMAL STABILITY AND HUMAN PATHOLOGY
Descriptor: ADENYLOSUCCINATE LYASE
Authors:Toth, E.A, Yeates, T.O, Goedken, E, Dixon, J.E, Marqusee, S.
Deposit date:1999-12-20
Release date:2001-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
J.Mol.Biol., 301, 2000
4E1Z
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BU of 4e1z by Molmil
Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor
Descriptor: N-[5-(4-{[(3-chlorophenyl)sulfonyl]amino}phenyl)-1H-indazol-3-yl]furan-2-carboxamide, Non-receptor tyrosine-protein kinase TYK2
Authors:Argiriadi, M.A, Talanian, R.V, Borhani, D.W.
Deposit date:2012-03-07
Release date:2012-10-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.
Bmc Struct.Biol., 12, 2012
4E20
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BU of 4e20 by Molmil
Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor
Descriptor: N-[4-(3-amino-1H-indazol-5-yl)phenyl]-3-chlorobenzenesulfonamide, Non-receptor tyrosine-protein kinase TYK2
Authors:Argiriadi, M.A, Talanian, R.V, Borhani, D.W.
Deposit date:2012-03-07
Release date:2012-10-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.
Bmc Struct.Biol., 12, 2012
3GLI
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BU of 3gli by Molmil
Crystal Structure of the E. coli clamp loader bound to Primer-Template DNA and Psi Peptide
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*AP*TP*A)-3'), ...
Authors:Simonetta, K.R, Cantor, A.J, Kuriyan, J.
Deposit date:2009-03-12
Release date:2009-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The mechanism of ATP-dependent primer-template recognition by a clamp loader complex.
Cell(Cambridge,Mass.), 137, 2009
3GLH
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BU of 3glh by Molmil
Crystal Structure of the E. coli clamp loader bound to Psi Peptide
Descriptor: DNA polymerase III subunit delta, DNA polymerase III subunit delta', DNA polymerase III subunit tau
Authors:Kazmirski, S.L, Simonetta, K.R, Kuriyan, J.
Deposit date:2009-03-12
Release date:2009-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.891 Å)
Cite:The mechanism of ATP-dependent primer-template recognition by a clamp loader complex.
Cell(Cambridge,Mass.), 137, 2009
3GLG
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BU of 3glg by Molmil
Crystal Structure of a Mutant (gammaT157A) E. coli Clamp Loader Bound to Primer-Template DNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*AP*TP*A)-3'), ...
Authors:Simonetta, K.R, Seyedin, S.N, Kuriyan, J.
Deposit date:2009-03-12
Release date:2009-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:The mechanism of ATP-dependent primer-template recognition by a clamp loader complex.
Cell(Cambridge,Mass.), 137, 2009
3GLF
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BU of 3glf by Molmil
Crystal Structure of the Ecoli Clamp Loader Bound to Primer-Template DNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*AP*TP*A)-3'), ...
Authors:Simonetta, K.R, Kuriyan, J.
Deposit date:2009-03-12
Release date:2009-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.388 Å)
Cite:The mechanism of ATP-dependent primer-template recognition by a clamp loader complex.
Cell(Cambridge,Mass.), 137, 2009
3K4X
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BU of 3k4x by Molmil
Eukaryotic Sliding Clamp PCNA Bound to DNA
Descriptor: DNA (5'-D(*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3'), DNA (5'-D(*TP*TP*TP*TP*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), Proliferating cell nuclear antigen
Authors:McNally, R, Kuriyan, J.
Deposit date:2009-10-06
Release date:2010-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Analysis of the role of PCNA-DNA contacts during clamp loading.
Bmc Struct.Biol., 10, 2010
3O2M
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BU of 3o2m by Molmil
Crystal Structure of JNK1-alpha1 isoform complex with a biaryl tetrazol (A-82118)
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, JIP1, 10MER PEPTIDE, ...
Authors:Abad-Zapatero, C.
Deposit date:2010-07-22
Release date:2011-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
Acs Chem.Biol., 6, 2011
1F1O
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BU of 1f1o by Molmil
STRUCTURAL STUDIES OF ADENYLOSUCCINATE LYASES
Descriptor: ADENYLOSUCCINATE LYASE
Authors:Toth, E.A, Yeates, T.
Deposit date:2000-05-19
Release date:2001-01-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
J.Mol.Biol., 301, 2000

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