Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1LAT
DownloadVisualize
BU of 1lat by Molmil
GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX
Descriptor: DNA (5'-D(*TP*TP*CP*CP*AP*GP*AP*AP*CP*AP*TP*GP*TP*TP*CP*TP*G P*GP*A)-3'), GLUCOCORTICOID RECEPTOR, ZINC ION
Authors:Gewirth, D.T, Sigler, P.B.
Deposit date:1995-12-18
Release date:1996-04-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The basis for half-site specificity explored through a non-cognate steroid receptor-DNA complex.
Nat.Struct.Biol., 2, 1995
1U0Z
DownloadVisualize
BU of 1u0z by Molmil
N-Domain Of Grp94 Lacking The Charged Domain In Complex With Radicicol
Descriptor: Endoplasmin, PENTAETHYLENE GLYCOL, RADICICOL, ...
Authors:Gewirth, D.T, Immormino, R.M.
Deposit date:2004-07-14
Release date:2005-07-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:N-Domain Of Grp94 Lacking The Charged Domain In Complex With Radicicol
TO BE PUBLISHED
6OLX
DownloadVisualize
BU of 6olx by Molmil
Hsp90-alpha S52A bound to PU-11-trans
Descriptor: 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine, Heat shock protein HSP 90-alpha
Authors:Gewirth, D.T, Huck, J.D.
Deposit date:2019-04-17
Release date:2019-07-03
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.43760586 Å)
Cite:Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.
Proteins, 87, 2019
6D1X
DownloadVisualize
BU of 6d1x by Molmil
N-Domain Of Grp94, with the Charged Domain, In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine
Descriptor: Endoplasmin, N-PROPYL CARBOXYAMIDO ADENOSINE, TETRAETHYLENE GLYCOL
Authors:Gewirth, D.T, Immormino, R.M.
Deposit date:2018-04-12
Release date:2018-05-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.
J.Biol.Chem., 294, 2019
1TBW
DownloadVisualize
BU of 1tbw by Molmil
Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation
Descriptor: ADENOSINE MONOPHOSPHATE, Endoplasmin, MAGNESIUM ION, ...
Authors:Gewirth, D.T, Immormino, R.M, Dollins, D.E, Shaffer, P.L, Walker, M.A, Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC0
DownloadVisualize
BU of 1tc0 by Molmil
Ligand Induced Conformational Shifts in the N-terminal Domain of GRP94, Open Conformation Complexed with the physiological partner ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Endoplasmin, MAGNESIUM ION, ...
Authors:Gewirth, D.T, Immormino, R.M, Dollins, D.E, Shaffer, P.L, Walker, M.A, Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC6
DownloadVisualize
BU of 1tc6 by Molmil
Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation ADP-Complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION, ...
Authors:Gewirth, D.T, Immormino, R.M, Dollins, D.E, Shaffer, P.L, Walker, M.A, Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
5ULS
DownloadVisualize
BU of 5uls by Molmil
Structure of GRP94 in the active conformation
Descriptor: Endoplasmin, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Huck, J.D, Que, N.L.S, Gewirth, D.T.
Deposit date:2017-01-25
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.622 Å)
Cite:Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.
Cell Rep, 20, 2017
5VYY
DownloadVisualize
BU of 5vyy by Molmil
Structure of human Hsp90-alpha bound to resorcinylic inhibitor BnIm
Descriptor: 1,2-ETHANEDIOL, FORMIC ACID, Heat shock protein HSP 90-alpha, ...
Authors:Que, N.S, Gewirth, D.T.
Deposit date:2017-05-26
Release date:2018-04-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
J. Med. Chem., 61, 2018
3O0I
DownloadVisualize
BU of 3o0i by Molmil
Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor PU-H54
Descriptor: 8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine, HSP90AA1 protein
Authors:Seidler, P.M, Gewirth, D.T.
Deposit date:2010-07-19
Release date:2011-10-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.
Nat.Chem.Biol., 9, 2013
3O2F
DownloadVisualize
BU of 3o2f by Molmil
Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54
Descriptor: 8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine, Endoplasmin, GLYCEROL, ...
Authors:Seidler, P.M, Gewirth, D.T.
Deposit date:2010-07-22
Release date:2011-10-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.
Nat.Chem.Biol., 9, 2013
3C0E
DownloadVisualize
BU of 3c0e by Molmil
Yeast Hsp82 N-terminal domain: effects of mutants 98-99 KS-AA
Descriptor: ATP-dependent molecular chaperone HSP82
Authors:Immormino, R.M, Gewirth, D.T.
Deposit date:2008-01-19
Release date:2008-07-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of GRP94 with the Specific Mutation KS168-169AA with Bound Geldanamycin
To be Published
3C11
DownloadVisualize
BU of 3c11 by Molmil
Yeast Hsp82 N-terminal domain-Geldanamycin complex: effects of mutants 98-99 KS-AA
Descriptor: ATP-dependent molecular chaperone HSP82, GELDANAMYCIN, GLYCEROL
Authors:Immormino, R.M, Gewirth, D.T.
Deposit date:2008-01-21
Release date:2008-07-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of GRP94 with the Specific Mutation KS168-169AA with Bound Geldanamycin
To be Published
2O1T
DownloadVisualize
BU of 2o1t by Molmil
Structure of Middle plus C-terminal domains (M+C) of GRP94
Descriptor: Endoplasmin
Authors:Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1U
DownloadVisualize
BU of 2o1u by Molmil
Structure of full length GRP94 with AMP-PNP bound
Descriptor: Endoplasmin, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1V
DownloadVisualize
BU of 2o1v by Molmil
Structure of full length GRP94 with ADP bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION
Authors:Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1W
DownloadVisualize
BU of 2o1w by Molmil
Structure of N-terminal plus middle domains (N+M) of GRP94
Descriptor: Endoplasmin
Authors:Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
6N8W
DownloadVisualize
BU of 6n8w by Molmil
Structure of Unliganded Hsp90-Beta N-Terminal Domain
Descriptor: GLYCEROL, Heat shock protein HSP 90-beta
Authors:Huck, J.D, Que, N.L.S, Gewirth, D.T.
Deposit date:2018-11-30
Release date:2019-07-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.09228134 Å)
Cite:Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.
Proteins, 87, 2019
6N8Y
DownloadVisualize
BU of 6n8y by Molmil
Hsp90-beta bound to PU-11-trans
Descriptor: 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine, Heat shock protein HSP 90-beta
Authors:Huck, J.D, Que, N.L.S, Gewirth, D.T.
Deposit date:2018-11-30
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.553908 Å)
Cite:Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.
Proteins, 87, 2019
6N8X
DownloadVisualize
BU of 6n8x by Molmil
Hsp90-alpha bound to PU-11-trans
Descriptor: 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine, Heat shock protein HSP 90-alpha
Authors:Huck, J.D, Que, N.L.S, Gewirth, D.T.
Deposit date:2018-11-30
Release date:2019-07-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.49484479 Å)
Cite:Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.
Proteins, 87, 2019
5WMT
DownloadVisualize
BU of 5wmt by Molmil
Structure of GRP94 N-terminal Domain bound to resorcinylic inhibitor BnIm.
Descriptor: 1,2-ETHANEDIOL, Endoplasmin, MAGNESIUM ION, ...
Authors:Que, N.S, Gewirth, D.T.
Deposit date:2017-07-31
Release date:2018-04-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.748 Å)
Cite:Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
J. Med. Chem., 61, 2018
1KB4
DownloadVisualize
BU of 1kb4 by Molmil
Crystal Structure of VDR DNA-binding Domain Bound to a Canonical Direct Repeat with Three Base Pair Spacer (DR3) Response Element
Descriptor: 5'-D(*CP*AP*CP*AP*GP*GP*TP*CP*AP*CP*GP*AP*AP*GP*GP*TP*CP*A)-3', 5'-D(*TP*GP*AP*CP*CP*TP*TP*CP*GP*TP*GP*AP*CP*CP*TP*GP*TP*G)-3', Vitamin D3 Receptor, ...
Authors:Shaffer, P.L, Gewirth, D.T.
Deposit date:2001-11-05
Release date:2002-05-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of VDR-DNA interactions on direct repeat response elements.
EMBO J., 21, 2002
1KB2
DownloadVisualize
BU of 1kb2 by Molmil
Crystal Structure of VDR DNA-binding Domain Bound to Mouse Osteopontin (SPP) Response Element
Descriptor: 5'-D(*CP*AP*CP*GP*GP*TP*TP*CP*AP*CP*GP*AP*GP*GP*TP*TP*CP*A)-3', 5'-D(*TP*GP*AP*AP*CP*CP*TP*CP*GP*TP*GP*AP*AP*CP*CP*GP*TP*G)-3', Vitamin D3 Receptor, ...
Authors:Shaffer, P.L, Gewirth, D.T.
Deposit date:2001-11-05
Release date:2002-05-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of VDR-DNA interactions on direct repeat response elements.
EMBO J., 21, 2002
1KB6
DownloadVisualize
BU of 1kb6 by Molmil
Crystal Structure of VDR DNA-binding Domain Bound to Rat Osteocalcin (OC) Response Element
Descriptor: 5'-D(*CP*AP*CP*GP*GP*GP*TP*GP*AP*AP*TP*GP*AP*GP*GP*AP*CP*A)-3', 5'-D(*TP*GP*TP*CP*CP*TP*CP*AP*TP*TP*CP*AP*CP*CP*CP*GP*TP*G)-3', Vitamin D3 Receptor, ...
Authors:Shaffer, P.L, Gewirth, D.T.
Deposit date:2001-11-05
Release date:2002-05-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of VDR-DNA interactions on direct repeat response elements.
EMBO J., 21, 2002
6B9A
DownloadVisualize
BU of 6b9a by Molmil
Hsp90-alpha N-domain bound to NPCA
Descriptor: Heat shock protein HSP 90-alpha, N-PROPYL CARBOXYAMIDO ADENOSINE
Authors:Huck, J.D, Gewirth, D.T.
Deposit date:2017-10-10
Release date:2018-10-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65381 Å)
Cite:Hsp90-alpha N-domain bound to NPCA
To Be Published

 

123>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon