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7O00
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BU of 7o00 by Molmil
Crystal structure of HLA-DR4 in complex with a HSP70 peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chaperone protein DnaK, ...
Authors:Ge, C, Holmdahl, R.
Deposit date:2021-03-25
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
Ann Rheum Dis, 81, 2022
7NZH
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BU of 7nzh by Molmil
Crystal structure of HLA-DR4 in complex with a citrullinated cilp peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, ...
Authors:Ge, C, Holmdahl, R.
Deposit date:2021-03-24
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.831 Å)
Cite:Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
Ann Rheum Dis, 81, 2022
7NZF
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BU of 7nzf by Molmil
Crystal structure of HLA-DR4 in complex with a mutated human collagen type II peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DR alpha chain, ...
Authors:Ge, C, Dobritzsch, D, Holmdahl, R.
Deposit date:2021-03-24
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
Ann Rheum Dis, 81, 2022
7NZE
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BU of 7nze by Molmil
Crystal structure of HLA-DR4 in complex with a human collagen type II peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Collagen alpha-1(II) chain, GLYCEROL, ...
Authors:Ge, C, Dobritzsch, D, Holmdahl, R.
Deposit date:2021-03-24
Release date:2022-06-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
Ann Rheum Dis, 81, 2022
6ZJG
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BU of 6zjg by Molmil
Crystal structure of ACPA E4 in complex with CII-C-48-CIT
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACPA E4 Fab fragment - heavy chain, ACPA E4 Fab fragment - light chain, ...
Authors:Ge, C, Holmdahl, R.
Deposit date:2020-06-29
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of ACPA E4 in complex with CII-C-48-CIT
To Be Published
6SF6
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BU of 6sf6 by Molmil
Crystal structure of the mAb 15A in complex with COMP-epitope P6
Descriptor: COMP-reactive monoclonal antibody 15A Fab fragment, heavy chain, light chain, ...
Authors:Dobritzsch, D, Ge, C, Holmdahl, R.
Deposit date:2019-08-01
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Antibodies to cartilage oligomeric matrix protein in vivo are pathogenic and clinically relevant in rheumatoid arthritis
To Be Published
6YXM
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BU of 6yxm by Molmil
Crystal structure of ACPA 1F2 in complex with CII-C-39-CIT
Descriptor: ACPA 1F2 Fab fragment - heavy chain, ACPA 1F2 Fab fragment - light chain, CII-C-39-CIT, ...
Authors:Ge, C, Holmdahl, R.
Deposit date:2020-05-03
Release date:2021-05-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation.
Sci Adv, 8, 2022
6YXK
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BU of 6yxk by Molmil
Crystal structure of ACPA 3F3 in complex with cit-vimentin 59-74
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACPA 3F3 Fab fragment - heavy chain, ACPA 3F3 Fab fragment - light chain, ...
Authors:Ge, C, Holmdahl, R.
Deposit date:2020-05-03
Release date:2021-05-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation.
Sci Adv, 8, 2022
6YXL
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BU of 6yxl by Molmil
Crystal structure of ACPA F3
Descriptor: ACPA F3 Fab fragment - heavy chain, ACPA F3 Fab fragment - light chain, GLYCEROL, ...
Authors:Ge, C, Holmdahl, R.
Deposit date:2020-05-03
Release date:2021-05-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation.
Sci Adv, 8, 2022
5MUB
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BU of 5mub by Molmil
ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05)
Descriptor: ACC1 Fab fragment heavy chain, ACC1 Fab fragment light chain, triple-helical peptide containing the citrullinated C1 epitope of collagen type II,Collagen alpha-1(II) chain,triple-helical peptide containing the citrullinated C1 epitope of collagen type II
Authors:Dobritzsch, D, Holmdahl, R, Ge, C.
Deposit date:2017-01-13
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
JCI Insight, 2, 2017
5MV4
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BU of 5mv4 by Molmil
ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23)
Descriptor: ACC1 antibody Fab fragment, heavy chain, light chain, ...
Authors:Dobritzsch, D, Holmdahl, R, Ge, C.
Deposit date:2017-01-15
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
JCI Insight, 2, 2017
5MU2
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BU of 5mu2 by Molmil
ACC1 Fab fragment in complex with CII583-591 (CG10)
Descriptor: ACC1 Fab fragment heavy chain, ACC1 Fab fragment light chain, synthetic peptide containing the CII583-591 epitope of collagen type II
Authors:Dobritzsch, D, Holmdahl, R, Ge, C.
Deposit date:2017-01-12
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
JCI Insight, 2, 2017
5MU0
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BU of 5mu0 by Molmil
ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03)
Descriptor: IA03 peptide containing the citrullinated C1 epitope of collagen type II,Collagen alpha-1(II) chain,IA03 peptide containing the citrullinated C1 epitope of collagen type II, heavy chain of ACC1 antibody Fab fragment, light chain of ACC1 antibody Fab fragment
Authors:Dobritzsch, D, Holmdahl, R, Ge, C.
Deposit date:2017-01-11
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
JCI Insight, 2, 2017
5MV3
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BU of 5mv3 by Molmil
ACC1 Fab fragment in complex with CII583-591 (CG10)
Descriptor: heavy chain of ACC1 Fab fragment, light chain of ACC1 Fab fragment, synthetic peptide containing the CII583-591 epitope of collagen type II,Collagen alpha-1(II) chain,synthetic peptide containing the CII583-591 epitope of collagen type II,
Authors:Dobritzsch, D, Holmdahl, R, Ge, C.
Deposit date:2017-01-15
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
JCI Insight, 2, 2017
8BBH
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BU of 8bbh by Molmil
The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307
Descriptor: Glucose-6-phosphate isomerase, Heavy Chain of TL1 Fab fragment, Light Chain of TL1 Fab fragment
Authors:Ge, C, Holmdahl, R, Li, T.
Deposit date:2022-10-13
Release date:2022-12-21
Last modified:2023-07-05
Method:X-RAY DIFFRACTION (1.619 Å)
Cite:Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage.
Ann Rheum Dis, 82, 2023
5OD8
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BU of 5od8 by Molmil
Crystal structure of the RA-associated mAb B2 (Fab fragment)
Descriptor: B2 Fab fragment - Light chain, B2 Fab fragment - heavy chain
Authors:Dobritzsch, D, Ge, C, Holmdahl, R, Amara, K, Malmstrom, V.
Deposit date:2017-07-05
Release date:2018-07-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71, 2019
5OD0
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BU of 5od0 by Molmil
Crystal structure of ACPA E4
Descriptor: Fab fragment of ACPA E4 - Light chain, Fab fragment of ACPA E4 - heavy chain, GLYCEROL
Authors:Dobritzsch, D, Ge, C, Holmdahl, R.
Deposit date:2017-07-04
Release date:2018-07-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71, 2019
5OCY
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BU of 5ocy by Molmil
Crystal structure of ACPA E4 in complex with CII-C-48-CIT
Descriptor: ACPA E4 Fab fragment - heavy chain, ACPA E4 Fab fragment - light chain, CII-C-48-CIT
Authors:Dobritzsch, D, Ge, C, Holmdahl, R.
Deposit date:2017-07-04
Release date:2018-07-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71, 2019
5OCK
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BU of 5ock by Molmil
Crystal structure of ACPA E4 in complex with CEP1
Descriptor: CEP1 peptide (from enolase), Human ACPA E4 Fab fragment - Heavy chain, Human ACPA E4 Fab fragment - Light chain
Authors:Dobritzsch, D, Ge, C, Holmdahl, R.
Deposit date:2017-07-03
Release date:2018-07-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71, 2019
5ODB
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BU of 5odb by Molmil
Crystal structure of the RA-associated mAb D10 (chimeric Fab fragment)
Descriptor: D10 Fab fragment - heavy chain, D10 Fab fragment - light chain, GLYCEROL, ...
Authors:Dobritzsch, D, Ge, C, Holmdahl, R, Amara, K, Malmstrom, V.
Deposit date:2017-07-05
Release date:2018-07-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71, 2019
5OCX
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BU of 5ocx by Molmil
Crystal structure of ACPA E4 in complex with CII-C-13-CIT
Descriptor: 1,2-ETHANEDIOL, CII-C-13-CIT, Fab fragment anti-citrullinated protein antibody E4 - light chain, ...
Authors:Dobritzsch, D, Ge, C, Holmdahl, R.
Deposit date:2017-07-04
Release date:2018-07-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71, 2019
2L7C
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BU of 2l7c by Molmil
Biophysical studies of lipid interacting regions of DGD2 in Arabidopsis thaliana
Descriptor: Digalactosyldiacylglycerol synthase 2, chloroplastic
Authors:Szpryngiel, S, Ge, C, Iakovleva, I, Lind, J, Wieslander, A, Maler, L.
Deposit date:2010-12-07
Release date:2011-10-19
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Lipid interacting regions in phosphate stress glycosyltransferase atDGD2 from Arabidopsis thaliana.
Biochemistry, 50, 2011
4BKL
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BU of 4bkl by Molmil
Crystal structure of the arthritogenic antibody M2139 (Fab fragment) in complex with the triple-helical J1 peptide
Descriptor: J1 EPITOPE, M2139 FAB FRAGMENT HEAVY CHAIN, M2139 FAB FRAGMENT LIGHT CHAIN
Authors:Raposo, B, Dobritzsch, D, Ge, C, Ekman, D, Lindh, I, Foerster, M, Uysal, H, Schneider, G, Holmdahl, R.
Deposit date:2013-04-26
Release date:2014-02-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Epitope-Specific Antibody Response is Controlled by Immunoglobulin Vh Polymorphisms.
J.Exp.Med., 211, 2014
5UK5
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BU of 5uk5 by Molmil
Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Garcia, K.C, Luca, V.C.
Deposit date:2017-01-19
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.
Science, 355, 2017
3R44
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BU of 3r44 by Molmil
Mycobacterium tuberculosis fatty acyl CoA synthetase
Descriptor: HISTIDINE, MALONATE ION, fatty acyl CoA synthetase FADD13 (FATTY-ACYL-CoA SYNTHETASE)
Authors:Andersson, C.S, Martinez Molina, D, Hogbom, M.
Deposit date:2011-03-17
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Mycobacterium tuberculosis Very-Long-Chain Fatty Acyl-CoA Synthetase: Structural Basis for Housing Lipid Substrates Longer than the Enzyme.
Structure, 20, 2012

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