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6I3N
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BU of 6i3n by Molmil
Helical MyD88 death domain filament
Descriptor: Myeloid differentiation primary response protein MyD88
Authors:Moncrieffe, M.C, Bollschweiler, D, Penczek, P.A.P, Gay, N.J.
Deposit date:2018-11-06
Release date:2019-11-20
Last modified:2020-03-11
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling.
Structure, 28, 2020
6SWS
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BU of 6sws by Molmil
The DBB dimerization domain of B-cell adaptor for PI3K (BCAP) is required for down regulation of inflammatory signalling through the Toll-like receptor pathway
Descriptor: Phosphoinositide 3-kinase adapter protein 1
Authors:Lauenstein, J.U, Scherm, M.J, Udgata, A, Moncrieffe, M.C, Fisher, D, Gay, N.J.
Deposit date:2019-09-23
Release date:2020-02-19
Last modified:2020-04-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain.
J Immunol., 204, 2020
4ARN
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BU of 4arn by Molmil
Crystal structure of the N-terminal domain of Drosophila Toll receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MALONATE ION, ...
Authors:Gangloff, M, Gay, N.J.
Deposit date:2012-04-25
Release date:2013-01-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Functional Insights from the Crystal Structure of the N-Terminal Domain of the Prototypical Toll Receptor.
Structure, 21, 2013
1MD6
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BU of 1md6 by Molmil
High resolution crystal structure of murine IL-1F5 reveals unique loop conformation for specificity
Descriptor: interleukin 1 family, member 5 (delta)
Authors:Pei, X.Y, Dunn, E.F, Gay, N.J, O'Neill, L.A.
Deposit date:2002-08-07
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-Resolution Structure of Murine Interleukin 1 Homologue IL-1F5 Reveals Unique Loop Conformations for Receptor Binding Specificity.
Biochemistry, 42, 2003
1YGO
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BU of 1ygo by Molmil
Solution Structure of the pelle Death Domain
Descriptor: Probable serine/threonine-protein kinase pelle
Authors:Moncrieffe, M.C, Stott, K.M, Gay, N.J.
Deposit date:2005-01-05
Release date:2005-07-26
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the isolated Pelle death domain.
Febs Lett., 579, 2005
4ARR
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BU of 4arr by Molmil
Crystal structure of the N-terminal domain of Drosophila Toll receptor with the magic triangle I3C
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, TOLL RECEPTOR, ...
Authors:Gangloff, M, Gay, N.J.
Deposit date:2012-04-26
Release date:2013-02-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Liesegang-Like Patterns of Toll Crystals Grown in Gel.
J.Appl.Crystallogr., 46, 2013
4BV4
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BU of 4bv4 by Molmil
Structure and allostery in Toll-Spatzle recognition
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN SPAETZLE C-106, PROTEIN TOLL, ...
Authors:Lewis, M.F, Arnot, C.J, Beeston, H, McCoy, A, Ashcroft, A.E, Gay, N.J, Gangloff, M.
Deposit date:2013-06-24
Release date:2013-12-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Cytokine Spatzle Binds to the Drosophila Immunoreceptor Toll with a Neurotrophin-Like Specificity and Couples Receptor Activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
2YJN
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BU of 2yjn by Molmil
Structure of the glycosyltransferase EryCIII from the erythromycin biosynthetic pathway, in complex with its activating partner, EryCII
Descriptor: DTDP-4-KETO-6-DEOXY-HEXOSE 3,4-ISOMERASE, GLYCOSYLTRANSFERASE
Authors:Moncrieffe, M.C, Fernandez, M.J, Spiteller, D, Matsumura, H, Gay, N.J, Luisi, B.F, Leadlay, P.F.
Deposit date:2011-05-20
Release date:2011-11-09
Last modified:2015-04-01
Method:X-RAY DIFFRACTION (3.091 Å)
Cite:Structure of the Glycosyltransferase Eryciii in Complex with its Activating P450 Homologue Erycii.
J.Mol.Biol., 415, 2012
5FOR
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BU of 5for by Molmil
Cryptic TIR
Descriptor: 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, PENTAETHYLENE GLYCOL, PHOSPHOINOSITIDE 3-KINASE ADAPTER PROTEIN 1
Authors:Halabi, S, Gay, N.J, Moncrieffe, M.C.
Deposit date:2015-11-25
Release date:2016-12-07
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome.
J. Biol. Chem., 292, 2017
7B1C
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BU of 7b1c by Molmil
Cryo-EM of Aedes Aegypti Toll5A trimer bound to Spz1C
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AAEL013433-PA, ...
Authors:Gangloff, M, Hardwick, S.W, Chirgadze, D.Y.
Deposit date:2020-11-24
Release date:2022-07-13
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
Nat Commun, 13, 2022
7B1D
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BU of 7b1d by Molmil
Cryo-EM of Aedes Aegypti Toll5A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor
Authors:Gangloff, M, Hardwick, S.W, Chirgadze, D.Y.
Deposit date:2020-11-24
Release date:2022-07-13
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
Nat Commun, 13, 2022
7B1B
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BU of 7b1b by Molmil
Cryo-EM of Aedes Aegypti Toll5A dimer bound to Spz1C
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AAEL013433-PA, ...
Authors:Gangloff, M, Hardwick, S.W, Chirgadze, D.Y.
Deposit date:2020-11-24
Release date:2022-07-13
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (4.23 Å)
Cite:Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
Nat Commun, 13, 2022
2Y92
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BU of 2y92 by Molmil
Crystal structure of MAL adaptor protein
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN,
Authors:Valkov, E, Stamp, A, Martin, J.L, Kobe, B.
Deposit date:2011-02-11
Release date:2011-09-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystal Structure of Toll-Like Receptor Adaptor Mal/Tirap Reveals the Molecular Basis for Signal Transduction and Disease Protection.
Proc.Natl.Acad.Sci.USA, 108, 2011

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