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2CKB
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BU of 2ckb by Molmil
STRUCTURE OF THE 2C/KB/DEV8 COMPLEX
Descriptor: ALPHA, BETA T CELL RECEPTOR, BETA-2 MICROGLOBULIN, ...
Authors:Garcia, K.C, Degano, M, Wilson, I.A.
Deposit date:1998-01-14
Release date:1998-04-29
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.
Science, 279, 1998
1TCR
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BU of 1tcr by Molmil
MURINE T-CELL ANTIGEN RECEPTOR 2C CLONE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Garcia, K.C, Degano, M, Stanfield, R.L, Wilson, I.A.
Deposit date:1996-09-12
Release date:1997-03-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex.
Science, 274, 1996
5UK5
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BU of 5uk5 by Molmil
Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Garcia, K.C, Luca, V.C.
Deposit date:2017-01-19
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.
Science, 355, 2017
2E7L
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BU of 2e7l by Molmil
Structure of a high-affinity mutant of the 2C TCR in complex with Ld/QL9
Descriptor: Beta-chain, Cytotoxic Tcell receptor, H-2 class I histocompatibility antigen, ...
Authors:Garcia, K.C, Colf, L.A.
Deposit date:2007-01-11
Release date:2007-04-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:How a single T cell receptor recognizes both self and foreign MHC.
Cell(Cambridge,Mass.), 129, 2007
3BPL
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BU of 3bpl by Molmil
Crystal structure of the IL4-IL4R-Common Gamma ternary complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Garcia, K.C.
Deposit date:2007-12-18
Release date:2008-02-05
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.
Cell(Cambridge,Mass.), 132, 2008
3BPO
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BU of 3bpo by Molmil
Crystal structure of the IL13-IL4R-IL13Ra ternary complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin 13, ...
Authors:Garcia, K.C.
Deposit date:2007-12-18
Release date:2008-02-05
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.
Cell(Cambridge,Mass.), 132, 2008
3BPN
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BU of 3bpn by Molmil
Crystal structure of the IL4-IL4R-IL13Ra ternary complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13 receptor alpha-1 chain, Interleukin-4, ...
Authors:Garcia, K.C.
Deposit date:2007-12-18
Release date:2008-02-05
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.
Cell(Cambridge,Mass.), 132, 2008
2OI9
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BU of 2oi9 by Molmil
Structure of the 2C/Ld/QL9 allogeneic complex
Descriptor: Major Histocompatibility Complex protein, T cell receptor alpha chain, T cell receptor beta chain, ...
Authors:Garcia, K.C, Colf, L.A.
Deposit date:2007-01-10
Release date:2007-04-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:How a single T cell receptor recognizes both self and foreign MHC.
Cell(Cambridge,Mass.), 129, 2007
2NYK
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BU of 2nyk by Molmil
Crystal structure of m157 from mouse cytomegalovirus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, M157
Authors:Garcia, K.C.
Deposit date:2006-11-20
Release date:2007-05-29
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors.
Proc.Natl.Acad.Sci.Usa, 104, 2007
1G6R
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BU of 1g6r by Molmil
A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX
Descriptor: ALPHA T CELL RECEPTOR, BETA T CELL RECEPTOR, BETA-2 MICROGLOBULIN, ...
Authors:Degano, M, Garcia, K.C, Apostolopoulos, V, Rudolph, M.G, Teyton, L, Wilson, I.A.
Deposit date:2000-11-07
Release date:2000-11-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A functional hot spot for antigen recognition in a superagonist TCR/MHC complex.
Immunity, 12, 2000
1XFD
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BU of 1xfd by Molmil
Structure of a human A-type Potassium Channel Accelerating factor DPPX, a member of the dipeptidyl aminopeptidase family
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl aminopeptidase-like protein 6, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Strop, P, Bankovich, A.J, Hansen, K.C, Garcia, K.C, Brunger, A.T.
Deposit date:2004-09-14
Release date:2004-10-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family
J.Mol.Biol., 343, 2004
1GNB
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BU of 1gnb by Molmil
DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM
Descriptor: GUANYLIN PRECURSOR
Authors:Skelton, N.J, Garcia, K.C.
Deposit date:1994-06-30
Release date:1994-09-30
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.
Biochemistry, 33, 1994
1GNA
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BU of 1gna by Molmil
DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM
Descriptor: GUANYLIN PRECURSOR
Authors:Skelton, N.J, Garcia, K.C.
Deposit date:1994-06-30
Release date:1994-09-30
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.
Biochemistry, 33, 1994
8CX4
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BU of 8cx4 by Molmil
TCR-antigen complex AS8.4-YEIH-HLA*B27
Descriptor: AS8.4a, AS8.4b, Beta-2-microglobulin, ...
Authors:Yang, X, Jude, K.M, Garcia, K.C.
Deposit date:2022-05-19
Release date:2022-12-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
8CTG
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BU of 8ctg by Molmil
Extracellular architecture of an engineered canonical Wnt signaling ternary complex
Descriptor: Frizzled-8, Low-density lipoprotein receptor-related protein 6, PALMITOLEIC ACID, ...
Authors:Tsutsumi, N, Jude, K.M, Garcia, K.C.
Deposit date:2022-05-14
Release date:2023-03-15
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination.
Proc.Natl.Acad.Sci.USA, 120, 2023
6OEL
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BU of 6oel by Molmil
Engineered Fab bound to IL-4 receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-4 receptor subunit alpha, ...
Authors:Jude, K.M, Moraga, I, Spangler, J.B, Garcia, K.C.
Deposit date:2019-03-27
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A strategy for the selection of monovalent antibodies that span protein dimer interfaces.
J.Biol.Chem., 294, 2019
1U3H
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BU of 1u3h by Molmil
Crystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 A
Descriptor: H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain, ...
Authors:Maynard, J, Petersson, K, Wilson, D.H, Adams, E.J, Blondelle, S.E, Boulanger, M.J, Wilson, D.B, Garcia, K.C.
Deposit date:2004-07-21
Release date:2005-05-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity
Immunity, 22, 2005
1YK1
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BU of 1yk1 by Molmil
structure of natriuretic peptide receptor-C complexed with brain natriuretic peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Atrial natriuretic peptide clearance receptor, ...
Authors:He, X, Garcia, K.C.
Deposit date:2005-01-16
Release date:2006-04-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural determinants of natriuretic peptide receptor specificity and degeneracy.
J.Mol.Biol., 361, 2006
1YK0
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BU of 1yk0 by Molmil
structure of natriuretic peptide receptor-C complexed with atrial natriuretic peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Atrial natriuretic factor, ...
Authors:He, X, Garcia, K.C.
Deposit date:2005-01-16
Release date:2006-04-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural determinants of natriuretic peptide receptor specificity and degeneracy.
J.Mol.Biol., 361, 2006
5T5W
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BU of 5t5w by Molmil
Structure of an affinity matured lambda-IFN/IFN-lambdaR1/IL-10Rbeta receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon lambda receptor 1, Interferon lambda-3, ...
Authors:Mendoza, J.L, Jude, K.M, Garcia, K.C.
Deposit date:2016-08-31
Release date:2017-03-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.847 Å)
Cite:The IFN-lambda-IFN-lambda R1-IL-10R beta Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.
Immunity, 46, 2017
5UN6
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BU of 5un6 by Molmil
Frizzled-8 complex with designed surrogate Wnt agonist, A1 dataset
Descriptor: Designed Wnt agonist B12, Frizzled-8
Authors:Janda, C.Y, Garcia, K.C, Jude, K.M.
Deposit date:2017-01-30
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling.
Nature, 545, 2017
5UN5
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BU of 5un5 by Molmil
Frizzled-8 complex with designed surrogate Wnt agonist, crystal form 1
Descriptor: Designed Wnt agonist B12, Frizzled-8
Authors:Janda, C.Y, Garcia, K.C.
Deposit date:2017-01-30
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.994 Å)
Cite:Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling.
Nature, 545, 2017
5UTZ
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BU of 5utz by Molmil
Human IL-2/Fab complex
Descriptor: Fab 5111 heavy chain, Fab 5111 light chain, GLYCEROL, ...
Authors:Jude, K.M, Garcia, K.C.
Deposit date:2017-02-15
Release date:2018-07-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.747 Å)
Cite:A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
Nat. Med., 24, 2018
5WB1
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BU of 5wb1 by Molmil
Ligand-free US28 with stabilizing intracellular nanobody
Descriptor: Envelope protein US28, nanobody 7 fusion protein
Authors:Jude, K.M, Burg, J.S, Garcia, K.C.
Deposit date:2017-06-27
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.508 Å)
Cite:Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.
Elife, 7, 2018
6DG5
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BU of 6dg5 by Molmil
Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ...
Authors:Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C.
Deposit date:2018-05-16
Release date:2019-01-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.516 Å)
Cite:De novo design of potent and selective mimics of IL-2 and IL-15.
Nature, 565, 2019

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