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2H4E
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BU of 2h4e by Molmil
Crystal structure of Cys10 sulfonated transthyretin
Descriptor: SULFATE ION, Transthyretin
Authors:Gales, L, Damas, A.M.
Deposit date:2006-05-24
Release date:2007-01-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural basis for the protective role of sulfite against transthyretin amyloid formation.
Biochim.Biophys.Acta, 1774, 2007
1Y1D
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BU of 1y1d by Molmil
Crystal structure of transthyretin in complex with iododiflunisal
Descriptor: 2',4'-DIFLUORO-4-HYDROXY-5-IODO-1,1'-BIPHENYL-3-CARBOXYLIC ACID, Transthyretin
Authors:Gales, L, Macedo-Ribeiro, S, Arsequell, G, Valencia, G, Saraiva, M.J, Damas, A.M.
Deposit date:2004-11-18
Release date:2005-07-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor.
Biochem.J., 388, 2005
3B56
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BU of 3b56 by Molmil
Crystal structure of transthyretin in complex with 3,5-diiodosalicylic acid
Descriptor: 2-HYDROXY-3,5-DIIODO-BENZOIC ACID, Transthyretin
Authors:Gales, L, Damas, A.M.
Deposit date:2007-10-25
Release date:2008-01-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Iodination of salicylic acid improves its binding to transthyretin
Biochim.Biophys.Acta, 1784, 2008
3FCB
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BU of 3fcb by Molmil
Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOH
Descriptor: N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINE, transthyretin
Authors:Gales, L, Damas, A.M.
Deposit date:2008-11-21
Release date:2009-02-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.
Plos One, 4, 2009
3FC8
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BU of 3fc8 by Molmil
Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOMe
Descriptor: METHYL N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINATE, transthyretin
Authors:Gales, L, Damas, A.M.
Deposit date:2008-11-21
Release date:2009-02-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.
Plos One, 4, 2009
4UB9
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BU of 4ub9 by Molmil
Structural and catalytic characterization of molinate hydrolase
Descriptor: Molinate hydrolase, ZINC ION
Authors:Leite, J.P, Duarte, M, Paiva, A, Ferreira-da-Silva, F, Matias, P.M, Nunes, O, Gales, L.
Deposit date:2014-08-12
Release date:2015-06-24
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structure-guided engineering of molinate hydrolase for the degradation of thiocarbamate pesticides.
Plos One, 10, 2015
7QH5
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BU of 7qh5 by Molmil
The crystal structure of the sigma factor SigG1 from Streptomyces tsukubaensis NRRL18488
Descriptor: GLYCEROL, RNA polymerase sigma factor
Authors:Lourenco, F, Leite, J.P, Gales, L.
Deposit date:2021-12-10
Release date:2022-12-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of Streptomyces tsukubaensis sigma factor SigG1 and anti-sigma RsfG.
J.Struct.Biol., 215, 2023
7QH3
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BU of 7qh3 by Molmil
Crystal structure of the anti-sigma factor RsfG from Streptomyces tsukubaensis NRRL18488
Descriptor: RsfG
Authors:Leite, J.P, Lourenco, F, Gales, L.
Deposit date:2021-12-10
Release date:2022-12-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of Streptomyces tsukubaensis sigma factor SigG1 and anti-sigma RsfG.
J.Struct.Biol., 215, 2023
2I5P
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BU of 2i5p by Molmil
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase isoform 1 from K. marxianus
Descriptor: BETA-MERCAPTOETHANOL, Glyceraldehyde-3-phosphate dehydrogenase 1, alpha-D-glucopyranose
Authors:Ferreira-da-Silva, F, Pereira, P.J.B, Gales, L, Moradas-Ferreira, P, Damas, A.M.
Deposit date:2006-08-25
Release date:2006-09-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Crystal and Solution Structures of Glyceraldehyde-3-phosphate Dehydrogenase Reveal Different Quaternary Structures.
J.Biol.Chem., 281, 2006
3SSG
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BU of 3ssg by Molmil
Structure of transthyretin L55P in complex with Zn
Descriptor: CACODYLATE ION, Transthyretin, ZINC ION
Authors:Castro-Rodrigues, A.F, Gales, L, Damas, A.M.
Deposit date:2011-07-08
Release date:2011-11-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils.
Acta Crystallogr.,Sect.D, 67, 2011
5O7B
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BU of 5o7b by Molmil
CRYSTAL STRUCTURE OF THE SLR0328 TYROSINE PHOSPHATASE WZB FROM SYNECHOCYSTIS SP. PCC 6803
Descriptor: Putative low molecular weight protein-tyrosine-phosphatase slr0328
Authors:Leite, J.P, Gales, L.
Deposit date:2017-06-08
Release date:2018-06-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.281 Å)
Cite:The role of the tyrosine kinase Wzc (Sll0923) and the phosphatase Wzb (Slr0328) in the production of extracellular polymeric substances (EPS) by Synechocystis PCC 6803.
Microbiologyopen, 2019
5ONP
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BU of 5onp by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Cd-substituted Thermolysin
Descriptor: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
Authors:Leite, J.P, Gales, L.
Deposit date:2017-08-04
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
5ONQ
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BU of 5onq by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd-substituted Thermolysin
Descriptor: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
Authors:Leite, J.P, Gales, L.
Deposit date:2017-08-04
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
5ONR
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BU of 5onr by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Thermolysin
Descriptor: Amyloid-beta A4 protein, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Leite, J.P, Gales, L.
Deposit date:2017-08-04
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
7ACU
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BU of 7acu by Molmil
Crystal structure of human transthyretin in complex with Benzbromarone
Descriptor: Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone
Authors:Leite, J.P, Gales, L.
Deposit date:2020-09-11
Release date:2020-10-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.541 Å)
Cite:Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer.
Int J Mol Sci, 21, 2020
6EP1
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BU of 6ep1 by Molmil
Transthyretin in complex with 5-(4-nitrophenylazo)-3-iodosalicylic acid
Descriptor: 5-(4-nitrophenylazo)-3-iodosalicylic acid, Transthyretin
Authors:Leite, J.P, Gales, L.
Deposit date:2017-10-10
Release date:2018-10-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease
Eur.J.Med.Chem., 2021
6EOY
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BU of 6eoy by Molmil
Transthyretin in complex with 4-(1,3-Benzothiazol-2-yl)-2-methylaniline
Descriptor: 4-(1,3-benzothiazol-2-yl)-2-methyl-aniline, Transthyretin
Authors:Leite, J.P, Gales, L.
Deposit date:2017-10-10
Release date:2021-10-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease.
Eur.J.Med.Chem., 226, 2021
6GHX
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BU of 6ghx by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 31-35 in Complex with Cd-substituted Thermolysin
Descriptor: CADMIUM ION, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Leite, J.P, Gales, L.
Deposit date:2018-05-09
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.156 Å)
Cite:Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019

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