Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
5H4J
DownloadVisualize
BU of 5h4j by Molmil
Crystal structure of Human dUTPase in complex with N-[(1R)-1-[3-(Cyclopentyloxy)-phenyl]-ethyl]-3-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methoxy]-1-propanesulfonamide
Descriptor: DIMETHYL SULFOXIDE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, ...
Authors:Chong, K.T, Miyahara, S, Miyakoshi, H, Fukuoka, M.
Deposit date:2016-11-01
Release date:2017-11-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy.
Mol. Cancer Ther., 17, 2018
3ARN
DownloadVisualize
BU of 3arn by Molmil
Human dUTPase in complex with novel uracil derivative
Descriptor: Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, N-{5-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]-2-methylpentan-2-yl}benzenesulfonamide
Authors:Chong, K.T, Miyahara, S, Miyakoshi, H, Fukuoka, M.
Deposit date:2010-12-03
Release date:2010-12-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors
J.Med.Chem., 55, 2012
1UC5
DownloadVisualize
BU of 1uc5 by Molmil
Structure of diol dehydratase complexed with (R)-1,2-propanediol
Descriptor: AMMONIUM ION, CYANOCOBALAMIN, POTASSIUM ION, ...
Authors:Shibata, N, Nakanishi, Y, Fukuoka, M, Yamanishi, M, Yasuoka, N, Toraya, T.
Deposit date:2003-04-08
Release date:2003-07-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural rationalization for the lack of stereospecificity in coenzyme B12-dependent diol dehydratase
J.Biol.Chem., 278, 2003
1UC4
DownloadVisualize
BU of 1uc4 by Molmil
Structure of diol dehydratase complexed with (S)-1,2-propanediol
Descriptor: AMMONIUM ION, CYANOCOBALAMIN, POTASSIUM ION, ...
Authors:Shibata, N, Nakanishi, Y, Fukuoka, M, Yamanishi, M, Yasuoka, N, Toraya, T.
Deposit date:2003-04-08
Release date:2003-07-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural rationalization for the lack of stereospecificity in coenzyme B12-dependent diol dehydratase
J.BIOL.CHEM., 278, 2003
3AUJ
DownloadVisualize
BU of 3auj by Molmil
Structure of diol dehydratase complexed with glycerol
Descriptor: CALCIUM ION, COBALAMIN, Diol dehydrase alpha subunit, ...
Authors:Yamanishi, M, Kinoshita, K, Fukuoka, M, Shibata, T, Tobimatsu, T, Toraya, T.
Deposit date:2011-02-07
Release date:2012-02-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Redesign of coenzyme B(12) dependent diol dehydratase to be resistant to the mechanism-based inactivation by glycerol and act on longer chain 1,2-diols
Febs J., 279, 2012
3ARA
DownloadVisualize
BU of 3ara by Molmil
Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors
Descriptor: 1-[3-({(2R)-2-[hydroxy(diphenyl)methyl]pyrrolidin-1-yl}sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione, Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION
Authors:Chong, K.T, Miyakoshi, H, Miyahara, S, Fukuoka, M.
Deposit date:2010-11-25
Release date:2010-12-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors
J.Med.Chem., 55, 2012

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon