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5I33
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BU of 5i33 by Molmil
Unligated adenylosuccinate synthetase from Cryptococcus neoformans
Descriptor: Adenylosuccinate synthetase
Authors:Blundell, R.D, Williams, S.J, Ericsson, D, Fraser, J.A, Kobe, B.
Deposit date:2016-02-09
Release date:2016-08-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.
Acs Infect Dis., 2, 2016
5I34
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BU of 5i34 by Molmil
Adenylosuccinate synthetase from Cryptococcus neoformans complexed with GDP and IMP
Descriptor: Adenylosuccinate synthetase, GUANOSINE-5'-DIPHOSPHATE, INOSINIC ACID
Authors:Blundell, R.D, Williams, S.J, Ericsson, D, Fraser, J.A, Kobe, B.
Deposit date:2016-02-09
Release date:2016-08-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.
Acs Infect Dis., 2, 2016
4AF0
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BU of 4af0 by Molmil
Crystal structure of cryptococcal inosine monophosphate dehydrogenase
Descriptor: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, INOSINIC ACID, MYCOPHENOLIC ACID, ...
Authors:Valkov, E, Stamp, A, Morrow, C.A, Kobe, B, Fraser, J.A.
Deposit date:2012-01-15
Release date:2012-10-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:De Novo GTP Biosynthesis is Critical for Virulence of the Fungal Pathogen Cryptococcus Neoformans
Plos Pathog., 8, 2012
7LVO
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BU of 7lvo by Molmil
Cryptococcus neoformans GAR synthetase
Descriptor: 1,2-ETHANEDIOL, phosphoribosyl-glycinamide (GAR) synthetase
Authors:Chua, S.M.H, Luo, Z, Lim, B.Y.J, Kobe, B, Fraser, J.A.
Deposit date:2021-02-26
Release date:2021-08-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets.
J.Biol.Chem., 297, 2021
7LVP
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BU of 7lvp by Molmil
Cryptococcus neoformans AIR synthetase
Descriptor: 1,2-ETHANEDIOL, AIR synthase, GLYCINE, ...
Authors:Chua, S.M.H, Luo, Z, Lim, B.Y.J, Kobe, B, Fraser, J.A.
Deposit date:2021-02-26
Release date:2021-08-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets.
J.Biol.Chem., 297, 2021
7MGQ
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BU of 7mgq by Molmil
AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans
Descriptor: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, MAGNESIUM ION
Authors:Wizrah, M.S, Chua, S.M.H, Luo, Z, Manik, M.K, Pan, M, Whyte, J.M, Robertson, A.B, Kappler, U, Kobe, B, Fraser, J.A.
Deposit date:2021-04-13
Release date:2022-04-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans.
J.Biol.Chem., 298, 2022
5V4L
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BU of 5v4l by Molmil
Cryptococcus neoformans adenylosuccinate lyase
Descriptor: Adenylosuccinate lyase
Authors:Chitty, J, Williams, S.J, Kobe, B, Fraser, J.A.
Deposit date:2017-03-09
Release date:2017-06-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.
J. Biol. Chem., 292, 2017
6BD9
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BU of 6bd9 by Molmil
Saccharomyces cerevisiae acetohydroxyacid synthase
Descriptor: Acetolactate synthase catalytic subunit, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Guddat, L.W, Lonhienne, T.
Deposit date:2017-10-22
Release date:2017-11-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.982 Å)
Cite:High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism
Chemistryselect, 2017
6BD3
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BU of 6bd3 by Molmil
Saccharomyces cerevisiae acetohydroxyacid synthase
Descriptor: 2-ACETYL-THIAMINE DIPHOSPHATE, ACETATE ION, Acetolactate synthase catalytic subunit, ...
Authors:Guddat, L.W, Lonhienne, T.
Deposit date:2017-10-21
Release date:2017-11-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism
Chemistryselect, 2017
6WO1
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BU of 6wo1 by Molmil
Hybrid acetohydroxyacid synthase complex structure with Cryptococcus neoformans AHAS catalytic subunit and Saccharomyces cerevisiae AHAS regulatory subunit
Descriptor: 2-methylpyrimidin-4-amine, Acetohydroxyacid synthase catalytic subunit, Acetohydroxyacid synthase regulatory subunit, ...
Authors:Guddat, L.W, Lonhienne, T.
Deposit date:2020-04-23
Release date:2020-07-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of fungal and plant acetohydroxyacid synthases.
Nature, 586, 2020
5FEM
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BU of 5fem by Molmil
Saccharomyces cerevisiae Acetohydroxyacid Synthase in complex with bensulfuron methyl
Descriptor: Acetolactate synthase catalytic subunit, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Guddat, L.W, Lonhienne, T.
Deposit date:2015-12-17
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.168 Å)
Cite:Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase.
Angew.Chem.Int.Ed.Engl., 55, 2016
6DEL
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BU of 6del by Molmil
Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl
Descriptor: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate, 2-[[[[(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)AMINO]CARBONYL]AMINO]SULFONYL]BENZOIC ACID ETHYL ESTER, ...
Authors:Garcia, M.D, Guddat, L.W.
Deposit date:2018-05-12
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.119 Å)
Cite:Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DES
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BU of 6des by Molmil
Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone
Descriptor: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Acetolactate synthase, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Garcia, M.D, Guddat, L.W.
Deposit date:2018-05-12
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DEP
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BU of 6dep by Molmil
Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl
Descriptor: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Acetolactate synthase, ...
Authors:Garcia, M.D, Guddat, L.W.
Deposit date:2018-05-12
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.149 Å)
Cite:Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DEM
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BU of 6dem by Molmil
Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl
Descriptor: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, Acetolactate synthase, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Garcia, M.D, Guddat, L.W.
Deposit date:2018-05-12
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.038 Å)
Cite:Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DEK
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BU of 6dek by Molmil
Crystal structure of Candida albicans acetohydroxyacid synthase catalytic subunit
Descriptor: Acetolactate synthase, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
Authors:Garcia, M.D, Guddat, L.W.
Deposit date:2018-05-12
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.971 Å)
Cite:Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DER
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BU of 6der by Molmil
Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam
Descriptor: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Acetolactate synthase, ...
Authors:Garcia, M.D, Guddat, L.W.
Deposit date:2018-05-12
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.126 Å)
Cite:Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DEN
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BU of 6den by Molmil
Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl
Descriptor: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, Acetolactate synthase, CARBON DIOXIDE, ...
Authors:Garcia, M.D, Guddat, L.W.
Deposit date:2018-05-12
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.806 Å)
Cite:Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DEO
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BU of 6deo by Molmil
Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl
Descriptor: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, Acetolactate synthase, CARBON DIOXIDE, ...
Authors:Garcia, M.D, Guddat, L.W.
Deposit date:2018-05-12
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.971 Å)
Cite:Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DEQ
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BU of 6deq by Molmil
Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam
Descriptor: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide, Acetolactate synthase, ...
Authors:Garcia, M.D, Guddat, L.W.
Deposit date:2018-05-12
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.127 Å)
Cite:Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6U9H
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BU of 6u9h by Molmil
Arabidopsis thaliana acetohydroxyacid synthase complex
Descriptor: Acetolactate synthase small subunit 2, chloroplastic, Acetolactate synthase, ...
Authors:Guddat, L.W, Low, Y.S, Rao, Z.
Deposit date:2019-09-08
Release date:2020-07-15
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures of fungal and plant acetohydroxyacid synthases.
Nature, 586, 2020
6U9D
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BU of 6u9d by Molmil
Saccharomyces cerevisiae acetohydroxyacid synthase
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Acetolactate synthase catalytic subunit, mitochondrial, ...
Authors:Guddat, L.W, Lonhienne, T.
Deposit date:2019-09-08
Release date:2020-07-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.194 Å)
Cite:Structures of fungal and plant acetohydroxyacid synthases.
Nature, 586, 2020
6VZ8
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BU of 6vz8 by Molmil
Arabidopsis thaliana acetohydroxyacid synthase complex with valine bound
Descriptor: Acetolactate synthase small subunit 2, chloroplastic, Acetolactate synthase, ...
Authors:Guddat, L.W, Low, Y.S.
Deposit date:2020-02-27
Release date:2020-07-15
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structures of fungal and plant acetohydroxyacid synthases.
Nature, 586, 2020

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PDB entries from 2024-03-27

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