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4A0L
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BU of 4a0l by Molmil
Structure of DDB1-DDB2-CUL4B-RBX1 bound to a 12 bp abasic site containing DNA-duplex
Descriptor: 12 BP DNA DUPLEX, 12 BP THF CONTAINING DNA DUPLEX, CULLIN-4B, ...
Authors:Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H.
Deposit date:2011-09-09
Release date:2011-12-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (7.4 Å)
Cite:The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
Cell(Cambridge,Mass.), 147, 2011
4A0K
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BU of 4a0k by Molmil
STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX
Descriptor: 12 BP DNA, 12 BP THF CONTAINING DNA, CULLIN-4A, ...
Authors:Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H.
Deposit date:2011-09-09
Release date:2011-12-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (5.93 Å)
Cite:The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
Cell(Cambridge,Mass.), 147, 2011
4CI3
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BU of 4ci3 by Molmil
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ...
Authors:Fischer, E.S, Boehm, K, Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4CI1
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BU of 4ci1 by Molmil
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Thalidomide, ...
Authors:Fischer, E.S, Boehm, K, Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4CI2
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BU of 4ci2 by Molmil
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ...
Authors:Fischer, E.S, Boehm, K, Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4A11
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BU of 4a11 by Molmil
Structure of the hsDDB1-hsCSA complex
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, DNA EXCISION REPAIR PROTEIN ERCC-8
Authors:Bohm, K, Scrima, A, Fischer, E.S, Gut, H, Thomae, N.H.
Deposit date:2011-09-13
Release date:2011-12-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
Cell(Cambridge,Mass.), 147, 2011
7JQ9
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BU of 7jq9 by Molmil
Cryo-EM structure of human HUWE1
Descriptor: E3 ubiquitin-protein ligase HUWE1
Authors:Hunkeler, M, Fischer, E.S.
Deposit date:2020-08-10
Release date:2021-07-28
Last modified:2021-09-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Mol.Cell, 81, 2021
8TNP
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BU of 8tnp by Molmil
Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40
Descriptor: DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ...
Authors:Roy Burman, S.S, Hunkeler, M, Fischer, E.S.
Deposit date:2023-08-02
Release date:2024-03-13
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Continuous evolution of compact protein degradation tags regulated by selective molecular glues
to be published
7U20
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BU of 7u20 by Molmil
Crystal structure of human METTL1 and WDR4 complex
Descriptor: SULFATE ION, tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
Authors:Li, J, Nowak, R.P, Fischer, E.S, Gregory, R.
Deposit date:2022-02-22
Release date:2022-12-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4.
Nature, 613, 2023
6BN8
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BU of 6bn8 by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET55 PROTAC.
Descriptor: Bromodomain-containing protein 4, DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, ...
Authors:Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S.
Deposit date:2017-11-16
Release date:2018-06-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.990035 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6BN9
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BU of 6bn9 by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET70 PROTAC
Descriptor: Bromodomain-containing protein 4, DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, ...
Authors:Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S.
Deposit date:2017-11-16
Release date:2018-05-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.382 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6BNB
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BU of 6bnb by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET57 PROTAC
Descriptor: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ...
Authors:Nowak, R.P, DeAngelo, S.L, Buckley, D, Ishoey, M, He, Z, Zhang, T, Bradner, J.E, Fischer, E.S.
Deposit date:2017-11-16
Release date:2018-05-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (6.343 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6BN7
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BU of 6bn7 by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET23 PROTAC.
Descriptor: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ...
Authors:Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S.
Deposit date:2017-11-16
Release date:2018-05-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
8E2F
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BU of 8e2f by Molmil
Cryo-EM structure of N-terminal arm of BIRC6 (from local refinement 2)
Descriptor: Baculoviral IAP repeat-containing protein 6
Authors:Hunkeler, M, Fischer, E.S.
Deposit date:2022-08-15
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (2.47 Å)
Cite:Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Science, 379, 2023
8E2J
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BU of 8e2j by Molmil
Cryo-EM structure of BIRC6/Smac (from local refinement 1)
Descriptor: Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein
Authors:Hunkeler, M, Fischer, E.S.
Deposit date:2022-08-15
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Science, 379, 2023
8E2E
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BU of 8e2e by Molmil
Cryo-EM structure of helical arch of BIRC6 (from local refinement 1)
Descriptor: Baculoviral IAP repeat-containing protein 6
Authors:Hunkeler, M, Fischer, E.S.
Deposit date:2022-08-15
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (1.98 Å)
Cite:Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Science, 379, 2023
8E2K
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BU of 8e2k by Molmil
Cryo-EM structure of BIRC6/HtrA2-S306A
Descriptor: Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial
Authors:Hunkeler, M, Fischer, E.S.
Deposit date:2022-08-15
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Science, 379, 2023
8E2H
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BU of 8e2h by Molmil
Cryo-EM structure of C-terminal arm of BIRC6 (from local refinement 4)
Descriptor: Baculoviral IAP repeat-containing protein 6
Authors:Hunkeler, M, Fischer, E.S.
Deposit date:2022-08-15
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Science, 379, 2023
8E2D
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BU of 8e2d by Molmil
Cryo-EM structure of BIRC6 (consensus)
Descriptor: Baculoviral IAP repeat-containing protein 6
Authors:Hunkeler, M, Fischer, E.S.
Deposit date:2022-08-15
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (2.07 Å)
Cite:Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Science, 379, 2023
8E2G
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BU of 8e2g by Molmil
Cryo-EM structure of N-terminal arm (aa68-966) of BIRC6 (from local refinement 3)
Descriptor: Baculoviral IAP repeat-containing protein 6
Authors:Hunkeler, M, Fischer, E.S.
Deposit date:2022-08-15
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Science, 379, 2023
8E2I
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BU of 8e2i by Molmil
Cryo-EM structure of BIRC6/Smac
Descriptor: Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein
Authors:Hunkeler, M, Fischer, E.S.
Deposit date:2022-08-15
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Science, 379, 2023
8G46
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BU of 8g46 by Molmil
Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2
Descriptor: Bromodomain-containing protein 4, DDB1- and CUL4-associated factor 16, DET1- and DDB1-associated protein 1, ...
Authors:Ma, M.W, Hunkeler, M, Jin, C.Y, Fischer, E.S.
Deposit date:2023-02-08
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
Biorxiv, 2023
6BOY
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BU of 6boy by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET6 PROTAC.
Descriptor: 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(8-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}octyl)acetamide, Bromodomain-containing protein 4, DNA damage-binding protein 1, ...
Authors:Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S.
Deposit date:2017-11-21
Release date:2018-05-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
5FQD
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BU of 5fqd by Molmil
Structural basis of Lenalidomide induced CK1a degradation by the crl4crbn ubiquitin ligase
Descriptor: CASEIN KINASE I ISOFORM ALPHA, DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ...
Authors:Petzold, G, Fischer, E.S, Thoma, N.H.
Deposit date:2015-12-09
Release date:2016-02-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Basis of Lenalidomide-Induced Ck1Alpha Degradation by the Crl4(Crbn) Ubiquitin Ligase.
Nature, 532, 2016
6XMX
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BU of 6xmx by Molmil
Cryo-EM structure of BCL6 bound to BI-3802
Descriptor: 2-[6-[[5-chloranyl-2-[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxidanylidene-quinolin-3-yl]oxy-~{N}-methyl-ethanamide, B-cell lymphoma 6 protein
Authors:Yoon, H, Burman, S.S.R, Hunkeler, M, Nowak, R.P, Fischer, E.S.
Deposit date:2020-07-01
Release date:2020-11-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Small-molecule-induced polymerization triggers degradation of BCL6.
Nature, 588, 2020

 

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