Author results

4UE3
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THE MECHANISM OF HYDROGEN ACTIVATION BY NIFE-HYDROGENASES AND THE IMPORTANCE OF THE ACTIVE SITE ARGININE
Descriptor:HYDROGENASE-1 SMALL CHAIN, HYDROGENASE-1 LARGE CHAIN, NI-FE OXIDIZED ACTIVE CENTER, ...
Authors:Evans, R.M., Wehlin, S.A.M., Nomerotskaia, E., Sargent, F., Carr, S.B., Phillips, S.E.V., Armstrong, F.A.
Deposit date:2014-12-15
Release date:2014-12-24
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mechanism of Hydrogen Activation by [Nife] Hydrogenases.
Nat.Chem.Biol., 12, 2016
5A4F
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THE MECHANISM OF HYDROGEN ACTIVATION BY NIFE-HYDROGENASES.
Descriptor:Hydrogenase-1 large chain, Hydrogenase-1 small chain, CARBONMONOXIDE-(DICYANO) IRON, ...
Authors:Evans, R.M., Brooke, E.J., Wehlin, S.A.M., Nomerotskaia, E., Sargent, F., Carr, S.B., Phillips, S.E.V., Armstrong, F.A.
Deposit date:2015-06-09
Release date:2015-11-25
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Mechanism of hydrogen activation by [NiFe] hydrogenases.
Nat. Chem. Biol., 12, 2016
5A4I
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THE MECHANISM OF HYDROGEN ACTIVATION BY NIFE-HYDROGENASES
Descriptor:Hydrogenase-1 large chain, Hydrogenase-1 small chain, CARBONMONOXIDE-(DICYANO) IRON, ...
Authors:Evans, R.M., Brooke, E.J., Wehlin, S.A.M., Nomerotskaia, E., Sargent, F., Carr, S.C., Phillips, S.E.V., Armstrong, F.A.
Deposit date:2015-06-10
Release date:2015-11-25
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Mechanism of hydrogen activation by [NiFe] hydrogenases.
Nat. Chem. Biol., 12, 2016
5A4M
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MECHANISM OF HYDROGEN ACTIVATION BY NIFE-HYDROGENASES
Descriptor:HYDROGENASE-1 LARGE CHAIN, HYDROGENASE-1 SMALL CHAIN, NI-FE OXIDIZED ACTIVE CENTER, ...
Authors:Evans, R.M., Brooke, E.J., Wehlin, S.A.M., Nomerotskaia, E., Sergent, F., Carr, S.B., Philips, S.E.V., Armstrong, F.A.
Deposit date:2015-06-10
Release date:2015-11-25
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanism of Hydrogen Activation by [Nife] Hydrogenases.
Nat.Chem.Biol., 12, 2016
5LRY
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E COLI [NIFE] HYDROGENASE HYD-1 MUTANT E28D
Descriptor:Hydrogenase-1 small chain, Hydrogenase-1 large chain, IRON/SULFUR CLUSTER, ...
Authors:Carr, S.B., Phillips, S.E.V., Evans, R.M., Brooke, E.J., Armstrong, F.A.
Deposit date:2016-08-22
Release date:2017-09-13
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mechanistic Exploitation of a Self-Repairing, Blocked Proton Transfer Pathway in an O2-Tolerant [NiFe]-Hydrogenase.
J.Am.Chem.Soc., 140, 2018
6FPI
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STRUCTURE OF FULLY REDUCED HYDROGENASE (HYD-1) VARIANT E28Q
Descriptor:Hydrogenase-1 small chain, Hydrogenase-1 large chain, IRON/SULFUR CLUSTER, ...
Authors:Carr, S.B., Armstrong, F.A., Evans, R.M.
Deposit date:2018-02-09
Release date:2018-12-19
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mechanistic Exploitation of a Self-Repairing, Blocked Proton Transfer Pathway in an O2-Tolerant [NiFe]-Hydrogenase.
J. Am. Chem. Soc., 140, 2018
6FPO
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HIGH RESOLUTION STRUCTURE OF NATIVE HYDROGENASE (HYD-1)
Descriptor:Hydrogenase-1 small chain, Hydrogenase-1 large chain, IRON/SULFUR CLUSTER, ...
Authors:Carr, S.B., Armstrong, F.A., Evans, R.M.
Deposit date:2018-02-11
Release date:2019-02-27
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Mechanistic Exploitation of a Self-Repairing, Blocked Proton Transfer Pathway in an O2-Tolerant [NiFe]-Hydrogenase.
J. Am. Chem. Soc., 140, 2018
6FPW
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STRUCTURE OF FULLY REDUCED HYDROGENASE (HYD-1)
Descriptor:Hydrogenase-1 small chain, Hydrogenase-1 large chain, IRON/SULFUR CLUSTER, ...
Authors:Carr, S.B., Armstrong, F.A., Evans, R.M.
Deposit date:2018-02-12
Release date:2019-02-27
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Mechanistic Exploitation of a Self-Repairing, Blocked Proton Transfer Pathway in an O2-Tolerant [NiFe]-Hydrogenase.
J. Am. Chem. Soc., 140, 2018
6G7R
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STRUCTURE OF FULLY REDUCED VARIANT E28Q OF E. COLI HYDROGENASE-1 AT PH 8
Descriptor:Hydrogenase-1 small chain, Hydrogenase-1 large chain, IRON/SULFUR CLUSTER, ...
Authors:Carr, S.B., Armstrong, F.A., Evans, R.M.
Deposit date:2018-04-06
Release date:2019-02-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Mechanistic Exploitation of a Self-Repairing, Blocked Proton Transfer Pathway in an O2-Tolerant [NiFe]-Hydrogenase.
J. Am. Chem. Soc., 140, 2018
6GAL
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STRUCTURE OF FULLY REDUCED HYDROGENASE (HYD-1) VARIANT E28Q COLLECTED AT PH 10
Descriptor:Hydrogenase-1 small chain, Hydrogenase-1 large chain, IRON/SULFUR CLUSTER, ...
Authors:Carr, S.B., Armstrong, F.A., Evans, R.M.
Deposit date:2018-04-11
Release date:2019-02-27
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Mechanistic Exploitation of a Self-Repairing, Blocked Proton Transfer Pathway in an O2-Tolerant [NiFe]-Hydrogenase.
J. Am. Chem. Soc., 140, 2018
6GAM
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STRUCTURE OF E14Q VARIANT OF E. COLI HYDROGENASE-2 (AS-ISOLATED ENZYME)
Descriptor:Hydrogenase-2 small chain, Hydrogenase-2 large chain, IRON/SULFUR CLUSTER, ...
Authors:Carr, S.B., Armstrong, F.A., Evans, R.M.
Deposit date:2018-04-11
Release date:2019-02-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mechanistic Exploitation of a Self-Repairing, Blocked Proton Transfer Pathway in an O2-Tolerant [NiFe]-Hydrogenase.
J. Am. Chem. Soc., 140, 2018
6GAN
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STRUCTURE OF FULLY REDUCED HYDROGENASE (HYD-2) VARIANT E14Q
Descriptor:Hydrogenase-2 small chain, Hydrogenase-2 large chain, IRON/SULFUR CLUSTER, ...
Authors:Carr, S.B., Armstrong, F.A., Evans, R.M.
Deposit date:2018-04-11
Release date:2019-02-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mechanistic Exploitation of a Self-Repairing, Blocked Proton Transfer Pathway in an O2-Tolerant [NiFe]-Hydrogenase.
J. Am. Chem. Soc., 140, 2018
1KBH
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MUTUAL SYNERGISTIC FOLDING IN THE INTERACTION BETWEEN NUCLEAR RECEPTOR COACTIVATORS CBP AND ACTR
Descriptor:nuclear receptor coactivator, CREB-BINDING PROTEIN
Authors:Demarest, S.J., Martinez-Yamout, M., Chung, J., Chen, H., Xu, W., Dyson, H.J., Evans, R.M., Wright, P.E.
Deposit date:2001-11-06
Release date:2002-02-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.
Nature, 415, 2002
1LO1
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ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA
Descriptor:5'-D(*GP*CP*TP*CP*AP*AP*GP*GP*TP*CP*AP*CP*G)-3', 5'-D(*CP*GP*TP*GP*AP*CP*CP*TP*TP*GP*AP*GP*C)-3', Steroid hormone receptor ERR2, ...
Authors:Gearhart, M.D., Holmbeck, S.M.A., Evans, R.M., Dyson, H.J., Wright, P.E.
Deposit date:2002-05-05
Release date:2003-04-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Monomeric Complex of Human Orphan Estrogen Related Receptor-2 with DNA: A Pseudo-dimer Interface Mediates Extended Half-site Recognition
J.Mol.Biol., 327, 2003
1OSH
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A CHEMICAL, GENETIC, AND STRUCTURAL ANALYSIS OF THE NUCLEAR BILE ACID RECEPTOR FXR
Descriptor:Bile acid receptor, METHYL 3-{3-[(CYCLOHEXYLCARBONYL){[4'-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE
Authors:Downes, M., Verdecia, M.A., Roecker, A.J., Hughes, R., Hogenesch, J.B., Kast-Woelbern, H.R., Bowman, M.E., Ferrer, J.-L., Anisfeld, A.M., Edwards, P.A., Rosenfeld, J.M., Alvarez, J.G.A., Noel, J.P., Nicolaou, K.C., Evans, R.M.
Deposit date:2003-03-19
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
Mol.Cell, 11, 2003
1Y0S
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CRYSTAL STRUCTURE OF PPAR DELTA COMPLEXED WITH GW2331
Descriptor:Peroxisome proliferator activated receptor delta, IODIDE ION, (2S)-2-(4-[2-(3-[2,4-DIFLUOROPHENYL]-1-HEPTYLUREIDO)ETHYL]PHENOXY)-2-METHYLBUTYRIC ACID, ...
Authors:Takada, I., Yu, R.T., Xu, H.E., Xu, R.X., Lambert, M.H., Montana, V.G., Kliewer, S.A., Evans, R.M., Umesono, K.
Deposit date:2004-11-16
Release date:2005-03-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Alteration of a Single Amino Acid in Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) Generates a PPAR delta Phenotype
MOL.ENDOCRINOL., 14, 2000
2NLL
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RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
Descriptor:DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3'), PROTEIN (RETINOIC ACID RECEPTOR), ...
Authors:Rastinejad, F., Perlmann, T., Evans, R.M., Sigler, P.B.
Deposit date:1996-11-20
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural determinants of nuclear receptor assembly on DNA direct repeats.
Nature, 375, 1995
3IA5
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MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR)
Descriptor:Dihydrofolate reductase, PHOSPHATE ION
Authors:Hay, S., Evans, R.M., Levy, C., Wang, X., Loveridge, E.J., Leys, D., Allemann, R.K., Scrutton, N.S.
Deposit date:2009-07-13
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Are the Catalytic Properties of Enzymes from Piezophilic Organisms Pressure Adapted?
Chembiochem, 10, 2009
5JRD
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E. COLI HYDROGENASE-1 VARIANT P508A
Descriptor:Hydrogenase-1 small chain, Hydrogenase-1 large chain, IRON/SULFUR CLUSTER, ...
Authors:Carr, S.B., Phillips, S.E.V., Armstrong, F.A., Evans, R.M., Brooke, E.J., Islam, S.T.A.
Deposit date:2016-05-06
Release date:2017-03-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Importance of the Active Site "Canopy" Residues in an O2-Tolerant [NiFe]-Hydrogenase.
Biochemistry, 56, 2017
5LMM
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STRUCTURE OF E COLI HYDROGENASE HYD-1 MUTANT E28Q
Descriptor:Hydrogenase-1 small chain, Hydrogenase-1 large chain, IRON/SULFUR CLUSTER, ...
Authors:Carr, S.B., Phillips, S.E.V., Evans, R.M., Brooke, E.J., Armstrong, F.A.
Deposit date:2016-08-01
Release date:2017-08-16
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Kinetic consequences of re-engineering the outer shell "canopy" above the active site of a [NiFe]-hydrogenase.
To Be Published
5U3Q
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 1
Descriptor:Peroxisome proliferator-activated receptor delta, 6-(2-{[([1,1'-biphenyl]-4-carbonyl)(propan-2-yl)amino]methyl}phenoxy)hexanoic acid, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3R
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 2
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-[2-({[4-(furan-2-yl)benzene-1-carbonyl](propan-2-yl)amino}methyl)phenoxy]hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3S
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 3
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({[4-(furan-3-yl)benzene-1-carbonyl](propan-2-yl)amino}methyl)phenoxy]hexanoic acid, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3T
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 4
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({(propan-2-yl)[4-(thiophen-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3U
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HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 5
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({cyclopentyl[4-(furan-2-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, S-1,2-PROPANEDIOL, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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