Author results

1HPX
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HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR KNI-272
Descriptor:HIV-1 PROTEASE, (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide
Authors:Bhat, T.N., Erickson, J.W.
Deposit date:1995-05-18
Release date:1996-03-08
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine.
Structure, 3, 1995
1HVC
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CRYSTAL STRUCTURE OF A TETHERED DIMER OF HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-(2S,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Bhat, T.N., Baldwin, E.T., Erickson, J.W.
Deposit date:1994-06-22
Release date:1994-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a tethered dimer of HIV-1 proteinase complexed with an inhibitor.
Nat.Struct.Biol., 1, 1994
1HVS
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STRUCTURAL BASIS OF DRUG RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEASE: BACKBONE FLEXIBILITY AND SUBSITE REPACKING
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-(2R,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Baldwin, E.T., Bhat, T.N., Liu, B., Pattabiraman, N., Erickson, J.W.
Deposit date:1994-11-17
Release date:1995-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase.
Nat.Struct.Biol., 2, 1995
1LYW
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CATHEPSIN D AT PH 7.5
Descriptor:CATHEPSIN D, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Lee, A.Y., Gulnik, S.V., Erickson, J.W.
Deposit date:1998-06-30
Release date:1999-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conformational switching in an aspartic proteinase.
Nat.Struct.Biol., 5, 1998
1HVI
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INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-(2R,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Bhat, T.N., Hosur, M.V., Baldwin, E.T., Erickson, J.W.
Deposit date:1994-01-26
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-Based Diol Inhibitors of HIV-1 Protease
J.Am.Chem.Soc., 116, 1994
1HVJ
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INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-3-HYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Bhat, T.N., Hosur, M.V., Baldwin, E.T., Erickson, J.W.
Deposit date:1994-01-26
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-Based Diol Inhibitors of HIV-1 Protease
J.Am.Chem.Soc., 116, 1994
1HVK
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INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-(2S,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Bhat, T.N., Hosur, M.V., Baldwin, E.T., Erickson, J.W.
Deposit date:1994-01-26
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-Based Diol Inhibitors of HIV-1 Protease
J.Am.Chem.Soc., 116, 1994
1HVL
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INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-{1-BENZYL-(2R,3R)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Bhat, T.N., Hosur, M.V., Baldwin, E.T., Erickson, J.W.
Deposit date:1994-01-26
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-Based Diol Inhibitors of HIV-1 Protease
J.Am.Chem.Soc., 116, 1994
1LYA
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CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN
Descriptor:CATHEPSIN D, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Baldwin, E.T., Bhat, T.N., Gulnik, S., Erickson, J.W.
Deposit date:1993-04-22
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Proc.Natl.Acad.Sci.USA, 90, 1993
1LYB
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CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN
Descriptor:CATHEPSIN D, PEPSTATIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Baldwin, E.T., Bhat, T.N., Gulnik, S., Erickson, J.W.
Deposit date:1993-04-22
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Proc.Natl.Acad.Sci.USA, 90, 1993
1DIF
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HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285
Descriptor:HIV-1 PROTEASE, BETA-MERCAPTOETHANOL, N-{1-BENZYL-2,2-DIFLUORO-3,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Silva, A.M., Cachau, R.E., Sham, H.L., Erickson, J.W.
Deposit date:1995-10-09
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition and catalytic mechanism of HIV-1 aspartic protease.
J.Mol.Biol., 255, 1996
1LEE
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CRYSTAL STRUCTURE OF PLASMEPSIN FROM P. FALCIPARUM IN COMPLEX WITH INHIBITOR RS367
Descriptor:Plasmepsin 2, 4-AMINO-N-{4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-1-ISOBUTYL-5-PHENYL-PENTYL}-BENZAMIDE
Authors:Asojo, O.A., Afonina, E., Gulnik, S.V., Yu, B., Erickson, J.W., Randad, R., Mehadjed, D., Silva, A.M.
Deposit date:2002-04-09
Release date:2002-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.
Acta Crystallogr.,Sect.D, 58, 2002
1LF2
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CRYSTAL STRUCTURE OF PLASMEPSIN II FROM P FALCIPARUM IN COMPLEX WITH INHIBITOR RS370
Descriptor:Plasmepsin 2, 3-AMINO-N-{4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-1-ISOBUTYL-5-PHENYL-PENTYL}-BENZAMIDE
Authors:Asojo, O.A., Afonina, E., Gulnik, S.V., Yu, B., Erickson, J.W., Randad, R., Mehadjed, D., Silva, A.M.
Deposit date:2002-04-10
Release date:2002-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.
Acta Crystallogr.,Sect.D, 58, 2002
1SME
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PLASMEPSIN II, A HEMOGLOBIN-DEGRADING ENZYME FROM PLASMODIUM FALCIPARUM, IN COMPLEX WITH PEPSTATIN A
Descriptor:PLASMEPSIN II, Pepstatin
Authors:Silva, A.M., Lee, A.Y., Gulnik, S.V., Goldberg, D.E., Erickson, J.W.
Deposit date:1996-06-11
Release date:1997-01-11
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.
Proc.Natl.Acad.Sci.USA, 93, 1996
6OY9
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STRUCTURE OF THE RHODOPSIN-TRANSDUCIN COMPLEX
Descriptor:Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
Authors:Gao, Y., Hu, H., Ramachandran, S., Erickson, J.W., Cerione, R.A., Skiniotis, G.
Deposit date:2019-05-14
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol.Cell, 2019
6OYA
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STRUCTURE OF THE RHODOPSIN-TRANSDUCIN-NANOBODY COMPLEX
Descriptor:Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
Authors:Gao, Y., Hu, H., Ramachandran, S., Erickson, J.W., Cerione, R.A., Skiniotis, G.
Deposit date:2019-05-14
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol.Cell, 2019
1R08
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STRUCTURAL ANALYSIS OF ANTIVIRAL AGENTS THAT INTERACT WITH THE CAPSID OF HUMAN RHINOVIRUSES
Descriptor:HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ...
Authors:Badger, J., Smith, T.J., Rossmann, M.G.
Deposit date:1988-10-03
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of antiviral agents that interact with the capsid of human rhinoviruses.
Proteins, 6, 1989
1R09
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HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837
Descriptor:HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ...
Authors:Chapman, M.S., Minor, I., Rossmann, M.G., Diana, G.D., Andries, K.
Deposit date:1990-05-04
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Human rhinovirus 14 complexed with antiviral compound R 61837.
J.Mol.Biol., 217, 1991
1RMU
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THREE-DIMENSIONAL STRUCTURES OF DRUG-RESISTANT MUTANTS OF HUMAN RHINOVIRUS 14
Descriptor:HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ...
Authors:Badger, J., Krishnaswamy, S., Kremer, M.J., Oliveira, M.A., Rossmann, M.G., Heinz, B.A., Rueckert, R.R., Dutko, F.J., Mckinlay, M.A.
Deposit date:1988-10-03
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Three-dimensional structures of drug-resistant mutants of human rhinovirus 14.
J.Mol.Biol., 207, 1989
2R04
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STRUCTURAL ANALYSIS OF ANTIVIRAL AGENTS THAT INTERACT WITH THE CAPSID OF HUMAN RHINOVIRUSES
Descriptor:HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ...
Authors:Badger, J., Smith, T.J., Rossmann, M.G.
Deposit date:1988-10-03
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of antiviral agents that interact with the capsid of human rhinoviruses.
Proteins, 6, 1989
2R06
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STRUCTURAL ANALYSIS OF ANTIVIRAL AGENTS THAT INTERACT WITH THE CAPSID OF HUMAN RHINOVIRUSES
Descriptor:HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ...
Authors:Badger, J., Smith, T.J., Rossmann, M.G.
Deposit date:1988-10-03
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of antiviral agents that interact with the capsid of human rhinoviruses.
Proteins, 6, 1989
2R07
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STRUCTURAL ANALYSIS OF ANTIVIRAL AGENTS THAT INTERACT WITH THE CAPSID OF HUMAN RHINOVIRUSES
Descriptor:HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ...
Authors:Badger, J., Smith, T.J., Rossmann, M.G.
Deposit date:1988-10-03
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of antiviral agents that interact with the capsid of human rhinoviruses.
Proteins, 6, 1989
2RM2
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STRUCTURAL ANALYSIS OF ANTIVIRAL AGENTS THAT INTERACT WITH THE CAPSID OF HUMAN RHINOVIRUSES
Descriptor:HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ...
Authors:Badger, J., Smith, T.J., Rossmann, M.G.
Deposit date:1988-10-03
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of antiviral agents that interact with the capsid of human rhinoviruses.
Proteins, 6, 1989
2RMU
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THREE-DIMENSIONAL STRUCTURES OF DRUG-RESISTANT MUTANTS OF HUMAN RHINOVIRUS 14
Descriptor:HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ...
Authors:Badger, J., Krishnaswamy, S., Kremer, M.J., Oliveira, M.A., Rossmann, M.G., Heinz, B.A., Rueckert, R.R., Dutko, F.J., Mckinlay, M.A.
Deposit date:1988-10-03
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Three-dimensional structures of drug-resistant mutants of human rhinovirus 14.
J.Mol.Biol., 207, 1989
2RR1
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STRUCTURAL ANALYSIS OF ANTIVIRAL AGENTS THAT INTERACT WITH THE CAPSID OF HUMAN RHINOVIRUSES
Descriptor:HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ...
Authors:Badger, J., Smith, T.J., Rossmann, M.G.
Deposit date:1988-10-03
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of antiviral agents that interact with the capsid of human rhinoviruses.
Proteins, 6, 1989
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