Author results

5CQF
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CRYSTAL STRUCTURE OF L-LYSINE 6-MONOOXYGENASE FROM PSEUDOMONAS SYRINGAE
分子名称:L-lysine 6-monooxygenase, IODIDE ION
著者Michalska, K., Bigelow, L., Jedrzejczak, R., Weerth, R.S., Cao, H., Yennamalli, R., Phillips Jr., G.N., Thomas, M.G., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-07-21
公開日2015-09-30
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Crystal structure of L-lysine 6-monooxygenase from Pseudomonas syringae
To Be Published
4ZNM
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CRYSTAL STRUCTURE OF SGCC5 PROTEIN FROM STREPTOMYCES GLOBISPORUS (APO FORM)
分子名称:C-domain type II peptide synthetase, SODIUM ION, CHLORIDE ION
著者Michalska, K., Bigelow, L., Jedrzejczak, R., Babnigg, G., Lohman, J., Ma, M., Rudolf, J., Chang, C.-Y., Shen, B., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-05-04
公開日2015-05-27
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献Crystal structure of SgcC5 protein from Streptomyces globisporus (apo form)
To Be Published
4ZXW
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CRYSTAL STRUCTURE OF SGCC5 PROTEIN FROM STREPTOMYCES GLOBISPORUS (COMPLEX WITH (R)-(-)-1-(2-NAPHTHYL)-1,2-ETHANEDIOL AND SUCROSE)
分子名称:C-domain type II peptide synthetase, (1R)-1-(naphthalen-2-yl)ethane-1,2-diol, SUCROSE, ...
著者Michalska, K., Bigelow, L., Jedrzejczak, R., Babnigg, G., Lohman, J., Ma, M., Rudolf, J., Chang, C.-Y., Shen, B., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-05-20
公開日2015-06-17
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (2.187 Å)
主引用文献Crystal structure of SgcC5 protein from Streptomyces globisporus
To Be Published
5BMO
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LNMX PROTEIN, A PUTATIVE GLCNAC-PI DE-N-ACETYLASE FROM STREPTOMYCES ATROOLIVACEUS
分子名称:Putative uncharacterized protein LnmX, POTASSIUM ION, ACETATE ION
著者Osipiuk, J., Hatzos-Skintges, C., Cuff, M., Endres, M., Babnigg, G., Lohman, J., Ma, M., Rudolf, J., Chang, C.-Y., Shen, B., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-05-22
公開日2015-06-10
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献LnmX protein, a putative GlcNAc-PI de-N-acetylase from Streptomyces atroolivaceus.
to be published
5DU2
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STRUCTURAL ANALYSIS OF ESPG2 GLYCOSYLTRANSFERASE
分子名称:EspG2 glycosyltransferase
著者Michalska, K., Elshahawi, S.I., Bigelow, L., Babnigg, G., Thorson, J.S., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-09-18
公開日2015-10-14
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural analysis of EspG2 glycosyltransferase
To Be Published
5W27
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CRYSTAL STRUCTURE OF TNMS3 IN COMPLEX WITH TIANCIMYCIN (TNM B)
分子名称:Glyoxalase/bleomycin resisance protein/dioxygenase, methyl (2E)-3-[(1aS,11S,11aS,14Z,18R)-3,18-dihydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]but-2-enoate
著者Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips, G.N., SHen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)
登録日2017-06-05
公開日2018-06-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of TnmS3 in complex with tiancimycin (TNM B)
To Be Published
5CJ3
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CRYSTAL STRUCTURE OF THE ZORBAMYCIN BINDING PROTEIN (ZBMA) FROM STREPTOMYCES FLAVOVIRIDIS WITH ZORBAMYCIN
分子名称:Zbm binding protein, Zorbamycin, COPPER (II) ION, ...
著者Chang, C., Bigelow, L., Clancy, S., Babnigg, G., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Rudolf, J.D., Ma, M., Chang, C.-Y., Lohman, J.R., Yang, D., Shen, B., Enzyme Discovery for Natural Product Biosynthesis, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-07-13
公開日2015-07-22
最終更新日2015-11-25
実験手法X-RAY DIFFRACTION (1.6499 Å)
主引用文献Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.
Biochemistry, 54, 2015
5UHJ
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THE CRYSTAL STRUCTURE OF A NATURAL PRODUCT BIOSYNTHETIC ENZYME FROM STREPTOMYCES SP. CB03234
分子名称:Glyoxalase/bleomycin resisance protein/dioxygenase, FORMIC ACID
著者Tan, K., Li, H., Endres, M., Phillips Jr, G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2017-01-11
公開日2017-01-25
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The crystal structure of a natural product biosynthetic enzyme from Streptomyces sp. CB03234
To Be Published
4GF5
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CRYSTAL STRUCTURE OF CALICHEAMICIN METHYLTRANSFERASE, CALS11
分子名称:CalS11, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION
著者Helmich, K.E., Singh, S., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Center for Eukaryotic Structural Genomics (CESG)
登録日2012-08-02
公開日2012-08-22
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献
to be published
4NEO
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STRUCTURE OF BLMI, A TYPE-II ACYL-CARRIER-PROTEIN FROM STREPTOMYCES VERTICILLUS INVOLVED IN BLEOMYCIN BIOSYNTHESIS
分子名称:Peptide synthetase NRPS type II-PCP, 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL
著者Cuff, M.E., Bigelow, L., Bearden, J., Babnigg, G., Bruno, C.J.P., Bingman, C., Yennamalli, R., Lohman, J., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)
登録日2013-10-29
公開日2014-01-29
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins.
Proteins, 82, 2014
4OQJ
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STREPTOMCYES ALBUS JA3453 OXAZOLOMYCIN KETOSYNTHASE DOMAIN OZMQ KS1
分子名称:PKS, POTASSIUM ION, PHOSPHATE ION, ...
著者Nocek, B., Mack, J., Endras, M., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2014-02-09
公開日2014-03-19
最終更新日2016-11-02
実験手法X-RAY DIFFRACTION (1.904 Å)
主引用文献Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4OVM
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CRYSTAL STRUCTURE OF SGCJ PROTEIN FROM STREPTOMYCES CARZINOSTATICUS
分子名称:uncharacterized protein SgcJ
著者Chang, C., Bigelow, L., Clancy, S., Bingman, C., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Babnigg, G., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2013-11-20
公開日2013-12-25
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.719 Å)
主引用文献Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.
J.Antibiot., 2016
4Q31
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THE CRYSTAL STRUCTURE OF CYSTATHIONE GAMMA LYASE (CALE6) FROM MICROMONOSPORA ECHINOSPORA
分子名称:cystathione gamma lyase CalE6, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
著者Tan, K., Bigelow, L., Jedrzejczak, R., Babnigg, G., Bingman, C.A., Yennamalli, R.M., Singh, S., Kharel, M.K., Thorson, J.S., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2014-04-10
公開日2014-05-07
最終更新日2017-03-08
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Structural dynamics of a methionine gamma-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate.
Struct Dyn, 3, 2016
4R82
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STREPTOMYCES GLOBISPORUS C-1027 NADH:FAD OXIDOREDUCTASE SGCE6 IN COMPLEX WITH NAD AND FAD FRAGMENTS
分子名称:Oxidoreductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, CALCIUM ION, ...
著者Tan, K., Bigelow, L., Clancy, S., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2014-08-29
公開日2014-10-01
最終更新日2016-11-02
実験手法X-RAY DIFFRACTION (1.659 Å)
主引用文献Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.
Biochemistry, 55, 2016
4XRR
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CRYSTAL STRUCTURE OF CALS8 FROM MICROMONOSPORA ECHINOSPORA (P294S MUTANT)
分子名称:CalS8, GLYCEROL
著者Michalska, K., Bigelow, L., Endres, M., Babnigg, G., Bingman, C.A., Yennamalli, R.M., Singh, S., Kharel, M.K., Thorson, J.S., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-01-21
公開日2015-02-11
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural Characterization of CalS8, a TDP-alpha-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis.
J. Biol. Chem., 290, 2015
4HVM
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CRYSTAL STRUCTURE OF TALLYSOMYCIN BIOSYNTHESIS PROTEIN TLMII
分子名称:TlmII, SULFATE ION
著者Chang, C., Bigelow, L., Bearden, J., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2012-11-06
公開日2012-11-21
最終更新日2014-04-16
実験手法X-RAY DIFFRACTION (2.704 Å)
主引用文献Crystal structure of tallysomycin biosynthesis protein TlmII
To be Published
4XQ2
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ENSEMBLE REFINEMENT OF CYSTATHIONE GAMMA LYASE (CALE6) D7G FROM MICROMONOSPORA ECHINOSPORA
分子名称:CalE6, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ...
著者Wang, F., Yennamalli, R.M., Singh, S., Tan, K., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-01-18
公開日2015-04-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora
To Be Published
6DA6
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CRYSTAL STRUCTURE OF THE TTND DECARBOXYLASE FROM THE TAUTOMYCETIN BIOSYNTHESIS PATHWAY OF STREPTOMYCES GRISEOCHROMOGENES, APO FORM AT 2.6 A RESOLUTION (P212121)
分子名称:UbiD-like decarboxylase, MAGNESIUM ION, GLYCEROL, ...
著者Han, L., Rudolf, J.D., Chang, C.-Y., Miller, M.D., Soman, J., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2018-05-01
公開日2018-10-03
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
ACS Chem. Biol., 13, 2018
6DA7
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CRYSTAL STRUCTURE OF THE TTND DECARBOXYLASE FROM THE TAUTOMYCETIN BIOSYNTHESIS PATHWAY OF STREPTOMYCES GRISEOCHROMOGENES WITH APO FORM AT 1.83 A RESOLUTION (I222)
分子名称:UbiD-like decarboxylase, SODIUM ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Han, L., Rudolf, J.D., Chang, C.-Y., Miller, M.D., Soman, J., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2018-05-01
公開日2018-10-03
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
ACS Chem. Biol., 13, 2018
6DA9
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CRYSTAL STRUCTURE OF THE TTND DECARBOXYLASE FROM THE TAUTOMYCETIN BIOSYNTHESIS PATHWAY OF STREPTOMYCES GRISEOCHROMOGENES WITH FMN BOUND AT 2.05 A RESOLUTION
分子名称:UbiD-like decarboxylase, FLAVIN MONONUCLEOTIDE, MANGANESE (II) ION, ...
著者Han, L., Rudolf, J.D., Chang, C.-Y., Miller, M.D., Soman, J., Xu, W., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2018-05-01
公開日2018-10-03
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
ACS Chem. Biol., 13, 2018
4FZR
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CRYSTAL STRUCTURE OF SSFS6, STREPTOMYCES SP. SF2575 GLYCOSYLTRANSFERASE
分子名称:SsfS6
著者Wang, F., Zhou, M., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2012-07-07
公開日2012-07-25
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.397 Å)
主引用文献Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis.
Proteins, 81, 2013
4G2T
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CRYSTAL STRUCTURE OF STREPTOMYCES SP. SF2575 GLYCOSYLTRANSFERASE SSFS6, COMPLEXED WITH THYMIDINE DIPHOSPHATE
分子名称:SsfS6, THYMIDINE-5'-DIPHOSPHATE
著者Wang, F., Zhou, M., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2012-07-12
公開日2012-07-25
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.405 Å)
主引用文献Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis.
Proteins, 81, 2013
4HZN
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THE STRUCTURE OF THE BIFUNCTIONAL ACETYLTRANSFERASE/DECARBOXYLASE LNMK FROM THE LEINAMYCIN BIOSYNTHETIC PATHWAY REVEALING NOVEL ACTIVITY FOR A DOUBLE HOT DOG FOLD
分子名称:Bifunctional Methylmalonyl-CoA:ACP Acyltransferase/Decarboxylase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ...
著者Lohman, J.R., Bingman, C.A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2012-11-15
公開日2013-01-30
最終更新日2013-02-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog Fold.
Biochemistry, 52, 2013
4HZO
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THE STRUCTURE OF THE BIFUNCTIONAL ACETYLTRANSFERASE/DECARBOXYLASE LNMK FROM THE LEINAMYCIN BIOSYNTHETIC PATHWAY REVEALING NOVEL ACTIVITY FOR A DOUBLE HOT DOG FOLD
分子名称:Bifunctional methylmalonyl-CoA:ACP acyltransferase/decarboxylase, CHLORIDE ION, COENZYME A
著者Lohman, J.R., Bingman, C.A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2012-11-15
公開日2013-01-30
最終更新日2013-02-20
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog Fold.
Biochemistry, 52, 2013
4HZP
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THE STRUCTURE OF THE BIFUNCTIONAL ACETYLTRANSFERASE/DECARBOXYLASE LNMK FROM THE LEINAMYCIN BIOSYNTHETIC PATHWAY REVEALING NOVEL ACTIVITY FOR A DOUBLE HOT DOG FOLD
分子名称:Bifunctional methylmalonyl-CoA:ACP Acyltransferase/Decarboxylase, COENZYME A, CHLORIDE ION, ...
著者Lohman, J.R., Bingman, C.A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2012-11-15
公開日2013-01-30
最終更新日2013-02-20
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog Fold.
Biochemistry, 52, 2013