Author results

5CQF
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CRYSTAL STRUCTURE OF L-LYSINE 6-MONOOXYGENASE FROM PSEUDOMONAS SYRINGAE
Descriptor:L-lysine 6-monooxygenase, IODIDE ION
Authors:Michalska, K., Bigelow, L., Jedrzejczak, R., Weerth, R.S., Cao, H., Yennamalli, R., Phillips Jr., G.N., Thomas, M.G., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-07-21
Release date:2015-09-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of L-lysine 6-monooxygenase from Pseudomonas syringae
To Be Published
4ZNM
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CRYSTAL STRUCTURE OF SGCC5 PROTEIN FROM STREPTOMYCES GLOBISPORUS (APO FORM)
Descriptor:C-domain type II peptide synthetase, SODIUM ION, CHLORIDE ION
Authors:Michalska, K., Bigelow, L., Jedrzejczak, R., Babnigg, G., Lohman, J., Ma, M., Rudolf, J., Chang, C.-Y., Shen, B., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-05-04
Release date:2015-05-27
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Crystal structure of SgcC5 protein from Streptomyces globisporus (apo form)
To Be Published
4ZXW
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CRYSTAL STRUCTURE OF SGCC5 PROTEIN FROM STREPTOMYCES GLOBISPORUS (COMPLEX WITH (R)-(-)-1-(2-NAPHTHYL)-1,2-ETHANEDIOL AND SUCROSE)
Descriptor:C-domain type II peptide synthetase, (1R)-1-(naphthalen-2-yl)ethane-1,2-diol, SUCROSE, ...
Authors:Michalska, K., Bigelow, L., Jedrzejczak, R., Babnigg, G., Lohman, J., Ma, M., Rudolf, J., Chang, C.-Y., Shen, B., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-05-20
Release date:2015-06-17
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.187 Å)
Cite:Crystal structure of SgcC5 protein from Streptomyces globisporus
To Be Published
5BMO
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LNMX PROTEIN, A PUTATIVE GLCNAC-PI DE-N-ACETYLASE FROM STREPTOMYCES ATROOLIVACEUS
Descriptor:Putative uncharacterized protein LnmX, POTASSIUM ION, ACETATE ION
Authors:Osipiuk, J., Hatzos-Skintges, C., Cuff, M., Endres, M., Babnigg, G., Lohman, J., Ma, M., Rudolf, J., Chang, C.-Y., Shen, B., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-05-22
Release date:2015-06-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:LnmX protein, a putative GlcNAc-PI de-N-acetylase from Streptomyces atroolivaceus.
to be published
5DU2
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STRUCTURAL ANALYSIS OF ESPG2 GLYCOSYLTRANSFERASE
Descriptor:EspG2 glycosyltransferase
Authors:Michalska, K., Elshahawi, S.I., Bigelow, L., Babnigg, G., Thorson, J.S., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-09-18
Release date:2015-10-14
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of EspG2 glycosyltransferase
To Be Published
5W27
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CRYSTAL STRUCTURE OF TNMS3 IN COMPLEX WITH TIANCIMYCIN (TNM B)
Descriptor:Glyoxalase/bleomycin resisance protein/dioxygenase, methyl (2E)-3-[(1aS,11S,11aS,14Z,18R)-3,18-dihydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]but-2-enoate
Authors:Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips, G.N., SHen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)
Deposit date:2017-06-05
Release date:2018-06-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of TnmS3 in complex with tiancimycin (TNM B)
To Be Published
5CJ3
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CRYSTAL STRUCTURE OF THE ZORBAMYCIN BINDING PROTEIN (ZBMA) FROM STREPTOMYCES FLAVOVIRIDIS WITH ZORBAMYCIN
Descriptor:Zbm binding protein, Zorbamycin, COPPER (II) ION, ...
Authors:Chang, C., Bigelow, L., Clancy, S., Babnigg, G., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Rudolf, J.D., Ma, M., Chang, C.-Y., Lohman, J.R., Yang, D., Shen, B., Enzyme Discovery for Natural Product Biosynthesis, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-07-13
Release date:2015-07-22
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.6499 Å)
Cite:Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.
Biochemistry, 54, 2015
4GF5
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CRYSTAL STRUCTURE OF CALICHEAMICIN METHYLTRANSFERASE, CALS11
Descriptor:CalS11, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION
Authors:Helmich, K.E., Singh, S., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2012-08-02
Release date:2012-08-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:
to be published
5UHJ
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THE CRYSTAL STRUCTURE OF A NATURAL PRODUCT BIOSYNTHETIC ENZYME FROM STREPTOMYCES SP. CB03234
Descriptor:Glyoxalase/bleomycin resisance protein/dioxygenase, FORMIC ACID
Authors:Tan, K., Li, H., Endres, M., Phillips Jr, G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2017-01-11
Release date:2017-01-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The crystal structure of a natural product biosynthetic enzyme from Streptomyces sp. CB03234
To Be Published
4OQJ
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STREPTOMCYES ALBUS JA3453 OXAZOLOMYCIN KETOSYNTHASE DOMAIN OZMQ KS1
Descriptor:PKS, POTASSIUM ION, PHOSPHATE ION, ...
Authors:Nocek, B., Mack, J., Endras, M., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-02-09
Release date:2014-03-19
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (1.904 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4OVM
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CRYSTAL STRUCTURE OF SGCJ PROTEIN FROM STREPTOMYCES CARZINOSTATICUS
Descriptor:uncharacterized protein SgcJ
Authors:Chang, C., Bigelow, L., Clancy, S., Bingman, C., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Babnigg, G., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2013-11-20
Release date:2013-12-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.719 Å)
Cite:Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.
J.Antibiot., 2016
4Q31
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THE CRYSTAL STRUCTURE OF CYSTATHIONE GAMMA LYASE (CALE6) FROM MICROMONOSPORA ECHINOSPORA
Descriptor:cystathione gamma lyase CalE6, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Tan, K., Bigelow, L., Jedrzejczak, R., Babnigg, G., Bingman, C.A., Yennamalli, R.M., Singh, S., Kharel, M.K., Thorson, J.S., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-04-10
Release date:2014-05-07
Last modified:2017-03-08
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural dynamics of a methionine gamma-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate.
Struct Dyn, 3, 2016
4R82
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STREPTOMYCES GLOBISPORUS C-1027 NADH:FAD OXIDOREDUCTASE SGCE6 IN COMPLEX WITH NAD AND FAD FRAGMENTS
Descriptor:Oxidoreductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, CALCIUM ION, ...
Authors:Tan, K., Bigelow, L., Clancy, S., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-08-29
Release date:2014-10-01
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (1.659 Å)
Cite:Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.
Biochemistry, 55, 2016
4XRR
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CRYSTAL STRUCTURE OF CALS8 FROM MICROMONOSPORA ECHINOSPORA (P294S MUTANT)
Descriptor:CalS8, GLYCEROL
Authors:Michalska, K., Bigelow, L., Endres, M., Babnigg, G., Bingman, C.A., Yennamalli, R.M., Singh, S., Kharel, M.K., Thorson, J.S., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-01-21
Release date:2015-02-11
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Characterization of CalS8, a TDP-alpha-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis.
J. Biol. Chem., 290, 2015
4HVM
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CRYSTAL STRUCTURE OF TALLYSOMYCIN BIOSYNTHESIS PROTEIN TLMII
Descriptor:TlmII, SULFATE ION
Authors:Chang, C., Bigelow, L., Bearden, J., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2012-11-06
Release date:2012-11-21
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Crystal structure of tallysomycin biosynthesis protein TlmII
To be Published
4NEO
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STRUCTURE OF BLMI, A TYPE-II ACYL-CARRIER-PROTEIN FROM STREPTOMYCES VERTICILLUS INVOLVED IN BLEOMYCIN BIOSYNTHESIS
Descriptor:Peptide synthetase NRPS type II-PCP, 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL
Authors:Cuff, M.E., Bigelow, L., Bearden, J., Babnigg, G., Bruno, C.J.P., Bingman, C., Yennamalli, R., Lohman, J., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-10-29
Release date:2014-01-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins.
Proteins, 82, 2014
4XQ2
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ENSEMBLE REFINEMENT OF CYSTATHIONE GAMMA LYASE (CALE6) D7G FROM MICROMONOSPORA ECHINOSPORA
Descriptor:CalE6, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ...
Authors:Wang, F., Yennamalli, R.M., Singh, S., Tan, K., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-01-18
Release date:2015-04-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora
To Be Published
4HZN
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THE STRUCTURE OF THE BIFUNCTIONAL ACETYLTRANSFERASE/DECARBOXYLASE LNMK FROM THE LEINAMYCIN BIOSYNTHETIC PATHWAY REVEALING NOVEL ACTIVITY FOR A DOUBLE HOT DOG FOLD
Descriptor:Bifunctional Methylmalonyl-CoA:ACP Acyltransferase/Decarboxylase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ...
Authors:Lohman, J.R., Bingman, C.A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2012-11-15
Release date:2013-01-30
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog Fold.
Biochemistry, 52, 2013
4HZO
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THE STRUCTURE OF THE BIFUNCTIONAL ACETYLTRANSFERASE/DECARBOXYLASE LNMK FROM THE LEINAMYCIN BIOSYNTHETIC PATHWAY REVEALING NOVEL ACTIVITY FOR A DOUBLE HOT DOG FOLD
Descriptor:Bifunctional methylmalonyl-CoA:ACP acyltransferase/decarboxylase, CHLORIDE ION, COENZYME A
Authors:Lohman, J.R., Bingman, C.A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2012-11-15
Release date:2013-01-30
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog Fold.
Biochemistry, 52, 2013
4HZP
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THE STRUCTURE OF THE BIFUNCTIONAL ACETYLTRANSFERASE/DECARBOXYLASE LNMK FROM THE LEINAMYCIN BIOSYNTHETIC PATHWAY REVEALING NOVEL ACTIVITY FOR A DOUBLE HOT DOG FOLD
Descriptor:Bifunctional methylmalonyl-CoA:ACP Acyltransferase/Decarboxylase, COENZYME A, CHLORIDE ION, ...
Authors:Lohman, J.R., Bingman, C.A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2012-11-15
Release date:2013-01-30
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog Fold.
Biochemistry, 52, 2013
4I19
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THE CRYSTAL STRUCTURE OF AN EPOXIDE HYDROLASE FROM STREPTOMYCES CARZINOSTATICUS SUBSP. NEOCARZINOSTATICUS.
Descriptor:Epoxide hydrolase, ACETATE ION, FORMIC ACID
Authors:Tan, K., Bigelow, L., Clancy, S., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2012-11-20
Release date:2012-12-05
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.148 Å)
Cite:The crystal structure of an epoxide hydrolase from Streptomyces carzinostaticus subsp. neocarzinostaticus.
To be Published
5E7Q
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ACYL-COA SYNTHETASE PTMA2 FROM STREPTOMYCES PLATENSIS
Descriptor:acyl-CoA synthetase, SULFATE ION, GLYCEROL
Authors:Osipiuk, J., Cuff, M.E., Hatzos-Skintges, C., Endres, M., Babnigg, G., Rudolf, J., Ma, M., Chang, C.Y., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-10-12
Release date:2015-10-21
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.
Nat. Chem. Biol., 14, 2018
5UPQ
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ACYL-COA SYNTHETASE PTMA2 FROM STREPTOMYCES PLATENSIS IN COMPLEX WITH SBNP465 LIGAND
Descriptor:Acyl-CoA synthetase PtmA2, 5'-O-[(R)-{[(7beta,8alpha,9beta,10alpha,13alpha,16beta)-7,16-dihydroxy-18-oxokauran-18-yl]oxy}(hydroxy)phosphoryl]adenosine, SULFATE ION, ...
Authors:Osipiuk, J., Hatzos-Skintges, C., Endres, M., Babnigg, G., Rudolf, J.D., Chang, C.Y., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2017-02-03
Release date:2017-02-22
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.
Nat. Chem. Biol., 14, 2018
5UPS
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ACYL-COA SYNTHETASE PTMA2 FROM STREPTOMYCES PLATENSIS IN COMPLEX WITH SBNP663 LIGAND
Descriptor:Acyl-CoA synthetase PtmA2, 5'-O-[(R)-hydroxy{[(7beta,8alpha,9beta,10alpha,11beta,13alpha)-7-hydroxy-19-oxo-11,16-epoxykauran-19-yl]oxy}phosphoryl]adenosine, SODIUM ION, ...
Authors:Osipiuk, J., Hatzos-Skintges, C., Endres, M., Babnigg, G., Rudolf, J.D., Chang, C.-Y., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2017-02-03
Release date:2017-02-22
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.
Nat. Chem. Biol., 14, 2018
5UPT
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ACYL-COA SYNTHETASE PTMA2 FROM STREPTOMYCES PLATENSIS IN COMPLEX WITH SBNP468 LIGAND
Descriptor:Acyl-CoA synthetase PtmA2, (7alpha,8alpha,10alpha,13alpha)-7,16-dihydroxykauran-18-oic acid, SULFATE ION, ...
Authors:Osipiuk, J., Hatzos-Skintges, C., Endres, M., Babnigg, G., Rudolf, J.D., Chang, C.Y., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2017-02-03
Release date:2017-02-22
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.
Nat. Chem. Biol., 14, 2018