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1Z9E
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BU of 1z9e by Molmil
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
Descriptor: PC4 and SFRS1 interacting protein 2
Authors:Cherepanov, P, Sun, Z.-Y.J, Rahman, S, Maertens, G, Wagner, G, Engelman, A.
Deposit date:2005-04-01
Release date:2005-05-17
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
Nat.Struct.Mol.Biol., 12, 2005
2B4J
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BU of 2b4j by Molmil
Structural basis for the recognition between HIV-1 integrase and LEDGF/p75
Descriptor: GLYCEROL, Integrase (IN), PC4 and SFRS1 interacting protein, ...
Authors:Cherepanov, P, Ambrosio, A.L, Rahman, S, Ellenberger, T, Engelman, A.
Deposit date:2005-09-24
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ITG
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BU of 1itg by Molmil
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES
Descriptor: CACODYLATE ION, HIV-1 INTEGRASE
Authors:Dyda, F, Hickman, A.B, Jenkins, T.M, Engelman, A, Craigie, R, Davies, D.R.
Deposit date:1994-11-21
Release date:1995-05-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases.
Science, 266, 1994
4TSX
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BU of 4tsx by Molmil
HIV-1 Integrase Catalytic Core Domain Mutant Complexed with Allosteric Inhibitor
Descriptor: (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, Integrase, SULFATE ION
Authors:Feng, L, Kvaratskhelia, M.
Deposit date:2014-06-19
Release date:2014-12-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:The mechanism of H171T resistance reveals the importance of N -protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.
Retrovirology, 11, 2014
4WHJ
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BU of 4whj by Molmil
Myxovirus Resistance Protein 2 (MxB)
Descriptor: Interferon-induced GTP-binding protein Mx2
Authors:Xiong, Y, Fribourgh, J.L, Nguyen, H.C.
Deposit date:2014-09-22
Release date:2014-10-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Insight into HIV-1 Restriction by MxB.
Cell Host Microbe, 16, 2014
5D7U
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BU of 5d7u by Molmil
Crystal structure of the C-terminal domain of MMTV integrase
Descriptor: ISOPROPYL ALCOHOL, Pr160
Authors:Cook, N.J, Pye, V.E, Ballandras-Colas, A, Engelman, A, Cherepanov, P.
Deposit date:2015-08-14
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
5CZ2
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BU of 5cz2 by Molmil
Crystal structure of a two-domain fragment of MMTV integrase
Descriptor: MAGNESIUM ION, Pol polyprotein, ZINC ION
Authors:Cook, N, Ballandras-Colas, A, Engelman, A, Cherepanov, P.
Deposit date:2015-07-31
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
5CZ1
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BU of 5cz1 by Molmil
Crystal structure of the catalytic core domain of MMTV integrase
Descriptor: integrase
Authors:Cook, N, Ballandras-Colas, A, Engelman, A, Cherepanov, P.
Deposit date:2015-07-31
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
3OY9
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BU of 3oy9 by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with manganese at 2.55 resolution
Descriptor: AMMONIUM ION, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ...
Authors:Hare, S, Cherepanov, P.
Deposit date:2010-09-23
Release date:2010-10-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Retroviral intasome assembly and inhibition of DNA strand transfer.
Nature, 464, 2010
3F9K
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BU of 3f9k by Molmil
Two domain fragment of HIV-2 integrase in complex with LEDGF IBD
Descriptor: Integrase, MAGNESIUM ION, PC4 and SFRS1-interacting protein, ...
Authors:Hare, S, Cherepanov, P.
Deposit date:2008-11-14
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75
Plos Pathog., 5, 2009
4GW6
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BU of 4gw6 by Molmil
HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
Descriptor: (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](tert-butoxy)ethanoic acid, ARSENIC, Gag-Pol polyprotein
Authors:Feng, L, Kvaratskhelia, M.
Deposit date:2012-08-31
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors.
J.Biol.Chem., 288, 2013
4GVM
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BU of 4gvm by Molmil
HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
Descriptor: (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](tert-butoxy)ethanoic acid, ARSENIC, Gag-Pol polyprotein
Authors:Feng, L, Kvaratskhelia, M.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors.
J.Biol.Chem., 288, 2013
4ID1
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BU of 4id1 by Molmil
HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
Descriptor: (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, Gag-Pol polyprotein, SULFATE ION
Authors:Feng, L, Kvaratskhelia, M.
Deposit date:2012-12-11
Release date:2013-05-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JLH
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BU of 4jlh by Molmil
HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
Descriptor: (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](methoxy)ethanoic acid, HIV-1 Integrase catalytic core domain, SULFATE ION
Authors:Feng, L, Kvaratskhelia, M.
Deposit date:2013-03-12
Release date:2013-05-01
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors.
J.Biol.Chem., 288, 2013
4C0O
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BU of 4c0o by Molmil
Transportin 3 in complex with phosphorylated ASF/SF2
Descriptor: POTASSIUM ION, SERINE/ARGININE-RICH SPLICING FACTOR 1, TRANSPORTIN-3
Authors:Maertens, G.N, Cook, N.J, Cherepanov, P.
Deposit date:2013-08-06
Release date:2014-01-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.557 Å)
Cite:Structural Basis for Nuclear Import of Splicing Factors by Human Transportin 3.
Proc.Natl.Acad.Sci.USA, 111, 2014
4C0Q
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BU of 4c0q by Molmil
Transportin 3 in complex with Ran(Q69L)GTP
Descriptor: GTP-BINDING NUCLEAR PROTEIN RAN, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Maertens, G, Hare, S, Cherepanov, P.
Deposit date:2013-08-06
Release date:2014-01-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Structural Basis for Nuclear Import of Splicing Factors by Human Transportin 3.
Proc.Natl.Acad.Sci.USA, 111, 2014
4C0P
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BU of 4c0p by Molmil
Unliganded Transportin 3
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, TRANSPORTIN-3
Authors:Maertens, G.N, Cook, N.J, Hare, S, Cherepanov, P.
Deposit date:2013-08-06
Release date:2014-01-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural Basis for Nuclear Import of Splicing Factors by Human Transportin 3.
Proc.Natl.Acad.Sci.USA, 111, 2014
4DMN
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BU of 4dmn by Molmil
HIV-1 Integrase Catalytical Core Domain
Descriptor: (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](methoxy)ethanoic acid, ARSENIC, HIV-1 Integrase, ...
Authors:Feng, L, Kvaratskhelia, M.
Deposit date:2012-02-08
Release date:2012-03-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.
J.Biol.Chem., 287, 2012
1IHW
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BU of 1ihw by Molmil
SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 40 STRUCTURES
Descriptor: HIV-1 INTEGRASE
Authors:Clore, G.M, Lodi, P.J, Ernst, J.A, Gronenborn, A.M.
Deposit date:1995-05-12
Release date:1996-07-11
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of the DNA binding domain of HIV-1 integrase.
Biochemistry, 34, 1995
1IHV
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BU of 1ihv by Molmil
SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: HIV-1 INTEGRASE
Authors:Clore, G.M, Lodi, P.J, Ernst, J.A, Gronenborn, A.M.
Deposit date:1995-05-12
Release date:1996-10-14
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of the DNA binding domain of HIV-1 integrase.
Biochemistry, 34, 1995
3HPG
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BU of 3hpg by Molmil
Visna virus integrase (residues 1-219) in complex with LEDGF IBD: examples of open integrase dimer-dimer interfaces
Descriptor: Integrase, PC4 and SFRS1-interacting protein, ZINC ION
Authors:Hare, S, Labeja, A, Cherepanov, P.
Deposit date:2009-06-04
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.28 Å)
Cite:Structural basis for functional tetramerization of lentiviral integrase
Plos Pathog., 5, 2009
3HPH
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BU of 3hph by Molmil
Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD
Descriptor: GLYCEROL, Integrase, PC4 and SFRS1-interacting protein, ...
Authors:Hare, S, Wang, J, Cherepanov, P.
Deposit date:2009-06-04
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural basis for functional tetramerization of lentiviral integrase
Plos Pathog., 5, 2009
2ITG
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BU of 2itg by Molmil
CATALYTIC DOMAIN OF HIV-1 INTEGRASE: ORDERED ACTIVE SITE IN THE F185H CONSTRUCT
Descriptor: HUMAN IMMUNODEFICIENCY VIRUS-1 INTEGRASE
Authors:Bujacz, G, Alexandratos, J, Wlodawer, A, Zhou-Liu, Q, Clement-Mella, C.
Deposit date:1996-09-13
Release date:1997-03-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The catalytic domain of human immunodeficiency virus integrase: ordered active site in the F185H mutant.
FEBS Lett., 398, 1996
3L2W
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BU of 3l2w by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with manganese and GS9137 (Elvitegravir)
Descriptor: 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', 6-(3-chloro-2-fluorobenzyl)-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, ...
Authors:Hare, S, Gupta, S.S, Cherepanov, P.
Deposit date:2009-12-15
Release date:2010-02-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Retroviral intasome assembly and inhibition of DNA strand transfer
Nature, 464, 2010
3L2Q
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BU of 3l2q by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in apo form
Descriptor: 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', GLYCEROL, ...
Authors:Hare, S, Gupta, S.S, Cherepanov, P.
Deposit date:2009-12-15
Release date:2010-02-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Retroviral intasome assembly and inhibition of DNA strand transfer
Nature, 464, 2010

 

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