Author results

5D11
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KINASE DOMAIN OF CSRC IN COMPLEX WITH RL235
Descriptor:Proto-oncogene tyrosine-protein kinase Src, GLYCEROL, N-[3-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}oxy)phenyl]prop-2-enamide
Authors:Becker, C., Gruetter, C., Engel, J., Rauh, D.
Deposit date:2015-08-03
Release date:2015-09-09
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
J.Med.Chem., 58, 2015
5D12
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KINASE DOMAIN OF CSRC IN COMPLEX WITH RL40
Descriptor:Proto-oncogene tyrosine-protein kinase Src, N-[2-phenyl-4-(1H-pyrazol-3-ylamino)quinazolin-7-yl]prop-2-enamide
Authors:Becker, C., Richters, A., Engel, J., Rauh, D.
Deposit date:2015-08-03
Release date:2015-09-09
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
J.Med.Chem., 58, 2015
5J9Y
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EGFR-T790M IN COMPLEX WITH PYRAZOLOPYRIMIDINE INHIBITOR 1B
Descriptor:Epidermal growth factor receptor, (R)-1-(3-(4-amino-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Authors:Becker, C., Engel, J., Rauh, D.
Deposit date:2016-04-11
Release date:2016-08-17
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR.
Angew.Chem.Int.Ed.Engl., 55, 2016
5J9Z
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EGFR-T790M IN COMPLEX WITH PYRAZOLOPYRIMIDINE INHIBITOR 1A
Descriptor:Epidermal growth factor receptor, (R)-1-(3-(4-amino-3-(1-methyl-1H-indol-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Authors:Becker, C., Engel, J., Rauh, D.
Deposit date:2016-04-11
Release date:2016-08-17
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR.
Angew.Chem.Int.Ed.Engl., 55, 2016
1SRA
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STRUCTURE OF A NOVEL EXTRACELLULAR CA2+-BINDING MODULE IN BM-40(SLASH)SPARC(SLASH)OSTEONECTIN
Descriptor:SPARC, CALCIUM ION
Authors:Hohenester, E., Maurer, P., Hohenadl, C., Timpl, R., Jansonius, J.N., Engel, J.
Deposit date:1995-08-21
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a novel extracellular Ca(2+)-binding module in BM-40.
Nat.Struct.Biol., 3, 1996
1AQ5
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HIGH-RESOLUTION SOLUTION NMR STRUCTURE OF THE TRIMERIC COILED-COIL DOMAIN OF CHICKEN CARTILAGE MATRIX PROTEIN, 20 STRUCTURES
Descriptor:CARTILAGE MATRIX PROTEIN
Authors:Dames, S.A., Wiltscheck, R., Kammerer, R.A., Engel, J., Alexandrescu, A.T.
Deposit date:1997-08-07
Release date:1998-02-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of a parallel homotrimeric coiled coil.
Nat.Struct.Biol., 5, 1998
1FF5
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STRUCTURE OF E-CADHERIN DOUBLE DOMAIN
Descriptor:EPITHELIAL CADHERIN, CALCIUM ION
Authors:Pertz, O., Bozic, D., Koch, A.W., Fauser, C., Brancaccio, A., Engel, J.
Deposit date:2000-07-25
Release date:2000-08-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation.
EMBO J., 18, 1999
2NX6
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STRUCTURE OF NOWA CYSTEINE RICH DOMAIN 6
Descriptor:Nematocyst outer wall antigen
Authors:Meier, S., Jensen, P.R., Adamczyk, P., Bachinger, H.P., Holstein, T.W., Engel, J., Ozbek, S., Grzesiek, S.
Deposit date:2006-11-17
Release date:2007-10-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.
J.Mol.Biol., 368, 2007
2NX7
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STRUCTURE OF NOWA CYSTEINE RICH DOMAIN 8
Descriptor:Nematocyst outer wall antigen
Authors:Meier, S., Jensen, P.R., Adamczyk, P., Bachinger, H.P., Holstein, T.W., Engel, J., Ozbek, S., Grzesiek, S.
Deposit date:2006-11-17
Release date:2007-10-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.
J.Mol.Biol., 368, 2007
3DMW
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CRYSTAL STRUCTURE OF HUMAN TYPE III COLLAGEN G982-G1023 CONTAINING C-TERMINAL CYSTINE KNOT
Descriptor:Collagen alpha-1(III) chain
Authors:Boudko, S.P., Engel, J., Okuyama, K., Mizuno, K., Bachinger, H.P., Schumacher, M.A.
Deposit date:2008-07-01
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human type III collagen Gly991-Gly1032 cystine knot-containing peptide shows both 7/2 and 10/3 triple helical symmetries.
J.Biol.Chem., 283, 2008
5D10
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KINASE DOMAIN OF CSRC IN COMPLEX WITH RL236
Descriptor:Proto-oncogene tyrosine-protein kinase Src, N-[4-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}oxy)phenyl]prop-2-enamide
Authors:Becker, C., Mayer-Wrangowski, S.C., Julian, E., Rauh, D.
Deposit date:2015-08-03
Release date:2015-09-02
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
J.Med.Chem., 58, 2015
1VDF
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ASSEMBLY DOMAIN OF CARTILAGE OLIGOMERIC MATRIX PROTEIN
Descriptor:CARTILAGE OLIGOMERIC MATRIX PROTEIN, CHLORIDE ION
Authors:Malashkevich, V.N.
Deposit date:1996-09-12
Release date:1997-10-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The crystal structure of a five-stranded coiled coil in COMP: a prototype ion channel?
Science, 274, 1996
1FE6
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CRYSTAL STRUCTURE OF A NATURALLY OCCURING PARALLEL RIGHT-HANDED COILED-COIL TETRAMER
Descriptor:TETRABRACHION
Authors:Stetefeld, J.
Deposit date:2000-07-21
Release date:2001-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a naturally occurring parallel right-handed coiled coil tetramer.
Nat.Struct.Biol., 7, 2000
1JB3
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THE LAMININ-BINDING DOMAIN OF AGRIN IS STRUCTURALLY RELATED TO N-TIMP-1
Descriptor:Agrin
Authors:Stetefeld, J.
Deposit date:2001-06-01
Release date:2001-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The laminin-binding domain of agrin is structurally related to N-TIMP-1.
Nat.Struct.Biol., 8, 2001
1JC7
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THE LAMININ-BINDING DOMAIN OF AGRIN IS STRUCTURALLY RELATED TO N-TIMP-1
Descriptor:Agrin, CHLORIDE ION
Authors:Stetefeld, J.
Deposit date:2001-06-08
Release date:2001-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:The laminin-binding domain of agrin is structurally related to N-TIMP-1.
Nat.Struct.Biol., 8, 2001
1MZ9
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STORAGE FUNCTION OF COMP:THE CRYSTAL STRUCTURE OF THE COILED-COIL DOMAIN IN COMPLEX WITH VITAMIN D3
Descriptor:cartilage oligomeric matrix protein, 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL
Authors:Stetefeld, J.
Deposit date:2002-10-07
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3).
EMBO J., 21, 2002
1NAY
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GPP-FOLDON:X-RAY STRUCTURE
Descriptor:Collagen-like peptide
Authors:Stetefeld, J.
Deposit date:2002-11-29
Release date:2003-03-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Collagen Stabilization at Atomic Level. Crystal Structure of Designed (GlyProPro)(10)foldon
Structure, 11, 2003
1OX3
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CRYSTAL STRUCTURE OF MINI-FIBRITIN
Descriptor:Fibritin
Authors:Boudko, S.P., Stetefeld, J.
Deposit date:2003-04-01
Release date:2004-04-13
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and Crystal Structure of Bacteriophage T4 Mini-Fibritin NCCF.
J.Mol.Biol., 339, 2004
1PXU
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CRYSTAL STRUCTURE OF CHICKEN NTA FROM A EUKARYOTIC SOURCE AT 2.2A RESOLUTION
Descriptor:agrin
Authors:Stetefeld, J.
Deposit date:2003-07-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and laminin-binding specificity of the NtA domain expressed in eukaryotic cells.
Matrix Biol., 23, 2005
1Q1P
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E-CADHERIN ACTIVATION
Descriptor:Epithelial-cadherin, CALCIUM ION
Authors:Haussinger, D., Stetefeld, J.
Deposit date:2003-07-22
Release date:2004-04-20
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography.
Embo J., 23, 2004
6IB0
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THE STRUCTURE OF MKK7 IN COMPLEX WITH THE COVALENT 4-AMINO-PYRAZOLOPYRIMIDINE 3A
Descriptor:Dual specificity mitogen-activated protein kinase kinase 7, 1-[(3~{R})-3-(4-azanyl-3-ethynyl-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]prop-2-en-1-one, TETRAETHYLENE GLYCOL
Authors:Wolle, P., Hardick, J., Mueller, M.P., Rauh, D.
Deposit date:2018-11-28
Release date:2019-02-27
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.
J.Med.Chem., 62, 2019
6IB2
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THE STRUCTURE OF MKK7 IN COMPLEX WITH THE COVALENT 4-AMINO-PYRAZOLOPYRIMIDINE 4A
Descriptor:Dual specificity mitogen-activated protein kinase kinase 7, 1-[(3~{R})-3-[4-azanyl-3-[1-(4-ethanoylphenyl)-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one
Authors:Wolle, P., Hardick, J., Mueller, M.P., Rauh, D.
Deposit date:2018-11-28
Release date:2019-02-27
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.
J.Med.Chem., 62, 2019
1BMO
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BM-40, FS/EC DOMAIN PAIR
Descriptor:BM-40, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION
Authors:Hohenester, E., Maurer, P., Timpl, R.
Deposit date:1997-03-25
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40.
EMBO J., 16, 1997
1FBM
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ASSEMBLY DOMAIN OF CARTILAGE OLIGOMERIC MATRIX PROTEIN IN COMPLEX WITH ALL-TRANS RETINOL
Descriptor:PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN), RETINOL
Authors:Guo, Y., Bozic, D., Malashkevich, V.N., Kammerer, R.A., Schulthess, T.
Deposit date:2000-07-16
Release date:2000-08-02
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:All-trans retinol, vitamin D and other hydrophobic compounds bind in the axial pore of the five-stranded coiled-coil domain of cartilage oligomeric matrix protein.
EMBO J., 17, 1998
2V37
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SOLUTION STRUCTURE OF THE N-TERMINAL EXTRACELLULAR DOMAIN OF HUMAN T- CADHERIN
Descriptor:CADHERIN-13
Authors:Dames, S.A., Bang, E.J., Ahrens, T., Haeussinger, D., Grzesiek, S.
Deposit date:2007-06-13
Release date:2008-06-10
Last modified:2018-03-28
Method:SOLUTION NMR
Cite:Insights into the low adhesive capacity of human T-cadherin from the NMR structure of Its N-terminal extracellular domain.
J. Biol. Chem., 283, 2008
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