Author results

6O9A
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CRYSTAL STRUCTURE OF MQNA COMPLEXED WITH 3-HYDROXYBENZOIC ACID
Descriptor:Chorismate dehydratase, ACETATE ION, 3-HYDROXYBENZOIC ACID
Authors:Hicks, K.A., Mahanta, N., Naseem, S., Fedoseyenko, D., Begley, T.P., Ealick, S.E.
Deposit date:2019-03-13
Release date:2019-04-03
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.326 Å)
Cite:Menaquinone Biosynthesis: Biochemical and Structural Studies of Chorismate Dehydratase.
Biochemistry, 58, 2019
6BXK
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CRYSTAL STRUCTURE OF PYROCOCCUS HORIKOSHII DPH2 WITH 4FE-4S CLUSTER AND MTA
Descriptor:2-(3-amino-3-carboxypropyl)histidine synthase, 5'-DEOXY-5'-METHYLTHIOADENOSINE, SULFATE ION, ...
Authors:Torelli, A.T., Fenwick, M.K., Zhang, Y., Dong, M., Kathiresan, V., Carantoa, J.D., Dzikovski, B., Lancaster, K.M., Freed, J.H., Hoffman, B.M., Lin, H., Ealick, S.E.
Deposit date:2017-12-18
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.347 Å)
Cite:Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
6BXL
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CRYSTAL STRUCTURE OF PYROCOCCUS HORIKOSHII DPH2 WITH 4FE-4S CLUSTER AND SAM
Descriptor:2-(3-amino-3-carboxypropyl)histidine synthase, S-ADENOSYLMETHIONINE, IRON/SULFUR CLUSTER
Authors:Torelli, A.T., Fenwick, M.K., Zhang, Y., Dong, M., Kathiresan, V., Carantoa, J.D., Dzikovski, B., Lancaster, K.M., Freed, J.H., Hoffman, B.M., Lin, H., Ealick, S.E.
Deposit date:2017-12-18
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
6BXM
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CRYSTAL STRUCTURE OF CANDIDATUS METHANOPEREDENS NITROREDUCENS DPH2 WITH 4FE-4S CLUSTER AND SAM/CLEAVED SAM
Descriptor:Diphthamide biosynthesis enzyme Dph2, IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE, ...
Authors:Fenwick, M.K., Torelli, A.T., Zhang, Y., Dong, M., Kathiresan, V., Carantoa, J.D., Dzikovski, B., Lancaster, K.M., Freed, J.H., Hoffman, B.M., Lin, H., Ealick, S.E.
Deposit date:2017-12-18
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.252 Å)
Cite:Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
6BXN
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CRYSTAL STRUCTURE OF CANDIDATUS METHANOPEREDENS NITROREDUCENS DPH2 WITH 4FE-4S CLUSTER AND SAM
Descriptor:Diphthamide biosynthesis enzyme Dph2, IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE
Authors:Fenwick, M.K., Torelli, A.T., Zhang, Y., Dong, M., Kathiresan, V., Carantoa, J.D., Dzikovski, B., Lancaster, K.M., Freed, J.H., Hoffman, B.M., Lin, H., Ealick, S.E.
Deposit date:2017-12-18
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.079 Å)
Cite:Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
6BXO
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CRYSTAL STRUCTURE OF CANDIDATUS METHANOPEREDENS NITROREDUCENS DPH2 WITH 4FE-4S CLUSTER AND SAH
Descriptor:Diphthamide biosynthesis enzyme Dph2, IRON/SULFUR CLUSTER, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Fenwick, M.K., Torelli, A.T., Zhang, Y., Dong, M., Kathiresan, V., Carantoa, J.D., Dzikovski, B., Lancaster, K.M., Freed, J.H., Hoffman, B.M., Lin, H., Ealick, S.E.
Deposit date:2017-12-18
Release date:2018-04-11
Method:X-RAY DIFFRACTION (1.655 Å)
Cite:Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
5UFM
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CRYSTAL STRUCTURE OF BURKHOLDERIA THAILANDENSIS 1,6-DIDEMETHYLTOXOFLAVIN-N1-METHYLTRANSFERASE WITH BOUND 1,6-DIDEMETHYLTOXOFLAVIN AND S-ADENOSYLHOMOCYSTEINE
Descriptor:Methyltransferase domain protein, S-ADENOSYL-L-HOMOCYSTEINE, pyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione, ...
Authors:Fenwick, M.K., Ealick, S.E., Almabruk, K.H., Begley, T.P., Philmus, B.
Deposit date:2017-01-05
Release date:2017-12-13
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Biochemistry, 56, 2017
5UFN
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CRYSTAL STRUCTURE OF BURKHOLDERIA THAILANDENSIS 1,6-DIDEMETHYLTOXOFLAVIN-N1-METHYLTRANSFERASE WITH BOUND S-ADENOSYLHOMOCYSTEINE
Descriptor:Methyltransferase domain protein, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Fenwick, M.K., Ealick, S.E., Almabruk, K.H., Begley, T.P., Philmus, B.
Deposit date:2017-01-05
Release date:2017-12-13
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Biochemistry, 56, 2017
5WAN
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CRYSTAL STRUCTURE OF A FLAVOENZYME RUTA IN THE PYRIMIDINE CATABOLIC PATHWAY
Descriptor:Pyrimidine monooxygenase RutA, URACIL, SULFATE ION, ...
Authors:Zhang, Y., Mukherjee, T., Abdelwahed, S., Begley, T.P., Ealick, S.E.
Deposit date:2017-06-26
Release date:2017-07-19
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Catalysis of a flavoenzyme-mediated amide hydrolysis.
J. Am. Chem. Soc., 132, 2010
5VSL
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CRYSTAL STRUCTURE OF VIPERIN WITH BOUND [4FE-4S] CLUSTER AND S-ADENOSYLHOMOCYSTEINE (SAH)
Descriptor:Radical S-adenosyl methionine domain-containing protein 2, IRON/SULFUR CLUSTER, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Fenwick, M.K., Li, Y., Cresswell, P., Modis, Y., Ealick, S.E.
Deposit date:2017-05-11
Release date:2017-06-14
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.972 Å)
Cite:Structural studies of viperin, an antiviral radical SAM enzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VSM
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CRYSTAL STRUCTURE OF VIPERIN WITH BOUND [4FE-4S] CLUSTER, 5'-DEOXYADENOSINE, AND L-METHIONINE
Descriptor:Radical S-adenosyl methionine domain-containing protein 2, IRON/SULFUR CLUSTER, 5'-DEOXYADENOSINE, ...
Authors:Fenwick, M.K., Li, Y., Cresswell, P., Modis, Y., Ealick, S.E.
Deposit date:2017-05-11
Release date:2017-06-14
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural studies of viperin, an antiviral radical SAM enzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5LNR
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA PDX1-PLP COMPLEX
Descriptor:Pyridoxal 5'-phosphate synthase subunit PDX1.3, PYRIDOXAL-5'-PHOSPHATE, GLYCEROL
Authors:Rodrigues, M.J., Windeisen, V., Zhang, Y., Guedez, G., Weber, S., Strohmeier, M., Hanes, J.W., Royant, A., Evans, G., Sinning, I., Ealick, S.E., Begley, T.P., Tews, I.
Deposit date:2016-08-06
Release date:2017-01-18
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.
Nat. Chem. Biol., 13, 2017
5LNS
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA PDX1-R5P COMPLEX
Descriptor:Pyridoxal 5'-phosphate synthase subunit PDX1.3, RIBULOSE-5-PHOSPHATE, PHOSPHATE ION
Authors:Rodrigues, M.J., Windeisen, V., Zhang, Y., Guedez, G., Weber, S., Strohmeier, M., Hanes, J.W., Royant, A., Evans, G., Sinning, I., Ealick, S.E., Begley, T.P., Tews, I.
Deposit date:2016-08-06
Release date:2017-01-18
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.
Nat. Chem. Biol., 13, 2017
5LNT
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA PDX1K166R-PREI320 COMPLEX
Descriptor:Pyridoxal 5'-phosphate synthase subunit PDX1.1, [(~{E},4~{S})-4-azanyl-3-oxidanylidene-pent-1-enyl] dihydrogen phosphate, PHOSPHATE ION
Authors:Rodrigues, M.J., Windeisen, V., Zhang, Y., Guedez, G., Weber, S., Strohmeier, M., Hanes, J.W., Royant, A., Evans, G., Sinning, I., Ealick, S.E., Begley, T.P., Tews, I.
Deposit date:2016-08-06
Release date:2017-01-18
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.
Nat. Chem. Biol., 13, 2017
5LNU
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA PDX1-I320 COMPLEX
Descriptor:Pyridoxal 5'-phosphate synthase subunit PDX1.3, PHOSPHATE ION, SULFATE ION, ...
Authors:Rodrigues, M.J., Windeisen, V., Zhang, Y., Guedez, G., Weber, S., Strohmeier, M., Hanes, J.W., Royant, A., Evans, G., Sinning, I., Ealick, S.E., Begley, T.P., Tews, I.
Deposit date:2016-08-06
Release date:2017-01-18
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.
Nat. Chem. Biol., 13, 2017
5LNV
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA PDX1-I320 COMPLEX FROM MULTIPLE CRYSTALS
Descriptor:Pyridoxal 5'-phosphate synthase subunit PDX1.3, PHOSPHATE ION, SULFATE ION, ...
Authors:Rodrigues, M.J., Windeisen, V., Zhang, Y., Guedez, G., Weber, S., Strohmeier, M., Hanes, J.W., Royant, A., Evans, G., Sinning, I., Ealick, S.E., Begley, T.P., Tews, I.
Deposit date:2016-08-06
Release date:2017-01-18
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.
Nat. Chem. Biol., 13, 2017
5LNW
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA PDX1-I320-G3P COMPLEX
Descriptor:Pyridoxal 5'-phosphate synthase subunit PDX1.3, [(2~{R},3~{R})-2,3-bis(oxidanyl)-3-[[(2~{S})-3-oxidanylidenepent-4-en-2-yl]amino]propyl] dihydrogen phosphate, 5-O-phosphono-beta-D-ribofuranose, ...
Authors:Rodrigues, M.J., Windeisen, V., Zhang, Y., Guedez, G., Weber, S., Strohmeier, M., Hanes, J.W., Royant, A., Evans, G., Sinning, I., Ealick, S.E., Begley, T.P., Tews, I.
Deposit date:2016-08-06
Release date:2017-01-18
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.
Nat. Chem. Biol., 13, 2017
5CLG
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STRUCTURE OF PURE (N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE) MUTANT H59N FROM THE ACIDOPHILIC BACTERIUM ACETOBACTER ACETI, AT PH 5.4
Descriptor:N5-carboxyaminoimidazole ribonucleotide mutase, CITRIC ACID
Authors:Starks, C.M., Kappock, T.J.
Deposit date:2015-07-16
Release date:2016-07-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of a single tryptophan mutant of Acetobacter aceti PurE
To Be Published
5CLJ
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STRUCTURE OF PURE (N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE) H59N FROM THE ACIDOPHILIC BACTERIUM ACETOBACTER ACETI, COMPLEXED WITH AIR (5-AMINOIMIDAZOLE RIBONUCLEOTIDE) AND CO2
Descriptor:N5-carboxyaminoimidazole ribonucleotide mutase, 5-AMINOIMIDAZOLE RIBONUCLEOTIDE, CARBON DIOXIDE, ...
Authors:Starks, C.M., Kappock, T.J.
Deposit date:2015-07-16
Release date:2016-07-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of a single tryptophan mutant of Acetobacter aceti PurE
To Be Published
5KTM
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CRYSTAL STRUCTURE OF PYROCOCCUS HORIKOSHII QUINOLINATE SYNTHASE (NADA) WITH A BOUND FE4S4 CLUSTER
Descriptor:Quinolinate synthase A, IRON/SULFUR CLUSTER, CHLORIDE ION
Authors:Fenwick, M.K., Ealick, S.E.
Deposit date:2016-07-12
Release date:2016-07-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate.
Biochemistry, 55, 2016
5KTN
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CRYSTAL STRUCTURE OF PYROCOCCUS HORIKOSHII QUINOLINATE SYNTHASE (NADA) WITH BOUND DIHYDROXYACETONE PHOSPHATE (DHAP) AND FE4S4 CLUSTER
Descriptor:Quinolinate synthase A, IRON/SULFUR CLUSTER, 1,3-DIHYDROXYACETONEPHOSPHATE, ...
Authors:Fenwick, M.K., Ealick, S.E.
Deposit date:2016-07-12
Release date:2016-07-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate.
Biochemistry, 55, 2016
5KTO
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CRYSTAL STRUCTURE OF PYROCOCCUS HORIKOSHII QUINOLINATE SYNTHASE (NADA) WITH BOUND QUINOLINATE AND FE4S4 CLUSTER
Descriptor:Quinolinate synthase A, IRON/SULFUR CLUSTER, QUINOLINIC ACID, ...
Authors:Fenwick, M.K., Ealick, S.E.
Deposit date:2016-07-12
Release date:2016-07-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.442 Å)
Cite:Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate.
Biochemistry, 55, 2016
5KTP
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CRYSTAL STRUCTURE OF PYROCOCCUS HORIKOSHII QUINOLINATE SYNTHASE (NADA) WITH BOUND ITACONATE AND FE4S4 CLUSTER
Descriptor:Quinolinate synthase A, IRON/SULFUR CLUSTER, CHLORIDE ION, ...
Authors:Fenwick, M.K., Ealick, S.E.
Deposit date:2016-07-12
Release date:2016-07-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.542 Å)
Cite:Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate.
Biochemistry, 55, 2016
5KTR
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CRYSTAL STRUCTURE OF PYROCOCCUS HORIKOSHII QUINOLINATE SYNTHASE (NADA) WITH BOUND MALEATE AND FE4S4 CLUSTER
Descriptor:Quinolinate synthase A, IRON/SULFUR CLUSTER, MALEIC ACID, ...
Authors:Fenwick, M.K., Ealick, S.E.
Deposit date:2016-07-12
Release date:2016-07-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate.
Biochemistry, 55, 2016
5KTS
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CRYSTAL STRUCTURE OF PYROCOCCUS HORIKOSHII QUINOLINATE SYNTHASE (NADA) WITH BOUND CITRACONATE AND FE4S4 CLUSTER
Descriptor:Quinolinate synthase A, IRON/SULFUR CLUSTER, (~{Z})-2-methylbut-2-enedioic acid, ...
Authors:Fenwick, M.K., Ealick, S.E.
Deposit date:2016-07-12
Release date:2016-07-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate.
Biochemistry, 55, 2016