Author results

2Q80
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CRYSTAL STRUCTURE OF HUMAN GERANYLGERANYL PYROPHOSPHATE SYNTHASE BOUND TO GGPP
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, GERANYLGERANYL DIPHOSPHATE
Authors:Kavanagh, K.L., Dunford, J.E., Bunkoczi, G., Smee, C., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-06-08
Release date:2007-06-19
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding
J.Biol.Chem., 281, 2006
2QIS
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CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE T210S MUTANT BOUND TO RISEDRONATE
Descriptor:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID
Authors:Kavanagh, K.L., Dunford, J.E., Hozjan, V., Evdokimov, A., Gileadi, O., von Delft, F., Weigelt, J., Arrowsmith, C.H., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-07-05
Release date:2007-07-24
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate.
To be Published
3B7L
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HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH MG AND MINODRONATE
Descriptor:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
Authors:Pilka, E.S., Dunford, J.E., Guo, K., Pike, A.C.W., Kavanagh, K.L., von Delft, F., Ebetino, F.H., Arrowsmith, C.H., Edwards, A.M., Russell, R.G.G., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Human farnesyl diphosphate synthase complexed with MG and minodronate.
TO BE PUBLISHED
3CP6
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CRYSTAL STRUCTURE OF HUMAN FARNESYL DIPHOSPHATE SYNTHASE (T201A MUTANT) COMPLEXED WITH MG AND BIPHOSPHONATE INHIBITOR
Descriptor:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, (4aS,7aR)-octahydro-1H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid)
Authors:Pilka, E.S., Dunford, J.E., Guo, K., Pike, A.C.W., von Delft, F., Barnett, B.L., Ebetino, F.H., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Russell, R.G.G., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-03-31
Release date:2008-04-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor.
To be Published
4N9U
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THE ROLE OF LYSINE 200 IN THE HUMAN FARNESYL PYROPHOSPHATE SYNTHASE CATALYTIC MECHANISM AND THE MODE OF INHIBITION BY THE NITROGEN-CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, ...
Authors:Tsoumpra, M.K., Muniz, J.R.C., Barnett, B.L., Pilka, E., Kwaasi, A.A., Kavanagh, K.L., Evdokimov, A., Walter, R.L., Ebetino, F.H., Oppermann, U., Russell, R.G.G., Dunford, J.E.
Deposit date:2013-10-21
Release date:2014-10-22
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
TO BE PUBLISHED
4NG6
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THE EFFECTS OF LYSINE 200 AND PHENYLALANINE 239 FARNESYL PYROPHOSPHATE SYNTHASE (FPPS) MUTATIONS ON THE CATALYTIC ACTIVITY, CRYSTAL STRUCTURE AND INHIBITION BY NITROGEN CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Tsoumpra, M.K., Muniz, J.R.C., Barnett, B.L., Pilka, E., Kwaasi, A.A., Kavanagh, K.L., Evdokimov, A., Walter, R.L., Ebetino, F.H., Oppermann, U., Russell, R.G.G., Dunford, J.E.
Deposit date:2013-11-01
Release date:2014-11-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
TO BE PUBLISHED
4NKE
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THE EFFECTS OF LYSINE 200 AND PHENYLALANINE 239 FARNESYL PYROPHOSPHATE SYNTHASE (FPPS) MUTATIONS ON THE CATALYTIC ACTIVITY, CRYSTAL STRUCTURE AND INHIBITION BY NITROGEN CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, ...
Authors:Tsoumpra, M.K., Barnett, B.L., Muniz, J.R.C., Walter, R.L., Ebetino, F.H., von Delft, F., Russell, R.G.G., Oppermann, U., Dunford, J.E.
Deposit date:2013-11-12
Release date:2014-11-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
4NKF
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THE EFFECTS OF LYSINE 200 AND PHENYLALANINE 239 FARNESYL PYROPHOSPHATE SYNTHASE (FPPS) MUTATIONS ON THE CATALYTIC ACTIVITY, CRYSTAL STRUCTURE AND INHIBITION BY NITROGEN CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, PAMIDRONATE, ...
Authors:Tsoumpra, M.K., Barnett, B.L., Muniz, J.R.C., Walter, R.L., Ebetino, F.H., von Delft, F., Russell, R.G.G., Oppermann, U., Dunford, J.E.
Deposit date:2013-11-12
Release date:2014-11-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
4NUA
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THE EFFECTS OF LYSINE 200 AND PHENYLALANINE 239 FARNESYL PYROPHOSPHATE SYNTHASE (FPPS) MUTATIONS ON THE CATALYTIC ACTIVITY, CRYSTAL STRUCTURE AND INHIBITION BY NITROGEN CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, MAGNESIUM ION, ...
Authors:Tsoumpra, M.K., Barnett, B.L., Muniz, J.R.C., Walter, R.L., Ebetino, F.H., von Delft, F., Russell, R.G.G., Oppermann, U., Dunford, J.E.
Deposit date:2013-12-03
Release date:2014-11-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
4OGU
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THE EFFECTS OF LYSINE 200 AND PHENYLALANINE 239 FARNESYL PYROPHOSPHATE SYNTHASE (FPPS) MUTATIONS ON THE CATALYTIC ACTIVITY, CRYSTAL STRUCTURE AND INHIBITION BY NITROGEN CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Tsoumpra, M.K., Barnett, B.L., Muniz, J.R.C., Walter, R.L., Ebetino, F.H., von Delft, F., Russell, R.G.G., Oppermann, U., Dunford, J.E.
Deposit date:2014-01-16
Release date:2015-01-21
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
4Q23
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THE ROLE OF THREONINE 201 AND TYROSINE 204 IN THE HUMAN FARNESYL PYROPHOSPHATE SYNTHASE CATALYTIC MECHANISM AND THE MODE OF INHIBITION BY THE NITROGEN-CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, MAGNESIUM ION, ...
Authors:Tsoumpra, M.K., Muniz, J.R.C., Barnett, B.L., Kwaasi, A.A., Pilka, E.S., Kavanagh, K.L., Evdokimov, A., Walter, R.L., Ebetino, F.H., von Delft, F., Oppermann, U., Russell, R.G.G., Dunford, J.E.
Deposit date:2014-04-05
Release date:2015-03-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
To be Published
4QPF
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NEW LOWER BONE AFFINITY BISPHOSPHONATE DRUG DESIGN FOR EFFECTIVE USE IN DISEASES CHARACTERIZED BY ABNORMAL BONE RESORPTION
Descriptor:Farnesyl pyrophosphate synthase, [1-fluoro-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid), MAGNESIUM ION
Authors:Ebetino, F.H., Lundy, M., Kwaasi, A.A., Dunford, J.E., Duan, Z., Triffitt, J., Mazur, A., Jeans, G., Barnett, B.L., Russell, R.G.G.
Deposit date:2014-06-23
Release date:2015-06-24
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption
To be Published
2O1O
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CRYPTOSPORIDIUM PARVUM PUTATIVE POLYPRENYL PYROPHOSPHATE SYNTHASE (CGD4_2550) IN COMPLEX WITH RISEDRONATE.
Descriptor:Putative farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID
Authors:Chruszcz, M., Artz, J.D., Dong, A., Dunford, J., Lew, J., Zhao, Y., Kozieradski, I., Kavanaugh, K.L., Oppermann, U., Sundstrom, M., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Hui, R., Minor, W., Structural Genomics Consortium (SGC)
Deposit date:2006-11-29
Release date:2006-12-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis
Chem.Biol., 15, 2008
2Q58
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CRYPTOSPORIDIUM PARVUM PUTATIVE POLYPRENYL PYROPHOSPHATE SYNTHASE (CGD4_2550) IN COMPLEX WITH ZOLEDRONATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID
Authors:Chruszcz, M., Artz, J., Zheng, H., Dong, A., Dunford, J., Lew, J., Zhao, Y., Kozieradski, I., Kavanaugh, K.L., Opperman, U., Sundstrom, M., Weigelt, J., Edwards, A., Arrowsmith, C., Bochkarev, A., Hui, R., Minor, W., Structural Genomics Consortium (SGC)
Deposit date:2007-05-31
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis
Chem.Biol., 15, 2008
3MAV
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CRYSTAL STRUCTURE OF PLASMODIUM VIVAX PUTATIVE FARNESYL PYROPHOSPHATE SYNTHASE (PV092040)
Descriptor:Farnesyl pyrophosphate synthase, SULFATE ION
Authors:Dong, A., Dunford, J., Lew, J., Wernimont, A.K., Ren, H., Zhao, Y., Koeieradzki, I., Opperman, U., Sundstrom, M., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Hui, R., Artz, J.D., Structural Genomics Consortium (SGC)
Deposit date:2010-03-24
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
J.Biol.Chem., 286, 2011
3PH7
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CRYSTAL STRUCTURE OF PLASMODIUM VIVAX PUTATIVE POLYPRENYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH GERANYLGERANYL DIPHOSPHATE
Descriptor:Farnesyl pyrophosphate synthase, GERANYLGERANYL DIPHOSPHATE
Authors:Wernimont, A.K., Dunford, J., Lew, J., Zhao, Y., Kozieradzki, I., Cossar, D., Schapiro, M., Bochkarev, A., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Hui, R., Artz, J.D., Structural Genomics Consortium (SGC)
Deposit date:2010-11-03
Release date:2010-11-17
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
J.Biol.Chem., 286, 2011
1YV5
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HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH MG AND RISEDRONATE
Descriptor:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Kavanagh, K.L., Guo, K., Von Delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-02-15
Release date:2005-03-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
1ZW5
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X-RAY STRUCTURE OF FARNESYL DIPHOSPHATE SYNTHASE PROTEIN
Descriptor:farnesyl diphosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Kavanagh, K.L., Guo, K., Wu, X., von Delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-06-03
Release date:2005-06-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
3LDW
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CRYSTAL STRUCTURE OF PLASMODIUM VIVAX GERANYLGERANYLPYROPHOSPHATE SYNTHASE PVX_092040 WITH ZOLEDRONATE AND IPP BOUND
Descriptor:Farnesyl pyrophosphate synthase, ZOLEDRONIC ACID, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Wernimont, A.K., Lew, J., Zhao, Y., Kozieradzki, I., Cossar, D., Schapira, M., Bochkarev, A., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Hui, R., Artz, J.D., Structural Genomics Consortium (SGC)
Deposit date:2010-01-13
Release date:2010-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
J.Biol.Chem., 286, 2011
4KFA
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CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE (T201A MUTANT) COMPLEXED WITH MG AND ZOLEDRONATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C., Walter, R.L.
Deposit date:2013-04-26
Release date:2014-04-30
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structure of human farnesyl pyrophosphate synthase (t201a mutant) complexed with mg and zoledronate
To be Published
4KPD
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CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE (Y204F) MUTANT COMPLEXED WITH MG, RISEDRONATE AND ISOPENTENYL PYROPHOSPHATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C., Walter, R.L.
Deposit date:2013-05-13
Release date:2014-04-30
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structure of Human Farnesyl Pyrophosphate Synthase (Y204F) Mutant Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate
To be Published
4KPJ
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CRYSTAL STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHASE (Y204A) MUTANT COMPLEXED WITH MG, PAMIDRONATE
Descriptor:Farnesyl pyrophosphate synthase, PAMIDRONATE, MAGNESIUM ION, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C., Walter, R.L.
Deposit date:2013-05-13
Release date:2014-04-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Farnesyl Pyrophosphate Synthase (Y204A) Mutant complexed with Mg, Pamidronate
To be Published
4KQ5
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CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE MUTANT (Y204A) COMPLEXED WITH MG AND ZOLEDRONATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C.
Deposit date:2013-05-14
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Human Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg and Zoledronate
To be Published
4KQS
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CRYSTAL STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHASE MUTANT (Y204A) COMPLEXED WITH MG, RISEDRONATE AND ISOPENTENYL PYROPHOSPHATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C.
Deposit date:2013-05-15
Release date:2014-04-30
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal Structure of Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate
To be Published
4KQU
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CRYSTAL STRUCTURE OF FARNESYL SYNTHASE MUTANT (Y204A) COMPLEXED WITH MG, ALENDRONATE AND ISOPENTENYL PYROPHOSPHATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C., Walter, R.L.
Deposit date:2013-05-15
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate
To be Published