Author results

4XCB
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CRYSTAL STRUCTURE OF HYGX FROM STREPTOMYCES HYGROSCOPICUS WITH NICKEL, 2-OXOGLUTARATE, AND HYGROMYCIN B BOUND
Descriptor:oxidase/hydroxylase, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-17
Release date:2015-08-05
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
6GTH
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SERIAL FEMTOSECOND CRYSTALLOGRAPHY AT MEGAHERTZ PULSE RATES
Descriptor:Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide
Authors:Wiedorn, M., Oberthuer, D., Werner, N., Schubert, R., White, T.A., Mancuso, A., Perbandt, M., Betzel, C., Barty, A., Chapman, H.
Deposit date:2018-06-18
Release date:2018-10-10
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Megahertz serial crystallography.
Nat Commun, 9, 2018
4XAB
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CRYSTAL STRUCTURE OF EVDO2 FROM MICROMONOSPORA CARBONACEA VAR. AURANTIACA
Descriptor:EvdO2, NICKEL (II) ION, IMIDAZOLE
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-13
Release date:2015-08-05
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
6FTR
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SERIAL FEMTOSECOND CRYSTALLOGRAPHY AT MEGAHERTZ PULSE RATES
Descriptor:Lysozyme C, CHLORIDE ION, SODIUM ION, ...
Authors:Wiedorn, M.O., Oberthuer, D., Barty, A., Chapman, H.N.
Deposit date:2018-02-23
Release date:2018-10-10
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.760001 Å)
Cite:Megahertz serial crystallography.
Nat Commun, 9, 2018
4XAC
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CRYSTAL STRUCTURE OF EVDO2 FROM MICROMONOSPORA CARBONACEA VAR. AURANTIACA COMPLEXED WITH 2-OXOGLUTARATE
Descriptor:EvdO2, NICKEL (II) ION, IMIDAZOLE, ...
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-13
Release date:2015-08-05
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
3PPQ
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STRUCTURES OF THE SUBSTRATE-BINDING PROTEIN PROVIDE INSIGHTS INTO THE MULTIPLE COMPATIBLE SOLUTES BINDING SPECIFICITIES OF BACILLUS SUBTILIS ABC TRANSPORTER OPUC
Descriptor:Glycine betaine/carnitine/choline-binding protein, CHOLINE ION
Authors:Du, Y., Shi, W.W., He, Y.X., Yang, Y.H., Zhou, C.Z., Chen, Y.
Deposit date:2010-11-25
Release date:2011-05-11
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC
Biochem.J., 436, 2011
5LU8
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CRYSTAL STRUCTURE OF YVAD-CMK BOUND HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11B
Descriptor:AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, Legumain, SULFATE ION, ...
Authors:Dall, E., Ye, K., Brandstetter, H.
Deposit date:2016-09-08
Release date:2017-03-29
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun, 8, 2017
3NZ3
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CRYSTAL STRUCTURE OF THE MUCIN-BINDING DOMAIN OF SPR1345 FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:Putative uncharacterized protein, TRIETHYLENE GLYCOL, SULFATE ION
Authors:Du, Y., He, Y.-X., Zhang, Z.-Y., Yang, Y.-H., Shi, W.-W., Frolet, C., Guilmi, A.M., Vernet, T., Zhou, C.-Z., Chen, Y.
Deposit date:2010-07-15
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the mucin-binding domain of Spr1345 from Streptococcus pneumoniae
J.Struct.Biol., 174, 2011
5LUA
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CRYSTAL STRUCTURE OF HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11B
Descriptor:Legumain, N-ACETYL-D-GLUCOSAMINE, 2,4-di(morpholin-4-yl)aniline
Authors:Dall, E., Ye, K., Brandstetter, H.
Deposit date:2016-09-08
Release date:2017-03-29
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun, 8, 2017
5YDR
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STRUCTURE OF DNMT1 RFTS DOMAIN IN COMPLEX WITH UBIQUITIN
Descriptor:Polyubiquitin-B, DNA (cytosine-5)-methyltransferase 1, PHOSPHATE ION, ...
Authors:Qian, C.
Deposit date:2017-09-14
Release date:2018-02-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation.
Nucleic Acids Res., 46, 2018
5GJK
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CRYSTAL STRUCTURE OF BAF47 AND BAF155 COMPLEX
Descriptor:SWI/SNF complex subunit SMARCC1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, GLYCEROL, ...
Authors:Yan, L., Qian, C.
Deposit date:2016-06-30
Release date:2017-06-07
Method:X-RAY DIFFRACTION (2.052 Å)
Cite:Structural Insights into BAF47 and BAF155 Complex Formation.
J. Mol. Biol., 429, 2017
3LOI
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CRYSTAL STRUCTURES OF CUPIN SUPERFAMILY BBDUF985 FROM BRANCHIOSTOMA BELCHERI TSINGTAUENSE IN THE APO AND GDP-BOUND FORMS
Descriptor:Putative uncharacterized protein
Authors:Zou, C.Z., Du, Y., He, Y.-X., Saren, G., Zhang, X., Chen, Y., Zhang, S.-C.
Deposit date:2010-02-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the apo and GDP-bound forms of a cupin-like protein BbDUF985 from Branchiostoma belcheri tsingtauense
Proteins, 2010
3PPR
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STRUCTURES OF THE SUBSTRATE-BINDING PROTEIN PROVIDE INSIGHTS INTO THE MULTIPLE COMPATIBLE SOLUTES BINDING SPECIFICITIES OF BACILLUS SUBTILIS ABC TRANSPORTER OPUC
Descriptor:Glycine betaine/carnitine/choline-binding protein, (4S)-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID
Authors:Du, Y., Shi, W.W., He, Y.X., Yang, Y.H., Zhou, C.Z., Chen, Y.
Deposit date:2010-11-25
Release date:2011-05-11
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC
Biochem.J., 436, 2011
5LUB
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CRYSTAL STRUCTURE OF HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11
Descriptor:Legumain, N-ACETYL-D-GLUCOSAMINE, 7-(morpholin-4-yl)-2,1,3-benzoxadiazol-4-amine
Authors:Dall, E., Ye, K., Brandstetter, H.
Deposit date:2016-09-08
Release date:2017-03-29
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun, 8, 2017
5YZ4
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STRUCTURE OF THE PIN DOMAIN ENDONUCLEASE UTP24
Descriptor:rRNA-processing protein fcf1, CALCIUM ION, ZINC ION
Authors:Du, Y., An, W., Ye, K.
Deposit date:2017-12-12
Release date:2018-12-19
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.135 Å)
Cite:Structural role of the Utp24 endonuclease in ribosome assembly
To Be Published
5LU9
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CRYSTAL STRUCTURE OF YVAD-CMK BOUND HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11
Descriptor:AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, Legumain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Dall, E., Ye, K., Brandstetter, H.
Deposit date:2016-09-08
Release date:2017-03-29
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun, 8, 2017
4XCA
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CRYSTAL STRUCTURE OF HYGX FROM STREPTOMYCES HYGROSCOPICUS WITH NICKEL AND 2-OXOGLUTARATE BOUND
Descriptor:oxidase/hydroxylase, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-17
Release date:2015-08-05
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
3PPN
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STRUCTURES OF THE SUBSTRATE-BINDING PROTEIN PROVIDE INSIGHTS INTO THE MULTIPLE COMPATIBLE SOLUTES BINDING SPECIFICITIES OF BACILLUS SUBTILIS ABC TRANSPORTER OPUC
Descriptor:Glycine betaine/carnitine/choline-binding protein
Authors:Du, Y., Shi, W.W., He, Y.X., Yang, Y.H., Zhou, C.Z., Chen, Y.
Deposit date:2010-11-24
Release date:2011-05-11
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC
Biochem.J., 436, 2011
4XAA
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CRYSTAL STRUCTURE OF AVIO1 FROM STREPTOMYCES VIRIDOCHROMOGENES TUE57
Descriptor:Putative oxygenase, NICKEL (II) ION
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-13
Release date:2015-08-05
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XBZ
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CRYSTAL STRUCTURE OF EVDO1 FROM MICROMONOSPORA CARBONACEA VAR. AURANTIACA
Descriptor:EvdO1, NICKEL (II) ION, GLYCEROL
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-17
Release date:2015-08-05
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
6HWE
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YEAST 20S PROTEASOME BETA2-G45A MUTANT IN COMPLEX WITH CARFILZOMIB
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-11
Release date:2019-01-30
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
6ASQ
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STRUCTURE OF GRP94 BOUND TO METHYL 2-[2-(2-BENZYLPYRIDIN-3-YL)ETHYL]-3-CHLORO-4,6-DIHYDROXYBENZOATE, A PAN-HSP90 INHIBITOR
Descriptor:Endoplasmin, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Huard, D.J.E., Lieberman, R.L.
Deposit date:2017-08-25
Release date:2018-04-18
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.
ACS Chem. Biol., 13, 2018
3RDH
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X-RAY INDUCED COVALENT INHIBITION OF 14-3-3
Descriptor:14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION
Authors:Horton, J.R., Upadhyay, A.K., Fu, H., Cheng, X.
Deposit date:2011-04-01
Release date:2011-09-28
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PPP
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STRUCTURES OF THE SUBSTRATE-BINDING PROTEIN PROVIDE INSIGHTS INTO THE MULTIPLE COMPATIBLE SOLUTES BINDING SPECIFICITIES OF BACILLUS SUBTILIS ABC TRANSPORTER OPUC
Descriptor:Glycine betaine/carnitine/choline-binding protein, TRIMETHYL GLYCINE
Authors:Du, Y., Shi, W.W., He, Y.X., Yang, Y.H., Zhou, C.Z., Chen, Y.
Deposit date:2010-11-25
Release date:2011-05-11
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC
Biochem.J., 436, 2011
4XC9
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CRYSTAL STRUCTURE OF APO HYGX FROM STREPTOMYCES HYGROSCOPICUS
Descriptor:oxidase/hydroxylase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-17
Release date:2015-08-05
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
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