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6O8B
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CRYSTAL STRUCTURE OF STING CTD IN COMPLEX WITH TBK1
分子名称:Stimulator of interferon genes protein, Serine/threonine-protein kinase TBK1, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide
著者Li, P., Zhao, B., Du, F.
登録日2019-03-09
公開日2019-05-22
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
6O8C
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CRYSTAL STRUCTURE OF STING CTT IN COMPLEX WITH TBK1
分子名称:Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide
著者Li, P., Zhao, B., Du, F.
登録日2019-03-09
公開日2019-05-22
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (3.17 Å)
主引用文献A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
5U0B
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STRUCTURE OF FULL-LENGTH ZIKA VIRUS NS5
分子名称:Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ...
著者Zhao, B., Du, F.
登録日2016-11-23
公開日2017-03-29
最終更新日2017-04-12
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure and function of the Zika virus full-length NS5 protein.
Nat Commun, 8, 2017
5U0C
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STRUCTURE OF ZIKA VIRUS NS5 RNA POLYMERASE DOMAIN
分子名称:NS5 RNA polymerase domain, ZINC ION
著者Zhao, B., Du, F.
登録日2016-11-23
公開日2017-03-29
最終更新日2017-04-12
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure and function of the Zika virus full-length NS5 protein.
Nat Commun, 8, 2017
4O67
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HUMAN CYCLIC GMP-AMP SYNTHASE (CGAS) IN COMPLEX WITH GAMP
分子名称:Cyclic GMP-AMP synthase, cGAMP, ZINC ION
著者Zhang, X., Chen, Z., Zhang, X.W., Chen, Z.J.
登録日2013-12-20
公開日2014-02-05
最終更新日2015-08-05
実験手法X-RAY DIFFRACTION (2.444 Å)
主引用文献The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
4O68
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STRUCTURE OF HUMAN CYCLIC GMP-AMP SYNTHASE (CGAS)
分子名称:Cyclic GMP-AMP synthase, ZINC ION
著者Zhang, X., Chen, Z., Zhang, X.W., Chen, Z.J.
登録日2013-12-20
公開日2014-02-05
最終更新日2014-03-05
実験手法X-RAY DIFFRACTION (2.436 Å)
主引用文献The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
4O69
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HUMAN CYCLIC GMP-AMP SYNTHASE (CGAS) IN COMPLEX WITH SULFATE ION
分子名称:Cyclic GMP-AMP synthase, ZINC ION, SULFATE ION
著者Zhang, X., Chen, Z., Zhang, X.W., Chen, Z.J.
登録日2013-12-20
公開日2014-02-05
最終更新日2014-03-05
実験手法X-RAY DIFFRACTION (2.252 Å)
主引用文献The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
4O6A
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MOUSE CYCLIC GMP-AMP SYNTHASE (CGAS) IN COMPLEX WITH DNA
分子名称:Cyclic GMP-AMP synthase, DNA1, DNA2, ...
著者Zhang, X., Chen, Z., Zhang, X.W., Chen, Z.J.
登録日2013-12-20
公開日2014-02-05
最終更新日2014-03-05
実験手法X-RAY DIFFRACTION (1.859 Å)
主引用文献The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
5JEJ
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PHOSPHORYLATED STING IN COMPLEX WITH IRF-3 CTD
分子名称:Stimulator of interferon genes protein, Interferon regulatory factor 3
著者Li, P., Shu, C.
登録日2016-04-18
公開日2016-06-15
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JEK
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PHOSPHORYLATED MAVS IN COMPLEX WITH IRF-3
分子名称:Interferon regulatory factor 3, MAVS peptide
著者Zhao, B., Li, P.
登録日2016-04-18
公開日2016-06-15
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JEL
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PHOSPHORYLATED TRIF IN COMPLEX WITH IRF-3
分子名称:Interferon regulatory factor 3, Phosphorylated TRIF peptide
著者Zhao, B., Li, P.
登録日2016-04-18
公開日2016-06-15
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JEM
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COMPLEX OF IRF-3 WITH CBP
分子名称:Interferon regulatory factor 3, CREB-binding protein
著者Zhao, B., Li, P.
登録日2016-04-18
公開日2016-06-15
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JEO
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PHOSPHORYLATED ROTAVIRUS NSP1 IN COMPLEX WITH IRF-3
分子名称:Rotavirus NSP1 peptide, Interferon regulatory factor 3, PHOSPHATE ION
著者Zhao, B., Li, P.
登録日2016-04-18
公開日2016-06-15
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (1.719 Å)
主引用文献Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JER
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STRUCTURE OF ROTAVIRUS NSP1 BOUND TO IRF-3
分子名称:Rotavirus NSP1 peptide, Interferon regulatory factor 3
著者Zhao, B., Li, P.
登録日2016-04-18
公開日2016-06-15
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (2.913 Å)
主引用文献Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016