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4ATZ
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BU of 4atz by Molmil
Ad5 knob in complex with a designed ankyrin repeat protein
Descriptor: DESIGNED ANKYRIN REPEAT PROTEIN, Fiber protein
Authors:Mittl, P.R.E, Hess, C, Dreier, B.
Deposit date:2012-05-11
Release date:2013-02-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
5OGI
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BU of 5ogi by Molmil
Complex of a binding protein and human adenovirus C 5 hexon
Descriptor: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A.
Deposit date:2017-07-13
Release date:2018-02-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.
Nat Commun, 9, 2018
6EQC
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BU of 6eqc by Molmil
Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon
Descriptor: Hexon protein, scFv of 9C12 antibody
Authors:Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A.
Deposit date:2017-10-12
Release date:2018-02-07
Last modified:2018-02-14
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.
Nat Commun, 9, 2018
4DUI
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BU of 4dui by Molmil
DARPIN D1 binding to tubulin beta chain (not in complex)
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D1
Authors:Pecqueur, L, Duellberg, C, Dreier, B, Wang, Q, Jiang, C, Pluckthun, A, Surrey, T, Gigant, B, Knossow, M.
Deposit date:2012-02-22
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:An Anti-Tubulin Darpin Caps the Microtubule Plus-End
To be Published
3HG0
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BU of 3hg0 by Molmil
Crystal structure of a DARPin in complex with ORF49 from Lactococcal phage TP901-1
Descriptor: Baseplate protein, Designed Ankyrin Repeat Protein (DARPin) 20
Authors:Veesler, D, Dreier, B, Blangy, S, Lichiere, J, Tremblay, D, Moineau, S, Spinelli, S, Tegoni, M, Pluckthun, A, Campanacci, V, Cambillau, C.
Deposit date:2009-05-13
Release date:2009-09-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure and function of a DARPin neutralizing inhibitor of lactococcal phage TP901-1: comparison of DARPin and camelid VHH binding mode.
J.Biol.Chem., 284, 2009
5EYL
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BU of 5eyl by Molmil
TUBULIN-BINDING DARPIN
Descriptor: DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), GLYCEROL, PHOSPHATE ION
Authors:Ahmad, S, Kossow, M, Gigant, B.
Deposit date:2015-11-25
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Sci Rep, 6, 2016
5EYP
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BU of 5eyp by Molmil
TUBULIN-DARPIN COMPLEX
Descriptor: DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Ahmad, S, Knossow, M, Gigant, B.
Deposit date:2015-11-25
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Sci Rep, 6, 2016
7Z7C
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BU of 7z7c by Molmil
Broadly neutralizing DARPin bnD.8 in complex with the HIV-1 envelope variable loop 3 peptide V3 (BF520)
Descriptor: 1,2-ETHANEDIOL, Broadly neutralizing DARPin bnD.8, Envelope glycoprotein gp160, ...
Authors:Mittl, P.R, Gloegl, M.
Deposit date:2022-03-15
Release date:2023-03-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.
Nat.Struct.Mol.Biol., 30, 2023
7ZYU
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BU of 7zyu by Molmil
HDAC6 ZnF domain inhibitor - DARPin (Designed Ankyrin repeat protein) F10
Descriptor: 1,2-ETHANEDIOL, Designed Ankyrin repeat protein F10, Histone deacetylase 6, ...
Authors:Wang, L, Kempf, G.
Deposit date:2022-05-25
Release date:2022-06-01
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways.
Cell Rep, 39, 2022
8A19
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BU of 8a19 by Molmil
Structure of a leucinostatin derivative determined by host lattice display : L1E4V1 construct
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-(2-methoxyethoxy)-11,15-dimethyl-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one, ...
Authors:Mittl, P.R.E.
Deposit date:2022-06-01
Release date:2022-12-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.358 Å)
Cite:Structure of a hydrophobic leucinostatin derivative determined by host lattice display.
Acta Crystallogr D Struct Biol, 78, 2022
8A1A
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BU of 8a1a by Molmil
Structure of a leucinostatin derivative determined by host lattice display : L1F11V1 construct
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-(2-methoxyethoxy)-11,15-dimethyl-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one, ...
Authors:Mittl, P.R.E.
Deposit date:2022-06-01
Release date:2022-12-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of a hydrophobic leucinostatin derivative determined by host lattice display.
Acta Crystallogr D Struct Biol, 78, 2022
8P9C
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BU of 8p9c by Molmil
Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 F11
Descriptor: 1,2-ETHANEDIOL, Darpin 1810 F11, Tumor protein 63, ...
Authors:Chaikuad, A, Strubel, A, Doetsch, V, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2023-06-05
Release date:2023-11-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma.
Cell Death Dis, 14, 2023
8P9D
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BU of 8p9d by Molmil
Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 A2
Descriptor: Darpin 1810 A2, Tumor protein 63, Tumor protein p73
Authors:Chaikuad, A, Strubel, A, Doetsch, V, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2023-06-05
Release date:2023-11-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma.
Cell Death Dis, 14, 2023
8P9E
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BU of 8p9e by Molmil
Crystal structure of wild type p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 F11
Descriptor: Darpin 1810 F11, GLYCEROL, Isoform 2 of Tumor protein 63, ...
Authors:Chaikuad, A, Strubel, A, Doetsch, V, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2023-06-05
Release date:2023-11-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma.
Cell Death Dis, 14, 2023
6GX7
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BU of 6gx7 by Molmil
Tubulin-CopN-alphaRep complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Gigant, B, Campanacci, V.
Deposit date:2018-06-26
Release date:2019-04-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Insight into microtubule nucleation from tubulin-capping proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019
6GVN
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BU of 6gvn by Molmil
Tubulin:TM-3 DARPin complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Gigant, B, Cantos Fernandes, S, Campanacci, V.
Deposit date:2018-06-21
Release date:2019-04-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Insight into microtubule nucleation from tubulin-capping proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019
6GVM
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BU of 6gvm by Molmil
Tubulin:F3II DARPin complex
Descriptor: F3II DARPIN, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Gigant, B, Campanacci, V, Cantos Fernandes, S.
Deposit date:2018-06-21
Release date:2019-04-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Insight into microtubule nucleation from tubulin-capping proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019
4DRX
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BU of 4drx by Molmil
GTP-Tubulin in complex with a DARPIN
Descriptor: Designed ankyrin repeat protein (DARPIN) D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Pecqueur, L, Gigant, B, Knossow, M.
Deposit date:2012-02-17
Release date:2012-07-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F61
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BU of 4f61 by Molmil
Tubulin:Stathmin-like domain complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Gigant, B, Mignot, I, Knossow, M.
Deposit date:2012-05-14
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4.17 Å)
Cite:Design and characterization of modular scaffolds for tubulin assembly.
J.Biol.Chem., 287, 2012
4F6R
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BU of 4f6r by Molmil
Tubulin:Stathmin-like domain complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Designed ankyrin repeat protein (DARPIN) D2, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Gigant, B, Mignot, I, Knossow, M.
Deposit date:2012-05-15
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Design and characterization of modular scaffolds for tubulin assembly.
J.Biol.Chem., 287, 2012
4HNA
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BU of 4hna by Molmil
Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D2, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Gigant, B, Knossow, M.
Deposit date:2012-10-19
Release date:2013-06-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of a kinesin-tubulin complex and implications for kinesin motility.
Nat.Struct.Mol.Biol., 20, 2013
7PD8
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BU of 7pd8 by Molmil
Structure of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP
Descriptor: Adenylate cyclase 9, DARPin C4
Authors:Qi, C, Korkhov, V.M.
Deposit date:2021-08-04
Release date:2022-01-19
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural basis of adenylyl cyclase 9 activation.
Nat Commun, 13, 2022
7PDG
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BU of 7pdg by Molmil
structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS
Descriptor: Adenylate cyclase 9, DARPin C4
Authors:Qi, C, Korkhov, V.M.
Deposit date:2021-08-05
Release date:2022-01-19
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of adenylyl cyclase 9 activation.
Nat Commun, 13, 2022
7PD4
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BU of 7pd4 by Molmil
structure of Adenylyl cyclase 9 in complex with MANT-GTP
Descriptor: Adenylate cyclase 9
Authors:Qi, C, Korkhov, V.M.
Deposit date:2021-08-04
Release date:2022-01-19
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structural basis of adenylyl cyclase 9 activation.
Nat Commun, 13, 2022
7PDE
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BU of 7pde by Molmil
Structure of Adenylyl cyclase 9 in complex with Gs protein alpha subunit and MANT-GTP
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Qi, C, Korkhov, V.M.
Deposit date:2021-08-05
Release date:2022-01-19
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural basis of adenylyl cyclase 9 activation.
Nat Commun, 13, 2022

 

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