Author results

5DCN
  • Download 5dcn
  • View 5dcn
Molmil generated image of 5dcn
CRYSTAL STRUCTURE OF LC3 IN COMPLEX WITH TECPR2 LIR
Descriptor:Microtubule-associated proteins 1A/1B light chain 3B, SULFATE ION
Authors:Stadel, D., Huber, J., Dotsch, V., Rogov, V.V., Behrends, C., Akutsu, M.
Deposit date:2015-08-24
Release date:2016-03-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.
Mol.Cell, 60, 2015
1AJE
  • Download 1aje
  • View 1aje
Molmil generated image of 1aje
CDC42 FROM HUMAN, NMR, 20 STRUCTURES
Descriptor:CDC42HS
Authors:Feltham, J.L., Dotsch, V., Raza, S., Manor, D., Cerione, R.A., Sutcliffe, M.J., Wagner, G., Oswald, R.E.
Deposit date:1997-05-02
Release date:1997-11-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Definition of the switch surface in the solution structure of Cdc42Hs.
Biochemistry, 36, 1997
1CI5
  • Download 1ci5
  • View 1ci5
Molmil generated image of 1ci5
GLYCAN-FREE MUTANT ADHESION DOMAIN OF HUMAN CD58 (LFA-3)
Descriptor:PROTEIN (LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3(CD58))
Authors:Sun, Z.Y.J., Dotsch, V., Kim, M., Li, J., Reinherz, E.L., Wagner, G.
Deposit date:1999-04-07
Release date:1999-06-22
Last modified:2018-03-14
Method:SOLUTION NMR
Cite:Functional glycan-free adhesion domain of human cell surface receptor CD58: design, production and NMR studies.
EMBO J., 18, 1999
1EYF
  • Download 1eyf
  • View 1eyf
Molmil generated image of 1eyf
REFINED STRUCTURE OF THE DNA METHYL PHOSPHOTRIESTER REPAIR DOMAIN OF E. COLI ADA
Descriptor:ADA REGULATORY PROTEIN, ZINC ION
Authors:Lin, Y., Dotsch, V., Wintner, T., Peariso, K., Myers, L.C., Penner-Hahn, J.E., Verdine, G.L., Wagner, G.
Deposit date:2000-05-06
Release date:2003-09-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for the functional switch of the E. coli Ada protein
Biochemistry, 40, 2001
1NFA
  • Download 1nfa
  • View 1nfa
Molmil generated image of 1nfa
HUMAN TRANSCRIPTION FACTOR NFATC DNA BINDING DOMAIN, NMR, 10 STRUCTURES
Descriptor:HUMAN TRANSCRIPTION FACTOR NFATC1
Authors:Wolfe, S.A., Zhou, P., Dotsch, V., Chen, L., You, A., Ho, S.N., Crabtree, G.R., Wagner, G., Verdine, G.L.
Deposit date:1997-01-18
Release date:1997-04-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc.
Nature, 385, 1997
1U8B
  • Download 1u8b
  • View 1u8b
Molmil generated image of 1u8b
CRYSTAL STRUCTURE OF THE METHYLATED N-ADA/DNA COMPLEX
Descriptor:5'-D(*TP*AP*AP*AP*TP*T)-3', 5'-D(P*AP*AP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*GP*CP*GP*CP*AP*AP*GP*AP*T)-3', ...
Authors:He, C., Hus, J.-C., Sun, L.J., Zhou, P., Norman, D.P.G., Dotsch, V., Gross, J.D., Lane, W.S., Wagner, G., Verdine, G.L.
Deposit date:2004-08-05
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada.
Mol.Cell, 20, 2005
1ZL8
  • Download 1zl8
  • View 1zl8
Molmil generated image of 1zl8
NMR STRUCTURE OF L27 HETERODIMER FROM C. ELEGANS LIN-7 AND H. SAPIENS LIN-2 SCAFFOLD PROTEINS
Descriptor:LIN-7, Peripheral plasma membrane protein CASK
Authors:Petrosky, K.Y., Ou, H.D., Lohr, F., Dotsch, V., Lim, W.A.
Deposit date:2005-05-05
Release date:2005-09-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A General Model for Preferential Hetero-oligomerization of LIN-2/7 Domains: Mechanism Underlying Directed Assembly of Supramolecular Signaling Complexes
J.Biol.Chem., 280, 2005
2AYX
  • Download 2ayx
  • View 2ayx
Molmil generated image of 2ayx
SOLUTION STRUCTURE OF THE E.COLI RCSC C-TERMINUS (RESIDUES 700-949) CONTAINING LINKER REGION AND PHOSPHORECEIVER DOMAIN
Descriptor:Sensor kinase protein rcsC
Authors:Rogov, V.V., Rogova, N.Y., Bernhard, F., Koglin, A., Lohr, F., Dotsch, V.
Deposit date:2005-09-09
Release date:2006-09-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A New Structural Domain in the Escherichia coli RcsC Hybrid Sensor Kinase Connects Histidine Kinase and Phosphoreceiver Domains
J.Mol.Biol., 364, 2006
2AYY
  • Download 2ayy
  • View 2ayy
Molmil generated image of 2ayy
SOLUTION STRUCTURE OF THE E.COLI RCSC C-TERMINUS (RESIDUES 700-816) CONTAINING LINKER REGION
Descriptor:Sensor kinase protein rcsC
Authors:Rogov, V.V., Rogova, N.Y., Bernhard, F., Koglin, A., Lohr, F., Dotsch, V.
Deposit date:2005-09-09
Release date:2006-09-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A New Structural Domain in the Escherichia coli RcsC Hybrid Sensor Kinase Connects Histidine Kinase and Phosphoreceiver Domains
J.Mol.Biol., 364, 2006
2AYZ
  • Download 2ayz
  • View 2ayz
Molmil generated image of 2ayz
SOLUTION STRUCTURE OF THE E.COLI RCSC C-TERMINUS (RESIDUES 817-949) CONTAINING PHOSPHORECEIVER DOMAIN
Descriptor:Sensor kinase protein rcsC
Authors:Rogov, V.V., Rogova, N.Y., Bernhard, F., Koglin, A., Lohr, F., Dotsch, V.
Deposit date:2005-09-09
Release date:2006-09-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A New Structural Domain in the Escherichia coli RcsC Hybrid Sensor Kinase Connects Histidine Kinase and Phosphoreceiver Domains
J.Mol.Biol., 364, 2006
2K2Q
  • Download 2k2q
  • View 2k2q
Molmil generated image of 2k2q
COMPLEX STRUCTURE OF THE EXTERNAL THIOESTERASE OF THE SURFACTIN-SYNTHETASE WITH A CARRIER DOMAIN
Descriptor:Tyrocidine synthetase 3 (Tyrocidine synthetase III), Surfactin synthetase thioesterase subunit
Authors:Koglin, A., Lohr, F., Bernhard, F., Rogov, V.V., Frueh, D.P., Strieter, E.R., Mofid, M.R., Guntert, P., Wagner, G., Walsh, C.T., Marahiel, M.A., Dotsch, V.
Deposit date:2008-04-10
Release date:2008-12-09
Last modified:2018-01-24
Method:SOLUTION NMR
Cite:Structural basis for the selectivity of the external thioesterase of the surfactin synthetase.
Nature, 454, 2008
2KT2
  • Download 2kt2
  • View 2kt2
Molmil generated image of 2kt2
STRUCTURE OF NMERA, THE N-TERMINAL HMA DOMAIN OF TN501 MERCURIC REDUCTASE
Descriptor:Mercuric reductase
Authors:Ledwidge, R., Danacea, F., Dotsch, V., Miller, S.M.
Deposit date:2010-01-17
Release date:2010-09-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NmerA of Tn501 mercuric ion reductase: structural modulation of the pKa values of the metal binding cysteine thiols.
Biochemistry, 49, 2010
2KT3
  • Download 2kt3
  • View 2kt3
Molmil generated image of 2kt3
STRUCTURE OF HG-NMERA, HG(II) COMPLEX OF THE N-TERMINAL DOMAIN OF TN501 MERCURIC REDUCTASE
Descriptor:Mercuric reductase, MERCURY (II) ION
Authors:Miller, S.M., Ledwidge, R., Danacea, F., Dotsch, V.
Deposit date:2010-01-17
Release date:2010-09-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NmerA of Tn501 mercuric ion reductase: structural modulation of the pKa values of the metal binding cysteine thiols.
Biochemistry, 49, 2010
2LIU
  • Download 2liu
  • View 2liu
Molmil generated image of 2liu
NMR STRUCTURE OF HOLO-ACPI DOMAIN FROM CURA MODULE FROM LYNGBYA MAJUSCULA
Descriptor:CurA
Authors:Busche, A.E., Gottstein, D., Hein, C., Ripin, N., Pader, I., Tufar, P., Eisman, E.B., Gu, L., Walsh, C.T., Loehr, F., Sherman, D.H., Guntert, P., Dotsch, V.
Deposit date:2011-09-01
Release date:2011-12-14
Last modified:2012-03-14
Method:SOLUTION NMR
Cite:Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide Synthase.
Acs Chem.Biol., 7, 2012
2LIW
  • Download 2liw
  • View 2liw
Molmil generated image of 2liw
NMR STRUCTURE OF HMG-ACPI DOMAIN FROM CURA MODULE FROM LYNGBYA MAJUSCULA
Descriptor:CurA, 4'-PHOSPHOPANTETHEINE, 3-HYDROXY-3-METHYL-GLUTARIC ACID
Authors:Busche, A.E., Gottstein, D., Hein, C., Ripin, N., Pader, I., Tufar, P., Eisman, E.B., Gu, L., Walsh, C.T., Loehr, F., Sherman, D.H., Guntert, P., Dotsch, V.
Deposit date:2011-09-01
Release date:2011-12-21
Last modified:2012-03-14
Method:SOLUTION NMR
Cite:Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide Synthase.
Acs Chem.Biol., 7, 2012
4A9Z
  • Download 4a9z
  • View 4a9z
Molmil generated image of 4a9z
CRYSTAL STRUCTURE OF HUMAN P63 TETRAMERIZATION DOMAIN
Descriptor:TUMOR PROTEIN 63, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL
Authors:Muniz, J.R.C., Coutandin, D., Salah, E., Chaikuad, A., Vollmar, M., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Dotsch, V., von Delft, F., Knapp, S.
Deposit date:2011-11-30
Release date:2011-12-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal Structure of Human P63 Tetramerization Domain
To be Published
5HOB
  • Download 5hob
  • View 5hob
Molmil generated image of 5hob
P73 HOMO-TETRAMERIZATION DOMAIN MUTANT I
Descriptor:Tumor protein p73, MAGNESIUM ION
Authors:Coutandin, D., Krojer, T., Salah, E., Mathea, S., Knapp, S., Dotsch, V.
Deposit date:2016-01-19
Release date:2016-10-19
Method:X-RAY DIFFRACTION (1.220013 Å)
Cite:Structural basis of p63/p73 hetero-tetramerization
To Be Published
5HOC
  • Download 5hoc
  • View 5hoc
Molmil generated image of 5hoc
P73 HOMO-TETRAMERIZATION DOMAIN MUTANT II
Descriptor:Tumor protein p73
Authors:Coutandin, D., Krojer, T., Salah, E., Mathea, S., Sumyk, M., Knapp, S., Dotsch, V.
Deposit date:2016-01-19
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.360078 Å)
Cite:Mechanism of TAp73 inhibition by Delta Np63 and structural basis of p63/p73 hetero-tetramerization.
Cell Death Differ., 23, 2016
5N6R
  • Download 5n6r
  • View 5n6r
Molmil generated image of 5n6r
SOLUTION STRUCTURE OF THE DBL-HOMOLOGY DOMAIN OF BCR-ABL
Descriptor:Breakpoint cluster region protein
Authors:Reckel, S., Lohr, F., Buchner, L., Guntert, P., Dotsch, V., Hantschel, O.
Deposit date:2017-02-16
Release date:2017-12-27
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Nat Commun, 8, 2017
6FGN
  • Download 6fgn
  • View 6fgn
Molmil generated image of 6fgn
SOLUTION STRUCTURE OF P300TAZ2-P63TA
Descriptor:Histone acetyltransferase p300,Tumor protein 63, ZINC ION
Authors:Gebel, J., Kazemi, S., Lohr, F., Guntert, P., Dotsch, V.
Deposit date:2018-01-11
Release date:2018-05-30
Last modified:2018-08-22
Method:SOLUTION NMR
Cite:Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain.
Structure, 26, 2018
6FGS
  • Download 6fgs
  • View 6fgs
Molmil generated image of 6fgs
SOLUTION STRUCTURE OF P300TAZ2-P73TA1
Descriptor:Histone acetyltransferase p300,Tumor protein p73, ZINC ION
Authors:Gebel, J., Kazemi, S., Lohr, F., Guntert, P., Dotsch, V.
Deposit date:2018-01-11
Release date:2018-05-30
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain.
Structure, 26, 2018
4XC2
  • Download 4xc2
  • View 4xc2
Molmil generated image of 4xc2
CRYSTAL STRUCTURE OF GABARAP IN COMPLEX WITH KBTBD6 LIR PEPTIDE
Descriptor:GABA(A) receptor-associated protein, Kelch repeat and BTB domain-containing protein 6
Authors:Huber, J., Genau, H.M., Baschieri, F., Doetsch, V., Farhan, H., Rogov, V.V., Behrends, C., Akutsu, M.
Deposit date:2014-12-17
Release date:2015-03-04
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:CUL3-KBTBD6/KBTBD7 Ubiquitin Ligase Cooperates with GABARAP Proteins to Spatially Restrict TIAM1-RAC1 Signaling.
Mol.Cell, 57, 2015
6H8C
  • Download 6h8c
  • View 6h8c
Molmil generated image of 6h8c
STRUCTURE OF THE HUMAN GABARAPL2 PROTEIN IN COMPLEX WITH THE UBA5 LIR MOTIF
Descriptor:Gamma-aminobutyric acid receptor-associated protein-like 2, Ubiquitin-like modifier-activating enzyme 5
Authors:Huber, J., Loehr, F., Gruber, J., Akutsu, M., Guentert, P., Doetsch, V., Rogov, V.V.
Deposit date:2018-08-02
Release date:2019-05-01
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.
Autophagy, 2019
6HB9
  • Download 6hb9
  • View 6hb9
Molmil generated image of 6hb9
CRYSTAL STRUCTURE OF THE GABARAP IN COMPLEX WITH THE UBA5 LIR MOTIF
Descriptor:Gamma-aminobutyric acid receptor-associated protein
Authors:Huber, J., Rogov, V., Akutsu, M.
Deposit date:2018-08-10
Release date:2019-05-01
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.
Autophagy, 2019
1A66
  • Download 1a66
  • View 1a66
Molmil generated image of 1a66
SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES
Descriptor:DNA (5'-D(*CP*GP*AP*GP*GP*AP*AP*AP*AP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*TP*TP*TP*TP*CP*CP*TP*CP*G)-3'), CORE NFATC1
Authors:Zhou, P., Sun, L.J., Doetsch, V., Wagner, G., Verdine, G.L.
Deposit date:1998-03-06
Release date:1998-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the core NFATC1/DNA complex.
Cell(Cambridge,Mass.), 92, 1998
<123>