Author results

4R8R
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DENGUE VIRUS SEROTYPE 3 METHYLTRANSFERASE WITHOUT A BOUND S-ADENOSYL METHIONINE
Descriptor:nonstructural protein NS5
Authors:Noble, C.G.
Deposit date:2014-09-02
Release date:2014-10-15
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
Antiviral Res., 111C, 2014
4R8S
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DENGUE SEROTYPE 3 METHYLTRANSFERASE BOUND TO SINEFUNGIN
Descriptor:nonstructural protein NS5, SINEFUNGIN
Authors:Noble, C.G.
Deposit date:2014-09-02
Release date:2014-10-15
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
Antiviral Res., 111C, 2014
5HDE
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CRYSTAL STRUCTURE OF PTPN12 CATALYTIC DOMAIN
Descriptor:Tyrosine-protein phosphatase non-receptor type 12, PHOSPHATE ION
Authors:Dong, H., Li, S., Shi, J.
Deposit date:2016-01-05
Release date:2017-01-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal Structure of PTPN12 Catalytic Domain
To Be Published
5I5D
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SALMONELLA GLOBAL DOMAIN 245
Descriptor:Inner membrane protein YejM
Authors:Dong, C., Dong, H.
Deposit date:2016-02-15
Release date:2017-04-19
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structural insights into cardiolipin transfer from the Inner membrane to the outer membrane by PbgA in Gram-negative bacteria.
Sci Rep, 6, 2016
5I5H
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ECOLI GLOBAL DOMAIN 245-586
Descriptor:Inner membrane protein YejM
Authors:Dong, C., Dong, H.
Deposit date:2016-02-15
Release date:2016-08-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural insights into cardiolipin transfer from the Inner membrane to the outer membrane by PbgA in Gram-negative bacteria.
Sci Rep, 6, 2016
5JJS
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DENGUE 3 NS5 PROTEIN WITH COMPOUND 27
Descriptor:Genome polyprotein, ZINC ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Lescar, J., El Sahili, A.
Deposit date:2016-04-25
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
4GV3
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STRUCTURES OF LASSA AND TACARIBE VIRAL NUCLEOPROTEINS WITH OR WITHOUT 5 TRIPHOSPHATE DSRNA SUBSTRATE REVEAL A UNIQUE 3 -5 EXORIBONUCLEASE MECHANISM TO SUPPRESS TYPE I INTERFERON PRODUCTION
Descriptor:RNA (5'-R(*(GTP)P*GP*GP*C)-3'), RNA (5'-R(P*CP*GP*CP*CP*C)-3'), Nucleoprotein, ...
Authors:Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
3P8Z
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DENGUE METHYLTRANSFERASE BOUND TO A SAM-BASED INHIBITOR
Descriptor:Non-structural protein 5, (S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Noble, C.G., Yap, L.J., Lescar, J.
Deposit date:2010-10-15
Release date:2010-12-08
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
3P97
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO THE SUBSTRATE S-ADENOSYL METHIONINE
Descriptor:Non-structural protein 5, S-ADENOSYLMETHIONINE
Authors:Noble, C.G., Yap, L.J., Lescar, J.
Deposit date:2010-10-16
Release date:2010-12-08
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
4MIW
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HIGH-RESOLUTION STRUCTURE OF THE N-TERMINAL ENDONUCLEASE DOMAIN OF THE LASSA VIRUS L POLYMERASE
Descriptor:RNA-directed RNA polymerase L, MAGNESIUM ION
Authors:Wallat, G.D., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
Deposit date:2013-09-02
Release date:2014-03-19
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:High-resolution structure of the N-terminal endonuclease domain of the lassa virus L polymerase in complex with magnesium ions.
Plos One, 9, 2014
4GVE
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TACARIBE NUCLEOPROTEIN STRUCTURE
Descriptor:Nucleoprotein, ZINC ION, MAGNESIUM ION
Authors:Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
3MWP
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NUCLEOPROTEIN STRUCTURE OF LASSA FEVER VIRUS
Descriptor:Nucleoprotein, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.795 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
4XZA
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THE CRYSTAL STRUCTURE OF ERVE VIRUS NUCLEOPROTEIN
Descriptor:Nucleoprotein
Authors:Guo, Y., Wang, W., Liu, X., Wang, X., Wang, J., Huo, T., Liu, B.
Deposit date:2015-02-04
Release date:2015-09-02
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins.
J.Virol., 89, 2015
5YYC
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CRYSTAL STRUCTURE OF ALANINE RACEMASE FROM BACILLUS PSEUDOFIRMUS (OF4)
Descriptor:Alanine racemase, PYRIDOXAL-5'-PHOSPHATE
Authors:Dong, H., Hu, T.T., He, G.Z., Lu, D.R., Qi, J.X., Dou, Y.S., Long, W., He, X., Su, D., Ju, J.S.
Deposit date:2017-12-08
Release date:2019-01-02
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structural features and kinetic characterization of alanine racemase from Bacillus pseudofirmus OF4.
Biochem. Biophys. Res. Commun., 497, 2018
5I5F
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SALMONELLA GLOBAL DOMAIN 191
Descriptor:Inner membrane protein YejM
Authors:Dong, C., Dong, H.
Deposit date:2016-02-15
Release date:2016-08-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural insights into cardiolipin transfer from the Inner membrane to the outer membrane by PbgA in Gram-negative bacteria.
Sci Rep, 6, 2016
5I3Q
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 29
Descriptor:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide
Authors:Noble, C.G.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
3MX5
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LASSA FEVER VIRUS NUCLEOPROTEIN COMPLEXED WITH UTP
Descriptor:Nucleoprotein, URIDINE 5'-TRIPHOSPHATE, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
3Q6S
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THE CRYSTAL STRUCTURE OF THE HETEROCHROMATIN PROTEIN 1 BETA CHROMOSHADOW DOMAIN COMPLEXED WITH A PEPTIDE FROM SHUGOSHIN 1
Descriptor:Chromobox protein homolog 1, Shugoshin-like 1
Authors:Brautigam, C.A., Chaudhary, J., Yu, H.
Deposit date:2011-01-03
Release date:2011-12-14
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.
Mol Biol Cell, 22, 2011
4GV6
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STRUCTURES OF LASSA AND TACARIBE VIRAL NUCLEOPROTEINS WITH OR WITHOUT 5 TRIPHOSPHATE DSRNA SUBSTRATE REVEAL A UNIQUE 3 -5 EXORIBONUCLEASE MECHANISM TO SUPPRESS TYPE I INTERFERON PRODUCTION
Descriptor:RNA (5'-R(*(GTP)P*GP*GP*C)-3'), RNA (5'-R(P*CP*GP*CP*CP*C)-3'), Nucleoprotein, ...
Authors:Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
3MWT
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CRYSTAL STRUCTURE OF LASSA FEVER VIRUS NUCLEOPROTEIN IN COMPLEX WITH MN2+
Descriptor:Nucleoprotein, MANGANESE (II) ION, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (1.982 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
3MX2
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LASSA FEVER VIRUS NUCLEOPROTEIN COMPLEXED WITH DTTP
Descriptor:Nucleoprotein, THYMIDINE-5'-TRIPHOSPHATE, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (1.983 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
5JJR
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DENGUE 3 NS5 PROTEIN WITH COMPOUND 29
Descriptor:Genome polyprotein, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Lescar, J., El Sahili, A.
Deposit date:2016-04-25
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
3LKZ
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STRUCTURAL AND FUNCTIONAL ANALYSES OF A CONSERVED HYDROPHOBIC POCKET OF FLAVIVIRUS METHYLTRANSFERASE
Descriptor:Non-structural protein 5, SINEFUNGIN, GLYCEROL
Authors:Liu, L.H., Li, H.M.
Deposit date:2010-01-28
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase.
J.Biol.Chem., 285, 2010
5K5M
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CO-CRYSTAL STRUCTURE OF DENGUE VIRUS SEROTYPE 2 RNA DEPENDENT RNA POLYMERASE WITH COMPOUND 27
Descriptor:RNA Dependent RNA Polymerase, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, ...
Authors:Arora, R., Benson, T.E.
Deposit date:2016-05-23
Release date:2016-08-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.
Plos Pathog., 12, 2016
4G9Z
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LASSA NUCLEOPROTEIN WITH DSRNA REVEALS NOVEL MECHANISM FOR IMMUNE SUPPRESSION
Descriptor:RNA (5'-R(P*GP*CP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*C)-3'), Nucleoprotein, ...
Authors:Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2012-07-24
Release date:2013-04-03
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
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