Author results

6N8U
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DRAFT MODEL OF SCHISTOSOMA JAPONICUM GLUTATHIONE S-TRANSFERASE EXPRESSION TAG
Descriptor:Glutathione S-transferase class-mu 26 kDa isozyme
Authors:Tempel, W., Dong, C.
Deposit date:2018-11-30
Release date:2019-01-16
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:DRAFT model of Schistosoma japonicum Glutathione S-transferase expression tag
To Be Published
6DUB
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CRYSTAL STRUCTURE OF A METHYLTRANSFERASE
Descriptor:Alpha N-terminal protein methyltransferase 1B, RCC1, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Dong, C., Tempel, W., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-06-20
Release date:2018-07-25
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.
Commun Biol, 1, 2018
6CCR
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SELENOMETHIONYL DERIVATIVE OF A GID4 FRAGMENT
Descriptor:Glucose-induced degradation protein 4 homolog, UNKNOWN ATOM OR ION
Authors:Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-07
Release date:2018-04-04
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018
5NXK
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L. REUTERI 53608 SRRP
Descriptor:Serine-rich secreted cell wall anchored (LPXTG-motif ) protein
Authors:Sequeira, S., Dong, C.
Deposit date:2017-05-10
Release date:2018-03-21
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.918 Å)
Cite:Structural basis for the role of serine-rich repeat proteins from Lactobacillus reuteriin gut microbe-host interactions.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5NY0
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L. REUTERS 100-23 SRRP
Descriptor:L. reuteris SRRP binding region
Authors:Sequeira, S., Dong, C.
Deposit date:2017-05-11
Release date:2018-03-21
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the role of serine-rich repeat proteins from Lactobacillus reuteriin gut microbe-host interactions.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CCT
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FRAGMENT OF GID4 IN COMPLEX WITH A SHORT PEPTIDE
Descriptor:Glucose-induced degradation protein 4 homolog, Tetrapeptide
Authors:Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-07
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018
6CCU
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COMPLEX BETWEEN A GID4 FRAGMENT AND A SHORT PEPTIDE
Descriptor:Glucose-induced degradation protein 4 homolog, Short peptide, UNKNOWN ATOM OR ION
Authors:Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-07
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018
6CD8
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COMPLEX OF GID4 FRAGMENT WITH SHORT PEPTIDE
Descriptor:Glucose-induced degradation protein 4 homolog, Tetrapeptide PSRV, UNKNOWN ATOM OR ION
Authors:Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-08
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018
6CD9
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GID4 IN COMPLEX WITH A PEPTIDE
Descriptor:Glucose-induced degradation protein 4 homolog, Tetrapeptide PSRW, UNKNOWN ATOM OR ION
Authors:Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-08
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018
6CDC
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GID4 IN COMPLEX WITH A TETRAPEPTIDE
Descriptor:Glucose-induced degradation protein 4 homolog, Tetrapeptide PGLW, UNKNOWN ATOM OR ION
Authors:Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-08
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018
6CDG
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GID4 FRAGMENT IN COMPLEX WITH A PEPTIDE
Descriptor:Glucose-induced degradation protein 4 homolog, Hexapeptide PGLWKS, UNKNOWN ATOM OR ION
Authors:Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-08
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018
5OR1
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BAMA STRUCTURE OF SALMONELLA ENTERICA
Descriptor:Outer membrane protein assembly factor BamA
Authors:Dong, C., Gu, Y.
Deposit date:2017-08-14
Release date:2018-02-14
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:BamA beta 16C strand and periplasmic turns are critical for outer membrane protein insertion and assembly.
Biochem. J., 474, 2017
5ONU
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TRIMERIC OMPU STRUCTURE
Descriptor:Outer membrane protein OmpU, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, GLYCEROL, ...
Authors:Li, H.Y., Dong, C.J.
Deposit date:2017-08-04
Release date:2018-01-03
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Crystal structure of the outer membrane protein OmpU from Vibrio cholerae at 2.2 angstrom resolution.
Acta Crystallogr D Struct Biol, 74, 2018
5WP3
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CRYSTAL STRUCTURE OF EED IN COMPLEX WITH EB22
Descriptor:Polycomb protein EED, EB22, UNKNOWN ATOM OR ION
Authors:Dong, C., Tempel, W., Zhu, L., Moody, J.D., Baker, D., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-08-03
Release date:2017-09-13
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5L75
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A PROTEIN STRUCTURE
Descriptor:Lipopolysaccharide ABC transporter, ATP-binding protein LptB, FIG000988: Predicted permease, ...
Authors:Dong, C., Dong, H., Zhang, Z., Paterson, N., Tang, X.
Deposit date:2016-06-01
Release date:2017-08-16
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG.
Nat Commun, 8, 2017
5K6J
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HUMAN PHOSPODIESTERASE 4B IN COMPLEX WITH PYRIDYLOXY-BENZOXABOROLE BASED INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Rock, F.L., Zhou, Y., Sullivan, D.
Deposit date:2016-05-24
Release date:2017-05-31
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:To be published
To Be Published
5I5D
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SALMONELLA GLOBAL DOMAIN 245
Descriptor:Inner membrane protein YejM
Authors:Dong, C., Dong, H.
Deposit date:2016-02-15
Release date:2017-04-19
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structural insights into cardiolipin transfer from the Inner membrane to the outer membrane by PbgA in Gram-negative bacteria.
Sci Rep, 6, 2016
5UBB
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CRYSTAL STRUCTURE OF HUMAN ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1B
Descriptor:Alpha N-terminal protein methyltransferase 1B, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION
Authors:Dong, C., Zhu, L., Tempel, W., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2016-12-20
Release date:2017-03-22
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.
Commun Biol, 1, 2018
5KCC
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH OXABICYCLIC HEPTENE SULFONAMIDE (OBHS-N)
Descriptor:Estrogen receptor, NCOA2, (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-N-phenyl-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide
Authors:Nwachukwu, J.C., Srinivasan, S., Zheng, Y., Wang, S., Min, J., Dong, C., Liao, Z., Cavett, V., Nowak, J., Houtman, R., Carlson, K.E., Josan, J.S., Elemento, O., Katzenellenbogen, J.A., Zhou, H.B., Nettles, K.W.
Deposit date:2016-06-06
Release date:2016-11-16
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.386 Å)
Cite:Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat. Chem. Biol., 13, 2017
5EJM
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THDP-MN2+ COMPLEX OF R413A VARIANT OF ECMEND SOAKED WITH 2-KETOGLUTARATE FOR 35 MIN
Descriptor:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, (4~{R})-4-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-3-ium-2-yl]-4-oxidanyl-butanoic acid, MANGANESE (II) ION, ...
Authors:Song, H.G., Dong, C., Chen, Y.Z., Sun, Y.R., Guo, Z.H.
Deposit date:2015-11-02
Release date:2016-11-02
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Two active site arginines are critical determinants of substrate binding and catalysis in MenD, a thiamine-dependent enzyme in menaquinone biosynthesis.
Biochem. J., 2018
5KYA
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BRAIN PENETRANT LIVER X RECEPTOR (LXR) MODULATORS BASED ON A 2,4,5,6-TETRAHYDROPYRROLO[3,4-C]PYRAZOLE CORE
Descriptor:Oxysterols receptor LXR-beta, Retinoic acid receptor RXR-beta, [2-[(6~{R})-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-4-(trifluoromethyl)pyrimidin-5-yl]methanol
Authors:Chen, G., McKeever, B.M.
Deposit date:2016-07-21
Release date:2016-09-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.598 Å)
Cite:Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Bioorg.Med.Chem.Lett., 26, 2016
5KYJ
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BRAIN PENETRANT LIVER X RECEPTOR (LXR) MODULATORS BASED ON A 2,4,5,6-TETRAHYDROPYRROLO[3,4-C]PYRAZOLE CORE
Descriptor:Oxysterols receptor LXR-beta, Retinoic acid receptor RXR-beta, (6~{R})-5-(5-fluoranyl-2-methoxy-pyrimidin-4-yl)-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazole
Authors:Chen, G., McKeever, B.M.
Deposit date:2016-07-21
Release date:2016-09-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Bioorg.Med.Chem.Lett., 26, 2016
5J0A
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CRYSTAL STRUCTURE OF PDZ-BINDING KINASE
Descriptor:Lymphokine-activated killer T-cell-originated protein kinase, SULFATE ION, 4'-HYDROXYCINNAMIC ACID
Authors:Zou, Q.W., Zhou, H., Yang, X.
Deposit date:2016-03-28
Release date:2016-09-07
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:The crystal structure of an inactive dimer of PDZ-binding kinase
Biochem.Biophys.Res.Commun., 476, 2016
5I5F
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SALMONELLA GLOBAL DOMAIN 191
Descriptor:Inner membrane protein YejM
Authors:Dong, C., Dong, H.
Deposit date:2016-02-15
Release date:2016-08-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural insights into cardiolipin transfer from the Inner membrane to the outer membrane by PbgA in Gram-negative bacteria.
Sci Rep, 6, 2016
5I5H
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ECOLI GLOBAL DOMAIN 245-586
Descriptor:Inner membrane protein YejM
Authors:Dong, C., Dong, H.
Deposit date:2016-02-15
Release date:2016-08-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural insights into cardiolipin transfer from the Inner membrane to the outer membrane by PbgA in Gram-negative bacteria.
Sci Rep, 6, 2016