Author results

6QTN
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TUBULIN-CYCLOSTREPTIN COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Balaguer, F.d.A., Muehlethaler, T., Estevez-Gallego, J., Calvo, E., Gimenez-Abian, J.F., Risinger, A.L., Sorensen, E.J., Vanderwal, C.D., Altmann, K.-H., Mooberry, S.L., Steinmetz, M.O., Oliva, M.A., Prota, A.E., Diaz, J.F.
Deposit date:2019-02-25
Release date:2019-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.
Int J Mol Sci, 20, 2019
4I50
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CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-EPOTHILONE A COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Prota, A.E., Bargsten, K., Zurwerra, D., Field, J.J., Diaz, J.F., Altmann, K.H., Steinmetz, M.O.
Deposit date:2012-11-28
Release date:2013-01-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Science, 339, 2013
4I55
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CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Prota, A.E., Bargsten, K., Zurwerra, D., Field, J.J., Diaz, J.F., Altmann, K.H., Steinmetz, M.O.
Deposit date:2012-11-28
Release date:2013-01-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Science, 339, 2013
4O4H
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TUBULIN-LAULIMALIDE COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O.
Deposit date:2013-12-18
Release date:2014-03-05
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of microtubule stabilization by laulimalide and peloruside a.
Angew.Chem.Int.Ed.Engl., 53, 2014
4O4I
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TUBULIN-LAULIMALIDE-EPOTHILONE A COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O.
Deposit date:2013-12-18
Release date:2014-03-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of microtubule stabilization by laulimalide and peloruside a.
Angew.Chem.Int.Ed.Engl., 53, 2014
4O4J
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TUBULIN-PELORUSIDE A COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O.
Deposit date:2013-12-18
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of microtubule stabilization by laulimalide and peloruside A.
Angew.Chem.Int.Ed.Engl., 53, 2014
4O4L
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TUBULIN-PELORUSIDE A-EPOTHILONE A COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O.
Deposit date:2013-12-18
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of microtubule stabilization by laulimalide and peloruside a.
Angew.Chem.Int.Ed.Engl., 53, 2014
4TUY
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TUBULIN-RHIZOXIN COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Prota, A.E., Bargsten, K., Diaz, J.F., Marsh, M., Cuevas, C., Liniger, M., Neuhaus, C., Andreu, J.M., Altmann, K.H., Steinmetz, M.O.
Deposit date:2014-06-25
Release date:2014-08-27
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TV8
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TUBULIN-MAYTANSINE COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Prota, A.E., Bargsten, K., Diaz, J.F., Marsh, M., Cuevas, C., Liniger, M., Neuhaus, C., Andreu, J.M., Altmann, K.H., Steinmetz, M.O.
Deposit date:2014-06-26
Release date:2014-08-27
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TV9
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TUBULIN-PM060184 COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Prota, A.E., Bargsten, K., Diaz, J.F., Marsh, M., Cuevas, C., Liniger, M., Neuhaus, C., Andreu, J.M., Altmann, K.H., Steinmetz, M.O.
Deposit date:2014-06-26
Release date:2014-08-20
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.
Proc.Natl.Acad.Sci.USA, 111, 2014
5JVD
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TUBULIN-TUB092 COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Canela, M.-D., Noppen, S., Bueno, O., Prota, A.E., Bargsten, K., Saez-Calvo, G., Jimeno, M.-L., Benkheil, M., Ribatti, D., Velazquez, S., Camarasa, M.-J., Diaz, J.F., Steinmetz, M.O., Priego, E.-M., Perez-Perez, M.-J., Liekens, S.
Deposit date:2016-05-11
Release date:2016-06-08
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Antivascular and antitumor properties of the tubulin-binding chalcone TUB091.
Oncotarget, 8, 2017
5LA6
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TUBULIN-PIRONETIN COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Prota, A.E., Setter, J., Waight, A.B., Bargsten, K., Murga, J., Diaz, J.F., Steinmetz, M.O.
Deposit date:2016-06-13
Release date:2016-07-20
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Pironetin Binds Covalently to alpha Cys316 and Perturbs a Major Loop and Helix of alpha-Tubulin to Inhibit Microtubule Formation.
J.Mol.Biol., 428, 2016
5MF4
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TUBULIN-DICTYOSTATIN COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Trigili, C., Barasoain, I., Sanchez-Murcia, P.A., Bargsten, K., Redondo-Horcajo, M., Nogales, A., Gardner, N.M., Meyer, A., Naylor, G.J., Gomez-Rubio, E., Gago, F., Steinmetz, M.O., Paterson, I., Prota, A.E., Diaz, J.F.
Deposit date:2016-11-17
Release date:2017-09-20
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.
ACS Omega, 1, 2016
5NFZ
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TUBULIN-MTC COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Field, J.J., Pera, B., Estevez Gallego, J., Calvo, E., Rodriguez-Salarichs, J., Saez-Calvo, G., Zuwerra, D., Jordi, M., Prota, A.E., Menchon, G., Miller, J.H., Altmann, K.-H., Diaz, J.F.
Deposit date:2017-03-16
Release date:2017-10-25
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites.
J. Nat. Prod., 81, 2018
5NG1
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TUBULIN-MTC-ZAMPANOLIDE COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Field, J.J., Pera, B., Estevez Gallego, J., Calvo, E., Rodriguez-Salarichs, J., Saez-Calvo, G., Zuwerra, D., Jordi, M., Prota, A.E., Menchon, G., Miller, J.H., Altmann, K.-H., Diaz, J.F.
Deposit date:2017-03-16
Release date:2017-10-25
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites.
J. Nat. Prod., 81, 2018
5NJH
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TRIAZOLOPYRIMIDINES STABILIZE MICROTUBULES BY BINDING TO THE VINCA INHIBITOR SITE OF TUBULIN
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Sharma, A., Calvo, G.S., Prota, A.E., Diaz, J.F., Steinmetz, M.O.
Deposit date:2017-03-28
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.394 Å)
Cite:Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.
Cell Chem Biol, 24, 2017
6FII
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TUBULIN-SPONGISTATIN COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Menchon, G., Prota, A.E., Lucena Angell, D., Bucher, P., Mueller, R., Paterson, I., Diaz, J.F., Altmann, K.-H., Steinmetz, M.O.
Deposit date:2018-01-18
Release date:2018-05-30
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
6FJF
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TUBULIN-FCMAYTANSINE COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Menchon, G., Prota, A.E., Lucena Angell, D., Bucher, P., Mueller, R., Paterson, I., Diaz, J.F., Altmann, K.-H., Steinmetz, M.O.
Deposit date:2018-01-22
Release date:2018-05-30
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
6FJM
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TUBULIN-DISORAZOLE Z COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Menchon, G., Prota, A.E., Lucena Agell, D., Bucher, P., Jansen, R., Irschik, H., Mueller, R., Paterson, I., Diaz, J.F., Altmann, K.-H., Steinmetz, M.O.
Deposit date:2018-01-22
Release date:2018-05-30
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
6GJ4
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TUBULIN-6J COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Brindisi, M., Ulivieri, C., Alfano, G., Gemma, S., Balaguer, F.d.A., Khan, T., Grillo, A., Chemi, G., Menchon, G., Prota, A.E., Olieric, N., Agell, D.L., Barasoain, I., Diaz, J.F., Nebbioso, A., Conte, M.R., Lopresti, L., Magnano, S., Amet, R., Kinsella, P., Zisterer, D.M., Ibrahim, O., O'Sullivan, J., Morbidelli, L., Spaccapelo, R., Baldari, C., Butini, S., Novellino, E., Campiani, G., Altucci, L., Steinmetz, M.O., Brogi, S.
Deposit date:2018-05-16
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.
Eur J Med Chem, 162, 2018
6GZE
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TUBULIN-GDP.BEF COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Oliva, M.A., Diaz, J.F.
Deposit date:2018-07-04
Release date:2020-01-22
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural model for differential cap maturation at growing microtubule ends.
Elife, 9, 2020
6S9E
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TUBULIN-GDP.ALF COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Oliva, M.A., Estevez-Gallego, J., Diaz, J.F., Prota, A.E., Steinmetz, M.O., Balaguer, F.A., Lucena-Agell, D.
Deposit date:2019-07-12
Release date:2020-02-19
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural model for differential cap maturation at growing microtubule ends.
Elife, 9, 2020
4I4T
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CRYSTAL STRUCTURE OF TUBULIN-RB3-TTL-ZAMPANOLIDE COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Prota, A.E., Steinmetz, M.O.
Deposit date:2012-11-28
Release date:2013-01-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Science, 339, 2013
5JHA
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STRUCTURE OF PHOSPHOINOSITIDE 3-KINASE GAMMA (PI3K) BOUND TO THE POTENT INHIBITOR PIKIN2
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)pyrimidin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol, SULFATE ION
Authors:Burke, J.E., Inglis, A.J., Williams, R.L.
Deposit date:2016-04-20
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
5JHB
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STRUCTURE OF PHOSPHOINOSITIDE 3-KINASE GAMMA (PI3K) BOUND TO THE POTENT INHIBITOR PIKIN3
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol, SULFATE ION
Authors:Burke, J.E., Inglis, A.J., Williams, R.L.
Deposit date:2016-04-20
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
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