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2R09
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BU of 2r09 by Molmil
Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ...
Authors:DiNitto, J.P, Delprato, A, Gabe Lee, M.T, Cronin, T.C, Huang, S, Guilherme, A, Czech, M.P, Lambright, D.G.
Deposit date:2007-08-17
Release date:2007-12-04
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors.
Mol.Cell, 28, 2007
2R0D
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BU of 2r0d by Molmil
Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor
Descriptor: Cytohesin-3, DI(HYDROXYETHYL)ETHER, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ...
Authors:DiNitto, J.P, Delprato, A, Gabe Lee, M.T, Cronin, T.C, Huang, S, Guilherme, A, Czech, M.P, Lambright, D.G.
Deposit date:2007-08-18
Release date:2007-12-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors.
Mol.Cell, 28, 2007
1U2B
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BU of 1u2b by Molmil
Triglycine variant of the Grp1 Pleckstrin Homology Domain unliganded
Descriptor: Cytohesin 3, SULFATE ION
Authors:Cronin, T.C, DiNitto, J.P, Czech, M.P, Lambright, D.G.
Deposit date:2004-07-16
Release date:2005-02-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains
Embo J., 23, 2004
1U27
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BU of 1u27 by Molmil
Triglycine variant of the ARNO Pleckstrin Homology Domain in complex with Ins(1,3,4,5)P4
Descriptor: Cytohesin 2, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
Authors:Cronin, T.C, DiNitto, J.P, Czech, M.P, Lambright, D.G.
Deposit date:2004-07-16
Release date:2005-02-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains
Embo J., 23, 2004
1U29
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BU of 1u29 by Molmil
Triglycine variant of the ARNO Pleckstrin Homology Domain in complex with Ins(1,4,5)P3
Descriptor: Cytohesin 2, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE
Authors:Cronin, T.C, DiNitto, J.P, Czech, M.P, Lambright, D.G.
Deposit date:2004-07-16
Release date:2005-02-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains
Embo J., 23, 2004
3K3I
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BU of 3k3i by Molmil
p38alpha bound to novel DGF-out compound PF-00215955
Descriptor: (3S)-3-[4-(4-bromophenyl)-1H-imidazol-2-yl]-1,2,3,4-tetrahydroisoquinoline, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, Mitogen-activated protein kinase 14
Authors:Kazmirski, S.L, DiNitto, J.P.
Deposit date:2009-10-02
Release date:2009-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay.
Chem.Biol.Drug Des., 74, 2009
3K3J
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BU of 3k3j by Molmil
P38alpha bound to novel DFG-out compound PF-00416121
Descriptor: 2-(4-fluorophenyl)-3-oxo-6-pyridin-4-yl-N-[2-(trifluoromethyl)benzyl]-2,3-dihydropyridazine-4-carboxamide, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, Mitogen-activated protein kinase 14
Authors:Kazmirski, S.L, DiNitto, J.P.
Deposit date:2009-10-02
Release date:2009-11-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38alpha for High Throughput Screening Binding Assay.
Chem.Biol.Drug Des., 74, 2009
3G0E
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BU of 3g0e by Molmil
KIT kinase domain in complex with sunitinib
Descriptor: Mast/stem cell growth factor receptor, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide
Authors:Gajiwala, K.S, Wu, J.C, Lunney, E.A, Gemetri, G.D.
Deposit date:2009-01-27
Release date:2009-02-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.
Proc.Natl.Acad.Sci.USA, 106, 2009
3G0F
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BU of 3g0f by Molmil
KIT kinase domain mutant D816H in complex with sunitinib
Descriptor: Mast/stem cell growth factor receptor, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, SULFATE ION
Authors:Gajiwala, K.S, Wu, J.C, Lunney, E.A, Demetri, G.D.
Deposit date:2009-01-27
Release date:2009-02-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.
Proc.Natl.Acad.Sci.USA, 106, 2009

217705

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