Author results

6BFS
  • Download 6bfs
  • View 6bfs
Molmil generated image of 6bfs
THE MECHANISM OF GM-CSF INHIBITION BY HUMAN GM-CSF AUTO-ANTIBODIES
Descriptor:Fab light Chain, Fab Heavy Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
6BFQ
  • Download 6bfq
  • View 6bfq
Molmil generated image of 6bfq
THE MECHANISM OF GM-CSF INHIBITION BY HUMAN GM-CSF AUTO-ANTIBODIES
Descriptor:Fab Heavy chain, Fab Light Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
5UWC
  • Download 5uwc
  • View 5uwc
Molmil generated image of 5uwc
CYTOKINE-RECEPTOR COMPLEX
Descriptor:Interleukin-3 receptor subunit alpha, Interleukin-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Broughton, S.E., Parker, M.W.
Deposit date:2017-02-21
Release date:2018-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018
5UV8
  • Download 5uv8
  • View 5uv8
Molmil generated image of 5uv8
INTERLEUKIN-3 RECEPTOR COMPLEX
Descriptor:Interleukin-3 receptor subunit alpha, Interleukin-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Broughton, S.E., Parker, M.W.
Deposit date:2017-02-19
Release date:2018-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018
5DWU
  • Download 5dwu
  • View 5dwu
Molmil generated image of 5dwu
BETA COMMON RECEPTOR IN COMPLEX WITH A FAB
Descriptor:Cytokine receptor common subunit beta, Fab - Heavy Chain, Fab - Light Chain, ...
Authors:Dhagat, U., Parker, M.W.
Deposit date:2015-09-23
Release date:2015-12-30
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.97 Å)
Cite:CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors.
Mabs, 8, 2016
4RS1
  • Download 4rs1
  • View 4rs1
Molmil generated image of 4rs1
CRYSTAL STRUCTURE OF RECEPTOR-CYTOKINE COMPLEX
Descriptor:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, Granulocyte-macrophage colony-stimulating factor, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Broughton, S.E., Parker, M.W., Dhagat, U.
Deposit date:2014-11-06
Release date:2015-11-11
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
4NKQ
  • Download 4nkq
  • View 4nkq
Molmil generated image of 4nkq
STRUCTURE OF A CYTOKINE RECEPTOR COMPLEX
Descriptor:Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, ...
Authors:Parker, M.W., Broughton, S.E.
Deposit date:2013-11-13
Release date:2015-09-23
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
4JZJ
  • Download 4jzj
  • View 4jzj
Molmil generated image of 4jzj
CRYSTAL STRUCTURE OF RECEPTOR-FAB COMPLEX
Descriptor:Interleukin-3 receptor subunit alpha, Fab Heavy Chain, Fab Light Chain, ...
Authors:Broughton, S.E., Parker, M.W.
Deposit date:2013-04-03
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody
Cell Rep, 8, 2014
3O3R
  • Download 3o3r
  • View 3o3r
Molmil generated image of 3o3r
CRYSTAL STRUCTURE OF AKR1B14 IN COMPLEX WITH NADP
Descriptor:Aldo-keto reductase family 1, member B7, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sundaram, K., Dhagat, U., El-Kabbani, O.
Deposit date:2010-07-26
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis
Bioorg.Med.Chem.Lett., 21, 2011
3NTY
  • Download 3nty
  • View 3nty
Molmil generated image of 3nty
CRYSTAL STRUCTURE OF AKR1C1 IN COMPLEX WITH NADP AND 5-PHENYL,3-CHLOROSALICYLIC ACID
Descriptor:Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-chloro-4-hydroxybiphenyl-3-carboxylic acid, ...
Authors:Dhagat, U., El-Kabbani, O.
Deposit date:2010-07-06
Release date:2011-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Probing the inhibitor selectivity pocket of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis
Bioorg.Med.Chem.Lett., 21, 2011
3GUG
  • Download 3gug
  • View 3gug
Molmil generated image of 3gug
CRYSTAL STRUCTURE OF AKR1C1 L308V MUTANT IN COMPLEX WITH NADP AND 3,5-DICHLOROSALICYLIC ACID
Descriptor:Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,5-dichloro-2-hydroxybenzoic acid, ...
Authors:Dhagat, U., El-Kabbani, O.
Deposit date:2009-03-30
Release date:2010-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of AKR1C1 L308V mutant in complex with NADP and 3,5-dichlorosalicylic acid
To be Published
3FJN
  • Download 3fjn
  • View 3fjn
Molmil generated image of 3fjn
THE CRYSTAL STRUCTURE OF 17-ALPHA HYDROXYSTEROID DEHYDROGENASE Y224D MUTANT.
Descriptor:Aldo-keto reductase family 1 member C21, ACETATE ION
Authors:Dhagat, U., El-Kabbani, O.
Deposit date:2008-12-14
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme
Acta Crystallogr.,Sect.D, 66, 2010
3CV6
  • Download 3cv6
  • View 3cv6
Molmil generated image of 3cv6
THE CRYSTAL STRUCTURE OF MOUSE 17-ALPHA HYDROXYSTEROID DEHYDROGENASE GG225.226PP MUTANT IN COMPLEX WITH INHIBITOR AND COFACTOR NADP+.
Descriptor:Aldo-keto reductase family 1 member C21, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[(1R,2S)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol, ...
Authors:Dhagat, U., El-Kabbani, O.
Deposit date:2008-04-17
Release date:2009-03-03
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.
Acta Crystallogr.,Sect.D, 65, 2009
3C3U
  • Download 3c3u
  • View 3c3u
Molmil generated image of 3c3u
CRYSTAL STRUCTURE OF AKR1C1 IN COMPLEX WITH NADP AND 3,5-DICHLOROSALICYLIC ACID
Descriptor:Aldo-keto reductase family 1 member C1, ZINC ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Dhagat, U., El-Kabbani, O.
Deposit date:2008-01-28
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid
J.Med.Chem., 51, 2008
2P5N
  • Download 2p5n
  • View 2p5n
Molmil generated image of 2p5n
CRYSTAL STRUCTURE OF MOUSE 17-ALPHA HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH COENZYME NADPH
Descriptor:Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:El-Kabbani, O., Dhagat, U.
Deposit date:2007-03-15
Release date:2007-10-09
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.
Acta Crystallogr.,Sect.F, 63, 2007