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2XX3
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE BUTENYL PHOSPHONATE MONOPHOSPHATE AND ADP
Descriptor:THYMIDYLATE KINASE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Caillat, C., Meyer, P.
Deposit date:2010-11-08
Release date:2011-12-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel Antiviral C5-Substituted Pyrimidine Acyclic Nucleoside Phosphonates Selected as Human Thymidylate Kinase Substrates.
J.Med.Chem., 54, 2011
3FKB
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STRUCTURE OF NDPK H122G AND TENOFOVIR-DIPHOSPHATE
Descriptor:Nucleoside diphosphate kinase, cytosolic, [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phosphonooxy-phosphinic acid, ...
Authors:Morera, S., Chen, Y.X.
Deposit date:2008-12-16
Release date:2009-09-29
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Nucleoside diphosphate kinase and the activation of antiviral phosphonate analogs of nucleotides: binding mode and phosphorylation of tenofovir derivatives
Nucleosides Nucleotides Nucleic Acids, 28, 2009
2W0S
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CRYSTAL STRUCTURE OF VACCINIA VIRUS THYMIDYLATE KINASE BOUND TO BRIVUDIN-5'-MONOPHOSPHATE
Descriptor:THYMIDYLATE KINASE, MAGNESIUM ION, (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ...
Authors:Caillat, C., Topalis, D., Agrofoglio, L.A., Pochet, S., Balzarini, J., Deville-Bonne, D., Meyer, P.
Deposit date:2008-10-08
Release date:2008-10-21
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.918 Å)
Cite:Crystal Structure of Poxvirus Thymidylate Kinase: An Unexpected Dimerization Has Implications for Antiviral Therapy
Proc.Natl.Acad.Sci.USA, 105, 2008
2V54
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CRYSTAL STRUCTURE OF VACCINIA VIRUS THYMIDYLATE KINASE BOUND TO TDP
Descriptor:THYMIDYLATE KINASE, THYMIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Caillat, C., Topalis, D., Agrofoglio, L.A., Pochet, S., Balzarini, J., Deville-Bonne, D., Meyer, P.
Deposit date:2008-10-01
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Poxvirus Thymidylate Kinase: An Unexpected Dimerization Has Implications for Antiviral Therapy
Proc.Natl.Acad.Sci.USA, 105, 2008
2HVD
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HUMAN NUCLEOSIDE DIPHOSPHATE KINASE A COMPLEXED WITH ADP
Descriptor:Nucleoside diphosphate kinase A, ADENOSINE-5'-DIPHOSPHATE
Authors:Giraud, M.-F., Georgescauld, F., Lascu, I., Dautant, A.
Deposit date:2006-07-28
Release date:2006-09-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structures of S120G Mutant and Wild Type of Human Nucleoside Diphosphate Kinase A in Complex with ADP
J.Bioenerg.Biomembr., 38, 2006
2HVE
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S120G MUTANT OF HUMAN NUCLEOSIDE DIPHOSPHATE KINASE A COMPLEXED WITH ADP
Descriptor:Nucleoside diphosphate kinase A, ADENOSINE-5'-DIPHOSPHATE
Authors:Giraud, M.-F., Georgescauld, F., Lascu, I., Dautant, A.
Deposit date:2006-07-28
Release date:2006-09-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Crystal Structures of S120G Mutant and Wild Type of Human Nucleoside Diphosphate Kinase A in Complex with ADP
J.Bioenerg.Biomembr., 38, 2006
1S5Z
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NDP KINASE IN COMPLEX WITH ADENOSINE PHOSPHONOACETIC ACID
Descriptor:Nucleoside diphosphate kinase, cytosolic, ADENOSINE PHOSPHONOACETIC ACID, ...
Authors:Chen, Y., Morera, S., Pasti, C., Angusti, A., Solaroli, N., Veron, M., Janin, J., Manfredini, S., Deville-Bonne, D.
Deposit date:2004-01-22
Release date:2005-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Adenosine phosphonoacetic acid is slowly metabolized by NDP kinase.
Med.Chem., 1, 2005
1UCN
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X-RAY STRUCTURE OF HUMAN NUCLEOSIDE DIPHOSPHATE KINASE A COMPLEXED WITH ADP AT 2 A RESOLUTION
Descriptor:nucleoside diphosphate kinase A, PHOSPHATE ION, CALCIUM ION, ...
Authors:Chen, Y., Gallois-Montbrun, S., Schneider, B., Veron, M., Morera, S., Deville-Bonne, D., Janin, J.
Deposit date:2003-04-16
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nucleotide Binding to Nucleoside Diphosphate Kinases: X-ray Structure of Human NDPK-A in Complex with ADP and Comparison to Protein Kinases
J.Mol.Biol., 332, 2003
1MN7
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NDP KINASE MUTANT (H122G;N119S;F64W) IN COMPLEX WITH ABAZTTP
Descriptor:NDP kinase, MAGNESIUM ION, 3'-AZIDO-3'-DEOXY-THYMIDINE-5'-ALPHA BORANO TRIPHOSPHATE
Authors:gallois-montbrun, s., schneider, b., chen, y., giacomoni-fernandes, v., mulard, l., morera, s., janin, j., deville-bonne, d., veron, m.
Deposit date:2002-09-05
Release date:2002-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Improving nucleoside diphosphate kinase for antiviral nucleotide analogs activation
J.BIOL.CHEM., 277, 2002
1MN9
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NDP KINASE MUTANT (H122G) COMPLEX WITH RTP
Descriptor:NDP kinase, MAGNESIUM ION, RIBAVIRIN TRIPHOSPHATE
Authors:Gallois-montbrun, S., Chen, Y., Dutartre, H., Morera, S., Guerreiro, C., Mulard, L., Schneider, B., Janin, J., Canard, B., Veron, M., Deville-bonne, D.
Deposit date:2002-09-05
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Analysis of the Activation of Ribavirin Analogs by NDP Kinase: Comparison with Other Ribavirin Targets
MOL.PHARMACOL., 63, 2003
1HHQ
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ROLE OF ACTIVE SITE RESIUDE LYS16 IN NUCLEOSIDE DIPHOSPHATE KINASE
Descriptor:NUCLEOSIDE DIPHOSPHATE KINASE, SULFATE ION
Authors:Schneider, B., Babolat, M., Xu, Y.W., Janin, J., Veron, M., Deville-Bonne, D.
Deposit date:2000-12-26
Release date:2001-05-31
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanism of Phosphoryl Transfer by Nucleoside Diphosphate Kinase Ph-Dependence and Role of Active Site Lys16 and Tyr56 Residues
Eur.J.Biochem., 268, 2001
1HLW
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STRUCTURE OF THE H122A MUTANT OF THE NUCLEOSIDE DIPHOSPHATE KINASE
Descriptor:NUCLEOSIDE DIPHOSPHATE KINASE
Authors:Admiraal, S.J., Meyer, P., Schneider, B., Deville-Bonne, D., Janin, J., Herschlag, D.
Deposit date:2000-12-04
Release date:2001-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Chemical rescue of phosphoryl transfer in a cavity mutant: a cautionary tale for site-directed mutagenesis.
Biochemistry, 40, 2001
1F6T
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STRUCTURE OF THE NUCLEOSIDE DIPHOSPHATE KINASE/ALPHA-BORANO(RP)-TDP.MG COMPLEX
Descriptor:PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE), MAGNESIUM ION, 2*-DEOXY-THYMIDINE-5*-ALPHA BORANO DIPHOSPHATE (ISOMER RP)
Authors:Guerreiro, C., Boretto, J., Janin, J., Veron, M., Canard, B., Schneider, B., Sarfati, S., Deville-Bonne, D.
Deposit date:2000-06-23
Release date:2000-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.
EMBO J., 19, 2000
1F3F
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STRUCTURE OF THE H122G NUCLEOSIDE DIPHOSPHATE KINASE / D4T-TRIPHOSPHATE.MG COMPLEX
Descriptor:PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE), MAGNESIUM ION, 2',3'-DEHYDRO-2',3'-DEOXY-THYMIDINE 5'-TRIPHOSPHATE, ...
Authors:Meyer, P., Schneider, B., Sarfati, S., Deville-Bonne, D., Guerreiro, C., Boretto, J., Janin, J., Veron, M., Canard, B.
Deposit date:2000-06-02
Release date:2000-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.
EMBO J., 19, 2000
1B4S
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STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE H122G MUTANT
Descriptor:NUCLEOSIDE DIPHOSPHATE KINASE, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Meyer, P., Janin, J.
Deposit date:1998-12-28
Release date:1999-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nucleophilic activation by positioning in phosphoryl transfer catalyzed by nucleoside diphosphate kinase.
Biochemistry, 38, 1999
1BUX
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3'-PHOSPHORYLATED NUCLEOTIDES BINDING TO NUCLEOSIDE DIPHOSPHATE KINASE
Descriptor:NUCLEOSIDE DIPHOSPHATE KINASE, 3'-PHOSPHATE-ADENOSINE-5'-PHOSPHATE SULFATE
Authors:Xu, Y., Schneider, B., Deville-Bonne, D., Veron, M., Janin, J.
Deposit date:1998-09-07
Release date:1999-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:3'-Phosphorylated nucleotides are tight binding inhibitors of nucleoside diphosphate kinase activity.
J.Biol.Chem., 273, 1998