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3TV0
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STRUCTURE OF DYNACTIN P27 SUBUNIT
Descriptor:Dynactin subunit 6
Authors:Derewenda, Z.S., Derewenda, U., Kowalska, A.
Deposit date:2011-09-19
Release date:2012-10-03
Method:X-RAY DIFFRACTION (2.1492 Å)
Cite:Dynactin targets Polo-like kinase 1 to kinetochores
To be Published
4TGL
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CATALYSIS AT THE INTERFACE: THE ANATOMY OF A CONFORMATIONAL CHANGE IN A TRIGLYCERIDE LIPASE
Descriptor:TRIACYL-GLYCEROL ACYLHYDROLASE, DIETHYL PHOSPHONATE
Authors:Derewenda, U., Brzozowski, A.M., Lawson, D., Derewenda, Z.S.
Deposit date:1991-07-29
Release date:1993-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Catalysis at the interface: the anatomy of a conformational change in a triglyceride lipase.
Biochemistry, 31, 1992
1TIB
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CONFORMATIONAL LABILITY OF LIPASES OBSERVED IN THE ABSENCE OF AN OIL-WATER INTERFACE: CRYSTALLOGRAPHIC STUDIES OF ENZYMES FROM THE FUNGI HUMICOLA LANUGINOSA AND RHIZOPUS DELEMAR
Descriptor:LIPASE
Authors:Derewenda, U., Swenson, L., Wei, Y., Derewenda, Z.S.
Deposit date:1993-12-06
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Conformational lability of lipases observed in the absence of an oil-water interface: crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar.
J.Lipid Res., 35, 1994
1TIC
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CONFORMATIONAL LABILITY OF LIPASES OBSERVED IN THE ABSENCE OF AN OIL-WATER INTERFACE: CRYSTALLOGRAPHIC STUDIES OF ENZYMES FROM THE FUNGI HUMICOLA LANUGINOSA AND RHIZOPUS DELEMAR
Descriptor:LIPASE
Authors:Derewenda, U., Swenson, L., Green, R., Joerger, R., Haas, M.J., Derewenda, Z.S.
Deposit date:1993-12-06
Release date:1995-01-26
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Conformational lability of lipases observed in the absence of an oil-water interface: crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar.
J.Lipid Res., 35, 1994
3TGL
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STRUCTURE AND MOLECULAR MODEL REFINEMENT OF RHIZOMUCOR MIEHEI TRIACYLGLYCERIDE LIPASE: A CASE STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT
Descriptor:TRIACYL-GLYCEROL ACYLHYDROLASE
Authors:Brady, L., Brzozowski, A.M., Derewenda, Z.S., Dodson, E.J., Dodson, G.G., Tolley, S.P., Turkenburg, J.P., Christiansen, L., Huge-Jensen, B., Norskov, L., Thim, L.
Deposit date:1991-07-29
Release date:1993-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:STRUCTURE AND MOLECULAR-MODEL REFINEMENT OF RHIZOMUCOR-MIEHEI TRIACYLGLYCERIDE LIPASE - A CASE-STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT.
Acta Crystallogr.,Sect.B, 48, 1992
1CC0
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CRYSTAL STRUCTURE OF THE RHOA.GDP-RHOGDI COMPLEX
Descriptor:transforming protein rhoA, rho GDP dissociation inhibitor alpha, MAGNESIUM ION, ...
Authors:Longenecker, K.L., Read, P., Derewenda, U., Dauter, Z., Garrard, S., Walker, L., Somlyo, A.V., Somlyo, A.P., Nakamoto, R.K., Derewenda, Z.S.
Deposit date:1999-03-03
Release date:2000-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (5 Å)
Cite:How RhoGDI binds Rho.
Acta Crystallogr.,Sect.D, 55, 1999
1E0V
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XYLANASE 10A FROM SREPTOMYCES LIVIDANS. CELLOBIOSYL-ENZYME INTERMEDIATE AT 1.7 A
Descriptor:ENDO-1,4-BETA-XYLANASE A, 2-DEOXY-2-FLUORO-B-D-CELLOBIOSIDE
Authors:Ducros, V., Charnock, S.J., Derewenda, U., Derewenda, Z.S., Dauter, Z., Dupont, C., Shareck, F., Morosoli, R., Kluepfel, D., Davies, G.J.
Deposit date:2000-04-10
Release date:2001-04-05
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Substrate Specificity in Glycoside Hydrolase Family 10. Structural and Kinetic Analysis of the Streptomyces Lividans Xylanase 10A
J.Biol.Chem., 275, 2000
1E0W
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XYLANASE 10A FROM SREPTOMYCES LIVIDANS. NATIVE STRUCTURE AT 1.2 ANGSTROM RESOLUTION
Descriptor:ENDO-1,4-BETA-XYLANASE A
Authors:Ducros, V., Charnock, S.J., Derewenda, U., Derewenda, Z.S., Dauter, Z., Dupont, C., Shareck, F., Morosoli, R., Kluepfel, D., Davies, G.J.
Deposit date:2000-04-10
Release date:2001-04-05
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Substrate Specificity in Glycoside Hydrolase Family 10. Structural and Kinetic Analysis of the Streptomyces Lividans Xylanase 10A
J.Biol.Chem., 275, 2000
1E0X
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XYLANASE 10A FROM SREPTOMYCES LIVIDANS. XYLOBIOSYL-ENZYME INTERMEDIATE AT 1.65 A
Descriptor:ENDO-1,4-BETA-XYLANASE A, GLYCEROL, 2-DEOXY-2-FLUORO XYLOPYRANOSE, ...
Authors:Ducros, V., Charnock, S.J., Derewenda, U., Derewenda, Z.S., Dauter, Z., Dupont, C., Shareck, F., Morosoli, R., Kluepfel, D., Davies, G.J.
Deposit date:2000-04-10
Release date:2001-04-05
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Substrate Specificity in Glycoside Hydrolase Family 10. Structural and Kinetic Analysis of the Streptomyces Lividans Xylanase 10A
J.Biol.Chem., 275, 2000
1ESC
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THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
Descriptor:ESTERASE
Authors:Wei, Y., Schottel, J.L., Derewenda, U., Swenson, L., Patkar, S., Derewenda, Z.S.
Deposit date:1994-10-07
Release date:1995-10-15
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1F7C
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CRYSTAL STRUCTURE OF THE BH DOMAIN FROM GRAF, THE GTPASE REGULATOR ASSOCIATED WITH FOCAL ADHESION KINASE
Descriptor:RHOGAP PROTEIN
Authors:Longenecker, K.L., Derewenda, U., Sheffield, P.J., Zheng, Y., Derewenda, Z.S.
Deposit date:2000-06-26
Release date:2000-12-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the BH domain from graf and its implications for Rho GTPase recognition.
J.Biol.Chem., 275, 2000
1TIA
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AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES
Descriptor:LIPASE
Authors:Derewenda, U., Swenson, L., Yamaguchi, S., Wei, Y., Derewenda, Z.S.
Deposit date:1993-12-06
Release date:1995-01-26
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An unusual buried polar cluster in a family of fungal lipases.
Nat.Struct.Biol., 1, 1994
5DSD
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THE CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF EBOLA (BUNDIBUGYO) NUCLEOPROTEIN
Descriptor:Nucleoprotein, GLYCEROL, CHLORIDE ION
Authors:Baker, L., Handing, K.B., Utepbergenov, D., Derewenda, U., Derewenda, Z.S.
Deposit date:2015-09-17
Release date:2015-09-30
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses.
Acta Crystallogr D Struct Biol, 72, 2016
5E2X
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THE CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF EBOLA (TAI FOREST) NUCLEOPROTEIN
Descriptor:NP, NONAETHYLENE GLYCOL
Authors:Baker, L.E., Handing, K.B., Derewenda, U., Utepbergenov, D., Derewenda, Z.S.
Deposit date:2015-10-01
Release date:2015-10-21
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses.
Acta Crystallogr D Struct Biol, 72, 2016
1MJD
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STRUCTURE OF N-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN
Descriptor:DOUBLECORTIN
Authors:Kim, M.H., Cierpicki, T., Derewenda, U., Krowarsch, D., Feng, Y., Devedjiev, Y., Dauter, Z., Walsh, C.A., Otlewski, J., Bushweller, J.H., Derewenda, Z.S.
Deposit date:2002-08-27
Release date:2003-04-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The DCX-domain Tandems of Doublecortin and Doublecortin-like Kinase
Nat.Struct.Biol., 10, 2003
5TGL
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A MODEL FOR INTERFACIAL ACTIVATION IN LIPASES FROM THE STRUCTURE OF A FUNGAL LIPASE-INHIBITOR COMPLEX
Descriptor:LIPASE, N-HEXYLPHOSPHONATE ETHYL ESTER
Authors:Brzozowski, A.M., Derewenda, U., Derewenda, Z.S., Dodson, G.G., Lawson, D., Turkenburg, J.P., Bjorkling, F., Huge-Jensen, B., Patkar, S.R., Thim, L.
Deposit date:1991-10-30
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex.
Nature, 351, 1991
1C8U
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CRYSTAL STRUCTURE OF THE E.COLI THIOESTERASE II, A HOMOLOGUE OF THE HUMAN NEF-BINDING ENZYME
Descriptor:ACYL-COA THIOESTERASE II, LAURYL DIMETHYLAMINE-N-OXIDE
Authors:Li, J., Derewenda, Z.S.
Deposit date:1999-07-29
Release date:2000-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme.
Nat.Struct.Biol., 7, 2000
1ZNJ
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INSULIN, MONOCLINIC CRYSTAL FORM
Descriptor:INSULIN, PHENOL, ZINC ION, ...
Authors:Turkenburg, M.G.W., Whittingham, J.L., Turkenburg, J.P., Dodson, G.G., Derewenda, U., Smith, G.D., Dodson, E.J., Derewenda, Z.S., Xiao, B.
Deposit date:1997-09-23
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure Determination and Refinement of Two Crystal Forms of Native Insulins
To be Published
1ES9
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X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES (PAF-AH)
Descriptor:PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB GAMMA SUBUNIT
Authors:McMullen, T.W.P., Li, J., Sheffield, P.J., Aoki, J., Martin, T.W., Arai, H., Inoue, K., Derewenda, Z.S.
Deposit date:2000-04-07
Release date:2000-05-31
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib).
Protein Eng., 13, 2000
1ESD
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THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
Descriptor:ESTERASE, METHYLPHOSPHONIC ACID ESTER GROUP
Authors:Wei, Y., Schottel, J.L., Derewenda, U., Swenson, L., Patkar, S., Derewenda, Z.S.
Deposit date:1994-10-07
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1ESE
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THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
Descriptor:ESTERASE, DIETHYL PHOSPHONATE
Authors:Wei, Y., Schottel, J.L., Derewenda, U., Swenson, L., Patkar, S., Derewenda, Z.S.
Deposit date:1994-10-07
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1FTN
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CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX
Descriptor:TRANSFORMING PROTEIN RHOA (H12), MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Wei, Y., Zhang, Y., Derewenda, U., Liu, X., Minor, W., Nakamoto, R.K., Somlyo, A.V., Somlyo, A.P., Derewenda, Z.S.
Deposit date:1997-03-13
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of RhoA-GDP and its functional implications.
Nat.Struct.Biol., 4, 1997
1JKM
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BREFELDIN A ESTERASE, A BACTERIAL HOMOLOGUE OF HUMAN HORMONE SENSITIVE LIPASE
Descriptor:BREFELDIN A ESTERASE
Authors:Wei, Y., Contreras, A.J., Sheffield, P., Osterlund, T., Derewenda, U., Matern, U.O., Derewenda, Z.S.
Deposit date:1998-02-04
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of brefeldin A esterase, a bacterial homolog of the mammalian hormone-sensitive lipase.
Nat.Struct.Biol., 6, 1999
1KLL
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MOLECULAR BASIS OF MITOMYCIN C RESICTANCE IN STREPTOMYCES: CRYSTAL STRUCTURES OF THE MRD PROTEIN WITH AND WITHOUT A DRUG DERIVATIVE
Descriptor:mitomycin-binding protein, 1,2-CIS-1-HYDROXY-2,7-DIAMINO-MITOSENE
Authors:Martin, T.W., Dauter, Z., Devedjiev, Y., Sheffield, P., Jelen, F., He, M., Sherman, D., Otlewski, J., Derewenda, Z.S., Derewenda, U.
Deposit date:2001-12-12
Release date:2002-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.
Structure, 10, 2002
1KMZ
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MOLECULAR BASIS OF MITOMYCIN C RESICTANCE IN STREPTOMYCES: CRYSTAL STRUCTURES OF THE MRD PROTEIN WITH AND WITHOUT A DRUG DERIVATIVE
Descriptor:mitomycin-binding protein
Authors:Martin, T.W., Dauter, Z., Devedjiev, Y., Sheffield, P., Jelen, F., He, M., Sherman, D., Otlewski, J., Derewenda, Z.S., Derewenda, U.
Deposit date:2001-12-17
Release date:2002-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.
Structure, 10, 2002