2EUD | | STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I COMPLEXED WITH LIGANDS AND SUBUNIT PEPTIDES | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Dealwis, C., Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J. | | Deposit date: | 2005-10-28 | | Release date: | 2006-03-07 | | Last modified: | 2016-02-17 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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1EPQ | | ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-133,450 (SOT PHE GLY+SCC GCL) | | Descriptor: | ENDOTHIAPEPSIN, N-[(1S)-2-{[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino}-1-(ethylsulfanyl)-2-oxoethyl]-Nalpha-(morpholin-4-ylsulfonyl)-L-phenylalaninamide, SULFATE ION | | Authors: | Dealwis, C., Cooper, J.B., Blundell, T.L. | | Deposit date: | 1994-07-27 | | Release date: | 1994-12-20 | | Last modified: | 2020-05-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.
J.Med.Chem., 36, 1993
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1PEW | | HIGH RESOLUTION CRYSTAL STRUCTURE OF JTO2, A MUTANT OF THE NON-AMYLOIDOGENIC LAMBA6 LIGHT CHAIN, JTO | | Descriptor: | Jto2, a LAMBDA-6 TYPE IMMUNOGLOBULIN LIGHT CHAIN, VARIABLE DOMAIN, ... | | Authors: | Dealwis, C., Gupta, V., Wilkerson, M. | | Deposit date: | 2003-05-22 | | Release date: | 2004-07-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four V(lambda)6 proteins
J.Mol.Recog., 17, 2004
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1PW3 | | CRYSTAL STRUCTURE OF JTOR68S | | Descriptor: | immunoglobulin lambda chain variable region, CADMIUM ION | | Authors: | Dealwis, C., Gupta, V., Wilkerson, M. | | Deposit date: | 2003-06-30 | | Release date: | 2004-08-17 | | Last modified: | 2018-04-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four Vlambda6 proteins.
J.Mol.Recog., 17, 2004
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1ZYZ | | STRUCTURES OF YEAST RIBONUCLOETIDE REDUCTASE I | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1, GLYCINE | | Authors: | Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C. | | Deposit date: | 2005-06-13 | | Release date: | 2006-03-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
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1ZZD | | STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1, Ribonucleoside-diphosphate reductase small chain 2 | | Authors: | Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C. | | Deposit date: | 2005-06-13 | | Release date: | 2006-03-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2CVS | | STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1 | | Authors: | Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C. | | Deposit date: | 2005-06-14 | | Release date: | 2006-03-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2CVT | | STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C. | | Deposit date: | 2005-06-14 | | Release date: | 2006-03-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2CVU | | STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C. | | Deposit date: | 2005-06-14 | | Release date: | 2006-03-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2CVV | | STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C. | | Deposit date: | 2005-06-14 | | Release date: | 2006-03-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2CVW | | STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C. | | Deposit date: | 2005-06-14 | | Release date: | 2006-03-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2CVX | | STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C. | | Deposit date: | 2005-06-14 | | Release date: | 2006-03-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2CVY | | STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1, 9-per peptide from Ribonucleoside-diphosphate reductase small chain 1, MAGNESIUM ION, ... | | Authors: | Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C. | | Deposit date: | 2005-06-14 | | Release date: | 2006-03-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
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1C29 | | CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC ACID | | Descriptor: | TRYPTOPHAN SYNTHASE, 4-(2-HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC ACID, SODIUM ION, ... | | Authors: | Sachpatzidis, A., Dealwis, C., Lubetsky, J.B., Liang, P.H., Anderson, K.S., Lolis, E. | | Deposit date: | 1999-07-23 | | Release date: | 2000-01-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.
Biochemistry, 38, 1999
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1C8V | | CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXYPHENYLTHIO)-BUTYLPHOSPHONIC ACID | | Descriptor: | TRYPTOPHAN SYNTHASE; ALPHA CHAIN, TRYPTOPHAN SYNTHASE; BETA CHAIN, 4-(2-HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC ACID, ... | | Authors: | Sachpatzidis, A., Dealwis, C., Lubetsky, J.B., Liang, P.H., Anderson, K.S., Lolis, E. | | Deposit date: | 1999-07-30 | | Release date: | 2000-01-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.
Biochemistry, 38, 1999
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1CW2 | | CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXYPHENYLSULFINYL)-BUTYLPHOSPHONIC ACID | | Descriptor: | TRYPTOPHAN SYNTHASE (ALPHA CHAIN), TRYPTOPHAN SYNTHASE (BETA CHAIN), 4-(2-HYDROXYPHENYLSULFINYL)-BUTYLPHOSPHONIC ACID, ... | | Authors: | Sachpatzidis, A., Dealwis, C., Lubetsky, J.B., Liang, P.H., Anderson, K.S., Lolis, E. | | Deposit date: | 1999-08-25 | | Release date: | 1999-12-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.
Biochemistry, 38, 1999
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1CX9 | | CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-AMINOPHENYLTHIO)-BUTYLPHOSPHONIC ACID | | Descriptor: | TRYPTOPHAN SYNTHASE (ALPHA CHAIN), TRYPTOPHAN SYNTHASE (BETA CHAIN), 4-(2-AMINOPHENYLTHIO)-BUTYLPHOSPHONIC ACID, ... | | Authors: | Sachpatzidis, A., Dealwis, C., Lubetsky, J.B., Liang, P.H., Anderson, K.S., Lolis, E. | | Deposit date: | 1999-08-29 | | Release date: | 1999-12-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.
Biochemistry, 38, 1999
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2IPT | | PFA1 FAB FRAGMENT | | Descriptor: | IgG2a Fab fragment Heavy Chain, IgG2a Fab fragment Light Chain Kappa, ACETAMIDE | | Authors: | Gardberg, A.S., Dealwis, C. | | Deposit date: | 2006-10-12 | | Release date: | 2007-10-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2IPU | | PFA1 FAB FRAGMENT COMPLEXED WITH ABETA 1-8 PEPTIDE | | Descriptor: | IgG2a Fab fragment Heavy Chain, IgG2a Fab fragment Light Chain Kappa, abeta 1-8 peptide, ... | | Authors: | Gardberg, A.S., Dealwis, C. | | Deposit date: | 2006-10-12 | | Release date: | 2007-10-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2IQ9 | | PFA2 FAB FRAGMENT, TRICLINIC APO FORM | | Descriptor: | IgG2a Fab fragment PFA2 Kappa light chain, IgG2a Fab fragment PFA2 heavy chain, ACETAMIDE | | Authors: | Gardberg, A.S., Dealwis, C. | | Deposit date: | 2006-10-13 | | Release date: | 2007-10-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2IQA | | PFA2 FAB FRAGMENT, MONOCLINIC APO FORM | | Descriptor: | IgG2a Fab fragment PFA2 Kappa light chain, IgG2a Fab fragment PFA2 heavy chain, ACETAMIDE, ... | | Authors: | Gardberg, A.S., Dealwis, C. | | Deposit date: | 2006-10-13 | | Release date: | 2007-10-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2R0W | | PFA2 FAB COMPLEXED WITH ABETA1-8 | | Descriptor: | IgG2a Fab fragment light chain, IgG2a Fab fragment heavy chain, Fd portion, ... | | Authors: | Gardberg, A.S., Dealwis, C. | | Deposit date: | 2007-08-21 | | Release date: | 2007-10-16 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.503 Å) | | Cite: | Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2R0Z | | PFA1 FAB COMPLEXED WITH GRIPI PEPTIDE FRAGMENT | | Descriptor: | IgG2a Fab fragment light chain, IgG2a Fab fragment heavy chain, Fd portion, ... | | Authors: | Gardberg, A.S., Dealwis, C. | | Deposit date: | 2007-08-21 | | Release date: | 2007-10-16 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.096 Å) | | Cite: | Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2ZLF | | THE STRUCTURAL BASIS FOR PEPTIDOMIMETIC INHIBITION OF EUKARYOTIC RIBONUCLEOTIDE REDUCTASE | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1, FTLDADF | | Authors: | Xu, H., Fairman, J.W., Wijerathna, S.R., LaMacchia, J., Kreischer, N.R., Helmbrecht, E., Cooperman, B.S., Dealwis, C. | | Deposit date: | 2008-04-09 | | Release date: | 2008-08-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore
J.Med.Chem., 51, 2008
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2ZLG | | THE STRUCTUAL BASIS FOR PEPTIDOMIMETIC INHIBITION OF EUKARYOTIC RIBONUCLEOTIDE REDUCTASE | | Descriptor: | Ribonucleoside-diphosphate reductase large chain 1, (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL | | Authors: | Xu, H., Fairman, J.W., Wijerathna, S.R., LaMacchia, J., Kreischer, N.R., Helmbrecht, E., Cooperman, B.S., Dealwis, C. | | Deposit date: | 2008-04-09 | | Release date: | 2008-08-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore
J.Med.Chem., 51, 2008
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