Author results

2EUD
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I COMPLEXED WITH LIGANDS AND SUBUNIT PEPTIDES
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Dealwis, C., Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J.
Deposit date:2005-10-28
Release date:2006-03-07
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly.
Proc.Natl.Acad.Sci.Usa, 103, 2006
1EPQ
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ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-133,450 (SOT PHE GLY+SCC GCL)
Descriptor:ENDOTHIAPEPSIN, N-[(1R)-2-{[(1R,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]amino}-1-(ethylsulfanyl)-2-oxoethyl]-Nalpha-(morpholin-4-ylsulfonyl)-D-phenylalaninamide, SULFATE ION
Authors:Dealwis, C., Cooper, J.B., Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.
J.Med.Chem., 36, 1993
1PEW
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HIGH RESOLUTION CRYSTAL STRUCTURE OF JTO2, A MUTANT OF THE NON-AMYLOIDOGENIC LAMBA6 LIGHT CHAIN, JTO
Descriptor:Jto2, a LAMBDA-6 TYPE IMMUNOGLOBULIN LIGHT CHAIN, VARIABLE DOMAIN, ...
Authors:Dealwis, C., Gupta, V., Wilkerson, M.
Deposit date:2003-05-22
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four V(lambda)6 proteins
J.Mol.Recog., 17, 2004
1PW3
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CRYSTAL STRUCTURE OF JTOR68S
Descriptor:immunoglobulin lambda chain variable region, CADMIUM ION
Authors:Dealwis, C., Gupta, V., Wilkerson, M.
Deposit date:2003-06-30
Release date:2004-08-17
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four Vlambda6 proteins.
J.Mol.Recog., 17, 2004
1ZYZ
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STRUCTURES OF YEAST RIBONUCLOETIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, GLYCINE
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-13
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
1ZZD
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, Ribonucleoside-diphosphate reductase small chain 2
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-13
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVS
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVT
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVU
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVV
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVW
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVX
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVY
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, 9-per peptide from Ribonucleoside-diphosphate reductase small chain 1, MAGNESIUM ION, ...
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
1C29
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CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC ACID
Descriptor:TRYPTOPHAN SYNTHASE, 4-(2-HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC ACID, SODIUM ION, ...
Authors:Sachpatzidis, A., Dealwis, C., Lubetsky, J.B., Liang, P.H., Anderson, K.S., Lolis, E.
Deposit date:1999-07-23
Release date:2000-01-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.
Biochemistry, 38, 1999
1C8V
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CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXYPHENYLTHIO)-BUTYLPHOSPHONIC ACID
Descriptor:TRYPTOPHAN SYNTHASE; ALPHA CHAIN, TRYPTOPHAN SYNTHASE; BETA CHAIN, 4-(2-HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC ACID, ...
Authors:Sachpatzidis, A., Dealwis, C., Lubetsky, J.B., Liang, P.H., Anderson, K.S., Lolis, E.
Deposit date:1999-07-30
Release date:2000-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.
Biochemistry, 38, 1999
1CW2
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CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXYPHENYLSULFINYL)-BUTYLPHOSPHONIC ACID
Descriptor:TRYPTOPHAN SYNTHASE (ALPHA CHAIN), TRYPTOPHAN SYNTHASE (BETA CHAIN), 4-(2-HYDROXYPHENYLSULFINYL)-BUTYLPHOSPHONIC ACID, ...
Authors:Sachpatzidis, A., Dealwis, C., Lubetsky, J.B., Liang, P.H., Anderson, K.S., Lolis, E.
Deposit date:1999-08-25
Release date:1999-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.
Biochemistry, 38, 1999
1CX9
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CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-AMINOPHENYLTHIO)-BUTYLPHOSPHONIC ACID
Descriptor:TRYPTOPHAN SYNTHASE (ALPHA CHAIN), TRYPTOPHAN SYNTHASE (BETA CHAIN), 4-(2-AMINOPHENYLTHIO)-BUTYLPHOSPHONIC ACID, ...
Authors:Sachpatzidis, A., Dealwis, C., Lubetsky, J.B., Liang, P.H., Anderson, K.S., Lolis, E.
Deposit date:1999-08-29
Release date:1999-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.
Biochemistry, 38, 1999
2IPT
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PFA1 FAB FRAGMENT
Descriptor:IgG2a Fab fragment Heavy Chain, IgG2a Fab fragment Light Chain Kappa, ACETAMIDE
Authors:Gardberg, A.S., Dealwis, C.
Deposit date:2006-10-12
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
2IPU
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PFA1 FAB FRAGMENT COMPLEXED WITH ABETA 1-8 PEPTIDE
Descriptor:IgG2a Fab fragment Heavy Chain, IgG2a Fab fragment Light Chain Kappa, abeta 1-8 peptide, ...
Authors:Gardberg, A.S., Dealwis, C.
Deposit date:2006-10-12
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
2IQ9
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PFA2 FAB FRAGMENT, TRICLINIC APO FORM
Descriptor:IgG2a Fab fragment PFA2 Kappa light chain, IgG2a Fab fragment PFA2 heavy chain, ACETAMIDE
Authors:Gardberg, A.S., Dealwis, C.
Deposit date:2006-10-13
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
2IQA
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PFA2 FAB FRAGMENT, MONOCLINIC APO FORM
Descriptor:IgG2a Fab fragment PFA2 Kappa light chain, IgG2a Fab fragment PFA2 heavy chain, ACETAMIDE, ...
Authors:Gardberg, A.S., Dealwis, C.
Deposit date:2006-10-13
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
2R0W
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PFA2 FAB COMPLEXED WITH ABETA1-8
Descriptor:IgG2a Fab fragment light chain, IgG2a Fab fragment heavy chain, Fd portion, ...
Authors:Gardberg, A.S., Dealwis, C.
Deposit date:2007-08-21
Release date:2007-10-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
2R0Z
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PFA1 FAB COMPLEXED WITH GRIPI PEPTIDE FRAGMENT
Descriptor:IgG2a Fab fragment light chain, IgG2a Fab fragment heavy chain, Fd portion, ...
Authors:Gardberg, A.S., Dealwis, C.
Deposit date:2007-08-21
Release date:2007-10-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
2ZLF
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THE STRUCTURAL BASIS FOR PEPTIDOMIMETIC INHIBITION OF EUKARYOTIC RIBONUCLEOTIDE REDUCTASE
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, FTLDADF
Authors:Xu, H., Fairman, J.W., Wijerathna, S.R., LaMacchia, J., Kreischer, N.R., Helmbrecht, E., Cooperman, B.S., Dealwis, C.
Deposit date:2008-04-09
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore
J.Med.Chem., 51, 2008
2ZLG
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THE STRUCTUAL BASIS FOR PEPTIDOMIMETIC INHIBITION OF EUKARYOTIC RIBONUCLEOTIDE REDUCTASE
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL
Authors:Xu, H., Fairman, J.W., Wijerathna, S.R., LaMacchia, J., Kreischer, N.R., Helmbrecht, E., Cooperman, B.S., Dealwis, C.
Deposit date:2008-04-09
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore
J.Med.Chem., 51, 2008
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