Author results

1NVO
  • Download 1nvo
  • View 1nvo
Molmil generated image of 1nvo
SOLUTION STRUCTURE OF A FOUR-HELIX BUNDLE MODEL, APO-DF1
分子名称:Homodimeric Alpha2 Four-Helix Bundle
著者Maglio, O., Nastri, F., Pavone, V., Lombardi, A., DeGrado, W.F.
登録日2003-02-04
公開日2003-03-25
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Preorganization of molecular binding sites in designed diiron proteins
Proc.Natl.Acad.Sci.USA, 100, 2003
1U7J
  • Download 1u7j
  • View 1u7j
Molmil generated image of 1u7j
SOLUTION STRUCTURE OF A DIIRON PROTEIN MODEL
分子名称:Four-helix bundle model, ZINC ION
著者Maglio, O., Nastri, F., Calhoun, J.R., Lahr, S., Pavone, V., DeGrado, W.F., Lombardi, A.
登録日2004-08-04
公開日2005-03-01
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Analysis and Design of Turns in alpha-Helical Hairpins
J.Mol.Biol., 346, 2005
1U7M
  • Download 1u7m
  • View 1u7m
Molmil generated image of 1u7m
SOLUTION STRUCTURE OF A DIIRON PROTEIN MODEL: DUE FERRI(II) TURN MUTANT
分子名称:Four-helix bundle model, ZINC ION
著者Maglio, O., Nastri, F., Calhoun, J.R., Lahr, S., Pavone, V., DeGrado, W.F., Lombardi, A.
登録日2004-08-04
公開日2005-03-01
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Analysis and Design of Turns in alpha-Helical Hairpins
J.Mol.Biol., 346, 2005
2HZ8
  • Download 2hz8
  • View 2hz8
Molmil generated image of 2hz8
QM/MM STRUCTURE REFINED FROM NMR-STRUCTURE OF A SINGLE CHAIN DIIRON PROTEIN
分子名称:De novo designed diiron protein, ZINC ION
著者Calhoun, J.R., Liu, W., Spiegel, K., Dal Peraro, M., Klein, M.L., Wand, A.J., DeGrado, W.F.
登録日2006-08-08
公開日2007-07-17
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement.
Structure, 16, 2008
1QP6
  • Download 1qp6
  • View 1qp6
Molmil generated image of 1qp6
SOLUTION STRUCTURE OF ALPHA2D
分子名称:PROTEIN (ALPHA2D)
著者Hill, R.B., DeGrado, W.F.
登録日1999-06-01
公開日1999-06-09
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution Structure of Alpha2D, A Nativelike De Novo Designed Protein
J.Am.Chem.Soc., 120, 1998
3AL1
  • Download 3al1
  • View 3al1
Molmil generated image of 3al1
DESIGNED PEPTIDE ALPHA-1, RACEMIC P1BAR FORM
分子名称:PROTEIN (D, L-ALPHA-1), (4S)-2-METHYL-2,4-PENTANEDIOL, ...
著者Patterson, W.R., Anderson, D.H., Degrado, W.F., Cascio, D., Eisenberg, D.
登録日1998-10-26
公開日1998-11-04
最終更新日2012-03-28
実験手法X-RAY DIFFRACTION (0.75 Å)
主引用文献Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1.
Protein Sci., 8, 1999
1AL1
  • Download 1al1
  • View 1al1
Molmil generated image of 1al1
CRYSTAL STRUCTURE OF ALPHA1: IMPLICATIONS FOR PROTEIN DESIGN
分子名称:ALPHA HELIX PEPTIDE: ELLKKLLEELKG, SULFATE ION
著者Hill, C.P., Anderson, D.H., Wesson, L., Degrado, W.F., Eisenberg, D.
登録日1990-07-02
公開日1991-10-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of alpha 1: implications for protein design.
Science, 249, 1990
1COI
  • Download 1coi
  • View 1coi
Molmil generated image of 1coi
DESIGNED TRIMERIC COILED COIL-VALD
分子名称:COIL-VALD, SULFATE ION
著者Ogihara, N.L., Weiss, M.S., Degrado, W.F., Eisenberg, D.
登録日1996-08-10
公開日1997-02-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies.
Protein Sci., 6, 1997
1G6U
  • Download 1g6u
  • View 1g6u
Molmil generated image of 1g6u
CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER
分子名称:DOMAIN SWAPPED DIMER, SULFATE ION, trifluoroacetic acid
著者Ogihara, N.L., Ghirlanda, G., Bryson, J.W., Gingery, M., DeGrado, W.F., Eisenberg, D.
登録日2000-11-07
公開日2001-02-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Design of three-dimensional domain-swapped dimers and fibrous oligomers.
Proc.Natl.Acad.Sci.USA, 98, 2001
1Y47
  • Download 1y47
  • View 1y47
Molmil generated image of 1y47
STRUCTURAL STUDIES OF DESIGNED ALPHA-HELICAL HAIRPINS
分子名称:dueferri (DF2), CADMIUM ION
著者Lahr, S.J., Engel, D.E., Stayrook, S.E., Maglio, O., North, B., Geremia, S., Lombardi, A., DeGrado, W.F.
登録日2004-11-30
公開日2005-03-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Analysis and design of turns in alpha-helical hairpins
J.Mol.Biol., 346, 2005
1YOD
  • Download 1yod
  • View 1yod
Molmil generated image of 1yod
CRYSTAL STRUCTURE OF A WATER SOLUBLE ANALOG OF PHOSPHOLAMBAN
分子名称:water-solublized phospholamban
著者Slovic, A.M., Stayrook, S.E., North, B., DeGrado, W.F.
登録日2005-01-27
公開日2005-04-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray structure of a water-soluble analog of the membrane protein phospholamban: sequence determinants defining the topology of tetrameric and pentameric coiled coils.
J.Mol.Biol., 348, 2005
2A3D
  • Download 2a3d
  • View 2a3d
Molmil generated image of 2a3d
SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D)
分子名称:PROTEIN (DE NOVO THREE-HELIX BUNDLE)
著者Walsh, S.T.R., Cheng, H., Bryson, J.W., Roder, H., Degrado, W.F.
登録日1999-04-01
公開日1999-05-05
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and dynamics of a de novo designed three-helix bundle protein.
Proc.Natl.Acad.Sci.USA, 96, 1999
2KQT
  • Download 2kqt
  • View 2kqt
Molmil generated image of 2kqt
SOLID-STATE NMR STRUCTURE OF THE M2 TRANSMEMBRANE PEPTIDE OF THE INFLUENZA A VIRUS IN DMPC LIPID BILAYERS BOUND TO DEUTERATED AMANTADINE
分子名称:M2 protein, (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine
著者Cady, S.D., Schmidt-Rohr, K., Wang, J., Soto, C.S., DeGrado, W.F., Hong, M.
登録日2009-11-18
公開日2010-02-09
最終更新日2011-10-26
実験手法SOLID-STATE NMR
主引用文献Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers
Nature, 463, 2010
2MUZ
  • Download 2muz
  • View 2muz
Molmil generated image of 2muz
SSNMR STRUCTURE OF A DESIGNED ROCKER PROTEIN
分子名称:designed rocker protein
著者Wang, T., Joh, N., Wu, Y., DeGrado, W.F., Hong, M.
登録日2014-09-18
公開日2014-12-24
最終更新日2015-01-14
実験手法SOLUTION NMR
主引用文献De novo design of a transmembrane Zn2+-transporting four-helix bundle.
Science, 346, 2014
3LBW
  • Download 3lbw
  • View 3lbw
Molmil generated image of 3lbw
HIGH RESOLUTION CRYSTAL STRUCTURE OF TRANSMEMBRANE DOMAIN OF M2
分子名称:M2 protein, 4-bromobenzoic acid, DI(HYDROXYETHYL)ETHER, ...
著者Acharya, R., Polishchuk, A.L., DeGrado, W.F.
登録日2010-01-08
公開日2010-07-28
最終更新日2011-08-10
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.
Proc.Natl.Acad.Sci.USA, 107, 2010
3S0R
  • Download 3s0r
  • View 3s0r
Molmil generated image of 3s0r
CRYSTAL STRUCTURE OF DE NOVO DESIGNED HELICAL ASSEMBLY PROTEIN
分子名称:De novo designed Helical Assembly
著者Acharya, R., Grigoryan, G., Kim, Y.H., DeGrado, W.F.
登録日2011-05-13
公開日2011-06-15
最終更新日2011-08-17
実験手法X-RAY DIFFRACTION (2.453 Å)
主引用文献Computational design of virus-like protein assemblies on carbon nanotube surfaces.
Science, 332, 2011
4JFX
  • Download 4jfx
  • View 4jfx
Molmil generated image of 4jfx
STRUCTURE OF PHOSPHOTYROSINE (PTYR) SCAFFOLD BOUND TO PTYR PEPTIDE
分子名称:Fab light chain, Fab heavy chain, Phosphopeptide, ...
著者Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A.
登録日2013-02-28
公開日2013-09-25
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
4JFY
  • Download 4jfy
  • View 4jfy
Molmil generated image of 4jfy
APO STRUCTURE OF PHOSPHOTYROSINE (PYAB) SCAFFOLD
分子名称:Fab light chain, Fab heavy chain, TETRAETHYLENE GLYCOL
著者Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A.
登録日2013-02-28
公開日2013-08-28
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
4JFZ
  • Download 4jfz
  • View 4jfz
Molmil generated image of 4jfz
STRUCTURE OF PHOSPHOSERINE (PSAB) SCAFFOLD BOUND TO PSER PEPTIDE
分子名称:Fab light chain, Fab heavy chain, Phosphopeptide, ...
著者Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A.
登録日2013-02-28
公開日2013-08-28
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
4JG0
  • Download 4jg0
  • View 4jg0
Molmil generated image of 4jg0
STRUCTURE OF PHOSPHOSERINE/THREONINE (PSTAB) SCAFFOLD BOUND TO PSER PEPTIDE
分子名称:Fab light chain, Fab heavy chain, Phosphopeptide, ...
著者Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A.
登録日2013-02-28
公開日2013-08-28
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
4JG1
  • Download 4jg1
  • View 4jg1
Molmil generated image of 4jg1
STRUCTURE OF PHOSPHOSERINE/THREONINE (PSTAB) SCAFFOLD BOUND TO PTHR PEPTIDE
分子名称:Fab light chain, Fab heavy chain, Phosphopeptide, ...
著者Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A.
登録日2013-02-28
公開日2013-08-28
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
4P6J
  • Download 4p6j
  • View 4p6j
Molmil generated image of 4p6j
CRYSTAL STRUCTURE OF THE COMPUTATIONALLY DESIGNED TRANSMEMBRANE METALLOTRANSPORTER WITH 4-BROMOPHENYLALANINE IN OCTYL GLUCOSIDE
分子名称:Computationally Designed Transporter of Zn(II) and Proton, SULFATE ION
著者Joh, N.H., Acharya, R., DeGrado, W.F.
登録日2014-03-25
公開日2014-12-24
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献De novo design of a transmembrane Zn2+-transporting four-helix bundle.
Science, 346, 2014
4P6K
  • Download 4p6k
  • View 4p6k
Molmil generated image of 4p6k
CRYSTAL STRUCTURE OF THE COMPUTATIONALLY DESIGNED TRANSMEMBRANE METALLOTRANSPORTER WITH 4-BROMOPHENYLALANINE IN LIPIDIC CUBIC PHASE
分子名称:Computationally Designed Transporter of Zn(II) and Proton
著者Joh, N.H., Acharya, R., DeGrado, W.F.
登録日2014-03-25
公開日2014-12-24
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.704 Å)
主引用文献De novo design of a transmembrane Zn2+-transporting four-helix bundle.
Science, 346, 2014
4P6L
  • Download 4p6l
  • View 4p6l
Molmil generated image of 4p6l
CRYSTAL STRUCTURE OF THE COMPUTATIONALLY DESIGNED TRANSMEMBRANE METALLOTRANSPORTER IN OCTYL GLUCOSIDE
分子名称:Computationally Designed Transporter of Zn(II) and proton
著者Joh, N.H., Acharya, R., DeGrado, W.F.
登録日2014-03-25
公開日2014-12-24
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.803 Å)
主引用文献De novo design of a transmembrane Zn2+-transporting four-helix bundle.
Science, 346, 2014
4QKC
  • Download 4qkc
  • View 4qkc
Molmil generated image of 4qkc
INFLUENZA A M2 WILD TYPE TM DOMAIN AT LOW PH IN THE LIPIDIC CUBIC PHASE UNDER CRYO DIFFRACTION CONDITIONS
分子名称:influenza M2 monomer, CALCIUM ION, CHLORIDE ION, ...
著者Thomaston, J.L., DeGrado, W.F.
登録日2014-06-05
公開日2015-11-11
最終更新日2015-12-16
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction.
Proc.Natl.Acad.Sci.USA, 112, 2015