1LCT
 
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1WSX
 | | Solution structure of MCL-1 | | Descriptor: | myeloid cell leukemia sequence 1 | | Authors: | Day, C.L, Chen, L, Richardson, S.J, Harrison, P.J, Huang, D.C, Hinds, M.G. | | Deposit date: | 2004-11-12 | | Release date: | 2004-11-23 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
J.Biol.Chem., 280, 2005
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1RE6
 | | Localisation of Dynein Light Chains 1 and 2 and their Pro-apoptotic Ligands | | Descriptor: | dynein light chain 2 | | Authors: | Day, C.L, Puthalakath, H, Skea, G, Strasser, A, Barsukov, I, Lian, L.Y, Huang, D.C, Hinds, M.G. | | Deposit date: | 2003-11-06 | | Release date: | 2004-03-23 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.
Biochem.J., 377, 2004
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1CWW
 | | SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1 | | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1 | | Authors: | Day, C.L, Dupont, C, Lackmann, M, Vaux, D.L, Hinds, M.G. | | Deposit date: | 1999-08-26 | | Release date: | 2000-01-21 | | Last modified: | 2022-12-21 | | Method: | SOLUTION NMR | | Cite: | Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.
Cell Death Differ., 6, 1999
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1DEB
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2ROD
 | | Solution Structure of MCL-1 Complexed with NoxaA | | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa | | Authors: | Day, C.L, Smits, C, Fan, F.C, Lee, E.F, Fairlie, W.D, Hinds, M.G. | | Deposit date: | 2008-03-17 | | Release date: | 2008-07-08 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
J.Mol.Biol., 380, 2008
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2ROC
 | | Solution structure of Mcl-1 Complexed with Puma | | Descriptor: | Bcl-2-binding component 3, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog | | Authors: | Day, C.L, Smits, C, Fan, F.C, Lee, E.F, Fairlie, W.D, Hinds, M.G. | | Deposit date: | 2008-03-17 | | Release date: | 2008-07-08 | | Last modified: | 2021-11-10 | | Method: | SOLUTION NMR | | Cite: | Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
J.Mol.Biol., 380, 2008
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2L9M
 | | Structure of cIAP1 CARD | | Descriptor: | Baculoviral IAP repeat-containing protein 2 | | Authors: | Day, C.L, Rautureau, G.J.P, Hinds, M.G. | | Deposit date: | 2011-02-21 | | Release date: | 2011-08-17 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration.
Mol.Cell, 42, 2011
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8GBQ
 | | Structure of RNF125 in complex with UbcH5b | | Descriptor: | E3 ubiquitin-protein ligase RNF125, GLYCEROL, Ubiquitin-conjugating enzyme E2 D2, ... | | Authors: | Middleton, A.J, Day, C.L, Fokkens, T.J. | | Deposit date: | 2023-02-27 | | Release date: | 2023-07-19 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation.
Structure, 31, 2023
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8GCB
 | | Structure of RNF125 in complex with a UbcH5b~Ub conjugate | | Descriptor: | E3 ubiquitin-protein ligase RNF125, Ubiquitin-conjugating enzyme E2 D2, ZINC ION | | Authors: | Middleton, A.J, Day, C.L, Fokkens, T.J. | | Deposit date: | 2023-03-01 | | Release date: | 2023-07-19 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation.
Structure, 31, 2023
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1VFE
 | | HUMAN LACTOFERRIN, N-TERMINAL LOBE MUTANT WITH ARG 121 REPLACED BY SER (R121S) | | Descriptor: | CARBONATE ION, FE (III) ION, HUMAN LACTOFERRIN | | Authors: | Faber, H.R, Day, C.L, Baker, E.N. | | Deposit date: | 1996-10-01 | | Release date: | 1997-04-01 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants.
Biochemistry, 35, 1996
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1VFD
 | | HUMAN LACTOFERRIN, N-TERMINAL LOBE MUTANT WITH ARG 121 REPLACED BY GLU (R121E) | | Descriptor: | CARBONATE ION, FE (III) ION, LACTOFERRIN | | Authors: | Faber, H.R, Day, C.L, Baker, E.N. | | Deposit date: | 1996-10-01 | | Release date: | 1997-04-21 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants.
Biochemistry, 35, 1996
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7L3L
 | | Structure of TRAF5 and TRAF6 RING Hetero dimer | | Descriptor: | TNF receptor-associated factor 5, TNF receptor-associated factor 6, ZINC ION | | Authors: | Das, A, Middleton, A.J, Padala, P, Day, C.L. | | Deposit date: | 2020-12-17 | | Release date: | 2021-02-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The structure and ubiquitin binding properties of TRAF RING heterodimers.
J.Mol.Biol., 2021
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7R71
 | | Crystal Structure of the UbArk2C-UbcH5b~Ub complex | | Descriptor: | Ubiquitin, Ubiquitin,E3 ubiquitin-protein ligase RNF165, Ubiquitin-conjugating enzyme E2 D2, ... | | Authors: | Paluda, A, Middleton, A.J, Mace, P.D, Day, C.L. | | Deposit date: | 2021-06-24 | | Release date: | 2022-03-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C.
Nat Commun, 13, 2022
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7R70
 | | Crystal Structure of the UbArk2C fusion protein | | Descriptor: | GLYCEROL, Ubiquitin,E3 ubiquitin-protein ligase RNF165, ZINC ION | | Authors: | Paluda, A, Middleton, A.J, Mace, P.D, Day, C.L. | | Deposit date: | 2021-06-24 | | Release date: | 2022-03-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.499 Å) | | Cite: | Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C.
Nat Commun, 13, 2022
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4IC2
 | | Crystal structure of the XIAP RING domain | | Descriptor: | E3 ubiquitin-protein ligase XIAP, NICKEL (II) ION, ZINC ION | | Authors: | Linke, K, Nakatani, Y, Day, C.L. | | Deposit date: | 2012-12-09 | | Release date: | 2012-12-19 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase
Biochem.J., 450, 2013
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4IC3
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3EB6
 | | Structure of the cIAP2 RING domain bound to UbcH5b | | Descriptor: | Baculoviral IAP repeat-containing protein 3, Ubiquitin-conjugating enzyme E2 D2, ZINC ION | | Authors: | Mace, P.D, Linke, K, Schumacher, F.-R, Smith, C.A, Day, C.L. | | Deposit date: | 2008-08-27 | | Release date: | 2008-09-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment.
J.Biol.Chem., 283, 2008
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3EB5
 | | Structure of the cIAP2 RING domain | | Descriptor: | Baculoviral IAP repeat-containing protein 3, SODIUM ION, ZINC ION | | Authors: | Mace, P.D, Linke, K, Smith, C.A, Day, C.L. | | Deposit date: | 2008-08-27 | | Release date: | 2008-09-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment.
J.Biol.Chem., 283, 2008
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1O0L
 | | THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY | | Descriptor: | Apoptosis regulator Bcl-W | | Authors: | Hinds, M.G, Lackmann, M, Skea, G.L, Harrison, P.J, Huang, D.C.S, Day, C.L. | | Deposit date: | 2003-02-22 | | Release date: | 2003-04-01 | | Last modified: | 2021-10-27 | | Method: | SOLUTION NMR | | Cite: | The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity
Embo J., 22, 2003
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1QBH
 | | SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT | | Descriptor: | INHIBITOR OF APOPTOSIS PROTEIN (2MIHB/C-IAP-1), ZINC ION | | Authors: | Hinds, M.G, Norton, R.S, Vaux, D.L, Day, C.L. | | Deposit date: | 1999-04-20 | | Release date: | 1999-10-20 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.
Nat.Struct.Biol., 6, 1999
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2JM6
 | | Solution structure of MCL-1 complexed with NOXAB | | Descriptor: | Myeloid cell leukemia-1 protein Mcl-1 homolog, Noxa | | Authors: | Czabotar, P.E, Lee, E.F, van Delft, M.F, Day, C.L, Smith, B.J, Huang, D.C.S, Fairlie, W.D, Hinds, M.G, Colman, P.M. | | Deposit date: | 2006-10-17 | | Release date: | 2007-03-20 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | Structural insights into the degradation of Mcl-1 induced by BH3 domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2KMF
 | | Solution Structure of Psb27 from cyanobacterial photosystem II | | Descriptor: | Photosystem II 11 kDa protein | | Authors: | Mabbitt, P.D, Rautureau, G.J.P, Day, C.L, Wilbanks, S.M, Eaton-Rye, J.J, Hinds, M.G. | | Deposit date: | 2009-07-28 | | Release date: | 2009-09-08 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of Psb27 from cyanobacterial photosystem II
Biochemistry, 48, 2009
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2KUA
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3M1D
 | | Structure of BIR1 from cIAP1 | | Descriptor: | Baculoviral IAP repeat-containing protein 2, ZINC ION | | Authors: | Mace, P.D, Day, C.L. | | Deposit date: | 2010-03-04 | | Release date: | 2010-05-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Asymmetric recruitment of cIAPs by TRAF2
J.Mol.Biol., 400, 2010
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