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2Z2S
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BU of 2z2s by Molmil
Crystal Structure of Rhodobacter sphaeroides SigE in complex with the anti-sigma ChrR
Descriptor: Anti-Sigma factor ChrR, transcriptional activator ChrR, RpoE, ...
Authors:Darst, S.A, Campbell, E.A.
Deposit date:2007-05-26
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.
Mol.Cell, 27, 2007
1GRJ
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BU of 1grj by Molmil
GREA TRANSCRIPT CLEAVAGE FACTOR FROM ESCHERICHIA COLI
Descriptor: GREA PROTEIN
Authors:Darst, S.A, Stebbins, C.E.
Deposit date:1995-05-02
Release date:1995-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the GreA transcript cleavage factor from Escherichia coli.
Nature, 373, 1995
3BMB
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BU of 3bmb by Molmil
Crystal structure of a new RNA polymerase interacting protein
Descriptor: CHLORIDE ION, Regulator of nucleoside diphosphate kinase, SULFATE ION
Authors:Darst, S.A, Lamour, V.
Deposit date:2007-12-12
Release date:2008-10-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of Escherichia coli Rnk, a new RNA polymerase-interacting protein.
J.Mol.Biol., 383, 2008
6C06
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BU of 6c06 by Molmil
Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C05
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BU of 6c05 by Molmil
Mycobacterium tuberculosis RNAP Holo/RbpA in relaxed state
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C04
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BU of 6c04 by Molmil
Mtb RNAP Holo/RbpA/double fork DNA -closed clamp
Descriptor: DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6M7J
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BU of 6m7j by Molmil
Mycobacterium tuberculosis RNAP with RbpA/us fork and Corallopyronin
Descriptor: DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J.
Deposit date:2018-08-20
Release date:2018-11-21
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
5TJG
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BU of 5tjg by Molmil
Thermus aquaticus delta1.1-sigmaA holoenzyme/downstream-fork promoter complex with an open clamp
Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*A)-3'), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Darst, S.A, Bae, B.
Deposit date:2016-10-04
Release date:2017-06-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:RNA polymerase motions during promoter melting.
Science, 356, 2017
4G8X
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BU of 4g8x by Molmil
G1 ORF67 / Staphyloccus aureus sigmaA domain 4 complex
Descriptor: ORF067, RNA polymerase sigma factor rpoD
Authors:Darst, S.A, Osmundson, J.S, Montero-Diaz, C.M, Hochschild, A.
Deposit date:2012-07-23
Release date:2013-08-07
Method:X-RAY DIFFRACTION (3.001 Å)
Cite:Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein.
Cell(Cambridge,Mass.), 151, 2012
4G6D
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BU of 4g6d by Molmil
G1 ORF67 / Staphyloccus aureus sigmaA domain 4 complex
Descriptor: ORF067, RNA polymerase sigma factor rpoD
Authors:Darst, S.A, Osmundson, J.S.
Deposit date:2012-07-18
Release date:2013-01-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9971 Å)
Cite:Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein.
Cell(Cambridge,Mass.), 151, 2012
4G94
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BU of 4g94 by Molmil
G1 ORF67 / Staphyloccus aureus sigmaA domain 4 complex
Descriptor: ORF067, RNA polymerase sigma factor rpoD
Authors:Darst, S.A, Osmundson, J.S, Montero-Diaz, C.M, Hochschild, A.
Deposit date:2012-07-23
Release date:2013-01-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9971 Å)
Cite:Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein.
Cell(Cambridge,Mass.), 151, 2012
5UI5
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BU of 5ui5 by Molmil
Crystal structure of Aquifex aeolicus sigmaN bound to promoter DNA
Descriptor: DNA (30-MER), DNA (31-MER), RNA polymerase sigma factor RpoN
Authors:Darst, S.A, Campbell, E.A, Rajashankar, K.
Deposit date:2017-01-12
Release date:2017-02-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of Aquifex aeolicus sigma (N) bound to promoter DNA and the structure of sigma (N)-holoenzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UI8
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BU of 5ui8 by Molmil
structure of sigmaN-holoenzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A, Campbell, E.A.
Deposit date:2017-01-13
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.76 Å)
Cite:Crystal structure of Aquifex aeolicus sigma (N) bound to promoter DNA and the structure of sigma (N)-holoenzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VI5
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BU of 5vi5 by Molmil
Structure of Mycobacterium smegmatis transcription initiation complex with a full transcription bubble
Descriptor: 1,2-ETHANEDIOL, DNA (44-MER), DNA (49-MER), ...
Authors:Darst, S.A, Campbell, E.A, Lilic, M.
Deposit date:2017-04-14
Release date:2017-07-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.196 Å)
Cite:Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Nat Commun, 8, 2017
6BZO
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BU of 6bzo by Molmil
Mtb RNAP Holo/RbpA/Fidaxomicin/upstream fork DNA
Descriptor: DNA (26-MER), DNA (32-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J.
Deposit date:2017-12-25
Release date:2018-03-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6EEC
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BU of 6eec by Molmil
Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter captured by Corallopyronin
Descriptor: DNA (63-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J.
Deposit date:2018-08-13
Release date:2018-11-21
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6EDT
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BU of 6edt by Molmil
Mycobacterium tuberculosis RNAP open promoter complex with RbpA/CarD and AP3 promoter
Descriptor: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J.
Deposit date:2018-08-10
Release date:2018-11-21
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6EE8
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BU of 6ee8 by Molmil
Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter
Descriptor: DNA (60-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J.
Deposit date:2018-08-13
Release date:2018-11-21
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
3LTI
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BU of 3lti by Molmil
Crystal structure of the Escherichia coli RNA polymerase beta subunit beta2-betai4 domains
Descriptor: DNA-directed RNA polymerase subunit beta
Authors:Darst, S.A, Opalka, N.
Deposit date:2010-02-16
Release date:2010-10-20
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Complete structural model of Escherichia coli RNA polymerase from a hybrid approach.
Plos Biol., 8, 2010
3LU0
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BU of 3lu0 by Molmil
Molecular model of Escherichia coli core RNA polymerase
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A.
Deposit date:2010-02-16
Release date:2010-09-29
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (11.2 Å)
Cite:Complete structural model of Escherichia coli RNA polymerase from a hybrid approach.
Plos Biol., 8, 2010
3MLQ
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BU of 3mlq by Molmil
Crystal structure of the Thermus thermophilus transcription-repair coupling factor RNA polymerase interacting domain with the Thermus aquaticus RNA polymerase beta1 domain
Descriptor: DNA-directed RNA polymerase subunit beta, PHOSPHATE ION, Transcription-repair coupling factor
Authors:Darst, S.A, Westblade, L.F, Campbell, E.A.
Deposit date:2010-04-18
Release date:2010-10-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction.
Nucleic Acids Res., 38, 2010
1BDF
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BU of 1bdf by Molmil
STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE ALPHA SUBUNIT N-TERMINAL DOMAIN
Descriptor: RNA POLYMERASE ALPHA SUBUNIT
Authors:Zhang, G, Darst, S.A.
Deposit date:1998-05-08
Release date:1999-05-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Escherichia coli RNA polymerase alpha subunit amino-terminal domain.
Science, 281, 1998
3GFK
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BU of 3gfk by Molmil
Crystal structure of Bacillus subtilis Spx/RNA polymerase alpha subunit C-terminal domain complex
Descriptor: DNA-directed RNA polymerase subunit alpha, Regulatory protein spx
Authors:Lamour, V, Westblade, L.F, Campbell, E.A, Darst, S.A.
Deposit date:2009-02-27
Release date:2009-03-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the in vivo-assembled Bacillus subtilis Spx/RNA polymerase alpha subunit C-terminal domain complex
J.Struct.Biol., 168, 2009
8SQ9
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BU of 8sq9 by Molmil
SARS-CoV-2 replication-transcription complex bound to nsp9 and UMPCPP, as a pre-catalytic NMPylation intermediate
Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]uridine, MAGNESIUM ION, Non-structural protein 7, ...
Authors:Small, G.I, Darst, S.A, Campbell, E.A.
Deposit date:2023-05-04
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain.
Mol.Cell, 83, 2023
8SQK
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BU of 8sqk by Molmil
SARS-CoV-2 replication-transcription complex bound to RNA-nsp9 and GDP-betaS, as a pre-catalytic deRNAylation/mRNA capping intermediate
Descriptor: 5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine, MAGNESIUM ION, Non-structural protein 7, ...
Authors:Small, G.I, Darst, S.A, Campbell, E.A.
Deposit date:2023-05-04
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain.
Mol.Cell, 83, 2023

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