Author results

1GRJ
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GREA TRANSCRIPT CLEAVAGE FACTOR FROM ESCHERICHIA COLI
Descriptor:GREA PROTEIN
Authors:Darst, S.A., Stebbins, C.E.
Deposit date:1995-05-02
Release date:1995-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the GreA transcript cleavage factor from Escherichia coli.
Nature, 373, 1995
6C04
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MTB RNAP HOLO/RBPA/DOUBLE FORK DNA -CLOSED CLAMP
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C05
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MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA IN RELAXED STATE
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C06
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MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA/FIDAXOMICIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
2Z2S
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CRYSTAL STRUCTURE OF RHODOBACTER SPHAEROIDES SIGE IN COMPLEX WITH THE ANTI-SIGMA CHRR
Descriptor:RpoE, ECF SigE, Anti-Sigma factor ChrR, ...
Authors:Darst, S.A., Campbell, E.A.
Deposit date:2007-05-26
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.
Mol.Cell, 27, 2007
3BMB
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CRYSTAL STRUCTURE OF A NEW RNA POLYMERASE INTERACTING PROTEIN
Descriptor:Regulator of nucleoside diphosphate kinase, SULFATE ION, CHLORIDE ION
Authors:Darst, S.A., Lamour, V.
Deposit date:2007-12-12
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of Escherichia coli Rnk, a new RNA polymerase-interacting protein.
J.Mol.Biol., 383, 2008
3LTI
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CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI RNA POLYMERASE BETA SUBUNIT BETA2-BETAI4 DOMAINS
Descriptor:DNA-directed RNA polymerase subunit beta
Authors:Darst, S.A., Opalka, N.
Deposit date:2010-02-16
Release date:2010-10-20
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Complete structural model of Escherichia coli RNA polymerase from a hybrid approach.
Plos Biol., 8, 2010
3LU0
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MOLECULAR MODEL OF ESCHERICHIA COLI CORE RNA POLYMERASE
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A.
Deposit date:2010-02-16
Release date:2010-09-29
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (11.2 Å)
Cite:Complete structural model of Escherichia coli RNA polymerase from a hybrid approach.
Plos Biol., 8, 2010
3MLQ
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS TRANSCRIPTION-REPAIR COUPLING FACTOR RNA POLYMERASE INTERACTING DOMAIN WITH THE THERMUS AQUATICUS RNA POLYMERASE BETA1 DOMAIN
Descriptor:DNA-directed RNA polymerase subunit beta, Transcription-repair coupling factor, PHOSPHATE ION
Authors:Darst, S.A., Westblade, L.F., Campbell, E.A.
Deposit date:2010-04-18
Release date:2010-10-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction.
Nucleic Acids Res., 38, 2010
4G6D
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G1 ORF67 / STAPHYLOCCUS AUREUS SIGMAA DOMAIN 4 COMPLEX
Descriptor:RNA polymerase sigma factor rpoD, ORF067
Authors:Darst, S.A., Osmundson, J.S.
Deposit date:2012-07-18
Release date:2013-01-23
Method:X-RAY DIFFRACTION (1.9971 Å)
Cite:Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein.
Cell(Cambridge,Mass.), 151, 2012
4G8X
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G1 ORF67 / STAPHYLOCCUS AUREUS SIGMAA DOMAIN 4 COMPLEX
Descriptor:RNA polymerase sigma factor rpoD, ORF067
Authors:Darst, S.A., Osmundson, J.S., Montero-Diaz, C.M., Hochschild, A.
Deposit date:2012-07-23
Release date:2013-08-07
Method:X-RAY DIFFRACTION (3.001 Å)
Cite:Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein.
Cell(Cambridge,Mass.), 151, 2012
4G94
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G1 ORF67 / STAPHYLOCCUS AUREUS SIGMAA DOMAIN 4 COMPLEX
Descriptor:RNA polymerase sigma factor rpoD, ORF067
Authors:Darst, S.A., Osmundson, J.S., Montero-Diaz, C.M., Hochschild, A.
Deposit date:2012-07-23
Release date:2013-01-23
Method:X-RAY DIFFRACTION (1.9971 Å)
Cite:Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein.
Cell(Cambridge,Mass.), 151, 2012
5TJG
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THERMUS AQUATICUS DELTA1.1-SIGMAA HOLOENZYME/DOWNSTREAM-FORK PROMOTER COMPLEX WITH AN OPEN CLAMP
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Bae, B.
Deposit date:2016-10-04
Release date:2017-06-21
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:RNA polymerase motions during promoter melting.
Science, 356, 2017
5UI5
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CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS SIGMAN BOUND TO PROMOTER DNA
Descriptor:DNA (31-MER), DNA (30-MER), RNA polymerase sigma factor RpoN
Authors:Darst, S.A., Campbell, E.A., Rajashankar, K.
Deposit date:2017-01-12
Release date:2017-02-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of Aquifex aeolicus sigma (N) bound to promoter DNA and the structure of sigma (N)-holoenzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UI8
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STRUCTURE OF SIGMAN-HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A.
Deposit date:2017-01-13
Release date:2017-02-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.76 Å)
Cite:Crystal structure of Aquifex aeolicus sigma (N) bound to promoter DNA and the structure of sigma (N)-holoenzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VI5
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STRUCTURE OF MYCOBACTERIUM SMEGMATIS TRANSCRIPTION INITIATION COMPLEX WITH A FULL TRANSCRIPTION BUBBLE
Descriptor:DNA (49-MER), DNA (44-MER), RNA (5'-R(*UP*CP*GP*A)-3'), ...
Authors:Darst, S.A., Campbell, E.A., Lilic, M.
Deposit date:2017-04-14
Release date:2017-07-26
Method:X-RAY DIFFRACTION (3.196 Å)
Cite:Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Nat Commun, 8, 2017
6BZO
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MTB RNAP HOLO/RBPA/FIDAXOMICIN/UPSTREAM FORK DNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2017-12-25
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6EDT
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MYCOBACTERIUM TUBERCULOSIS RNAP OPEN PROMOTER COMPLEX WITH RBPA/CARD AND AP3 PROMOTER
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-10
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6EE8
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MYCOBACTERIUM TUBERCULOSIS RNAP PROMOTER UNWINDING INTERMEDIATE COMPLEX WITH RBPA/CARD AND AP3 PROMOTER
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-13
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6EEC
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MYCOBACTERIUM TUBERCULOSIS RNAP PROMOTER UNWINDING INTERMEDIATE COMPLEX WITH RBPA/CARD AND AP3 PROMOTER CAPTURED BY CORALLOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-13
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6M7J
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MYCOBACTERIUM TUBERCULOSIS RNAP WITH RBPA/US FORK AND CORALLOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-20
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
1SIG
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CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE
Descriptor:RNA POLYMERASE PRIMARY SIGMA FACTOR
Authors:Malhotra, A., Severinova, E., Darst, S.A.
Deposit date:1997-02-18
Release date:1997-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.
Cell(Cambridge,Mass.), 87, 1996
1YNN
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TAQ RNA POLYMERASE-RIFAMPICIN COMPLEX
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A., Pavlova, O., Zenkin, N., Leon, F., Irschik, H., Jansen, R., Severinov, K., Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
1BDF
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STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE ALPHA SUBUNIT N-TERMINAL DOMAIN
Descriptor:RNA POLYMERASE ALPHA SUBUNIT
Authors:Zhang, G., Darst, S.A.
Deposit date:1998-05-08
Release date:1999-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Escherichia coli RNA polymerase alpha subunit amino-terminal domain.
Science, 281, 1998
1HQM
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CRYSTAL STRUCTURE OF THERMUS AQUATICUS CORE RNA POLYMERASE-INCLUDES COMPLETE STRUCTURE WITH SIDE-CHAINS (EXCEPT FOR DISORDERED REGIONS)-FURTHER REFINED FROM ORIGINAL DEPOSITION-CONTAINS ADDITIONAL SEQUENCE INFORMATION
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Minakhin, L., Bhagat, S., Brunning, A., Campbell, E.A., Darst, S.A., Ebright, R.H., Severinov, K.
Deposit date:2000-12-18
Release date:2001-02-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.
Proc.Natl.Acad.Sci.USA, 98, 2001
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