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2QBZ
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BU of 2qbz by Molmil
Structure of the M-Box Riboswitch Aptamer Domain
Descriptor: M-Box RNA, ykoK riboswitch aptamer, MAGNESIUM ION, ...
Authors:Dann III, C.E, Winkler, W.C.
Deposit date:2007-06-18
Release date:2007-09-18
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and mechanism of a metal-sensing regulatory RNA
Cell(Cambridge,Mass.), 130, 2007
1IJX
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BU of 1ijx by Molmil
CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF SECRETED FRIZZLED-RELATED PROTEIN 3 (SFRP-3;FZB)
Descriptor: SECRETED FRIZZLED-RELATED SEQUENCE PROTEIN 3, SULFATE ION
Authors:Dann III, C.E, Hsieh, J.C, Rattner, A, Sharma, D, Nathans, J, Leahy, D.J.
Deposit date:2001-04-30
Release date:2001-07-11
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Nature, 412, 2001
1IJY
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BU of 1ijy by Molmil
CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF MOUSE FRIZZLED 8 (MFZ8)
Descriptor: FRIZZLED HOMOLOG 8
Authors:Dann III, C.E, Hsieh, J.C, Rattner, A, Sharma, D, Nathans, J, Leahy, D.J.
Deposit date:2001-05-01
Release date:2001-07-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Nature, 412, 2001
1MZF
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BU of 1mzf by Molmil
Human Factor inhibiting HIF (FIH1) in Complex with 2-oxoglutarate
Descriptor: 2-OXOGLUTARIC ACID, FE (II) ION, factor inhibiting HIF1
Authors:Dann III, C.E, Bruick, R.K, Deisenhofer, J.
Deposit date:2002-10-07
Release date:2002-11-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor 1: An Asparaginyl Hydroxylase Involved in the Hypoxic Response Pathway.
Proc.Natl.Acad.Sci.USA, 99, 2002
1MZE
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BU of 1mze by Molmil
Human Factor Inhibiting HIF (FIH1)
Descriptor: D(-)-TARTARIC ACID, FE (II) ION, factor inhibiting HIF1
Authors:Dann III, C.E, Bruick, R.K, Deisenhofer, J.
Deposit date:2002-10-07
Release date:2002-11-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor 1: An Asparaginyl Hydroxylase Involved in the Hypoxic Response Pathway
Proc.Natl.Acad.Sci.USA, 99, 2002
1SZH
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BU of 1szh by Molmil
Crystal Structure of C. elegans HER-1
Descriptor: ACETATE ION, Her-1 protein
Authors:Hamaoka, B.Y, Dann III, C.E, Geisbrecht, B.V, Leahy, D.J.
Deposit date:2004-04-05
Release date:2004-08-10
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A.
Proc.Natl.Acad.Sci.USA, 101, 2004
3HD4
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BU of 3hd4 by Molmil
MHV Nucleocapsid Protein NTD
Descriptor: Nucleoprotein
Authors:Giedroc, D.P, Keane, S.C, Dann III, C.E.
Deposit date:2009-05-06
Release date:2009-11-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.747 Å)
Cite:Coronavirus N Protein N-Terminal Domain (NTD) Specifically Binds the Transcriptional Regulatory Sequence (TRS) and Melts TRS-cTRS RNA Duplexes.
J.Mol.Biol., 394, 2009
4HEH
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BU of 4heh by Molmil
Crystal structure of AppA SCHIC domain from Rb. sphaeroides
Descriptor: AppA protein
Authors:Dragnea, V, Yin, L, Dann III, C.E, Bauer, C.E.
Deposit date:2012-10-03
Release date:2013-09-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Redox and light control the heme-sensing activity of AppA.
MBio, 4, 2013
7JG4
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BU of 7jg4 by Molmil
Human GAR transformylase in complex with GAR substrate and AGF131 inhibitor
Descriptor: GLYCINAMIDE RIBONUCLEOTIDE, N-(5-{3-[(1S,7R,8R,9S)-4-amino-2-oxo-7lambda~4~-thia-3,5-diazatetracyclo[4.3.0.0~1,7~.0~7,9~]nona-3,5-dien-8-yl]propyl}thiophene-2-carbonyl)-L-glutamic acid, SODIUM ION, ...
Authors:Wong-Roushar, J, Dann III, C.E.
Deposit date:2020-07-18
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.455 Å)
Cite:Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors
Bioorg.Med.Chem., 37, 2021
8T4P
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BU of 8t4p by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and di-glutamate AGF347 inhibitor
Descriptor: N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-gamma-glutamyl-L-glutamic acid, Serine hydroxymethyltransferase, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-06-09
Release date:2024-02-21
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
8T4O
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BU of 8t4o by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF347 inhibitor with no glutamate
Descriptor: 4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoic acid, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], Serine hydroxymethyltransferase, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-06-09
Release date:2024-02-21
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
8TLC
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BU of 8tlc by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and tri-glutamate AGF347 inhibitor
Descriptor: N-{4-[4-(2-amino-4-oxo-1,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-D-gamma-glutamyl-L-gamma-glutamyl-D-glutamic acid, Serine hydroxymethyltransferase, mitochondrial
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-07-26
Release date:2024-02-21
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
8GKT
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BU of 8gkt by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF320 inhibitor
Descriptor: N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-{5-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]thiophene-2-carbonyl}-L-glutamic acid, Serine hydroxymethyltransferase, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-03-20
Release date:2024-03-20
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
8GKZ
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BU of 8gkz by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) Y105F in complex with PLP, glycine and AGF362 inhibitor
Descriptor: GLYCINE, N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-03-20
Release date:2024-03-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
8GKS
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BU of 8gks by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF291 inhibitor
Descriptor: GLYCINE, N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]benzoyl}-L-glutamic acid, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-03-20
Release date:2024-03-20
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
8GKU
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BU of 8gku by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF355 inhibitor
Descriptor: GLYCINE, N-{4-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]-2-fluorobenzoyl}-D-glutamic acid, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-03-20
Release date:2024-03-20
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
8GKW
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BU of 8gkw by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF359 inhibitor
Descriptor: GLYCINE, N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]-2-fluorobenzoyl}-L-glutamic acid, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-03-20
Release date:2024-03-20
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
8GKY
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BU of 8gky by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) Y105F in complex with PLP, glycine and AGF359 inhibitor
Descriptor: GLYCINE, N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]-2-fluorobenzoyl}-L-glutamic acid, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-03-20
Release date:2024-03-20
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
8FJW
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BU of 8fjw by Molmil
Human GAR transformylase in complex with GAR substrate and AGF347 inhibitor
Descriptor: GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3
Authors:Wong-Roushar, J, Dann III, C.E.
Deposit date:2022-12-20
Release date:2023-09-06
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.
J.Med.Chem., 66, 2023
8FJV
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BU of 8fjv by Molmil
Human GAR transformylase in complex with GAR substrate and AGF362 inhibitor
Descriptor: GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3
Authors:Wong-Roushar, J, Dann III, C.E.
Deposit date:2022-12-20
Release date:2023-09-06
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.
J.Med.Chem., 66, 2023
8FJT
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BU of 8fjt by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF362 inhibitor
Descriptor: GLYCINE, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2022-12-20
Release date:2023-09-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.
J.Med.Chem., 66, 2023
8FJU
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BU of 8fju by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF347 inhibitor
Descriptor: N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-glutamic acid, Serine hydroxymethyltransferase, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2022-12-20
Release date:2023-09-06
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.
J.Med.Chem., 66, 2023
8FJX
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BU of 8fjx by Molmil
Human GAR transformylase in complex with GAR substrate and AGF320 inhibitor
Descriptor: GLYCINAMIDE RIBONUCLEOTIDE, N-{5-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]thiophene-2-carbonyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3
Authors:Wong-Roushar, J, Dann III, C.E.
Deposit date:2022-12-20
Release date:2023-09-06
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.
J.Med.Chem., 66, 2023
8FJY
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BU of 8fjy by Molmil
Human GAR transformylase in complex with GAR substrate and AGF291 inhibitor
Descriptor: GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]benzoyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3
Authors:Wong-Roushar, J, Dann III, C.E.
Deposit date:2022-12-20
Release date:2023-09-06
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.
J.Med.Chem., 66, 2023
3TGN
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BU of 3tgn by Molmil
Crystal Structure of the zinc-dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-bound State
Descriptor: Adc operon repressor AdcR, ZINC ION
Authors:Guerra, A.J, Dann III, C.E, Giedroc, D.P.
Deposit date:2011-08-17
Release date:2011-11-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Zinc-Dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-Bound State.
J.Am.Chem.Soc., 133, 2011

 

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