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2QL1
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BU of 2ql1 by Molmil
Structural Characterization of a Mutated, ADCC-Enhanced Human Fc Fragment
Descriptor: IGHM protein, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Oganesyan, V, Wu, H, Dall'Acqua, W.F.
Deposit date:2007-07-12
Release date:2008-04-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.534 Å)
Cite:Structural characterization of a mutated, ADCC-enhanced human Fc fragment
Mol.Immunol., 45, 2008
5HVW
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BU of 5hvw by Molmil
Monomeric IgG4 Fc
Descriptor: GLYCEROL, Ig gamma-4 chain C region, ZINC ION, ...
Authors:Oganesyan, V.Y, Shan, L, Dall'Acqua, W.F.
Deposit date:2016-01-28
Release date:2016-08-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Generation and Characterization of an IgG4 Monomeric Fc Platform.
Plos One, 11, 2016
3SKJ
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BU of 3skj by Molmil
Structural And Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody
Descriptor: Antibody, heavy chain, light chain, ...
Authors:Oganesyan, V.Y, Wu, H, Dall'Acqua, W.F.
Deposit date:2011-06-22
Release date:2011-08-31
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody.
J.Mol.Biol., 413, 2011
3C2S
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BU of 3c2s by Molmil
Structural Characterization of a Human Fc Fragment Engineered for Lack of Effector Functions
Descriptor: IGHM protein, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Oganesyan, V, Wu, H, Dall'Acqua, W.F.
Deposit date:2008-01-25
Release date:2008-08-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural characterization of a human Fc fragment engineered for lack of effector functions.
Acta Crystallogr.,Sect.D, 64, 2008
3FJT
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BU of 3fjt by Molmil
Crystal structure of a human Fc fragment engineered for extended serum half-life
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region
Authors:Oganesyan, V, Wu, H, Dall'Acqua, W.F.
Deposit date:2008-12-15
Release date:2009-03-24
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural characterization of a human Fc fragment engineered for extended serum half-life.
Mol.Immunol., 46, 2009
6WOL
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BU of 6wol by Molmil
Next generation monomeric IgG4 Fc bound to neonatal Fc receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, IgG receptor FcRn large subunit p51, ...
Authors:Oganesyan, V.Y, Shan, L, van Dyk, N, Dall'Acqua, W.F.
Deposit date:2020-04-24
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Commun Biol, 4, 2021
6WNA
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BU of 6wna by Molmil
Next generation monomeric IgG4 Fc
Descriptor: Beta-2-microglobulin, IgG receptor FcRn large subunit p51, Immunoglobulin heavy constant gamma 4, ...
Authors:Oganesyan, V.Y, Shan, L, van Dyk, N, Dall'Acqua, W.F.
Deposit date:2020-04-22
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Commun Biol, 4, 2021
6WMH
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BU of 6wmh by Molmil
Next generation monomeric IgG4 Fc
Descriptor: Immunoglobulin heavy constant gamma 4
Authors:Oganesyan, V.Y, Shan, L, van Dyk, N, Dall'Acqua, W.F.
Deposit date:2020-04-21
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Commun Biol, 4, 2021
4YPG
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BU of 4ypg by Molmil
Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal Antibody
Descriptor: Interferon alpha-2, NICKEL (II) ION, Sifalimumab heavy chain, ...
Authors:Oganesyan, V, Dall'Acqua, W.F.
Deposit date:2015-03-12
Release date:2015-05-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab.
J.Biol.Chem., 290, 2015
4ZNE
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BU of 4zne by Molmil
IgG1 Fc-FcgammaRI ecd complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Oganesyan, V.Y, Dall'Acqua, W.F.
Deposit date:2015-05-04
Release date:2015-11-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural insights into the interaction of human IgG1 with Fc gamma RI: no direct role of glycans in binding.
Acta Crystallogr.,Sect.D, 71, 2015
4QXG
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BU of 4qxg by Molmil
Antigen binding fragment of an anti IFNAR1 antibody
Descriptor: Fab, heavy chain, IgG1, ...
Authors:Oganesyan, V.Y, Dall'Acqua, W.F.
Deposit date:2014-07-20
Release date:2015-02-25
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-alpha receptor 1 antibody.
MAbs, 7, 2015
4U6V
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BU of 4u6v by Molmil
Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody
Descriptor: Alpha-hemolysin, Fab, antigen binding fragment, ...
Authors:Oganesyan, V.Y, Peng, L, Damschroder, M.M, Cheng, L, Sadowska, A, Tkaczyk, C, Sellman, B, Wu, H, Dall'Acqua, W.F.
Deposit date:2014-07-29
Release date:2014-09-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody.
J.Biol.Chem., 289, 2014
4N0F
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BU of 4n0f by Molmil
Human FcRn complexed with human serum albumin
Descriptor: Beta-2-microglobulin, IgG receptor FcRn large subunit p51, Serum albumin
Authors:Oganesyan, V, Wu, H, Dall'Acqua, W.F.
Deposit date:2013-10-01
Release date:2014-02-05
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms.
J.Biol.Chem., 289, 2014
4N0U
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BU of 4n0u by Molmil
Ternary complex between Neonatal Fc receptor, serum albumin and Fc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Ig gamma-1 chain C region, ...
Authors:Oganesyan, V, Wu, H, Dall'Acqua, W.F.
Deposit date:2013-10-02
Release date:2014-02-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms.
J.Biol.Chem., 289, 2014
6WIB
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BU of 6wib by Molmil
Next generation monomeric IgG4 Fc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin heavy constant gamma 4, ZINC ION
Authors:Oganesyan, V.Y, Shan, L, Dall'Acqua, W, van Dyk, N.
Deposit date:2020-04-09
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Commun Biol, 4, 2021
6ATT
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BU of 6att by Molmil
39S Fab bound to HER2 ecd
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 39S Fab heavy chain, ...
Authors:Oganesyan, V.Y, Dall'Acqua, W.F.
Deposit date:2017-08-29
Release date:2018-04-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.77 Å)
Cite:Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody.
J. Biol. Chem., 293, 2018
4UB0
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BU of 4ub0 by Molmil
New design for monovalent bispecific IgG through cysteine engineering of the CH1-CL interface
Descriptor: IgG1, heavy chain, light chain
Authors:Oganesyan, V.Y, Dall'Acqua, W.F.
Deposit date:2014-08-11
Release date:2015-07-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Improving target cell specificity using a novel monovalent bispecific IgG design.
Mabs, 7, 2015
6BRB
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BU of 6brb by Molmil
Novel non-antibody protein scaffold targeting CD40L
Descriptor: CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Oganesyan, V, Baca, M, Thisted, T, Grinberg, L, Wu, H, Dall'Acqua, W.F.
Deposit date:2017-11-30
Release date:2018-12-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity.
Sci Transl Med, 11, 2019

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