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2YKI
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BU of 2yki by Molmil
Tricyclic series of Hsp90 inhibitors
Descriptor: 1-H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID [4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-9H-FLUOREN-9-YL]-AMIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Dupuy, A, Vallee, F.
Deposit date:2011-05-27
Release date:2011-10-19
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 54, 2011
2YJX
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BU of 2yjx by Molmil
Tricyclic series of Hsp90 inhibitors
Descriptor: 1-(3H-imidazo[4,5-c]pyridin-2-yl)-3,4-dihydropyrido[2,1-a]isoindol-6(2H)-one, HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Dupuy, A, Vallee, F.
Deposit date:2011-05-24
Release date:2011-10-19
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 54, 2011
2YK2
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BU of 2yk2 by Molmil
Tricyclic series of Hsp90 inhibitors
Descriptor: 1-(3H-imidazo[4,5-c]pyridin-2-yl)-3,4-dihydropyrido[2,1-a]isoindol-6(2H)-one, 4-(5-METHYL-4-PHENYLISOXAZOL-3-YL)BENZENE-1,3-DIOL, HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Dupuy, A, Vallee, F.
Deposit date:2011-05-25
Release date:2011-10-19
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 54, 2011
2YK9
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BU of 2yk9 by Molmil
Tricyclic series of Hsp90 inhibitors
Descriptor: 4-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)FLUOREN-9-ONE, HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Dupuy, A, Vallee, F.
Deposit date:2011-05-26
Release date:2011-10-26
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 54, 2011
2YKB
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BU of 2ykb by Molmil
Tricyclic series of Hsp90 inhibitors
Descriptor: HEAT SHOCK PROTEIN HSP 90-ALPHA, N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-9H-FLUOREN-9-YL]-SUCCINAMIDE
Authors:Dupuy, A, Vallee, F.
Deposit date:2011-05-26
Release date:2011-10-19
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 54, 2011
2YKC
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BU of 2ykc by Molmil
Tricyclic series of Hsp90 inhibitors
Descriptor: HEAT SHOCK PROTEIN HSP 90-ALPHA, N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-9H-FLUOREN-9-YL-ISONICOTINAMIDE
Authors:Dupuy, A, Vallee, F.
Deposit date:2011-05-26
Release date:2011-10-19
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 54, 2011
2YJW
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BU of 2yjw by Molmil
Tricyclic series of Hsp90 inhibitors
Descriptor: 4-(5-METHYL-4-PHENYLISOXAZOL-3-YL)BENZENE-1,3-DIOL, HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Dupuy, A, Vallee, F.
Deposit date:2011-05-24
Release date:2011-10-19
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 54, 2011
2YKJ
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BU of 2ykj by Molmil
Tricyclic series of Hsp90 inhibitors
Descriptor: 2-AMINO-N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)--9H-FLUOREN-9-YL]-ISONICOTINAMIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Dupuy, A, Vallee, F.
Deposit date:2011-05-27
Release date:2011-10-19
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 54, 2011
2YKE
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BU of 2yke by Molmil
Tricyclic series of Hsp90 inhibitors
Descriptor: HEAT SHOCK PROTEIN HSP 90-ALPHA, N-[(4R)-4-(3H-imidazo[4,5-c]pyridin-2-yl)-4H-fluoren-9-yl]quinoline-5-carboxamide
Authors:Dupuy, A, Vallee, F.
Deposit date:2011-05-26
Release date:2011-10-19
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 54, 2011
5HCG
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BU of 5hcg by Molmil
CRYSTAL STRUCTURE OF FREE-CODV.
Descriptor: CODV heavy-chain, CODV light chain
Authors:Vallee, F, Dupuy, A, Rak, A.
Deposit date:2016-01-04
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.
Mabs, 8, 2016
5T21
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BU of 5t21 by Molmil
CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR148019.
Descriptor: 2-[(4-oxidanylcyclohexyl)amino]-4-(3,6,6-trimethyl-4-oxidanylidene-5,7-dihydroindol-1-yl)benzamide, Heat shock protein HSP 90-alpha
Authors:Vallee, F, Dupuy, A.
Deposit date:2016-08-23
Release date:2017-08-23
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR148019.
To Be Published
5FHX
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BU of 5fhx by Molmil
CRYSTAL STRUCTURE OF CODV IN COMPLEX WITH IL4 AT 2.55 Ang. RESOLUTION.
Descriptor: Antibody fragment light chain, Interleukin-4, PHOSPHATE ION, ...
Authors:Vallee, F, Dupuy, A, Rak, A.
Deposit date:2015-12-22
Release date:2016-03-30
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.
Mabs, 8, 2016
2BM2
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BU of 2bm2 by Molmil
human beta-II tryptase in complex with 4-(3-Aminomethyl-phenyl)- piperidin-1-yl-(5-phenethyl- pyridin-3-yl)-methanone
Descriptor: 1-[3-(1-{[5-(2-PHENYLETHYL)PYRIDIN-3-YL]CARBONYL}PIPERIDIN-4-YL)PHENYL]METHANAMINE, HUMAN BETA2 TRYPTASE
Authors:Maignan, S, Guilloteau, J.-P, Dupuy, A, Levell, J, Astles, P, Eastwood, P, Cairns, J, Houille, O, Aldous, S, Merriman, G, Whiteley, B, Pribish, J, Czekaj, M, Liang, G, Davidson, J, Harrison, T, Morley, A, Watson, S, Fenton, G, Mccarthy, C, Romano, J, Mathew, R, Engers, D, Gardyan, M, Sides, K, Kwong, J, Tsay, J, Rebello, S, Shen, L, Wang, J, Luo, Y, Giardino, O, Lim, H.-K, Smith, K, Pauls, H.
Deposit date:2005-03-09
Release date:2005-03-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure Based Design of 4-(3-Aminomethylphenyl) Piperidinyl-1-Amides: Novel, Potent, Selective, and Orally Bioavailable Inhibitors of Bii Tryptase
Bioorg.Med.Chem., 13, 2005
1LRU
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BU of 1lru by Molmil
Crystal Structure of E.coli Peptide Deformylase Complexed with Antibiotic Actinonin
Descriptor: ACTINONIN, PEPTIDE DEFORMYLASE, SULFATE ION, ...
Authors:Guilloteau, J.-P, Mathieu, M, Giglione, C, Blanc, V, Dupuy, A, Chevrier, M, Gil, P, Famechon, A, Meinnel, T, Mikol, V.
Deposit date:2002-05-16
Release date:2002-07-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol., 320, 2002
1LRY
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BU of 1lry by Molmil
Crystal Structure of P. aeruginosa Peptide Deformylase Complexed with Antibiotic Actinonin
Descriptor: ACTINONIN, PEPTIDE deformylase, ZINC ION
Authors:Guilloteau, J.-P, Mathieu, M, Giglione, C, Blanc, V, Dupuy, A, Chevrier, M, Gil, P, Famechon, A, Meinnel, T, Mikol, V.
Deposit date:2002-05-16
Release date:2002-07-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol., 320, 2002
4ASZ
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BU of 4asz by Molmil
Crystal structure of apo TrkB kinase domain
Descriptor: BDNF/NT-3 GROWTH FACTORS RECEPTOR
Authors:Bertrand, T, Kothe, M, Liu, J, Dupuy, A, Rak, A, Berne, P.F, Davis, S, Gladysheva, T, Valtre, C, Crenne, J.Y, Mathieu, M.
Deposit date:2012-05-03
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structures of Trka and Trkb Suggest Key Regions for Achieving Selective Inhibition.
J.Mol.Biol., 423, 2012
4AT4
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BU of 4at4 by Molmil
CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH EX429
Descriptor: 1-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea, BDNF/NT-3 GROWTH FACTORS RECEPTOR
Authors:Bertrand, T, Kothe, M, Liu, J, Dupuy, A, Rak, A, Berne, P.F, Davis, S, Gladysheva, T, Valtre, C, Crenne, J.Y, Mathieu, M.
Deposit date:2012-05-03
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:The Crystal Structures of Trka and Trkb Suggest Key Regions for Achieving Selective Inhibition.
J.Mol.Biol., 423, 2012
5LR7
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BU of 5lr7 by Molmil
CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR567530
Descriptor: Heat shock protein HSP 90-alpha, ~{N}-[(9~{R})-4-(5-fluoranyl-1~{H}-benzimidazol-2-yl)-9~{H}-fluoren-9-yl]-1~{H}-pyrrolo[2,3-b]pyridine-4-carboxamide
Authors:Vallee, F, Dupuy, A.
Deposit date:2016-08-18
Release date:2017-08-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR567530
To Be Published
5LQ9
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BU of 5lq9 by Molmil
CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR200323.
Descriptor: 4-(3-methyl-4-quinolin-3-yl-indazol-1-yl)-2-[(4-oxidanylcyclohexyl)amino]benzamide, Heat shock protein HSP 90-alpha
Authors:Vallee, F, Dupuy, A.
Deposit date:2016-08-16
Release date:2017-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR200323.
To Be Published
5LS1
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BU of 5ls1 by Molmil
CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR166475
Descriptor: 2-[(4-oxidanylidenecyclohexyl)amino]-4-(3,6,6-trimethyl-4-oxidanylidene-5,7-dihydroindol-1-yl)benzamide, Heat shock protein HSP 90-alpha
Authors:Vallee, F, Dupuy, A.
Deposit date:2016-08-22
Release date:2017-08-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR166475
To Be Published
4AT5
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BU of 4at5 by Molmil
CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH GW2580
Descriptor: 5-{3-methoxy-4-[(4-methoxybenzyl)oxy]benzyl}pyrimidine-2,4-diamine, BDNF/NT-3 GROWTH FACTORS RECEPTOR, GLYCEROL
Authors:Bertrand, T, Kothe, M, Liu, J, Dupuy, A, Rak, A, Berne, P.F, Davis, S, Gladysheva, T, Valtre, C, Crenne, J.Y, Mathieu, M.
Deposit date:2012-05-03
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:The Crystal Structures of Trka and Trkb Suggest Key Regions for Achieving Selective Inhibition.
J.Mol.Biol., 423, 2012
5LR1
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BU of 5lr1 by Molmil
CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003498614A.
Descriptor: 4-chloranyl-7-[(4-chloranyl-3,5-dimethyl-pyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-2-amine, Heat shock protein HSP 90-alpha
Authors:Vallee, F, Dupuy, A.
Deposit date:2016-08-18
Release date:2017-08-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003498614A.
To Be Published
5LRZ
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BU of 5lrz by Molmil
CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003643501
Descriptor: 6-bromanyl-~{N}-[(9~{R})-4-quinolin-3-yl-9~{H}-fluoren-9-yl]-3~{H}-imidazo[4,5-b]pyridine-7-carboxamide, Heat shock protein HSP 90-alpha
Authors:Vallee, F, Dupuy, A.
Deposit date:2016-08-22
Release date:2017-09-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003643501
To Be Published
4AT3
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BU of 4at3 by Molmil
CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH CPD5N
Descriptor: (5Z)-5-(carbamoylimino)-3-[(5R)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylsulfanyl]-2,5-dihydroisothiazole-4-carboxamide, BDNF/NT-3 GROWTH FACTORS RECEPTOR
Authors:Bertrand, T, Kothe, M, Liu, J, Dupuy, A, Rak, A, Berne, P.F, Davis, S, Gladysheva, T, Valtre, C, Crenne, J.Y, Mathieu, M.
Deposit date:2012-05-03
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:The Crystal Structures of Trka and Trkb Suggest Key Regions for Achieving Selective Inhibition.
J.Mol.Biol., 423, 2012
4F0I
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BU of 4f0i by Molmil
Crystal structure of apo TrkA
Descriptor: High affinity nerve growth factor receptor
Authors:Liu, J.
Deposit date:2012-05-04
Release date:2012-09-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:The Crystal Structures of TrkA and TrkB Suggest Key Regions for Achieving Selective Inhibition.
J.Mol.Biol., 423, 2012

 

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