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1TYA
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STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS
分子名称:TYROSYL-tRNA SYNTHETASE, TYROSINE
著者Brown, K.A., De Meester, P., Blow, D.M.
登録日1992-07-06
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions
To be Published
1TYB
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STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS
分子名称:TYROSYL-tRNA SYNTHETASE, TYROSINE
著者Brown, K.A., De Meester, P., Blow, D.M.
登録日1992-07-06
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions
To be Published
1TYC
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STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS
分子名称:TYROSYL-tRNA SYNTHETASE
著者Brown, K.A., Brick, P., De Meester, P., Blow, D.M.
登録日1992-07-06
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions
To be Published
1TYD
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STRUCTURE OF TYROSYL-TRNA SYNTHETASE REFINED AT 2.3 ANGSTROMS RESOLUTION. INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE
分子名称:TYROSYL-tRNA SYNTHETASE, TYROSINE
著者Brown, K.A., De Meester, P., Blow, D.M.
登録日1992-07-06
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate.
J.Mol.Biol., 208, 1989
4CHA
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STRUCTURE OF ALPHA-*CHYMOTRYPSIN REFINED AT 1.68 ANGSTROMS RESOLUTION
分子名称:ALPHA-CHYMOTRYPSIN A
著者Tsukada, H., Blow, D.M.
登録日1984-11-26
公開日1985-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Structure of alpha-chymotrypsin refined at 1.68 A resolution.
J.Mol.Biol., 184, 1985
2CHA
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THE STRUCTURE OF CRYSTALLINE ALPHA-CHYMOTRYPSIN, $V.THE ATOMIC STRUCTURE OF TOSYL-ALPHA-CHYMOTRYPSIN AT 2 ANGSTROMS RESOLUTION
分子名称:ALPHA-CHYMOTRYPSIN A, PARA-TOLUENE SULFONATE
著者Birktoft, J.J., Blow, D.M.
登録日1975-01-01
公開日1977-01-18
最終更新日2011-08-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of crystalline -chymotrypsin. V. The atomic structure of tosyl- -chymotrypsin at 2 A resolution.
J.Mol.Biol., 68, 1972
2TS1
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STRUCTURE OF TYROSYL-T/RNA SYNTHETASE REFINED AT 2.3 ANGSTROMS RESOLUTION. INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE
分子名称:TYROSYL-TRNA SYNTHETASE
著者Brick, P., Bhat, T.N., Blow, D.M.
登録日1989-06-29
公開日1989-10-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate.
J.Mol.Biol., 208, 1989
3TS1
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STRUCTURE OF TYROSYL-T/RNA SYNTHETASE REFINED AT 2.3 ANGSTROMS RESOLUTION. INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE
分子名称:TYROSYL-TRNA SYNTHETASE, PHOSPHORIC ACID 2-AMINO-3-(4-HYDROXY-PHENYL)-PROPYL ESTER ADENOSIN-5'YL ESTER
著者Monteilhet, C., Brick, P., Blow, D.M.
登録日1989-06-29
公開日1989-10-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate.
J.Mol.Biol., 208, 1989
1XMZ
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CRYSTAL STRUCTURE OF THE DARK STATE OF KINDLING FLUORESCENT PROTEIN KFP FROM ANEMONIA SULCATA
分子名称:GFP-like chromoprotein FP595, AMINO GROUP, BETA-MERCAPTOETHANOL
著者Quillin, M.L., Anstrom, D.M., Shu, X., O'Leary, S., Kallio, K., Chudakov, D.M., Remington, S.J.
登録日2004-10-04
公開日2005-04-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Kindling Fluorescent Protein from Anemonia sulcata: Dark-State Structure at 1.38 Resolution
Biochemistry, 44, 2005
1EST
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THE ATOMIC STRUCTURE OF CRYSTALLINE PORCINE PANCREATIC ELASTASE AT 2.5 ANGSTROMS RESOLUTION. COMPARISONS WITH THE STRUCTURE OF ALPHA-CHYMOTRYPSIN
分子名称:PORCINE PANCREATIC ELASTASE, SULFATE ION, PARA-TOLUENE SULFONATE
著者Sawyer, L., Shotton, D.M., Watson, H.C.
登録日1976-05-17
公開日1976-05-27
最終更新日2011-08-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The atomic structure of crystalline porcine pancreatic elastase at 2.5 A resolution: comparisons with the structure of alpha-chymotrypsin.
J.Mol.Biol., 118, 1978
1M7Q
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CRYSTAL STRUCTURE OF P38 MAP KINASE IN COMPLEX WITH A DIHYDROQUINAZOLINONE INHIBITOR
分子名称:Mitogen-activated protein kinase 14, SULFATE ION, 1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERAZIN-1-YL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE
著者Stelmach, J.E., Liu, L., Patel, S.B., Pivnichny, J.V., Scapin, G., Singh, S., Hop, C.E.C.A., Wang, Z., Cameron, P.M., Nichols, E.A., O'Keefe, S.J., O'Neill, E.A., Schmatz, D.M., Schwartz, C.D., Thompson, C.M., Zaller, D.M., Doherty, J.B.
登録日2002-07-22
公開日2002-12-11
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.
Bioorg.Med.Chem.Lett., 13, 2003
1MS6
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DIPEPTIDE NITRILE INHIBITOR BOUND TO CATHEPSIN S.
分子名称:Cathepsin S, MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE
著者Ward, Y.D., Thomson, D.S., Frye, L.L., Cywin, C.L., Morwick, T., Emmanuel, M.J., Zindell, R., McNeil, D., Bekkali, Y., Giradot, M., Hrapchak, M., DeTuri, M., Crane, K., White, D., Pav, S., Wang, Y., Hao, M.H., Grygon, C.A., Labadia, M.E., Freeman, D.M., Davidson, W., Hopkins, J.L., Brown, M.L., Spero, D.M.
登録日2002-09-19
公開日2003-04-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors
J.Med.Chem., 45, 2002
1W2Z
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PSAO AND XENON
分子名称:AMINE OXIDASE, COPPER CONTAINING, COPPER (II) ION, ...
著者Duff, A.P., Trambaiolo, D.M., Cohen, A.E., Ellis, P.J., Juda, G.A., Shepard, E.M., Langley, D.B., Dooley, D.M., Freeman, H.C., Guss, J.M.
登録日2004-07-11
公開日2004-11-17
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Using Xenon as a Probe for Dioxygen-Binding Sites in Copper Amine Oxidases.
J.Mol.Biol., 344, 2004
1W4N
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AGAO COVALENT COMPLEX WITH TRANYLCYPROMINE
分子名称:PHENYLETHYLAMINE OXIDASE, COPPER (II) ION, SODIUM ION, ...
著者Duff, A.P., Trambaiolo, D.M., Langley, D.B., Juda, G.A., Shepard, E.M., Dooley, D.M., Freeman, H.C., Guss, J.M.
登録日2004-07-27
公開日2005-12-08
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Complexes of the Copper-Containing Amine Oxidase from Arthrobacter Globiformis with the Inhibitors Benzylhydrazine and Tranylcypromine.
Acta Crystallogr.,Sect.F, 64, 2008
1W5Z
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AGAO COVALENT COMPLEX WITH BENZYLHYDRAZINE
分子名称:PHENYLETHYLAMINE OXIDASE, COPPER (II) ION, SODIUM ION, ...
著者Duff, A.P., Trambaiolo, D.M., Langley, D.B., Juda, G.A., Shepard, E.M., Dooley, D.M., Freeman, H.C., Guss, J.M.
登録日2004-08-11
公開日2005-12-08
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Complexes of the Copper-Containing Amine Oxidase from Arthrobacter Globiformis with the Inhibitors Benzylhydrazine and Tranylcypromine.
Acta Crystallogr.,Sect.F, 64, 2008
2R9M
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CATHEPSIN S COMPLEXED WITH COMPOUND 15
分子名称:Cathepsin S, N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
著者Ward, Y.D., Emmanuel, M.J., Thomson, D.S., Liu, W., Bekkali, Y., Frye, L.L., Girardot, M., Morwick, T., Young, E.R.R., Zindell, R., Hrapchak, M., DeTuri, M., White, A., Crane, K.M., White, D.M., Wang, Y., Hao, M.-H., Grygon, C.A., Labadia, M.E., Wildeson, J., Freeman, D., Nelson, R., Capolino, A., Peterson, J.D., Raymond, E.L., Brown, M.L., Spero, D.M.
登録日2007-09-13
公開日2007-12-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation
To be Published
2R9N
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CATHEPSIN S COMPLEXED WITH COMPOUND 26
分子名称:Cathepsin S, N-[(1S)-2-{[(3S)-1-benzyl-3-cyanopyrrolidin-3-yl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
著者Ward, Y.D., Emmanuel, M.J., Thomson, D.S., Liu, W., Bekkali, Y., Frye, L.L., Girardot, M., Morwick, T., Young, E.R.R., Zindell, R., Hrapchak, M., DeTuri, M., White, A., Crane, K.M., White, D.M., Wang, Y., Hao, M.-H., Grygon, C.A., Labadia, M.E., Wildeson, J., Freeman, D., Nelson, R., Capolino, A., Peterson, J.D., Raymond, E.L., Brown, M.L., Spero, D.M.
登録日2007-09-13
公開日2007-12-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation
to be published
2R9O
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CATHEPSIN S COMPLEXED WITH COMPOUND 8
分子名称:Cathepsin S, N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
著者Ward, Y.D., Emmanuel, M.J., Thomson, D.S., Liu, W., Bekkali, Y., Frye, L.L., Girardot, M., Morwick, T., Young, E.R.R., Zindell, R., Hrapchak, M., DeTuri, M., White, A., Crane, K.M., White, D.M., Wang, Y., Hao, M.-H., Grygon, C.A., Labadia, M.E., Wildeson, J., Freeman, D., Nelson, R., Capolino, A., Peterson, J.D., Raymond, E.L., Brown, M.L., Spero, D.M.
登録日2007-09-13
公開日2007-12-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation
to be published
4TS1
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CRYSTAL STRUCTURE OF A DELETION MUTANT OF A TYROSYL-T/RNA SYNTHETASE COMPLEXED WITH TYROSINE
分子名称:TYROSYL-tRNA SYNTHETASE, TYROSINE
著者Brick, P., Blow, D.M.
登録日1989-06-29
公開日1989-10-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of a deletion mutant of a tyrosyl-tRNA synthetase complexed with tyrosine.
J.Mol.Biol., 194, 1987
5DO7
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CRYSTAL STRUCTURE OF THE HUMAN STEROL TRANSPORTER ABCG5/ABCG8
分子名称:ATP-binding cassette sub-family G member 5, ATP-binding cassette sub-family G member 8
著者Lee, J.-Y., Kinch, L.N., Borek, D.M., Urbatsch, I.L., Xie, X.-S., Grishin, N.V., Cohen, J.C., Otwinowski, Z., Hobbs, H.H., Rosenbaum, D.M.
登録日2015-09-10
公開日2016-05-11
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (3.93 Å)
主引用文献Crystal structure of the human sterol transporter ABCG5/ABCG8.
Nature, 533, 2016
1MWN
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SOLUTION NMR STRUCTURE OF S100B BOUND TO THE HIGH-AFFINITY TARGET PEPTIDE TRTK-12
分子名称:S-100 protein, beta chain, F-actin capping protein alpha-1 subunit, ...
著者Inman, K.G., Yang, R., Rustandi, R.R., Miller, K.E., Baldisseri, D.M., Weber, D.J.
登録日2002-09-30
公開日2002-12-18
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12
J.Mol.Biol., 324, 2002
1OKK
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HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES
分子名称:SIGNAL RECOGNITION PARTICLE PROTEIN, CELL DIVISION PROTEIN FTSY, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
著者Focia, P.J., Freymann, D.M.
登録日2003-07-26
公開日2004-01-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Heterodimeric Gtpase Core of the Srp Targeting Complex
Science, 303, 2004
1XLA
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MECHANISM FOR ALDOSE-KETOSE INTERCONVERSION BY D-XYLOSE ISOMERASE INVOLVING RING OPENING FOLLOWED BY A 1,2-HYDRIDE SHIFT
分子名称:D-XYLOSE ISOMERASE
著者Collyer, C.A., Henrick, K., Blow, D.M.
登録日1991-10-09
公開日1993-07-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift.
J.Mol.Biol., 212, 1990
1XLB
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MECHANISM FOR ALDOSE-KETOSE INTERCONVERSION BY D-XYLOSE ISOMERASE INVOLVING RING OPENING FOLLOWED BY A 1,2-HYDRIDE SHIFT
分子名称:D-XYLOSE ISOMERASE, MAGNESIUM ION
著者Collyer, C.A., Henrick, K., Blow, D.M.
登録日1991-10-09
公開日1993-07-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift.
J.Mol.Biol., 212, 1990
1XLC
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MECHANISM FOR ALDOSE-KETOSE INTERCONVERSION BY D-XYLOSE ISOMERASE INVOLVING RING OPENING FOLLOWED BY A 1,2-HYDRIDE SHIFT
分子名称:D-XYLOSE ISOMERASE, D-XYLITOL, MAGNESIUM ION
著者Collyer, C.A., Henrick, K., Blow, D.M.
登録日1991-10-09
公開日1993-07-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift.
J.Mol.Biol., 212, 1990