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1H3N
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE
分子名称:LEUCYL-TRNA SYNTHETASE, LEUCINE, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE, ...
著者Cusack, S., Yaremchuk, A., Tukalo, M.
登録日2002-09-11
公開日2002-09-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The 2A Structure of Leucyl-tRNA Synthetase and its Complex with a Leucyl-Adenylate Analogue
Embo J., 19, 2000
1SES
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CRYSTAL STRUCTURES AT 2.5 ANGSTROMS RESOLUTION OF SERYL-TRNA SYNTHETASE COMPLEXED WITH TWO DIFFERENT ANALOGUES OF SERYL-ADENYLATE
分子名称:SERYL-tRNA SYNTHETASE, SERYL-HYDROXAMATE-ADENOSINE MONOPHOSPHATE, ADENOSINE MONOPHOSPHATE
著者Cusack, S., Belrhali, H.
登録日1994-02-21
公開日1994-07-31
最終更新日2012-02-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate.
Science, 263, 1994
1SET
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CRYSTAL STRUCTURES AT 2.5 ANGSTROMS RESOLUTION OF SERYL-TRNA SYNTHETASE COMPLEXED WITH TWO DIFFERENT ANALOGUES OF SERYL-ADENYLATE
分子名称:SERYL-tRNA SYNTHETASE, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
著者Cusack, S., Belrhali, H.
登録日1994-02-21
公開日1994-07-31
最終更新日2012-02-29
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate.
Science, 263, 1994
1OBC
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A POST-TRANSFER EDITING SUBSTRATE ANALOGUE
分子名称:LEUCYL-TRNA SYNTHETASE, LEUCINE, ZINC ION, ...
著者Cusack, S., Yaremchuk, A., Tukalo, M.
登録日2003-01-30
公開日2003-05-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1OBH
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A PRE-TRANSFER EDITING SUBSTRATE ANALOGUE IN BOTH SYNTHETIC ACTIVE SITE AND EDITING SITE
分子名称:LEUCYL-TRNA SYNTHETASE, SULFATE ION, MERCURY (II) ION, ...
著者Cusack, S., Yaremchuk, A., Tukalo, M.
登録日2003-01-31
公開日2003-05-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1H4V
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HISTIDYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS (LIGAND FREE)
分子名称:HISTIDYL-TRNA SYNTHETASE, SULFATE ION
著者Cusack, S., Yaremchuk, A., Tukalo, M.
登録日2001-05-14
公開日2001-06-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase
J.Mol.Biol., 309, 2001
6EUW
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CRYSTAL STRUCTURE OF THE CAP-BINDING DOMAIN OF THE PB2 SUBUNIT OF INFLUENZA A/H5N1 POLYMERASE BOUND TO AN AZAINDAZOLE INHIBITOR
分子名称:Polymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL
著者Cusack, S., Gaudon, S.
登録日2017-10-31
公開日2017-12-13
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUX
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STRUCTURE OF THE MIDLINK AND CAP-BINDING DOMAINS OF INFLUENZA B POLYMERASE PB2 SUBUNIT WITH A BOUND AZAINDAZOLE CAP-BINDING INHIBITOR
分子名称:Polymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid
著者Cusack, S., Gaudon, S.
登録日2017-10-31
公開日2017-12-13
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUY
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STRUCTURE OF THE MIDLINK AND CAP-BINDING DOMAINS OF INFLUENZA A POLYMERASE PB2 SUBUNIT WITH A BOUND AZAINDAZOLE CAP-BINDING INHIBITOR
分子名称:Polymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, SULFATE ION
著者Cusack, S., Gaudon, S.
登録日2017-10-31
公開日2017-12-13
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
2BTE
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THERMUS THERMOPHILUS LEUCYL-TRNA SYNTHETASE COMPLEXED WITH A TRNALEU TRANSCRIPT IN THE POST-EDITING CONFORMATION AND A POST- TRANSFER EDITING SUBSTRATE ANALOGUE
分子名称:AMINOACYL-TRNA SYNTHETASE, TRNALEU TRANSCRIPT WITH ANTICODON CAG, ZINC ION, ...
著者Cusack, S., Tukalo, M., Yaremchuk, A., Fukunaga, R., Yokoyama, S.
登録日2005-05-31
公開日2005-09-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer- Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
2BYT
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THERMUS THERMOPHILUS LEUCYL-TRNA SYNTHETASE COMPLEXED WITH A TRNALEU TRANSCRIPT IN THE POST-EDITING CONFORMATION
分子名称:LEUCYL-TRNA SYNTHETASE, TRNALEU TRANSCRIPT WITH ANTICODON CAG, LEUCINE, ...
著者Cusack, S., Tukalo, M., Yaremchuk, A., Fukunaga, R., Yokoyama, S.
登録日2005-08-04
公開日2005-09-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer-Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
3ZJT
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TERNARY COMPLEX OF E.COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU)574 AND THE BENZOXABOROLE AN3017 IN THE EDITING CONFORMATION
分子名称:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJU
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3016 IN THE EDITING CONFORMATION
分子名称:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJV
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3213 IN THE EDITING CONFORMATION
分子名称:LEUCINE--TRNA LIGASE, TRNALEU5 UAA ISOACCEPTOR
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
4WSB
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BAT INFLUENZA A POLYMERASE WITH BOUND VRNA PROMOTER
分子名称:Polymerase PA, RNA-directed RNA polymerase catalytic subunit, Polymerase PB2, ...
著者Cusack, S., Pflug, A., Guilligay, D., Reich, S.
登録日2014-10-26
公開日2014-11-19
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
Nature, 516, 2014
5MSG
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INFLUENZA B POLYMERASE BOUND TO VRNA PROMOTER AND CAPPED RNA PRIMER
分子名称:Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ...
著者Cusack, S., Guilligay, D.
登録日2017-01-04
公開日2017-02-08
最終更新日2017-05-03
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献An in vitro fluorescence based study of initiation of RNA synthesis by influenza B polymerase.
Nucleic Acids Res., 45, 2017
6EUV
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STRUCTURE OF THE MIDLINK AND CAP-BINDING DOMAINS OF INFLUENZA A POLYMERASE PB2 SUBUNIT WITH A BOUND AZAINDOLE CAP-BINDING INHIBITOR (VX-787)
分子名称:Polymerase basic protein 2, (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION
著者Cusack, S., Lethier, M.
登録日2017-10-31
公開日2017-12-13
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6FS6
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INFLUENZA A/CALIFORNIA/04/2009 (PH1N1) ENDONUCLEASE WITH BOUND INHIBITOR, BALOXAVIR ACID (BXA)
分子名称:Polymerase acidic protein,Polymerase acidic protein, MANGANESE (II) ION, Baloxavir acid
著者Cusack, S., Speranzini, V.
登録日2018-02-19
公開日2018-07-11
実験手法X-RAY DIFFRACTION (2.291 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FS7
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INFLUENZA A/CALIFORNIA/04/2009 (PH1N1) ENDONUCLEASE WITH I38T MUTATION WITH BOUND INHIBITOR, BALOXAVIR ACID (BXA)
分子名称:Polymerase acidic protein,Polymerase acidic protein, MANGANESE (II) ION, Baloxavir acid
著者Cusack, S., Speranzini, V.
登録日2018-02-19
公開日2018-07-11
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FS8
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INFLUENZA B/MEMPHIS/13/03 ENDONUCLEASE WITH BOUND INHIBITOR, BALOXAVIR ACID (BXA)
分子名称:Polymerase acidic protein, Baloxavir acid, MANGANESE (II) ION
著者Cusack, S., Speranzini, V.
登録日2018-02-19
公開日2018-07-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FS9
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INFLUENZA B/MEMPHIS/13/03 ENDONUCLEASE WITH I38T MUTATION WITH BOUND INHIBITOR, BALOXAVIR ACID (BXA)
分子名称:Polymerase acidic protein, MANGANESE (II) ION, Baloxavir acid, ...
著者Cusack, S., Speranzini, V.
登録日2018-02-19
公開日2018-07-11
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FSB
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INFLUENZA B/MEMPHIS/13/03 ENDONUCLEASE WITH I38T MUTATION
分子名称:Polymerase acidic protein, MANGANESE (II) ION, MAGNESIUM ION
著者Cusack, S., Speranzini, V.
登録日2018-02-19
公開日2018-07-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
1ADJ
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HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDINE
分子名称:HISTIDYL-TRNA SYNTHETASE, SULFATE ION, HISTIDINE
著者Cusack, S., Aberg, A.
登録日1997-02-18
公開日1997-08-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
Biochemistry, 36, 1997
1ADY
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HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDYL-ADENYLATE
分子名称:HISTIDYL-TRNA SYNTHETASE, SULFATE ION, HISTIDYL-ADENOSINE MONOPHOSPHATE
著者Cusack, S., Aberg, A.
登録日1997-02-19
公開日1997-08-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
Biochemistry, 36, 1997
1H3E
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TYROSYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH WILD-TYPE TRNATYR(GUA) AND WITH ATP AND TYROSINOL
分子名称:TYROSYL-TRNA SYNTHETASE, WILD-TYPE TRNATYR(GUA), ADENOSINE-5'-TRIPHOSPHATE, ...
著者Cusack, S., Yaremchuk, A., Kriklivyi, I., Tukalo, M.
登録日2002-08-28
公開日2002-10-27
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Class I Tyrosyl-tRNA Synthetase Has a Class II Mode or tRNA Recognition
Embo J., 21, 2002