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4UIH
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BU of 4uih by Molmil
Cryo-EM structure of Dengue virus serotype 2 strain New Guinea-C complexed with human antibody 2D22 Fab at 37 degree C. The Fab molecules were added to the virus before 37 degree C incubation.
Descriptor: ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -LIGHT CHAIN, DENGUE VIRUS SEROTYPE 2 STRAIN NEW GUINEA-C E PROTEIN ECTODOMAIN
Authors:Fibriansah, G, Ibarra, K.D, Ng, T.-S, Smith, S.A, Tan, J.L, Lim, X.N, Ooi, J.S.G, Kostyuchenko, V.A, Wang, J, de Silva, A.M, Harris, E, Crowe, J.E, Lok, S.-M.
Deposit date:2015-03-30
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
8EKD
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BU of 8ekd by Molmil
Cryo-EM map of SARS-CoV-2 Omicron BA.2 spike in complex with 2130-1-0114-112
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab LLNL-199 HC, Fab LLNL-199 LC, ...
Authors:Binshtein, E, Crowe, J.E.
Deposit date:2022-09-20
Release date:2024-02-21
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM map of SARS-CoV-2 Omicron BA.2 spike in complex with 2130-1-0114-112
To Be Published
5ITB
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BU of 5itb by Molmil
Crystal structure of the anti-RSV F Fab 14N4
Descriptor: anti-RSV F Fab 14N4 Heavy chain, anti-RSV F Fab 14N4 Light chain
Authors:Mousa, J.J, Crowe, J.E.
Deposit date:2016-03-16
Release date:2016-10-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
5J3D
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BU of 5j3d by Molmil
Crystal structure of human Fab 14N4 in complex with post-fusion RSV F
Descriptor: 14N4 heavy chain, 14N4 light chain, Fusion glycoprotein F0
Authors:Mousa, J.J, Crowe, J.E.
Deposit date:2016-03-30
Release date:2016-10-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.077 Å)
Cite:Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
5UQY
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BU of 5uqy by Molmil
Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP1, ...
Authors:Hashiguchi, T, Fusco, M.L, Hastie, K.M, Bomholdt, Z.A, Lee, J.E, Flyak, A.I, Matsuoka, R, Kohda, D, Yanagi, Y, Hammel, M, Crowe, J.E, Saphire, E.O.
Deposit date:2017-02-08
Release date:2017-03-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
Cell, 160, 2015
7SFV
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BU of 7sfv by Molmil
CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, Spike glycoprotein E1, ...
Authors:Binshtein, E, Crowe, J.E.
Deposit date:2021-10-04
Release date:2022-03-16
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge.
J.Exp.Med., 219, 2022
5CGY
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BU of 5cgy by Molmil
Fab fragment of Chikungunya virus neutralizing human monoclonal antibody 4J21
Descriptor: Heavy Chain of Fab, Light Chain of Fab
Authors:Long, F, Crowe, J.E, Rossmann, M.G.
Deposit date:2015-07-09
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity.
Proc.Natl.Acad.Sci.USA, 112, 2015
5CHN
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BU of 5chn by Molmil
Fab fragments of chikungunya virus neutralizing human monoclonal antibody 5M16
Descriptor: Antibody 5M16 Fab Heavy Chain, Antibody 5M16 Fab Light Chain
Authors:Long, F, Crowe, J.E, Rossmann, M.G.
Deposit date:2015-07-10
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity.
Proc.Natl.Acad.Sci.USA, 112, 2015
5WEQ
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BU of 5weq by Molmil
The crystal structure of a MR78 mutant
Descriptor: MR78 mutant Fab heavy chain, MR78 mutant light chain
Authors:Dong, J, Williamson, L.E, Crowe, J.E.
Deposit date:2017-07-10
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
6P3S
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BU of 6p3s by Molmil
Crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Human Fab H5.28 heavy chain, ...
Authors:Dong, J, Crowe, J.E.
Deposit date:2019-05-24
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4 Å)
Cite:crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain
To Be Published
6P3R
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BU of 6p3r by Molmil
crystal structure of human Fab H5.31 in complex with influenza A H5N1 Vietnam hemagglutinin head domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:Dong, J, Crowe, J.E.
Deposit date:2019-05-24
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human Fab H5.31 in complex with influenza A H5N1 Vietnam hemagglutinin head domain
To Be Published
5TPN
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BU of 5tpn by Molmil
Crystal structure of RSV F in complex with human antibody hRSV90
Descriptor: Fusion glycoprotein F0,Fibritin, hRSV0 light chain, hRSV90 heavy chain
Authors:Mousa, J.J, Crowe, J.E.
Deposit date:2016-10-20
Release date:2017-02-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.141 Å)
Cite:Crystal structure of RSV F in complex with human antibody hRSV90
To Be Published
7SFW
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BU of 7sfw by Molmil
CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63 (focus refine of the asymmetric unit)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, Spike glycoprotein E1, ...
Authors:Binshtein, E, Crowe, J.E.
Deposit date:2021-10-04
Release date:2022-03-16
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge.
J.Exp.Med., 219, 2022
7SFU
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BU of 7sfu by Molmil
CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, Spike glycoprotein E1, ...
Authors:Binshtein, E, Crowe, J.E.
Deposit date:2021-10-04
Release date:2022-03-16
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge.
J.Exp.Med., 219, 2022
4HFW
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BU of 4hfw by Molmil
Anti Rotavirus Antibody
Descriptor: 6-26 Fab Heavy chain, 6-26 Fab Light chain, SULFATE ION
Authors:Spiller, B.W, Aiyegbo, M, Crowe, J.E.
Deposit date:2012-10-05
Release date:2013-05-29
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore.
Plos One, 8, 2013
6CHX
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BU of 6chx by Molmil
High Resolution Crystal Structure of the Hemagglutinin H1 Head Domain of Influenza A virus Solomon Islands
Descriptor: Hemagglutinin
Authors:Dong, J, Sevy, A.M, Crowe, J.E.
Deposit date:2018-02-23
Release date:2019-02-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High Resolution Crystal Structure of the Hemagglutinin H1 Head Domain of Influenza A virus Solomon Islands
To Be Published
4UIF
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BU of 4uif by Molmil
Cryo-EM structure of Dengue virus serotype 2 in complex with antigen-binding fragments of human antibody 2D22
Descriptor: ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - LIGHT CHAIN, DENGUE VIRUS SEROTYPE 2 STRAIN PVP94 07 - ENVELOPE PROTEIN, ...
Authors:Fibriansah, G, Ibarra, K.D, Ng, T.-S, Smith, S.A, Tan, J.L, Lim, X.-N, Ooi, J.S.G, Kostyuchenko, V.A, Wang, J, de Silva, A.M, Harris, E, Crowe Junior, J.E, Lok, S.-M.
Deposit date:2015-03-30
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
5KEM
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BU of 5kem by Molmil
EBOV sGP in complex with variable Fab domains of IgGs c13C6 and BDBV91
Descriptor: BDBV91 variable Fab domain heavy chain, BDBV91 variable Fab domain light chain, Ebola secreted glycoprotein, ...
Authors:Pallesen, J, Murin, C.D, de Val, N, Cottrell, C.A, Hastie, K.M, Turner, H.L, Fusco, M.L, Flyak, A.I, Zeitlin, L, Crowe Jr, J.E, Andersen, K.G, Saphire, E.O, Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
8DBZ
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BU of 8dbz by Molmil
CryoEM structure of Hantavirus ANDV Gn(H) protein complex with 2Fabs ANDV-5 and ANDV-34
Descriptor: COV44-79 heavy chain constant domain, Fab Fc (L) KappaC, Fv (H) ANDV-34, ...
Authors:Binshtein, E, Crowe, J.E.
Deposit date:2022-06-15
Release date:2023-04-05
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Antigenic mapping and functional characterization of human new world hantavirus neutralizing antibodies.
Elife, 12, 2023
5A1Z
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BU of 5a1z by Molmil
Cryo-EM structure of Dengue virus serotype 2 strain PVP94-07 complexed with human antibody 2D22 Fab at 37 degrees C
Descriptor: ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - LIGHT CHAIN, ENVELOPE PROTEIN, ...
Authors:Fibriansah, G, Ibarra, K.D, Ng, T.S, Smith, S.A, Tan, J.L, Lim, X.N, Ooi, J.S.G, Kostyuchenko, V.A, Wang, J, de Silva, A.M, Harris, E, Crowe Jr, J.E, Lok, S.M.
Deposit date:2015-05-06
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
6WDT
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BU of 6wdt by Molmil
Enterovirus D68 in complex with human monoclonal antibody EV68-228
Descriptor: EV68-228 heavy chain, EV68-228 light chain, viral protein 1, ...
Authors:Fu, J, Vogt, M.R, Klose, T, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-04-01
Release date:2020-07-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease.
Sci Immunol, 5, 2020
6WDS
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BU of 6wds by Molmil
Enterovirus D68 in complex with human monoclonal antibody EV68-159
Descriptor: EV68-159 heavy chain, EV68-159 light chain, viral protein 1, ...
Authors:Fu, J, Klose, T, Vogt, M.R, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-04-01
Release date:2020-07-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease.
Sci Immunol, 5, 2020
6UIG
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BU of 6uig by Molmil
Crystal structure of human monoclonal antibody H7.200 in complex with H7N9 hemagglutinin HA1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, H7.200 Fab heavy chain, H7.200 Fab light chain, ...
Authors:Dong, J, Crowe, J.E.
Deposit date:2019-09-30
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface.
J.Clin.Invest., 130, 2020
6V4R
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BU of 6v4r by Molmil
Crystal structure of a chimeric MR78-like antibody chimera-1 Fab
Descriptor: Chimera-1 Fab heavy chain, Chimera-1 Fab light chain
Authors:Bozhanova, N.G, Crowe, J.E, Meiler, J.
Deposit date:2019-11-28
Release date:2020-11-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Discovery of Marburg virus neutralizing antibodies from virus-naive human antibody repertoires using large-scale structural predictions.
Proc.Natl.Acad.Sci.USA, 117, 2020
6V4Q
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BU of 6v4q by Molmil
Crystal structure of a MR78-like antibody naive-1 Fab
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Naive-1 Fab heavy chain, ...
Authors:Bozhanova, N.G, Crowe, J.E, Meiler, J.
Deposit date:2019-11-28
Release date:2020-11-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Discovery of Marburg virus neutralizing antibodies from virus-naive human antibody repertoires using large-scale structural predictions.
Proc.Natl.Acad.Sci.USA, 117, 2020

 

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