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3CL3
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BU of 3cl3 by Molmil
Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome
Descriptor: NF-kappa-B essential modulator, ORF K13
Authors:Bagneris, C, Ageichik, A.V, Cronin, N, Boshoff, C, Waksman, G, Barrett, T.
Deposit date:2008-03-18
Release date:2008-06-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.
Mol.Cell, 30, 2008
5JU5
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BU of 5ju5 by Molmil
Crystal structure of the human Tankyrase 1 (TNKS) SAM domain (D1055R), crystal form 1
Descriptor: Tankyrase-1
Authors:Guetter, S, Mariotti, L, Cronin, N.
Deposit date:2016-05-10
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-beta-Catenin Signaling.
Mol.Cell, 63, 2016
5JTI
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BU of 5jti by Molmil
Crystal structure of the human Tankyrase 1 (TNKS) SAM domain (D1055R), crystal form 2
Descriptor: Tankyrase-1
Authors:Guetter, S, Mariotti, L, Cronin, N.
Deposit date:2016-05-09
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-beta-Catenin Signaling.
Mol.Cell, 63, 2016
6TKY
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BU of 6tky by Molmil
Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42
Descriptor: Cell division control protein 42 homolog, Dedicator of cytokinesis protein 10, GLYCEROL
Authors:Barford, D, Fan, D, Cronin, N, Yang, J.
Deposit date:2019-11-29
Release date:2020-01-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10
Biorxiv, 2022
6TM1
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BU of 6tm1 by Molmil
Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3
Descriptor: Dedicator of cytokinesis protein 10, Ras-related C3 botulinum toxin substrate 3
Authors:Barford, D, Fan, D, Cronin, N, Yang, J.
Deposit date:2019-12-03
Release date:2020-01-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.71 Å)
Cite:Structural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10
Biorxiv, 2022
3O7W
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BU of 3o7w by Molmil
The Crystal Structure of Human Leucine Carboxyl Methyltransferase 1
Descriptor: GLYCEROL, Leucine carboxyl methyltransferase 1, S-ADENOSYLMETHIONINE, ...
Authors:Tsai, M.L, Cronin, N, Djordjevic, S.
Deposit date:2010-08-01
Release date:2010-09-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A
Acta Crystallogr.,Sect.D, 67, 2011
5JRT
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BU of 5jrt by Molmil
Crystal structure of the human Tankyrase 2 (TNKS2) SAM domain (DH902/924RE)
Descriptor: Tankyrase-2
Authors:Guettler, S, Mariotti, L, Cronin, N.
Deposit date:2016-05-06
Release date:2016-08-03
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-beta-Catenin Signaling.
Mol.Cell, 63, 2016
4CAD
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BU of 4cad by Molmil
Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Kulkarni, K, Manolaridis, I, Dodd, R.B, Cronin, N, Ogasawara, S, Iwata, S, Barford, D.
Deposit date:2013-10-08
Release date:2013-11-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism of Farnesylated Caax Protein Processing by the Intramembrane Protease Rce1
Nature, 504, 2013
5EHL
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BU of 5ehl by Molmil
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
Descriptor: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea, Dual specificity protein kinase TTK
Authors:Innocenti, P, Woodward, H.L, Solanki, S, Naud, N, Westwood, I.M, Cronin, N, Hayes, A, Roberts, J, Henley, A.T, Baker, R, Faisal, A, Mak, G, Box, G, Valenti, M, De Haven Brandon, A, O'Fee, L, Saville, J, Schmitt, J, Burke, R, van Montfort, R.L.M, Raymaud, F.I, Eccles, S.A, Linardopoulos, S, Blagg, J, Hoelder, S.
Deposit date:2015-10-28
Release date:2016-11-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
To Be Published
5EHO
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BU of 5eho by Molmil
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
Descriptor: DIMETHYL SULFOXIDE, Dual specificity protein kinase TTK, ~{N}8-cyclohexyl-~{N}2-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine
Authors:Innocenti, P, Woodward, H.L, Solanki, S, Naud, N, Westwood, I.M, Cronin, N, Hayes, A, Roberts, J, Henley, A.T, Baker, R, Faisal, A, Mak, G, Box, G, Valenti, M, De Haven Brandon, A, O'Fee, L, Saville, J, Schmitt, J, Burke, R, van Montfort, R.L.M, Raymaud, F.I, Eccles, S.A, Linardopoulos, S, Blagg, J, Hoelder, S.
Deposit date:2015-10-28
Release date:2016-11-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
To Be Published
2XW7
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BU of 2xw7 by Molmil
Structure of Mycobacterium smegmatis putative reductase MS0308
Descriptor: DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SODIUM ION, ...
Authors:Evangelopoulos, D, Gupta, A, Lack, N, Cronin, N, Daviter, T, Sim, E, Keep, N.H, Bhakta, S.
Deposit date:2010-11-01
Release date:2010-12-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of an Oxidoreductase from the Arylamine N-Acetyltransferase Operon in Mycobacterium Smegmatis.
FEBS J., 278, 2011
5EH0
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BU of 5eh0 by Molmil
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
Descriptor: DIMETHYL SULFOXIDE, Dual specificity protein kinase TTK, N2-(2-Methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine
Authors:Innocenti, P, Woodward, H.L, Solanki, S, Naud, N, Westwood, I.M, Cronin, N, Hayes, A, Roberts, J, Henley, A.T, Baker, R, Faisal, A, Mak, G, Box, G, Valenti, M, De Haven Brandon, A, O'Fee, L, Saville, J, Schmitt, J, Burke, R, van Montfort, R.L.M, Raymaud, F.I, Eccles, S.A, Linardopoulos, S, Blagg, J, Hoelder, S.
Deposit date:2015-10-27
Release date:2016-04-20
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
J.Med.Chem., 59, 2016
5EI2
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BU of 5ei2 by Molmil
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
Descriptor: Dual specificity protein kinase TTK, ~{N}-(2,4-dimethoxyphenyl)-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amine
Authors:Innocenti, P, Woodward, H.L, Solanki, S, Naud, N, Westwood, I.M, Cronin, N, Hayes, A, Roberts, J, Henley, A.T, Baker, R, Faisal, A, Mak, G, Box, G, Valenti, M, De Haven Brandon, A, O'Fee, L, Saville, J, Schmitt, J, Burke, R, van Montfort, R.L.M, Raymaud, F.I, Eccles, S.A, Linardopoulos, S, Blagg, J, Hoelder, S.
Deposit date:2015-10-29
Release date:2016-04-20
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
J.Med.Chem., 59, 2016
5EI6
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BU of 5ei6 by Molmil
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
Descriptor: DIMETHYL SULFOXIDE, Dual specificity protein kinase TTK, ~{N}-(2,4-dimethoxyphenyl)-5-(1-methylpyrazol-4-yl)isoquinolin-3-amine
Authors:Innocenti, P, Woodward, H.L, Solanki, S, Naud, N, Westwood, I.M, Cronin, N, Hayes, A, Roberts, J, Henley, A.T, Baker, R, Faisal, A, Mak, G, Box, G, Valenti, M, De Haven Brandon, A, O'Fee, L, Saville, J, Schmitt, J, Burke, R, van Montfort, R.L.M, Raymaud, F.I, Eccles, S.A, Linardopoulos, S, Blagg, J, Hoelder, S.
Deposit date:2015-10-29
Release date:2016-04-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
J.Med.Chem., 59, 2016
5EHY
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BU of 5ehy by Molmil
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
Descriptor: 1,2-ETHANEDIOL, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 4-(furan-3-yl)-3-phenyl-2~{H}-pyrazolo[4,3-c]pyridine, ...
Authors:Innocenti, P, Woodward, H.L, Solanki, S, Naud, N, Westwood, I.M, Cronin, N, Hayes, A, Roberts, J, Henley, A.T, Baker, R, Faisal, A, Mak, G, Box, G, Valenti, M, De Haven Brandon, A, O'Fee, L, Saville, J, Schmitt, J, Burke, R, van Montfort, R.L.M, Raymaud, F.I, Eccles, S.A, Linardopoulos, S, Blagg, J, Hoelder, S.
Deposit date:2015-10-29
Release date:2016-04-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
J.Med.Chem., 59, 2016
5EI8
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BU of 5ei8 by Molmil
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
Descriptor: DIMETHYL SULFOXIDE, Dual specificity protein kinase TTK, ~{N}-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amine
Authors:Innocenti, P, Woodward, H.L, Solanki, S, Naud, N, Westwood, I.M, Cronin, N, Hayes, A, Roberts, J, Henley, A.T, Baker, R, Faisal, A, Mak, G, Box, G, Valenti, M, De Haven Brandon, A, O'Fee, L, Saville, J, Schmitt, J, Burke, R, van Montfort, R.L.M, Raymaud, F.I, Eccles, S.A, Linardopoulos, S, Blagg, J, Hoelder, S.
Deposit date:2015-10-29
Release date:2016-04-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
J.Med.Chem., 59, 2016
2WJ7
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BU of 2wj7 by Molmil
human alphaB crystallin
Descriptor: ALPHA-CRYSTALLIN B CHAIN
Authors:Naylor, C.E, Bagneris, C, Bateman, O.A, Cronin, N, Keep, N.H, Slingsby, C.
Deposit date:2009-05-22
Release date:2009-08-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.631 Å)
Cite:Crystal Structures of Alpha-Crystallin Domain Dimers of Alphab-Crystallin and Hsp20.
J.Mol.Biol., 392, 2009
2WJ5
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BU of 2wj5 by Molmil
Rat alpha crystallin domain
Descriptor: HEAT SHOCK PROTEIN BETA-6
Authors:Naylor, C.E, Bagneris, C, Bateman, O.A, Cronin, N, Keep, N.H, Slingsby, C.
Deposit date:2009-05-22
Release date:2009-08-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Crystal Structures of Alpha-Crystallin Domain Dimers of Alphab-Crystallin and Hsp20.
J.Mol.Biol., 392, 2009
4BH6
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BU of 4bh6 by Molmil
Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex
Descriptor: APC/C ACTIVATOR PROTEIN CDH1, APC/C-CDH1 MODULATOR 1
Authors:He, J, Chao, W.C.H, Zhang, Z, Yang, J, Cronin, N, Barford, D.
Deposit date:2013-03-29
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights Into Degron Recognition by Apc/C Coactivators from the Structure of an Acm1-Cdh1 Complex.
Mol.Cell, 50, 2013
3JQO
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BU of 3jqo by Molmil
Crystal structure of the outer membrane complex of a type IV secretion system
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, LAURYL DIMETHYLAMINE-N-OXIDE, TraF protein, ...
Authors:Chandran, V, Fronzes, R, Duquerroy, S, Cronin, N, Navaza, J, Waksman, G.
Deposit date:2009-09-07
Release date:2009-12-01
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the outer membrane complex of a type IV secretion system
Nature, 462, 2009
5BPT
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BU of 5bpt by Molmil
Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain
Descriptor: MGC81278 protein
Authors:Cronin, N, Yang, J, Zhang, Z, Barford, D.
Deposit date:2015-05-28
Release date:2015-09-02
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
5BPZ
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BU of 5bpz by Molmil
Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain
Descriptor: 1,2-ETHANEDIOL, Anapc5 protein
Authors:Cronin, N, Yang, J, Zhang, Z, Barford, D.
Deposit date:2015-05-28
Release date:2015-09-02
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
6TKZ
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BU of 6tkz by Molmil
Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42
Descriptor: Cell division control protein 42 homolog, Dedicator of cytokinesis protein 10, GLYCEROL, ...
Authors:Barford, D.
Deposit date:2019-11-29
Release date:2020-01-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10
Biorxiv, 2022
6R6H
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BU of 6r6h by Molmil
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Descriptor: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Morris, E.P, Faull, S.V, Lau, A.M.C, Politis, A, Beuron, F, Cronin, N.
Deposit date:2019-03-27
Release date:2019-08-28
Last modified:2019-09-04
Method:ELECTRON MICROSCOPY (8.4 Å)
Cite:Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
7ZBU
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BU of 7zbu by Molmil
CryoEM structure of SARS-CoV-2 spike monomer in complex with neutralising antibody P008_60
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-2-[[5-[(3-ethyl-4-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, P008_60 antibody, ...
Authors:Rosa, A, Pye, V.E, Cronin, N, Cherepanov, P.
Deposit date:2022-03-24
Release date:2022-08-17
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (4.31 Å)
Cite:A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination.
Cell Rep, 40, 2022

 

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