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6O97
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PROPYLAMYCIN AND BOUND TO MRNA AND A-, P-, AND E-SITE TRNAS AT 2.75A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Matsushita, T., Sati, G.C., Kondasinghe, N., Pirrone, M.G., Kato, T., Waduge, P., Kumar, H.S., Sanchon, A.C., Dobosz-Bartoszek, M., Shcherbakov, D., Juhas, M., Hobbie, S.N., Schrepfer, T., Chow, C.S., Polikanov, Y.S., Schacht, J., Vasella, A., Bottger, E.C., Crich, D.
Deposit date:2019-03-13
Release date:2019-04-17
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
J. Am. Chem. Soc., 141, 2019
1TX7
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BOVINE TRYPSIN COMPLEXED WITH P-AMIDINOPHENYLMETHYLPHOSPHINIC ACID (AMPA)
Descriptor:Trypsinogen, CALCIUM ION, (4-CARBAMIMIDOYLPHENYL)-METHYL-PHOSPHINIC ACID
Authors:Cui, J., Marankan, F., Fu, W., Crich, D., Mesecar, A., Johnson, M.E.
Deposit date:2004-07-02
Release date:2005-09-20
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:An oxyanion-hole selective serine protease inhibitor in complex with trypsin.
Bioorg.Med.Chem., 10, 2002
1TX8
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BOVINE TRYPSIN COMPLEXED WITH AMSO
Descriptor:Trypsinogen, CALCIUM ION, 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE
Authors:Mesecar, A.D.
Deposit date:2004-07-02
Release date:2005-10-18
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa
Bioorg.Med.Chem.Lett., 14, 2004