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6O97
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BU of 6o97 by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution
Descriptor: (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxyc yclohexyl 2-amino-2,4-dideoxy-4-propyl-alpha-D-glucopyranoside, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Matsushita, T, Sati, G.C, Kondasinghe, N, Pirrone, M.G, Kato, T, Waduge, P, Kumar, H.S, Sanchon, A.C, Dobosz-Bartoszek, M, Shcherbakov, D, Juhas, M, Hobbie, S.N, Schrepfer, T, Chow, C.S, Polikanov, Y.S, Schacht, J, Vasella, A, Bottger, E.C, Crich, D.
Deposit date:2019-03-13
Release date:2019-04-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
J. Am. Chem. Soc., 141, 2019
1TX7
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BU of 1tx7 by Molmil
Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)
Descriptor: (4-CARBAMIMIDOYLPHENYL)-METHYL-PHOSPHINIC ACID, CALCIUM ION, Trypsinogen
Authors:Cui, J, Marankan, F, Fu, W, Crich, D, Mesecar, A, Johnson, M.E.
Deposit date:2004-07-02
Release date:2005-09-20
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:An oxyanion-hole selective serine protease inhibitor in complex with trypsin.
Bioorg.Med.Chem., 10, 2002
1TX8
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BU of 1tx8 by Molmil
Bovine Trypsin complexed with AMSO
Descriptor: 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE, CALCIUM ION, Trypsinogen
Authors:Mesecar, A.D.
Deposit date:2004-07-02
Release date:2005-10-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa
Bioorg.Med.Chem.Lett., 14, 2004
7SKR
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BU of 7skr by Molmil
BtSCoV-Rf1.2004 Papain-Like protease bound to the non-covalent inhibitor 37
Descriptor: 3C-like proteinase, DIMETHYL SULFOXIDE, N-[(2-methoxypyridin-4-yl)methyl]-2-[(1R)-1-(naphthalen-1-yl)ethyl]-2-azaspiro[3.3]heptane-6-carboxamide, ...
Authors:Durie, I, Shepard, J, Freitas, B, O'Boyle, B, Enos, S, Pegan, S.D.
Deposit date:2021-10-21
Release date:2022-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses.
Acs Infect Dis., 8, 2022
7SKQ
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BU of 7skq by Molmil
BtSCoV-Rf1.2004 Papain-Like protease bound to the non-covalent inhibitor GRL-0617
Descriptor: 3C-like proteinase, 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, ZINC ION
Authors:Freitas, B, Durie, I, Shepard, J, O'Boyle, B, Enos, S, Pegan, S.D.
Deposit date:2021-10-21
Release date:2022-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses.
Acs Infect Dis., 8, 2022

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