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1TC1
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BU of 1tc1 by Molmil
A 1.4 ANGSTROM CRYSTAL STRUCTURE FOR THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE OF TRYPANOSOMA CRUZI
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FORMYCIN B, PROTEIN (HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE)
Authors:Focia, P.J, Craig III, S.P, Nieves-Alicea, R, Fletterick, R.J, Eakin, A.E.
Deposit date:1998-09-30
Release date:1999-10-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi.
Biochemistry, 37, 1998
1TC2
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TERNARY SUBSTRATE COMPLEX OF THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE FROM TRYPANOSOMA CRUZI
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, MAGNESIUM ION, ...
Authors:Focia, P.J, Craig III, S.P, Eakin, A.E.
Deposit date:1998-11-04
Release date:2000-03-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Approaching the transition state in the crystal structure of a phosphoribosyltransferase.
Biochemistry, 37, 1998
1P19
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Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, in complex with the product IMP
Descriptor: INOSINIC ACID, hypoxanthine phosphoribosyltransferase
Authors:Medrano, F.J, Eakin, A.E, Craig III, S.P.
Deposit date:2003-04-11
Release date:2004-05-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase.
J.Mol.Biol., 335, 2004
1P18
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BU of 1p18 by Molmil
Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, K68R mutant, ternary substrates complex
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, MAGNESIUM ION, ...
Authors:Canyuk, B, Eakin, A.E, Craig III, S.P.
Deposit date:2003-04-11
Release date:2004-05-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase
J.Mol.Biol., 335, 2004
1P17
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BU of 1p17 by Molmil
Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, K68R mutant, complexed with the product IMP
Descriptor: INOSINIC ACID, hypoxanthine phosphoribosyltransferase
Authors:Medrano, F.J, Eakin, A.E, Craig III, S.P.
Deposit date:2003-04-11
Release date:2004-05-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase.
J.Mol.Biol., 335, 2004
1D6N
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BU of 1d6n by Molmil
TERNARY COMPLEX STRUCTURE OF HUMAN HGPRTASE, PRPP, MG2+, AND THE INHIBITOR HPP REVEALS THE INVOLVEMENT OF THE FLEXIBLE LOOP IN SUBSTRATE BINDING
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 3H-PYRAZOLO[4,3-D]PYRIMIDIN-7-OL, MAGNESIUM ION, ...
Authors:Balendiran, G.K.
Deposit date:1999-10-14
Release date:1999-12-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding.
Protein Sci., 8, 1999

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